LOCUS       NM_000864               3319 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 1D (HTR1D), mRNA.
ACCESSION   NM_000864
VERSION     NM_000864.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3319)
  AUTHORS   Jin,X., Li,H., Li,B., Zhang,C. and He,Y.
  TITLE     Knockdown and inhibition of hydroxytryptamine receptor 1D suppress
            proliferation and migration of gastric cancer cells
  JOURNAL   Biochem Biophys Res Commun 620, 143-149 (2022)
   PUBMED   35785570
  REMARK    GeneRIF: Knockdown and inhibition of hydroxytryptamine receptor 1D
            suppress proliferation and migration of gastric cancer cells.
REFERENCE   2  (bases 1 to 3319)
  AUTHORS   Wu,W., Li,Q., Zhu,Z., Li,C., Lu,P., Zhou,X., Huang,Y., Liu,Y.,
            Wang,M. and Gong,J.
  TITLE     HTR1D functions as a key target of HOXA10-AS/miR-340-3p axis to
            promote the malignant outcome of pancreatic cancer via PI3K-AKT
            signaling pathway
  JOURNAL   Int J Biol Sci 18 (9), 3777-3794 (2022)
   PUBMED   35813473
  REMARK    GeneRIF: HTR1D functions as a key target of HOXA10-AS/miR-340-3p
            axis to promote the malignant outcome of pancreatic cancer via
            PI3K-AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3319)
  AUTHORS   Xu,P., Huang,S., Zhang,H., Mao,C., Zhou,X.E., Cheng,X., Simon,I.A.,
            Shen,D.D., Yen,H.Y., Robinson,C.V., Harpsoe,K., Svensson,B.,
            Guo,J., Jiang,H., Gloriam,D.E., Melcher,K., Jiang,Y., Zhang,Y. and
            Xu,H.E.
  TITLE     Structural insights into the lipid and ligand regulation of
            serotonin receptors
  JOURNAL   Nature 592 (7854), 469-473 (2021)
   PUBMED   33762731
REFERENCE   4  (bases 1 to 3319)
  AUTHORS   Zuo,X., Chen,Z., Cai,J., Gao,W., Zhang,Y., Han,G., Pu,L., Wu,Z.,
            You,W., Qin,J., Dai,X., Shen,H., Wu,J. and Wang,X.
  TITLE     5-Hydroxytryptamine Receptor 1D Aggravates Hepatocellular Carcinoma
            Progression Through FoxO6 in AKT-Dependent and Independent Manners
  JOURNAL   Hepatology 69 (5), 2031-2047 (2019)
   PUBMED   30561038
  REMARK    GeneRIF: significantly promotes hepatocellular carcinoma (HCC)
            proliferation, epithelial-mesenchymal transition, and metastasis;
            elevated expression level predicts poor overall survival and high
            recurrence probability in HCC patients
REFERENCE   5  (bases 1 to 3319)
  AUTHORS   Sui,H., Xu,H., Ji,Q., Liu,X., Zhou,L., Song,H., Zhou,X., Xu,Y.,
            Chen,Z., Cai,J., Ji,G. and Li,Q.
  TITLE     5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer
            metastasis by regulating Axin1/beta-catenin/MMP-7 signaling pathway
  JOURNAL   Oncotarget 6 (28), 25975-25987 (2015)
   PUBMED   26214021
  REMARK    GeneRIF: Data show that 5-hydroxytryptamine receptor (5-HT1DR)
            played an important role in cell invasion via
            Axin1/beta-catenin/matrix metalloproteinase 7 (MMP-7) pathway.
REFERENCE   6  (bases 1 to 3319)
  AUTHORS   Hamblin,M.W., Metcalf,M.A., McGuffin,R.W. and Karpells,S.
  TITLE     Molecular cloning and functional characterization of a human 5-HT1B
            serotonin receptor: a homologue of the rat 5-HT1B receptor with
            5-HT1D-like pharmacological specificity
  JOURNAL   Biochem Biophys Res Commun 184 (2), 752-759 (1992)
   PUBMED   1315531
REFERENCE   7  (bases 1 to 3319)
  AUTHORS   Weinshank,R.L., Zgombick,J.M., Macchi,M.J., Branchek,T.A. and
            Hartig,P.R.
  TITLE     Human serotonin 1D receptor is encoded by a subfamily of two
            distinct genes: 5-HT1D alpha and 5-HT1D beta
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3630-3634 (1992)
   PUBMED   1565658
REFERENCE   8  (bases 1 to 3319)
  AUTHORS   Libert,F., Passage,E., Parmentier,M., Simons,M.J., Vassart,G. and
            Mattei,M.G.
  TITLE     Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor,
            and a new subtype of serotonin receptor
  JOURNAL   Genomics 11 (1), 225-227 (1991)
   PUBMED   1662665
  REMARK    Erratum:[Genomics 1994 Sep 1;23(1):305]
REFERENCE   9  (bases 1 to 3319)
  AUTHORS   Hamblin,M.W. and Metcalf,M.A.
  TITLE     Primary structure and functional characterization of a human
            5-HT1D-type serotonin receptor
  JOURNAL   Mol Pharmacol 40 (2), 143-148 (1991)
   PUBMED   1652050
REFERENCE   10 (bases 1 to 3319)
  AUTHORS   Libert,F., Parmentier,M., Lefort,A., Dinsart,C., Van Sande,J.,
            Maenhaut,C., Simons,M.J., Dumont,J.E. and Vassart,G.
  TITLE     Selective amplification and cloning of four new members of the G
            protein-coupled receptor family
  JOURNAL   Science 244 (4904), 569-572 (1989)
   PUBMED   2541503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353585.34 and AL049576.19.
            
            On Jun 8, 2020 this sequence version replaced NM_000864.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.419.1,
                                           SRR1803612.167795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2153733
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374619.2/ ENSP00000363748.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AL353585.34        6027-6238           c
            213-3319            AL049576.19        45170-48276         c
FEATURES             Location/Qualifiers
     source          1..3319
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..3319
                     /gene="HTR1D"
                     /gene_synonym="5-HT1D; HT1DA; HTR1DA; HTRL; RDC4"
                     /note="5-hydroxytryptamine receptor 1D"
                     /db_xref="GeneID:3352"
                     /db_xref="HGNC:HGNC:5289"
                     /db_xref="MIM:182133"
     exon            1..212
                     /gene="HTR1D"
                     /gene_synonym="5-HT1D; HT1DA; HTR1DA; HTRL; RDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            213..3319
                     /gene="HTR1D"
                     /gene_synonym="5-HT1D; HT1DA; HTR1DA; HTRL; RDC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             995..2128
                     /gene="HTR1D"
                     /gene_synonym="5-HT1D; HT1DA; HTR1DA; HTRL; RDC4"
                     /note="5-HT-1D; 5-HT-1D-alpha; serotonin receptor 1D;
                     serotonin 1D alpha receptor; 5-hydroxytryptamine
                     (serotonin) receptor 1D, G protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1D"
                     /protein_id="NP_000855.1"
                     /db_xref="CCDS:CCDS231.1"
                     /db_xref="GeneID:3352"
                     /db_xref="HGNC:HGNC:5289"
                     /db_xref="MIM:182133"
                     /translation="MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVV
                     LSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITH
                     TWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIA
                     IVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYG
                     RIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNH
                     VKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIH
                     PALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS"
     regulatory      3293..3298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR1D"
                     /gene_synonym="5-HT1D; HT1DA; HTR1DA; HTRL; RDC4"
                     /note="hexamer: AATAAA"
     polyA_site      3319
                     /gene="HTR1D"
                     /gene_synonym="5-HT1D; HT1DA; HTR1DA; HTRL; RDC4"
                     /note="major polyA site"
ORIGIN      
        1 ggagaaggag ccgcagggct ctgggagagg cggaggcagg tgcgggatcg cgagggcgcg
       61 agccggaaag ggccccgggg cggcggggcg ggcggccccc gagttcggcg ggggtcgcgg
      121 cggagacaag gcggccgcga cggggagacg ccgcgcgagg aagtggatcg ggcgggtacg
      181 ccgggtgtgc gcacctgccc gccgggcagc ggatcttctg aatgtgtccc tgctctgtga
      241 gcccacagtg atctgtttgt tttgcctggt cccagcttat gcattcttcg agtcttggta
      301 accaggatgt tttgtctgtt caggctctaa aacgatcagt gggataggaa ccgaagttaa
      361 gtagctcagg atgcgtcaag atgaacctgg gaaaaccgcg agctgctgtg ctgactggac
      421 tgcttctctg aatcggctgg aacttctttt tgtgtctagt tttaaaagct cctcagaagc
      481 aaccctaaat ccagaatcgt ttcaattact gtgaggggaa ttctgaagtt ctcattaaac
      541 acacgaatgt ctcaagcttt gaaaagagcc agatgccaaa ggcaagaatc ccagggcatt
      601 gcccacctgg gtgtgatccc ctgataattg tctaacaaat tcagcatgtg tcccctgggc
      661 atgaccatct gctgggaaaa gttccaggac cctgagacat cttgggattc ctgtggttta
      721 ggaaagacct ttaactacca gctggtagtt gtctcagcat tcttcaaata gtccggtctt
      781 gtttaatatt attattatta ttgttattta attttatttt attgcaactg tacttagaga
      841 atagtctggt cttgagacct tttcactgtg gtctgttctg gtgtacggct cccaccagtg
      901 tgaagcagaa ggatgacttt gctctgttgt caggacaacc ttgaaggaag gagccaaatg
      961 tgtggaggtc tgtgggaaga gagagccacc tagcatgtcc ccactgaacc agtcagcaga
     1021 aggccttccc caggaggcct ccaacagatc cctgaatgcc acagaaacct cagaggcttg
     1081 ggatcccagg accctccagg cgctcaagat ctcccttgcc gtggtccttt ccgtcatcac
     1141 actggccaca gtcctctcca atgcctttgt actcaccacc atcttactca ccaggaagct
     1201 ccacacccct gccaactacc tgattggctc cctggccacc accgacctct tggtttccat
     1261 cttggtaatg cccatcagca tcgcctatac catcacccac acctggaact ttggccaaat
     1321 cttgtgtgac atctggctgt cctctgacat cacgtgctgc acagcctcca tcctgcatct
     1381 ctgtgtcatt gctctggaca ggtactgggc aatcacagat gccctggaat acagtaaacg
     1441 caggacggct ggccacgcgg ccaccatgat cgccattgtc tgggccatct ccatctgcat
     1501 ctccatcccc ccgctcttct ggcggcaggc caaggcccag gaggagatgt cggactgtct
     1561 ggtgaacacc tctcagatct cctacaccat ctactccacc tgtggggcct tctacattcc
     1621 ctcggtgttg ctcatcatcc tatatggccg gatctaccgg gctgcccgga accgcatcct
     1681 gaatccaccc tcactctatg ggaagcgctt caccacggcc cacctcatca caggctctgc
     1741 cgggtcctcg ctctgctcgc tcaactccag cctccatgag gggcactcgc actcggctgg
     1801 ctcccctctc tttttcaacc acgtgaaaat caagcttgct gacagtgccc tggaacgcaa
     1861 gaggatttct gctgctcgag aaaggaaagc cactaaaatc ctgggcatca ttctgggggc
     1921 ctttatcatc tgctggctgc ccttcttcgt ggtgtctctg gtcctcccca tctgccggga
     1981 ctcctgctgg atccacccgg cgctctttga cttcttcacc tggctaggct atttaaactc
     2041 cctcatcaat ccaataatct acactgtgtt taatgaagag tttcggcaag cttttcagaa
     2101 aattgtccct ttccggaagg cctcctagtc ttattcggtg atgactcttg ttatcttttg
     2161 tgtcctgtaa cctcatcggg attgtctttt ttttttttaa ttattttctg agacttggat
     2221 taattcatgg tatcttgagt cttggttcaa tcaacagaat tgttcttttt cctgttgttt
     2281 tcttaacttc tgaaagagct gtgggtggtg gggggcgggg ggcaggactg aagatttcac
     2341 tacttagcat aatattttct ttcttttttt ttttttttga gacggagtct tgccctctcg
     2401 ccaggctgga gtgtagtggc acaatctcag ctcactgcaa cctccgcatc ccgggttcaa
     2461 gagattctgc ctcagcctcc agagtagctg ggactacaaa cgtgtgtcac caggcccagc
     2521 taatttttgt atttttaata aagacggggt ttcatcatgt tggccagggt ggtctcgatc
     2581 tcttgacctc gtgatccgcc cgcctcagca tcccaaagtg ctgggattac aggcatgagc
     2641 cactgtgcct ggccaacata atgttttcac agttcctctt tgttggaaga agtgtgtgac
     2701 ctacaagatt cctggttgat acagttcagg tgagaaactg tttgattata gaaaagaccc
     2761 cagactcaga gggaaggctc tctggtctac ctgagatcta tatggagctt aaaggagggt
     2821 gaataagatt aatgacctga attgaaagag aatttggagc caggatgggt ctccattctg
     2881 tgtggcacct tgattggaaa ataatatcca tgcgtttctt ccactgagtc tttcttagat
     2941 taaatctctc ccagttgtcc gtgaagagaa agacagtatt tgcagtgccg atgatataga
     3001 gtgacttgga gagagattca gaagttaggg gtagcggggg taggatggtt gggaccagat
     3061 tgactaccct gtacccttcc ttcttcccca atatgcctgc gccatcttca cattctgaag
     3121 ttgaaaccca tgatcacccc tttgaggtag attgaccggc tttagacgcc caccccccac
     3181 ccaccgcaag ctttgagtgg gacaccattc tgaatttttt ttctgaattt ttttttaaca
     3241 tctctttctc attagagatc tgaaaactca ttagagatgt tgagtcttat caaataaaaa
     3301 gcatgagaca tcatggcca
//
