LOCUS       NM_000524               4572 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens 5-hydroxytryptamine receptor 1A (HTR1A), mRNA.
ACCESSION   NM_000524
VERSION     NM_000524.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4572)
  AUTHORS   Zhu,C.P., Liu,S.Q., Wang,K.Q., Xiong,H.L., Aristu-Zabalza,P.,
            Boyer-Diaz,Z., Feng,J.F., Song,S.H., Luo,C., Chen,W.S., Zhang,X.,
            Dong,W.H., Gracia-Sancho,J. and Xie,W.F.
  TITLE     Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to
            Decrease Portal Hypertension
  JOURNAL   Gastroenterology 167 (5), 993-1007 (2024)
   PUBMED   38906512
  REMARK    GeneRIF: Targeting 5-Hydroxytryptamine Receptor 1A in the Portal
            Vein to Decrease Portal Hypertension.
REFERENCE   2  (bases 1 to 4572)
  AUTHORS   Zhu,W., Bu,Y., Wu,L., Li,J., Song,C. and Hao,Y.
  TITLE     Association between 5-HT1A receptor C-1019G, 5-HTTLPR polymorphisms
            and panic disorder: a meta-analysis
  JOURNAL   Aging (Albany NY) 16 (17), 12293-12311 (2024)
   PUBMED   39207450
  REMARK    GeneRIF: Association between 5-HT1A receptor C-1019G, 5-HTTLPR
            polymorphisms and panic disorder: a meta-analysis.
REFERENCE   3  (bases 1 to 4572)
  AUTHORS   Obermanns,J., Meiser,H., Hoberg,S., Vesterager,C.S., Schulz,F.,
            Juckel,G. and Emons,B.
  TITLE     Genetic variation of the 5-HT1A rs6295, 5-HT2A rs6311, and CNR1
            rs1049353 and an altered endocannabinoid system in depressed
            patients
  JOURNAL   Brain Behav 13 (12), e3323 (2023)
   PUBMED   37984468
  REMARK    GeneRIF: Genetic variation of the 5-HT1A rs6295, 5-HT2A rs6311, and
            CNR1 rs1049353 and an altered endocannabinoid system in depressed
            patients.
REFERENCE   4  (bases 1 to 4572)
  AUTHORS   Liu,H., Zheng,Y., Wang,Y., Wang,Y., He,X., Xu,P., Huang,S.,
            Yuan,Q., Zhang,X., Wang,L., Jiang,K., Chen,H., Li,Z., Liu,W.,
            Wang,S., Xu,H.E. and Xu,F.
  TITLE     Recognition of methamphetamine and other amines by trace amine
            receptor TAAR1
  JOURNAL   Nature 624 (7992), 663-671 (2023)
   PUBMED   37935377
REFERENCE   5  (bases 1 to 4572)
  AUTHORS   Harkin,E.F., Nasrallah,G., Le Francois,B. and Albert,P.R.
  TITLE     Transcriptional Regulation of the Human 5-HT1A Receptor Gene by
            Lithium: Role of Deaf1 and GSK3beta
  JOURNAL   Int J Mol Sci 24 (21), 15620 (2023)
   PUBMED   37958600
  REMARK    GeneRIF: Transcriptional Regulation of the Human 5-HT1A Receptor
            Gene by Lithium: Role of Deaf1 and GSK3beta.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4572)
  AUTHORS   Varrault,A., Bockaert,J. and Waeber,C.
  TITLE     Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces
            focus formation and potentiates EGF effect on DNA synthesis
  JOURNAL   Mol Biol Cell 3 (9), 961-969 (1992)
   PUBMED   1330092
REFERENCE   7  (bases 1 to 4572)
  AUTHORS   Levy,F.O., Gudermann,T., Perez-Reyes,E., Birnbaumer,M.,
            Kaumann,A.J. and Birnbaumer,L.
  TITLE     Molecular cloning of a human serotonin receptor (S12) with a
            pharmacological profile resembling that of the 5-HT1D subtype
  JOURNAL   J Biol Chem 267 (11), 7553-7562 (1992)
   PUBMED   1559993
REFERENCE   8  (bases 1 to 4572)
  AUTHORS   Parks,C.L., Chang,L.S. and Shenk,T.
  TITLE     A polymerase chain reaction mediated by a single primer: cloning of
            genomic sequences adjacent to a serotonin receptor protein coding
            region
  JOURNAL   Nucleic Acids Res 19 (25), 7155-7160 (1991)
   PUBMED   1766875
REFERENCE   9  (bases 1 to 4572)
  AUTHORS   Melmer,G., Sherrington,R., Mankoo,B., Kalsi,G., Curtis,D. and
            Gurling,H.M.
  TITLE     A cosmid clone for the 5HT1A receptor (HTR1A) reveals a TaqI RFLP
            that shows tight linkage to dna loci D5S6, D5S39, and D5S76
  JOURNAL   Genomics 11 (3), 767-769 (1991)
   PUBMED   1685484
REFERENCE   10 (bases 1 to 4572)
  AUTHORS   el Mestikawy,S., Fargin,A., Raymond,J.R., Gozlan,H. and
            Hnatowich,M.
  TITLE     The 5-HT1A receptor: an overview of recent advances
  JOURNAL   Neurochem Res 16 (1), 1-10 (1991)
   PUBMED   2052135
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122707.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 27, 2019 this sequence version replaced NM_000524.3.
            
            Summary: This gene encodes a G protein-coupled receptor for
            5-hydroxytryptamine (serotonin), and belongs to the
            5-hydroxytryptamine receptor subfamily. Serotonin has been
            implicated in a number of physiologic processes and pathologic
            conditions. Inactivation of this gene in mice results in behavior
            consistent with an increased anxiety and stress response. Mutation
            in the promoter of this gene has been associated with menstrual
            cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK314187.1, AK291429.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323865.5/ ENSP00000316244.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4572              AC122707.2         102843-107414
FEATURES             Location/Qualifiers
     source          1..4572
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     gene            1..4572
                     /gene="HTR1A"
                     /gene_synonym="5-HT-1A; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1;
                     G-21; PFMCD"
                     /note="5-hydroxytryptamine receptor 1A"
                     /db_xref="GeneID:3350"
                     /db_xref="HGNC:HGNC:5286"
                     /db_xref="MIM:109760"
     exon            1..4572
                     /gene="HTR1A"
                     /gene_synonym="5-HT-1A; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1;
                     G-21; PFMCD"
                     /inference="alignment:Splign:2.1.0"
     CDS             727..1995
                     /gene="HTR1A"
                     /gene_synonym="5-HT-1A; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1;
                     G-21; PFMCD"
                     /note="guanine nucleotide-binding regulatory
                     protein-coupled receptor; 5-HT1a receptor;
                     5-hydroxytryptamine (serotonin) receptor 1A, G
                     protein-coupled"
                     /codon_start=1
                     /product="5-hydroxytryptamine receptor 1A"
                     /protein_id="NP_000515.2"
                     /db_xref="CCDS:CCDS34168.1"
                     /db_xref="GeneID:3350"
                     /db_xref="HGNC:HGNC:5286"
                     /db_xref="MIM:109760"
                     /translation="MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLG
                     TLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKW
                     TLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLT
                     WLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRI
                     FRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALC
                     ANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRK
                     MALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSN
                     SLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ"
     regulatory      4548..4553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTR1A"
                     /gene_synonym="5-HT-1A; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1;
                     G-21; PFMCD"
                     /note="hexamer: AATAAA"
     polyA_site      4572
                     /gene="HTR1A"
                     /gene_synonym="5-HT-1A; 5-HT1A; 5HT1a; ADRB2RL1; ADRBRL1;
                     G-21; PFMCD"
                     /note="major polyA site"
ORIGIN      
        1 gttgacaaaa agagactcga atgcaaagac gctgagctag agggagagga gggcggggac
       61 ccagaggaaa gaggcactcc tcggggttgg ggaagtatta ggaggggagg gttagagtgg
      121 gagggaagga gcctggcttt cgaagcgact cacagaggga taaataaagg gaagtgagga
      181 ggaagaggga gactgaaagg gaaggcaggt ggggagaagg gggacgaaag aggcagaaga
      241 gagagaagag aggaggagag agggggagag agggaaggaa ggaaataggg agaggagggt
      301 cacagagtga ccgtggagga tggggcttct cggttctaga tatttctggg attggagact
      361 gtttgctagt ggggagactc cagctccggc agccagttcg ggagcggcaa agtaaaatgg
      421 acagcgacag acagacgttc cagccacctc tccgccgccg ggagatcctg gagctgcttt
      481 caggccaact ccagtttccc agctggagct tctgaacgcg ctggactgcg agagcccagg
      541 gagcgcctga aagctgctcc tcggagatac ccttcgccga agcagtaaga acttcctgct
      601 tgggtctctg cattcccttc ctccgaaact tcccaggaga agggcggaag accccagggg
      661 aaggggcgag gcgaatcttc gcgctgcttt ttcttccctc ccccttcccg cgccgggcgc
      721 gcaggcatgg atgtgctcag ccctggtcag ggcaacaaca ccacatcacc accggctccc
      781 tttgagaccg gcggcaacac tactggtatc tccgacgtga ccgtcagcta ccaagtgatc
      841 acctctctgc tgctgggcac gctcatcttc tgcgcggtgc tgggcaatgc gtgcgtggtg
      901 gctgccatcg ccttggagcg ctccctgcag aacgtggcca attatcttat tggctctttg
      961 gcggtcaccg acctcatggt gtcggtgttg gtgctgccca tggccgcgct gtatcaggtg
     1021 ctcaacaagt ggacactggg ccaggtaacc tgcgacctgt tcatcgccct cgacgtgctg
     1081 tgctgcacct catccatctt gcacctgtgc gccatcgcgc tggacaggta ctgggccatc
     1141 acggacccca tcgactacgt gaacaagagg acgccccggc gcgccgctgc gctcatctcg
     1201 ctcacttggc ttattggctt cctcatctct atcccgccca tgctgggctg gcgcaccccg
     1261 gaagaccgct cggaccccga cgcatgcacc attagcaagg atcatggcta cactatctat
     1321 tccacctttg gagctttcta catcccgctg ctgctcatgc tggttctcta tgggcgcata
     1381 ttccgagctg cgcgcttccg catccgcaag acggtcaaaa aggtggagaa gaccggagcg
     1441 gacacccgcc atggagcatc tcccgccccg cagcccaaga agagtgtgaa tggagagtcg
     1501 gggagcagga actggaggct gggcgtggag agcaaggctg ggggtgctct gtgcgccaat
     1561 ggcgcggtga ggcaaggtga cgatggcgcc gccctggagg tgatcgaggt gcaccgagtg
     1621 ggcaactcca aagagcactt gcctctgccc agcgaggctg gtcctacccc ttgtgccccc
     1681 gcctctttcg agaggaaaaa tgagcgcaac gccgaggcga agcgcaagat ggccctggcc
     1741 cgagagagga agacagtgaa gacgctgggc atcatcatgg gcaccttcat cctctgctgg
     1801 ctgcccttct tcatcgtggc tcttgttctg cccttctgcg agagcagctg ccacatgccc
     1861 accctgttgg gcgccataat caattggctg ggctactcca actctctgct taaccccgtc
     1921 atttacgcat acttcaacaa ggactttcaa aacgcgttta agaagatcat taagtgtaag
     1981 ttctgccgcc agtgatgacg gaggagtagc cggccagtcg aggctacagg atccgtccca
     2041 ttcactatgc ttcccccaac cctagggaat caacacttaa gataattcgc cacttctcct
     2101 ctttctctct gctccgctca cggcttgcag acctggtccc ctccccactt cctgctccac
     2161 ggcagggccc tttgtgcaaa ggagacccag cggaggagcg ttgagagccc aggaaattca
     2221 gagagtttgt gagaagcgac attggctcag acttcgcctg tatcatcagt tttgatccca
     2281 gtaattgcct cttctctctt ctatctccta aatctttgcg gtggatgttt aatgcttagt
     2341 tcaaggcaga aaatccaaaa aataaataaa ctgtacacac agccgccgcg cccactaagg
     2401 ggctccaccc catcacccaa cttctagaac ttggacttga ggtttgggaa tttgctccat
     2461 ctctcccgcc ctgtggccct tgaaatattc acctttttct ccccattttt atcttttctt
     2521 tttttcattg cttccctctc tgccctcgcc catccttatg cacgaatctg ctggtccgga
     2581 gaggcggaag aggctgcttt tccccgtgcc agcggtgccc ccgggattcc ccgtcttctc
     2641 gcagacttga gattaactct ctcgtgcagt gcacaacccc tatttccttt gtttccttgg
     2701 actcaaagca agtggctaga aggtatcttt tagagtggac ttgtaagtac aaggccgggc
     2761 cagtggggga gagcaaggag gaggagggtg tgcagaccac tttgtttatg cttgccttgg
     2821 tgtcagcact caccaaagaa actgacaatc atacagtgga gagagcggac gctgtttgta
     2881 caggtagctg gcgagtgtgt acgacctgac atcgccactt acttactgcg ggaggcgcca
     2941 gccggccgct gtttgcgctc tggggaagct gagaggcctg gaatccgcgc gcctccccag
     3001 ccatctgtgc tctcgcagcg cgctaggcgc tcccggctgc tgacttacag gatctgggtt
     3061 cctccgccta cgctctgggg cgccctgaag cgcgggtaga cacctgaggt ttttgcctta
     3121 gccagtggcg caagatgccg cggaactctt gggattggag agaccaagaa ggctttaaag
     3181 gggcgacacg caggggcggc aaagaggaaa ggttccccag ggcgcgcgtg cccaaggctc
     3241 cagctggctc ccccagtaaa acctgaaaga gcaattttat ccttacgatg tagaattttt
     3301 cctcctaatt cacgctcttg tcctttttgg atcggggaat aattctgttt agcgtgtccc
     3361 aacactcgct gcatttgctt tacaggacat ccaagacaca aagttagcag aactttgttt
     3421 tccaaatagg aattctgggc tttcaatgga atgcccagat agtccatagg ttagcactat
     3481 ctgtgacaac aggcagatag tttaaatagc agggtcctaa aggactagtt aggaggtggt
     3541 cttcctgggg aggctgagtc ttttatggga ttaattgctc cctagcgtga ccattctgct
     3601 gtaccaaggg tctgcggaaa ccaccttttt gccctttgaa ttgtgcagca ttccaggctt
     3661 tctctccttc agttattctt gaagccttgc cactcctgcc gagaaactgg ttaaaatctt
     3721 tgctgcccca gaaagggaag ttatttaggt actctggatg taaatttcca actacatgat
     3781 ggagatctag aggtttgtca ttgtttgatc tagcctccaa ttttcttatg aataatggtc
     3841 ttgttttcca gaaaattcac aaagtaattg atccctactc ttttctctct tcagctgtac
     3901 ctttcgaatg ttttcatttg ctgttttgag aaccgtatta catttacaga ttgcaaaaat
     3961 tgccagtgaa aagttcattt gtttataatt aagaaagtga aaggacagct ctgtcagttg
     4021 aagccatttt attgtttgtc agactgaaca aagctttcct ttggtgtctg cttctgtatt
     4081 ctaaactgga agtagacatc atatcccagc taaacaggga aagttttaga actttgggaa
     4141 tagtttgtct atgcatgtat aatgctgaga agggtctgca gtgaagaaga taagatagac
     4201 ttctccagca caactattac tcatttgata attcagtttc atttttgctc acataatcta
     4261 agtaaagcca tatcagaaac caagtttttc tgtatgttac actaaatttt aagaacaaag
     4321 tctatattta aaataatcca aaccccaaat ttgctcatcc aaattatgtc ttggccagca
     4381 agttttacat tagaagtttt gagacttcca tttatttgtg tcttttacag aattgtgtga
     4441 caatgacttt tggacatttg ttctttcggc tttggaatat ttacacaaga atggagaagg
     4501 aacatccaac tggagcataa ttgtcaaggc aatagagaat ttagagaaat aaaatagctg
     4561 catatctcaa aa
//
