LOCUS       NM_002159                547 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens histatin 1 (HTN1), transcript variant 1, mRNA.
ACCESSION   NM_002159
VERSION     NM_002159.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 547)
  AUTHORS   Ma,D., Sun,W., Fu,C., Nazmi,K., Veerman,E.C.I., Jaspers,R.T.,
            Bolscher,J.G.M., Bikker,F.J. and Wu,G.
  TITLE     GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of
            the internalization, mitochondria-targeting and -activating
            properties of human salivary histatin 1
  JOURNAL   Int J Oral Sci 14 (1), 42 (2022)
   PUBMED   35970844
  REMARK    GeneRIF: GPCR/endocytosis/ERK signaling/S2R is involved in the
            regulation of the internalization, mitochondria-targeting and
            -activating properties of human salivary histatin 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 547)
  AUTHORS   Wongpanuwich,W., Yodsanga,S., Chaisuparat,R. and Amornphimoltham,P.
  TITLE     Association Between PD-L1 and Histatin1, 3 Expression in Advanced
            Head and Neck Squamous Cell Carcinoma
  JOURNAL   Anticancer Res 42 (5), 2689-2699 (2022)
   PUBMED   35489730
  REMARK    GeneRIF: Association Between PD-L1 and Histatin1, 3 Expression in
            Advanced Head and Neck Squamous Cell Carcinoma.
REFERENCE   3  (bases 1 to 547)
  AUTHORS   Son,K.N., Lee,H., Shah,D., Kalmodia,S., Miller,R.C., Ali,M.,
            Balasubramaniam,A., Cologna,S.M., Kong,H., Shukla,D. and
            Aakalu,V.K.
  TITLE     Histatin-1 is an endogenous ligand of the sigma-2 receptor
  JOURNAL   FEBS J 288 (23), 6815-6827 (2021)
   PUBMED   34233061
  REMARK    GeneRIF: Histatin-1 is an endogenous ligand of the sigma-2
            receptor.
REFERENCE   4  (bases 1 to 547)
  AUTHORS   Sun,P., Shi,A., Shen,C., Liu,Y., Wu,G. and Feng,J.
  TITLE     Human salivary histatin-1 (Hst1) promotes bone morphogenetic
            protein 2 (BMP2)-induced osteogenesis and angiogenesis
  JOURNAL   FEBS Open Bio 10 (8), 1503-1515 (2020)
   PUBMED   32484586
  REMARK    GeneRIF: Human salivary histatin-1 (Hst1) promotes bone
            morphogenetic protein 2 (BMP2)-induced osteogenesis and
            angiogenesis.
REFERENCE   5  (bases 1 to 547)
  AUTHORS   Ma,D., Sun,W., Nazmi,K., Veerman,E.C.I., Bikker,F.J., Jaspers,R.T.,
            Bolscher,J.G.M. and Wu,G.
  TITLE     Salivary Histatin 1 and 2 Are Targeted to Mitochondria and
            Endoplasmic Reticulum in Human Cells
  JOURNAL   Cells 9 (4), 795 (2020)
   PUBMED   32225006
  REMARK    GeneRIF: Salivary Histatin 1 and 2 Are Targeted to Mitochondria and
            Endoplasmic Reticulum in Human Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 547)
  AUTHORS   Troxler,R.F., Offner,G.D., Xu,T., Vanderspek,J.C. and
            Oppenheim,F.G.
  TITLE     Structural relationship between human salivary histatins
  JOURNAL   J Dent Res 69 (1), 2-6 (1990)
   PUBMED   2303595
  REMARK    GeneRIF: Histatins are salivary proteins with antimicrobial
            activity.
REFERENCE   7  (bases 1 to 547)
  AUTHORS   Sugiyama,K., Ogino,T. and Ogata,K.
  TITLE     Rapid purification and characterization of histatins
            (histidine-rich polypeptides) from human whole saliva
  JOURNAL   Arch Oral Biol 35 (6), 415-419 (1990)
   PUBMED   2372245
REFERENCE   8  (bases 1 to 547)
  AUTHORS   vanderSpek,J.C., Wyandt,H.E., Skare,J.C., Milunsky,A.,
            Oppenheim,F.G. and Troxler,R.F.
  TITLE     Localization of the genes for histatins to human chromosome 4q13
            and tissue distribution of the mRNAs
  JOURNAL   Am J Hum Genet 45 (3), 381-387 (1989)
   PUBMED   2773933
REFERENCE   9  (bases 1 to 547)
  AUTHORS   Sabatini,L.M. and Azen,E.A.
  TITLE     Histatins, a family of salivary histidine-rich proteins, are
            encoded by at least two loci (HIS1 and HIS2)
  JOURNAL   Biochem Biophys Res Commun 160 (2), 495-502 (1989)
   PUBMED   2719677
REFERENCE   10 (bases 1 to 547)
  AUTHORS   Oppenheim,F.G., Xu,T., McMillian,F.M., Levitz,S.M., Diamond,R.D.,
            Offner,G.D. and Troxler,R.F.
  TITLE     Histatins, a novel family of histidine-rich proteins in human
            parotid secretion. Isolation, characterization, primary structure,
            and fungistatic effects on Candida albicans
  JOURNAL   J Biol Chem 263 (16), 7472-7477 (1988)
   PUBMED   3286634
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC063956.7.
            
            On Mar 11, 2019 this sequence version replaced NM_002159.3.
            
            Summary: This gene encodes a member of the histatin family of
            small, histidine-rich, cationic proteins. They function as
            antimicrobial peptides and are important components of the innate
            immune system. Histatins are found in saliva and exhibit
            antibacterial, antifungal activities and function in wound healing.
            [provided by RefSeq, Aug 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP335073.2, BP334413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000246896.8/
                                                  ENSP00000246896.3
            Protein has antimicrobial activity :: PMID: 2303595
            RefSeq Select criteria             :: based on expression, longest
                                                  protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC063956.7         92567-92624
            59-122              AC063956.7         95193-95256
            123-143             AC063956.7         96451-96471
            144-173             AC063956.7         96550-96579
            174-278             AC063956.7         97627-97731
            279-547             AC063956.7         100709-100977
FEATURES             Location/Qualifiers
     source          1..547
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..547
                     /gene="HTN1"
                     /gene_synonym="HIS1; Hst1"
                     /note="histatin 1"
                     /db_xref="GeneID:3346"
                     /db_xref="HGNC:HGNC:5283"
                     /db_xref="MIM:142701"
     exon            1..58
                     /gene="HTN1"
                     /gene_synonym="HIS1; Hst1"
                     /inference="alignment:Splign:2.1.0"
     exon            59..122
                     /gene="HTN1"
                     /gene_synonym="HIS1; Hst1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..245
                     /gene="HTN1"
                     /gene_synonym="HIS1; Hst1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; PPB; post-PB protein; histidine-rich protein 1"
                     /codon_start=1
                     /product="histatin-1 isoform 1 precursor"
                     /protein_id="NP_002150.1"
                     /db_xref="CCDS:CCDS3534.1"
                     /db_xref="GeneID:3346"
                     /db_xref="HGNC:HGNC:5283"
                     /db_xref="MIM:142701"
                     /translation="MKFFVFALVLALMISMISADSHEKRHHGYRRKFHEKHHSHREFP
                     FYGDYGSNYLYDN"
     exon            123..143
                     /gene="HTN1"
                     /gene_synonym="HIS1; Hst1"
                     /inference="alignment:Splign:2.1.0"
     exon            144..173
                     /gene="HTN1"
                     /gene_synonym="HIS1; Hst1"
                     /inference="alignment:Splign:2.1.0"
     exon            174..278
                     /gene="HTN1"
                     /gene_synonym="HIS1; Hst1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..547
                     /gene="HTN1"
                     /gene_synonym="HIS1; Hst1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctcttgag acttcacttc agcttcactg acttcttgac tctcctcttg agtaaaagga
       61 ctcagccaac tatgaagttt tttgtctttg ctttagtctt ggctctcatg atttccatga
      121 ttagcgctga ttcacatgaa aagagacatc atgggtatag aagaaaattc catgaaaagc
      181 atcattcaca tcgagaattt ccattttatg gggactatgg atcaaattat ctatatgaca
      241 attgatatcc ttagtaatca tggggcatga ttatagaggt ttgactggca aattcacttt
      301 ttactcattt attctcattc atcataccgc atcacactac cactgctttt tgaagaatta
      361 tcataaggca atggagaata aaagaaagac catgatttag tgaattctgt gtttcatgat
      421 acttcccttc ctaattatca tttgattaga tacttgcaat ttaaactgtt aagctgtttt
      481 cactgctgtt tctgagtaat agaaattcat tcctctccaa aagcaataaa tttctagcac
      541 attatta
//
