LOCUS       NM_000865               1826 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 1E (HTR1E), mRNA.
ACCESSION   NM_000865
VERSION     NM_000865.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1826)
  AUTHORS   Tan,Y., Xu,P., Huang,S., Yang,G., Zhou,F., He,X., Ma,H., Xu,H.E.
            and Jiang,Y.
  TITLE     Structural insights into the ligand binding and Gi coupling of
            serotonin receptor 5-HT5A
  JOURNAL   Cell Discov 8 (1), 50 (2022)
   PUBMED   35610220
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1826)
  AUTHORS   Sharma,V.K., Yang,X., Kim,S.K., Mafi,A., Saiz-Sanchez,D.,
            Villanueva-Anguita,P., Xiao,L., Inoue,A., Goddard,W.A. 3rd and
            Loh,Y.P.
  TITLE     Novel interaction between neurotrophic
            factor-alpha1/carboxypeptidase E and serotonin receptor, 5-HTR1E,
            protects human neurons against oxidative/neuroexcitotoxic stress
            via beta-arrestin/ERK signaling
  JOURNAL   Cell Mol Life Sci 79 (1), 24 (2021)
   PUBMED   34966948
  REMARK    GeneRIF: Novel interaction between neurotrophic
            factor-alpha1/carboxypeptidase E and serotonin receptor, 5-HTR1E,
            protects human neurons against oxidative/neuroexcitotoxic stress
            via beta-arrestin/ERK signaling.
            Erratum:[Cell Mol Life Sci. 2023 Feb 20;80(3):65. doi:
            10.1007/s00018-023-04711-0.. PMID: 36808009]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1826)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1826)
  AUTHORS   Qin,X., Li,J., Wang,S., Lv,J., Luan,F., Liu,Y., Chen,Y., Chen,X.,
            Zhao,Y., Zhu,J., Piao,Y., Zhang,W., Shi,Y., Xiang,R., Qu,P. and
            Wang,L.
  TITLE     Serotonin/HTR1E signaling blocks chronic stress-promoted
            progression of ovarian cancer
  JOURNAL   Theranostics 11 (14), 6950-6965 (2021)
   PUBMED   34093864
  REMARK    GeneRIF: Serotonin/HTR1E signaling blocks chronic stress-promoted
            progression of ovarian cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1826)
  AUTHORS   Xu,P., Huang,S., Zhang,H., Mao,C., Zhou,X.E., Cheng,X., Simon,I.A.,
            Shen,D.D., Yen,H.Y., Robinson,C.V., Harpsoe,K., Svensson,B.,
            Guo,J., Jiang,H., Gloriam,D.E., Melcher,K., Jiang,Y., Zhang,Y. and
            Xu,H.E.
  TITLE     Structural insights into the lipid and ligand regulation of
            serotonin receptors
  JOURNAL   Nature 592 (7854), 469-473 (2021)
   PUBMED   33762731
REFERENCE   6  (bases 1 to 1826)
  AUTHORS   Levy,F.O., Holtgreve-Grez,H., Tasken,K., Solberg,R., Ried,T. and
            Gudermann,T.
  TITLE     Assignment of the gene encoding the 5-HT1E serotonin receptor (S31)
            (locus HTR1E) to human chromosome 6q14-q15
  JOURNAL   Genomics 22 (3), 637-640 (1994)
   PUBMED   8001977
REFERENCE   7  (bases 1 to 1826)
  AUTHORS   Zgombick,J.M., Schechter,L.E., Macchi,M., Hartig,P.R.,
            Branchek,T.A. and Weinshank,R.L.
  TITLE     Human gene S31 encodes the pharmacologically defined serotonin
            5-hydroxytryptamine1E receptor
  JOURNAL   Mol Pharmacol 42 (2), 180-185 (1992)
   PUBMED   1513320
REFERENCE   8  (bases 1 to 1826)
  AUTHORS   McAllister,G., Charlesworth,A., Snodin,C., Beer,M.S., Noble,A.J.,
            Middlemiss,D.N., Iversen,L.L. and Whiting,P.
  TITLE     Molecular cloning of a serotonin receptor from human brain (5HT1E):
            a fifth 5HT1-like subtype
  JOURNAL   Proc Natl Acad Sci U S A 89 (12), 5517-5521 (1992)
   PUBMED   1608964
REFERENCE   9  (bases 1 to 1826)
  AUTHORS   Levy,F.O., Gudermann,T., Birnbaumer,M., Kaumann,A.J. and
            Birnbaumer,L.
  TITLE     Molecular cloning of a human gene (S31) encoding a novel serotonin
            receptor mediating inhibition of adenylyl cyclase
  JOURNAL   FEBS Lett 296 (2), 201-206 (1992)
   PUBMED   1733778
REFERENCE   10 (bases 1 to 1826)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL521170.3, AL157777.5, BC069751.1 and M91467.1.
            
            On Nov 23, 2018 this sequence version replaced NM_000865.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.49482.1,
                                           SRR1660805.202329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305344.7/ ENSP00000307766.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL521170.3         223-232
            11-199              AL157777.5         68093-68281
            200-1011            BC069751.1         1-812
            1012-1826           M91467.1           1097-1911
FEATURES             Location/Qualifiers
     source          1..1826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.3"
     gene            1..1826
                     /gene="HTR1E"
                     /gene_synonym="5-HT1E"
                     /note="5-hydroxytryptamine receptor 1E"
                     /db_xref="GeneID:3354"
                     /db_xref="HGNC:HGNC:5291"
                     /db_xref="MIM:182132"
     exon            1..296
                     /gene="HTR1E"
                     /gene_synonym="5-HT1E"
                     /inference="alignment:Splign:2.1.0"
     exon            297..1826
                     /gene="HTR1E"
                     /gene_synonym="5-HT1E"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..1579
                     /gene="HTR1E"
                     /gene_synonym="5-HT1E"
                     /note="S31; 5-HT-1E; serotonin receptor 1E;
                     5-hydroxytryptamine (serotonin) receptor 1E, G
                     protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1E"
                     /protein_id="NP_000856.1"
                     /db_xref="CCDS:CCDS5006.1"
                     /db_xref="GeneID:3354"
                     /db_xref="HGNC:HGNC:5291"
                     /db_xref="MIM:182132"
                     /translation="MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVI
                     MAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVD
                     MTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFW
                     RSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGS
                     SRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPG
                     ERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGY
                     VNSLINPLLYTSFNEDFKLAFKKLIRCREHT"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR1E"
                     /gene_synonym="5-HT1E"
                     /note="hexamer: AATAAA"
     polyA_site      1826
                     /gene="HTR1E"
                     /gene_synonym="5-HT1E"
                     /note="major polyA site"
ORIGIN      
        1 agtccaggcg cccagactcg gcgaagcgca gcgcctgcca ccagcggtgc ctcgggctgc
       61 ccggcgcgcc gcgctcccag gttctgtctc gccgcacccc ggcgggcact ggcgcgggca
      121 aggacgctgg cggggagaac gccctgggct caacgtactc cagaatcgaa tgttgagaga
      181 agcagtgctc tgatccagct caggagaaaa aggagcgggt tccgagtgag acttctggag
      241 ccagctggac gtgccggttt gcccagtgcg gcgcggctgc acgcaccgtc cacaaggaac
      301 cttcactcag aagaaatgct gtggcccttc cctttaccaa cagaaaatgg aacacaagag
      361 accacatagc tgaacaaatt atagcctcct tacaagtgag aaaccttcga ggctacatag
      421 ttttcagcca aaggaaaata accaacagct tctccacagt gtagactgaa acaagggaaa
      481 catgaacatc acaaactgta ccacagaggc cagcatggct ataagaccca agaccatcac
      541 tgagaagatg ctcatttgca tgactctggt ggtcatcacc accctcacca cgttgctgaa
      601 cttggctgtg atcatggcta ttggcaccac caagaagctc caccagcctg ccaactacct
      661 aatctgttct ctggccgtga cggacctcct ggtggcagtg ctcgtcatgc ccctgagcat
      721 catctacatt gtcatggatc gctggaagct tgggtacttc ctctgtgagg tgtggctgag
      781 tgtggacatg acctgctgca cctgctccat cctccacctc tgtgtcattg ccctggacag
      841 gtactgggcc atcaccaatg ctattgaata cgccaggaag aggacggcca agagggccgc
      901 gctgatgatc cttaccgtct ggaccatctc cattttcatc tccatgcccc ctctgttctg
      961 gagaagccac cgccgcctaa gccctccccc tagtcagtgc accatccagc acgaccatgt
     1021 tatctacacc atttactcca cgctgggtgc gttttatatc cccttgactt tgatactgat
     1081 tctctattac cggatttacc acgcggccaa gagcctttac cagaaaaggg gatcaagtcg
     1141 gcacttaagc aacagaagca cagatagcca gaattctttt gcaagttgta aacttacaca
     1201 gactttctgt gtgtctgact tctccacctc agaccctacc acagagtttg aaaagttcca
     1261 tgcctccatc aggatccccc ccttcgacaa tgatctagat cacccaggag aacgtcagca
     1321 gatctctagc accagggaac ggaaggcagc acgcatcctg gggctgattc tgggtgcatt
     1381 cattttatcc tggctgccat ttttcatcaa agagttgatt gtgggtctga gcatctacac
     1441 cgtgtcctcg gaagtggccg actttctgac gtggctcggt tatgtgaatt ctctgatcaa
     1501 ccctctgctc tatacgagtt ttaatgaaga ctttaagctg gcttttaaaa agctcattag
     1561 atgccgagag catacttaga ctgtaaaaag ctaaaaggca cgactttttc cagagcctca
     1621 tgagtggatg ggggtaaggg gtgcaactta ttaattcttg aacatacttg gttcaggaga
     1681 gtttgtaagt atgtgtggtc ttgtttcctt gtttgtttgt ttgttttgtt ctgttttgtt
     1741 tgaggattgt tatttggcgt gctgttttct acctctggtc ttatctgtga tacataattt
     1801 caaataaaca ttatcataca aaaaca
//
