LOCUS       NM_000863               2568 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 1B (HTR1B), mRNA.
ACCESSION   NM_000863
VERSION     NM_000863.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Gurban,P., Mambet,C., Botezatu,A., Necula,L.G., Matei,L.,
            Neagu,A.I., Pitica,I.M., Dragu,L.D., Nastasie Schulman,A.,
            Ataman,M., Nedeianu,S., Chivu-Economescu,M., Bleotu,C., Anton,G.
            and Diaconu,C.C.
  TITLE     Increased mRNA expression for serotonin receptor 1B (HTR1B) is
            associated with thrombosis in BCR::ABL1-negative myeloproliferative
            neoplasms
  JOURNAL   J Cell Mol Med 28 (16), e70024 (2024)
   PUBMED   39183370
  REMARK    GeneRIF: Increased mRNA expression for serotonin receptor 1B
            (HTR1B) is associated with thrombosis in BCR::ABL1-negative
            myeloproliferative neoplasms.
REFERENCE   2  (bases 1 to 2568)
  AUTHORS   Fernandez-de-Las-Penas,C., Ambite-Quesada,S.,
            Fernandez-Mendez,L.M., Jimenez-Antona,C., Gomez-Calero,C.,
            Pocinho,R., Valera-Calero,J.A., Cigaran-Mendez,M. and
            Arendt-Nielsen,L.
  TITLE     Association of OPRM1 rs1799971, HTR1B rs6296 and COMT rs4680
            polymorphisms with clinical phenotype among women with fibromyalgia
  JOURNAL   Sci Rep 14 (1), 11273 (2024)
   PUBMED   38760456
  REMARK    GeneRIF: Association of OPRM1 rs1799971, HTR1B rs6296 and COMT
            rs4680 polymorphisms with clinical phenotype among women with
            fibromyalgia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2568)
  AUTHORS   van Raaij,J.J. and Janssen,P.K.C.
  TITLE     The rs6296 polymorphism in the 5-HT1b receptor in Dutch men with
            lifelong premature ejaculation: a genetic case-control association
            study
  JOURNAL   J Sex Med 21 (2), 122-128 (2024)
   PUBMED   38050328
  REMARK    GeneRIF: The rs6296 polymorphism in the 5-HT1b receptor in Dutch
            men with lifelong premature ejaculation: a genetic case-control
            association study.
REFERENCE   4  (bases 1 to 2568)
  AUTHORS   Rybakova,E.Y., Avdonin,P.P., Trufanov,S.K., Goncharov,N.V. and
            Avdonin,P.V.
  TITLE     Synergistic Interaction of 5-HT1B and 5-HT2B Receptors in
            Cytoplasmic Ca2+ Regulation in Human Umbilical Vein Endothelial
            Cells: Possible Involvement in Pathologies
  JOURNAL   Int J Mol Sci 24 (18), 13833 (2023)
   PUBMED   37762136
  REMARK    GeneRIF: Synergistic Interaction of 5-HT1B and 5-HT2B Receptors in
            Cytoplasmic Ca[2+] Regulation in Human Umbilical Vein Endothelial
            Cells: Possible Involvement in Pathologies.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2568)
  AUTHORS   Palumbo,S., Mariotti,V., Vellucci,S., Antonelli,K., Anderson,N.,
            Harenski,C., Pietrini,P., Kiehl,K.A. and Pellegrini,S.
  TITLE     HTR1B genotype and psychopathy: Main effect and interaction with
            paternal maltreatment
  JOURNAL   Psychoneuroendocrinology 144, 105861 (2022)
   PUBMED   35853382
  REMARK    GeneRIF: HTR1B genotype and psychopathy: Main effect and
            interaction with paternal maltreatment.
REFERENCE   6  (bases 1 to 2568)
  AUTHORS   Zifa,E. and Fillion,G.
  TITLE     5-Hydroxytryptamine receptors
  JOURNAL   Pharmacol Rev 44 (3), 401-458 (1992)
   PUBMED   1359584
  REMARK    Review article
REFERENCE   7  (bases 1 to 2568)
  AUTHORS   Veldman,S.A. and Bienkowski,M.J.
  TITLE     Cloning and pharmacological characterization of a novel human
            5-hydroxytryptamine1D receptor subtype
  JOURNAL   Mol Pharmacol 42 (3), 439-444 (1992)
   PUBMED   1328844
REFERENCE   8  (bases 1 to 2568)
  AUTHORS   Demchyshyn,L., Sunahara,R.K., Miller,K., Teitler,M., Hoffman,B.J.,
            Kennedy,J.L., Seeman,P., Van Tol,H.H. and Niznik,H.B.
  TITLE     A human serotonin 1D receptor variant (5HT1D beta) encoded by an
            intronless gene on chromosome 6
  JOURNAL   Proc Natl Acad Sci U S A 89 (12), 5522-5526 (1992)
   PUBMED   1351684
REFERENCE   9  (bases 1 to 2568)
  AUTHORS   Hamblin,M.W., Metcalf,M.A., McGuffin,R.W. and Karpells,S.
  TITLE     Molecular cloning and functional characterization of a human 5-HT1B
            serotonin receptor: a homologue of the rat 5-HT1B receptor with
            5-HT1D-like pharmacological specificity
  JOURNAL   Biochem Biophys Res Commun 184 (2), 752-759 (1992)
   PUBMED   1315531
REFERENCE   10 (bases 1 to 2568)
  AUTHORS   Jin,H., Oksenberg,D., Ashkenazi,A., Peroutka,S.J., Duncan,A.M.,
            Rozmahel,R., Yang,Y., Mengod,G., Palacios,J.M. and O'Dowd,B.F.
  TITLE     Characterization of the human 5-hydroxytryptamine1B receptor
  JOURNAL   J Biol Chem 267 (9), 5735-5738 (1992)
   PUBMED   1348246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049595.5.
            
            On Aug 6, 2019 this sequence version replaced NM_000863.2.
            
            Summary: The protein encoded by this intronless gene is a G-protein
            coupled receptor for serotonin (5-hydroxytryptamine). Ligand
            binding activates second messengers that inhibit the activity of
            adenylate cyclase and manage the release of serotonin, dopamine,
            and acetylcholine in the brain. The encoded protein may be involved
            in several neuropsychiatric disorders and therefore is often a
            target of antidepressant and other psychotherapeutic drugs.
            [provided by RefSeq, Nov 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK290080.1, SRR1803617.112365.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369947.5/ ENSP00000358963.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2568              AL049595.5         3594-6161
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     gene            1..2568
                     /gene="HTR1B"
                     /gene_synonym="5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB;
                     HTR1D2; HTR1DB; S12"
                     /note="5-hydroxytryptamine receptor 1B"
                     /db_xref="GeneID:3351"
                     /db_xref="HGNC:HGNC:5287"
                     /db_xref="MIM:182131"
     exon            1..2568
                     /gene="HTR1B"
                     /gene_synonym="5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB;
                     HTR1D2; HTR1DB; S12"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1261
                     /gene="HTR1B"
                     /gene_synonym="5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB;
                     HTR1D2; HTR1DB; S12"
                     /note="serotonin receptor 1B; serotonin 1D beta receptor;
                     5-hydroxytryptamine (serotonin) receptor 1B, G
                     protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1B"
                     /protein_id="NP_000854.1"
                     /db_xref="CCDS:CCDS4986.1"
                     /db_xref="GeneID:3351"
                     /db_xref="HGNC:HGNC:5287"
                     /db_xref="MIM:182131"
                     /translation="MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSI
                     SLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILV
                     MPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAK
                     RTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFY
                     FPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPD
                     VPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIIS
                     LVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS"
     regulatory      2240..2245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR1B"
                     /gene_synonym="5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB;
                     HTR1D2; HTR1DB; S12"
                     /note="hexamer: AATATA"
     polyA_site      2264
                     /gene="HTR1B"
                     /gene_synonym="5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB;
                     HTR1D2; HTR1DB; S12"
                     /note="major polyA site"
     regulatory      2550..2555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR1B"
                     /gene_synonym="5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB;
                     HTR1D2; HTR1DB; S12"
                     /note="hexamer: AATAAA"
     polyA_site      2568
                     /gene="HTR1B"
                     /gene_synonym="5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB;
                     HTR1D2; HTR1DB; S12"
ORIGIN      
        1 aaacctgcga tcgccacggt ccttccgccc tctccttcgt ccgctccatg cccaagagct
       61 gcgctccgga gctggggcga ggagagccat ggaggaaccg ggtgctcagt gcgctccacc
      121 gccgcccgcg ggctccgaga cctgggttcc tcaagccaac ttatcctctg ctccctccca
      181 aaactgcagc gccaaggact acatttacca ggactccatc tccctaccct ggaaagtact
      241 gctggttatg ctattggcgc tcatcacctt ggccaccacg ctctccaatg cctttgtgat
      301 tgccacagtg taccggaccc ggaaactgca caccccggct aactacctga tcgcctctct
      361 ggcggtcacc gacctgcttg tgtccatcct ggtgatgccc atcagcacca tgtacactgt
      421 caccggccgc tggacactgg gccaggtggt ctgtgacttc tggctgtcgt cggacatcac
      481 ttgttgcact gcctccatcc tgcacctctg tgtcatcgcc ctggaccgct actgggccat
      541 cacggacgcc gtggagtact cagctaaaag gactcccaag agggcggcgg tcatgatcgc
      601 gctggtgtgg gtcttctcca tctctatctc gctgccgccc ttcttctggc gtcaggctaa
      661 ggccgaagag gaggtgtcgg aatgcgtggt gaacaccgac cacatcctct acacggtcta
      721 ctccacggtg ggtgctttct acttccccac cctgctcctc atcgccctct atggccgcat
      781 ctacgtagaa gcccgctccc ggattttgaa acagacgccc aacaggaccg gcaagcgctt
      841 gacccgagcc cagctgataa ccgactcccc cgggtccacg tcctcggtca cctctattaa
      901 ctcgcgggtt cccgacgtgc ccagcgaatc cggatctcct gtgtatgtga accaagtcaa
      961 agtgcgagtc tccgacgccc tgctggaaaa gaagaaactc atggccgcta gggagcgcaa
     1021 agccaccaag accctaggga tcattttggg agcctttatt gtgtgttggc tacccttctt
     1081 catcatctcc ctagtgatgc ctatctgcaa agatgcctgc tggttccacc tagccatctt
     1141 tgacttcttc acatggctgg gctatctcaa ctccctcatc aaccccataa tctataccat
     1201 gtccaatgag gactttaaac aagcattcca taaactgata cgttttaagt gcacaagttg
     1261 acttgccgtt tgcagtgggg tcgcctaagc gacctttggg gaccaagttg tgtctggttc
     1321 cacaggtagg tcgaatcttc tttcgcggtt tctgggtccc agcgaggctc tctctcctgg
     1381 gcaagggcaa tggatcctga gaagccagaa tagtcctgag agagagctct gaaaggagaa
     1441 gtgttgaaac taaatgtaga gcttccctgc ccaggaggag gctcacttcc tcccctcaag
     1501 ccccgggctc agcactgacc ctgcggcagc caatcccaaa gggggttgca acttttaaaa
     1561 attgataatg gaagggaatc cctgccctgc tttggtatcg tggataatgc ccactagaag
     1621 cagtgtactt gtaattgttg tctgaagcct gtctgagaca gatctacata cagcctggca
     1681 gtacttgaac tagacgctta atgccctgtg tttttggggg gagaactttg tgttacagct
     1741 taatttaaga acagttactt tggcatcatt cagtcttcac tttttgtcta tttaaacttg
     1801 gttggagaaa cttgtggatt tggtgcttca aaccctatgt gtggcttgga tggcgcagag
     1861 aaaccttgaa gagttaacag caaaattctg atgctgagat ctctattttt attatacttg
     1921 aaactatatg ggggtgggtg ggtgggaatg ggagatgagg agtgttaaac tgagaatcaa
     1981 cacctatgat tgtttgtttt ctgcagattt acaattttgt aattcctgtt tagcgattgt
     2041 caagccacaa ctctaacaaa caaaccatta tgtgtgctag tgccgaagtc tgcagactgc
     2101 tttatttttt ctcttaattt catgtacctg tcactttaca catttaaatc cccataaatg
     2161 aagggtatga tgggtgactc agcccacact gctgctatat ttcttactaa tgcaattggt
     2221 aaaaccgatt agtattggaa atatactgtt tcttaacaag aaaagtgtct ttatttctta
     2281 tccaatttag tgagatgtga aggagactga tgacatgggg atagttctta cacaattgag
     2341 gaatggggtg ggggcaatag gaggatgtat attttgactt gtaaaaaaat cttaaaatgc
     2401 atgaaacttt tatctgatag tcatttgcac tctccttccc atctgtgatt ccttgtgtgc
     2461 taacatataa agaaaccaag agaactatct tccttctcca gaaaccttaa aaatacagtt
     2521 aagggcccta aaaacgatat tgaaaagaaa ataaacttgt ttcttttt
//
