LOCUS       NM_000200                532 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens histatin 3 (HTN3), mRNA.
ACCESSION   NM_000200
VERSION     NM_000200.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 532)
  AUTHORS   Stewart,L.J., Hong,Y., Holmes,I.R., Firth,S.J., Ahmed,Y., Quinn,J.,
            Santos,Y., Cobb,S.L., Jakubovics,N.S. and Djoko,K.Y.
  TITLE     Salivary Antimicrobial Peptide Histatin-5 Does Not Display
            Zn(II)-Dependent or -Independent Activity against Streptococci
  JOURNAL   ACS Infect Dis 9 (3), 631-642 (2023)
   PUBMED   36826226
  REMARK    GeneRIF: Salivary Antimicrobial Peptide Histatin-5 Does Not Display
            Zn(II)-Dependent or -Independent Activity against Streptococci.
REFERENCE   2  (bases 1 to 532)
  AUTHORS   Wongpanuwich,W., Yodsanga,S., Chaisuparat,R. and Amornphimoltham,P.
  TITLE     Association Between PD-L1 and Histatin1, 3 Expression in Advanced
            Head and Neck Squamous Cell Carcinoma
  JOURNAL   Anticancer Res 42 (5), 2689-2699 (2022)
   PUBMED   35489730
  REMARK    GeneRIF: Association Between PD-L1 and Histatin1, 3 Expression in
            Advanced Head and Neck Squamous Cell Carcinoma.
REFERENCE   3  (bases 1 to 532)
  AUTHORS   Moghaddam-Taaheri,P., Leissa,J.A., Eppler,H.B., Jewell,C.M. and
            Karlsson,A.J.
  TITLE     Histatin 5 variant reduces Candida albicans biofilm viability and
            inhibits biofilm formation
  JOURNAL   Fungal Genet Biol 149, 103529 (2021)
   PUBMED   33596477
  REMARK    GeneRIF: Histatin 5 variant reduces Candida albicans biofilm
            viability and inhibits biofilm formation.
REFERENCE   4  (bases 1 to 532)
  AUTHORS   Norris,H.L., Kumar,R., Ong,C.Y., Xu,D. and Edgerton,M.
  TITLE     Zinc Binding by Histatin 5 Promotes Fungicidal Membrane Disruption
            in C. albicans and C. glabrata
  JOURNAL   J Fungi (Basel) 6 (3), 124 (2020)
   PUBMED   32751915
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 532)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 532)
  AUTHORS   Troxler,R.F., Offner,G.D., Xu,T., Vanderspek,J.C. and
            Oppenheim,F.G.
  TITLE     Structural relationship between human salivary histatins
  JOURNAL   J Dent Res 69 (1), 2-6 (1990)
   PUBMED   2303595
REFERENCE   7  (bases 1 to 532)
  AUTHORS   Sugiyama,K., Ogino,T. and Ogata,K.
  TITLE     Rapid purification and characterization of histatins
            (histidine-rich polypeptides) from human whole saliva
  JOURNAL   Arch Oral Biol 35 (6), 415-419 (1990)
   PUBMED   2372245
REFERENCE   8  (bases 1 to 532)
  AUTHORS   vanderSpek,J.C., Offner,G.D., Troxler,R.F. and Oppenheim,F.G.
  TITLE     Molecular cloning of human submandibular histatins
  JOURNAL   Arch Oral Biol 35 (2), 137-143 (1990)
   PUBMED   2344289
REFERENCE   9  (bases 1 to 532)
  AUTHORS   vanderSpek,J.C., Wyandt,H.E., Skare,J.C., Milunsky,A.,
            Oppenheim,F.G. and Troxler,R.F.
  TITLE     Localization of the genes for histatins to human chromosome 4q13
            and tissue distribution of the mRNAs
  JOURNAL   Am J Hum Genet 45 (3), 381-387 (1989)
   PUBMED   2773933
REFERENCE   10 (bases 1 to 532)
  AUTHORS   Sabatini,L.M. and Azen,E.A.
  TITLE     Histatins, a family of salivary histidine-rich proteins, are
            encoded by at least two loci (HIS1 and HIS2)
  JOURNAL   Biochem Biophys Res Commun 160 (2), 495-502 (1989)
   PUBMED   2719677
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC063956.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 12, 2019 this sequence version replaced NM_000200.2.
            
            Summary: This gene encodes a member of the histatin family of
            small, histidine-rich, cationic proteins. They function as
            antimicrobial peptides and are important components of the innate
            immune system. Histatins are found in saliva and exhibit
            antibacterial, antifungal activities and function in wound healing.
            [provided by RefSeq, Sep 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP332860.1, BP333327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000673563.1/
                                                  ENSP00000500623.1
            Protein has antimicrobial activity :: PMID: 2303595
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC063956.7         70588-70645
            59-122              AC063956.7         72857-72920
            123-143             AC063956.7         74108-74128
            144-173             AC063956.7         74207-74236
            174-260             AC063956.7         75296-75382
            261-532             AC063956.7         78396-78667
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..532
                     /gene="HTN3"
                     /gene_synonym="HIS2; Hst 3; HTN2; HTN5; PB"
                     /note="histatin 3"
                     /db_xref="GeneID:3347"
                     /db_xref="HGNC:HGNC:5284"
                     /db_xref="MIM:142702"
     exon            1..58
                     /gene="HTN3"
                     /gene_synonym="HIS2; Hst 3; HTN2; HTN5; PB"
                     /inference="alignment:Splign:2.1.0"
     exon            59..122
                     /gene="HTN3"
                     /gene_synonym="HIS2; Hst 3; HTN2; HTN5; PB"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..227
                     /gene="HTN3"
                     /gene_synonym="HIS2; Hst 3; HTN2; HTN5; PB"
                     /note="histidine-rich protein 3; basic histidine-rich
                     protein; histatin-6; histatin-5; histatin-4; histatin-9;
                     histatin-7; histatin-8"
                     /codon_start=1
                     /product="histatin-3 precursor"
                     /protein_id="NP_000191.1"
                     /db_xref="CCDS:CCDS33999.1"
                     /db_xref="GeneID:3347"
                     /db_xref="HGNC:HGNC:5284"
                     /db_xref="MIM:142702"
                     /translation="MKFFVFALILALMLSMTGADSHAKRHHGYKRKFHEKHHSHRGYR
                     SNYLYDN"
     exon            123..143
                     /gene="HTN3"
                     /gene_synonym="HIS2; Hst 3; HTN2; HTN5; PB"
                     /inference="alignment:Splign:2.1.0"
     exon            144..173
                     /gene="HTN3"
                     /gene_synonym="HIS2; Hst 3; HTN2; HTN5; PB"
                     /inference="alignment:Splign:2.1.0"
     exon            174..260
                     /gene="HTN3"
                     /gene_synonym="HIS2; Hst 3; HTN2; HTN5; PB"
                     /inference="alignment:Splign:2.1.0"
     exon            261..532
                     /gene="HTN3"
                     /gene_synonym="HIS2; Hst 3; HTN2; HTN5; PB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctcttgag acttcacttc agcttcactg acttctggat tctcctcttg agtaaaagga
       61 ctcagccaac tatgaagttt tttgtttttg ctttaatctt ggctctcatg ctttccatga
      121 ctggagctga ttcacatgca aagagacatc atgggtataa aagaaaattc catgaaaagc
      181 atcattcaca tcgaggctat agatcaaatt atctgtatga caattgatat cttcagtaat
      241 cacggggcat gattatggag gtttgactgg caaattcgct ttggactcgt gtattctcat
      301 ttgtcatacc gcatcacact accactgctt tttgaagaat tatcataagg caatgcagaa
      361 taaaagaaat accatgattt agtgaattct gtgtttcagg atacttccct tcctaattat
      421 catttgatta gatacttgca atttaaatgt taagctgttt tcactgctgt ttctgagtaa
      481 tagaaattca ttcctctcca aaagcaataa aattcaagca cattattatg tg
//
