LOCUS       NM_001348712            3127 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens hydroxyacyl-thioester dehydratase type 2 (HTD2),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001348712
VERSION     NM_001348712.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3127)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3127)
  AUTHORS   Mouilleron,H., Delcourt,V. and Roucou,X.
  TITLE     Death of a dogma: eukaryotic mRNAs can code for more than one
            protein
  JOURNAL   Nucleic Acids Res 44 (1), 14-23 (2016)
   PUBMED   26578573
  REMARK    Review article
REFERENCE   3  (bases 1 to 3127)
  AUTHORS   Vanderperre,B., Lucier,J.F., Bissonnette,C., Motard,J.,
            Tremblay,G., Vanderperre,S., Wisztorski,M., Salzet,M.,
            Boisvert,F.M. and Roucou,X.
  TITLE     Direct detection of alternative open reading frames translation
            products in human significantly expands the proteome
  JOURNAL   PLoS One 8 (8), e70698 (2013)
   PUBMED   23950983
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3127)
  AUTHORS   Autio,K.J., Kastaniotis,A.J., Pospiech,H., Miinalainen,I.J.,
            Schonauer,M.S., Dieckmann,C.L. and Hiltunen,J.K.
  TITLE     An ancient genetic link between vertebrate mitochondrial fatty acid
            synthesis and RNA processing
  JOURNAL   FASEB J 22 (2), 569-578 (2008)
   PUBMED   17898086
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098479.2.
            
            On Jun 5, 2020 this sequence version replaced NM_001348712.1.
            
            Summary: This gene encodes a protein that localizes to the
            mitochondria and can function as a 3-hydroxyacyl thioester
            dehydratase. This gene is located just downstream of the gene for
            ribonuclease P/MRP subunit p14 (RPP14) in a genomic context that is
            conserved among animals. The upstream RPP14 gene is thought to be
            co-transcribed with this gene, and bicistronic transcripts may
            include open reading frames for both proteins. [provided by RefSeq,
            May 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK311396.1, DC424134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000461393.7/
                                                  ENSP00000484277.1
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC098479.2         118085-118216
            133-217             AC098479.2         122072-122156
            218-294             AC098479.2         128080-128156
            295-373             AC098479.2         128480-128558
            374-3127            AC098479.2         129005-131758
FEATURES             Location/Qualifiers
     source          1..3127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..3127
                     /gene="HTD2"
                     /note="hydroxyacyl-thioester dehydratase type 2"
                     /db_xref="GeneID:109703458"
                     /db_xref="HGNC:HGNC:53111"
                     /db_xref="MIM:620769"
     exon            1..132
                     /gene="HTD2"
                     /inference="alignment:Splign:2.1.0"
     exon            133..217
                     /gene="HTD2"
                     /inference="alignment:Splign:2.1.0"
     exon            218..294
                     /gene="HTD2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..373
                     /gene="HTD2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..3127
                     /gene="HTD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             548..1054
                     /gene="HTD2"
                     /EC_number="4.2.1.59"
                     /note="3-hydroxyacyl-[acyl-carrier-protein] dehydratase"
                     /codon_start=1
                     /product="hydroxyacyl-thioester dehydratase type 2,
                     mitochondrial"
                     /protein_id="NP_001335641.1"
                     /db_xref="CCDS:CCDS87096.1"
                     /db_xref="GeneID:109703458"
                     /db_xref="HGNC:HGNC:53111"
                     /db_xref="MIM:620769"
                     /translation="MFPLISSHHLWWGGLRRTVCLNLPVLTLQHFQHMHIKVGDRAEL
                     RRAFTQTDVATFSELTGDVNPLHLNEDFAKHTKFGNTIVHGVLINGLISALLGTKMPG
                     PGCVFLSQEISFPAPLYIGEVVLASAEVKKLKRFIAIIAVSCSVIESKKTVMEGWVKV
                     MVPEASKS"
     regulatory      2102..2107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTD2"
                     /note="hexamer: AATGAA"
     polyA_site      2122
                     /gene="HTD2"
                     /note="major polyA site"
     regulatory      3101..3106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTD2"
                     /note="hexamer: AATAAT"
     polyA_site      3127
                     /gene="HTD2"
                     /note="major polyA site"
ORIGIN      
        1 gtcctctccg accccgggcg ctgagggcct ctgtacggcg ccgcgtaggg tctcggccgc
       61 agaacgtggc cgagaggccc gggcgagact tcgggaccgt gtcctgagcg ctctccatgc
      121 gcccggcgcg agagaatttc aagattgtgg agttggactg aatgctgcac agttcaaaca
      181 gctgcttatt tcggctgtga aggacctgtt tggggaggtt gatgccgcct tacctttgga
      241 catcctaacc tatgaagaga agaccttgtc agccatcttg agaatatgta gcagtggtct
      301 tgtcaaattg tggagctctt tgaccctgtt aggatcctat aaaggcaaaa aatgtgcttt
      361 ccgggtgatt caggtttctc catttcttct tgcattatct ggtaatagta gggaactagt
      421 attggattga atgaatagtc ttccattttg gaaacgttca tccactctca tatttatttt
      481 ttggtgcctg catgtttgaa gactgaagca ggctaaaagc tcttgatgaa atttgagggt
      541 gctgaagatg ttcccactaa tttccagcca tcacctttgg tggggtgggc ttcggaggac
      601 agtctgtctg aacctgccag tgctgaccct gcagcacttt cagcatatgc acatcaaagt
      661 tggagaccgc gctgaactta ggagggcctt cacacagact gatgtggcta ccttctcaga
      721 attaacaggg gatgtcaatc ctttgcattt gaatgaagac tttgcaaaac acaccaagtt
      781 tggaaataca attgtacatg gagttttgat caacggactt atctcagctc tcctaggaac
      841 taaaatgcca gggccaggct gtgtatttct ttcccaggaa attagctttc cagccccttt
      901 atatattgga gaagttgttt tagcttctgc agaagtgaaa aagctgaagc ggttcattgc
      961 tattattgca gtgtcatgtt ctgtaataga aagtaaaaag actgttatgg aaggctgggt
     1021 taaagttatg gttccagaag cttccaaatc ctgaaataga tgttttaaag atgcaacctc
     1081 aaacaccaat gctgttgtta aagagcctat ggggaattgc tgctctttac caaagaatgg
     1141 ttgataggcc cagaagccca tcttagttag gggaagggag caggaagagg gttgttcaaa
     1201 tgcccacttt ccagtttggc cttatgcttc atgcagactt gagtgtatgc aggatttcat
     1261 tatctgcctg ggttttttgt ttgttttttg ttttttaatt caagaagtag gctgggcccg
     1321 gtggctcatg cctgtaatcc tggcactttg ggaggctgcg gcaggcggat cacttgaggt
     1381 caggagtcca agaccagcct ggccaacatg gtgaaacccc atctctacca aaaaaaaaaa
     1441 aaaaaaaaaa gtgcaactag ctgtgcttgg tgacttggcc ctgtagtccc agttgcttgg
     1501 gaggctgagg tgggagaatt gcttgggcct gagagctgga ggttatggtg agaaactgag
     1561 attgcaccac tgcactgtag cctgagtgac agagcgagac cctgtctcaa gaaagaagta
     1621 ttgggaaggt tatttaaaga ctctactttt aaatcaggcg tggcagctca cgcctgtaat
     1681 cccagcattt tgggaggctg aggcaggcga atcacttgag gtcaggagtt caagaccagc
     1741 ctggccaaca tgtgaaaccc catctctact aaaaatacaa aaactaaccg ggcatggtgg
     1801 cgggcacctg taatcccagc tacttgggag gctgaggcag gagaatctct tgaacctggg
     1861 aggttgcagt gagctgaaat cacaccactg cacttcagcc tgggtgacag agcaaaactc
     1921 cacctcaaaa aaaaaaaaaa gattctactt ttagaaattc agacctagat agatttgcat
     1981 ttggataaca aatccctacc tatagccatg tggaagcagc ttgtcactgt attttaactg
     2041 tgtaacaatt attgaaggcg aaaatagaag ttgggtcatc tttgaacacc taccttttat
     2101 caatgaatat ttttagactg ttcttcagta tctgagtcag agtttattgt aatttgttat
     2161 ttacaccaag gtggcatctt agtctacctt cagtgagact tgcgtttcag gggaggggcg
     2221 tatgtgcatc ctcggtctca gttatgtaaa cggtctgatc tgtaaaatag tggtagcaca
     2281 tgccatgtgg gatagttggt ggagatgata gatggagtta agcacagggc ccagcctgtc
     2341 agcagtagct actattattg ttgcccattt cccctgcaac tgaggtgaga ggttttcctg
     2401 agtttgaagc tgactggccc acagttaaac gtaacagacc agtttttcag ggtgtcagcc
     2461 aacctctatt agtgttctta agtacagttt ctgttataaa agttcagatt attccttgaa
     2521 aatttggatc tacctcccat tattatgagt aatacatgct tatagtaaaa aaaaaaaaat
     2581 tgtaagaaat aaatattaag aagattatgg aggccaaatt cttaagactt tgggggctgg
     2641 ggtcagggag gttatattga aggggagatg tgcctaacat gttactacta aatggccatc
     2701 ccaacacagc caacactttt gtttcccatt tttttttgtt tcccgttttt taataaaatt
     2761 gagatataat tcacatacca taaaattcac cttttaaaag tgtacagttt agtggttttc
     2821 agaatatcca caaagttgta caaccatcac caaatcaatt ttttatagca tttttcatca
     2881 cccccaaaag aacctcccat tagcagtcaa tccatttctc tcctccagtc tttgggaatc
     2941 accagtctac tttctgtctc tatgggtttc cctgttctgg acatttcata aaagttcata
     3001 caatgtatga tcctttggaa ctggcttctt tgatatagca tgttttcagg gttcatccat
     3061 gttacagcat gtatcagtac atcattttat tttatggctg aataatattc cattgtattt
     3121 acccata
//
