LOCUS       NM_001098522            1830 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens HIV-1 Tat interactive protein 2 (HTATIP2), transcript
            variant 4, mRNA.
ACCESSION   NM_001098522
VERSION     NM_001098522.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Park,S.Y., Park,J.H., Yang,J.W., Jung,E.J., Ju,Y.T., Jeong,C.Y.,
            Kim,J.Y., Park,T., Park,M., Lee,Y.J. and Jeong,S.H.
  TITLE     HTATIP2 Overexpression was Associated With a Good Prognosis in
            Gastric Cancer
  JOURNAL   Technol Cancer Res Treat 23, 15330338231187254 (2024)
   PUBMED   38303513
  REMARK    GeneRIF: HTATIP2 Overexpression was Associated With a Good
            Prognosis in Gastric Cancer.
REFERENCE   2  (bases 1 to 1830)
  AUTHORS   Patel,A.S., Ludwinski,F.E., Mondragon,A., Nuthall,K., Saha,P.,
            Lyons,O., Squadrito,M.L., Siow,R., De Palma,M., Smith,A. and
            Modarai,B.
  TITLE     HTATIP2 regulates arteriogenic activity in monocytes from patients
            with limb ischemia
  JOURNAL   JCI Insight 8 (24), e131419 (2023)
   PUBMED   37847559
  REMARK    GeneRIF: HTATIP2 regulates arteriogenic activity in monocytes from
            patients with limb ischemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1830)
  AUTHORS   Cardinale,C.J., Chang,X., Wei,Z., Qu,H.Q., Bradfield,J.P.,
            Polychronakos,C. and Hakonarson,H.
  TITLE     Genome-wide association study of the age of onset of type 1
            diabetes reveals HTATIP2 as a novel T cell regulator
  JOURNAL   Front Immunol 14, 1101488 (2023)
   PUBMED   36817429
  REMARK    GeneRIF: Genome-wide association study of the age of onset of type
            1 diabetes reveals HTATIP2 as a novel T cell regulator.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1830)
  AUTHORS   Metin,M.S., Bilen,H., Elmas,O.F. and Akdeniz,N.
  TITLE     The potential role of human HIV-1 TAT-Interactive Protein 2 levels
            in the pathogenesis of contact dermatitis
  JOURNAL   Turk J Med Sci 51 (6), 3017-3021 (2021)
   PUBMED   34688245
  REMARK    GeneRIF: The potential role of human HIV-1 TAT-Interactive Protein
            2 levels in the pathogenesis of contact dermatitis
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1830)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 1830)
  AUTHORS   Xiao,H., Palhan,V., Yang,Y. and Roeder,R.G.
  TITLE     TIP30 has an intrinsic kinase activity required for up-regulation
            of a subset of apoptotic genes
  JOURNAL   EMBO J 19 (5), 956-963 (2000)
   PUBMED   10698937
REFERENCE   7  (bases 1 to 1830)
  AUTHORS   Whitman,S., Wang,X., Shalaby,R. and Shtivelman,E.
  TITLE     Alternatively spliced products CC3 and TC3 have opposing effects on
            apoptosis
  JOURNAL   Mol Cell Biol 20 (2), 583-593 (2000)
   PUBMED   10611237
REFERENCE   8  (bases 1 to 1830)
  AUTHORS   Baker,M.E.
  TITLE     TIP30, a cofactor for HIV-1 Tat-activated transcription, is
            homologous to short-chain dehydrogenases/reductases
  JOURNAL   Curr Biol 9 (13), R471 (1999)
   PUBMED   10395547
REFERENCE   9  (bases 1 to 1830)
  AUTHORS   Xiao,H., Tao,Y., Greenblatt,J. and Roeder,R.G.
  TITLE     A cofactor, TIP30, specifically enhances HIV-1 Tat-activated
            transcription
  JOURNAL   Proc Natl Acad Sci U S A 95 (5), 2146-2151 (1998)
   PUBMED   9482853
REFERENCE   10 (bases 1 to 1830)
  AUTHORS   Shtivelman,E.
  TITLE     A link between metastasis and resistance to apoptosis of variant
            small cell lung carcinoma
  JOURNAL   Oncogene 14 (18), 2167-2173 (1997)
   PUBMED   9174052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025972.6, AI193677.1, AK222969.1 and BC015358.2.
            
            On May 21, 2020 this sequence version replaced NM_001098522.1.
            
            Transcript Variant: This variant (4) has an alternate 5' end and
            differs in the 5' UTR, compared to variant 1. These differences
            cause translation initiation at a downstream AUG and an isoform (b,
            also known as CC3) with a shorter N-terminus compared to isoform a.
            Variants 2, 3 and 4 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222969.1, AK223010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451739.7/ ENSP00000394259.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC025972.6         135260-135402
            144-709             AI193677.1         1-566
            710-1827            AK222969.1         241-1358
            1828-1830           BC015358.2         1381-1383
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..1830
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
                     /note="HIV-1 Tat interactive protein 2"
                     /db_xref="GeneID:10553"
                     /db_xref="HGNC:HGNC:16637"
                     /db_xref="MIM:605628"
     exon            1..719
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
                     /inference="alignment:Splign:2.1.0"
     CDS             525..1253
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
                     /EC_number="1.1.1.-"
                     /note="isoform b is encoded by transcript variant 4; short
                     chain dehydrogenase/reductase family 44U, member 1;
                     Tat-interacting protein (30kD); oxidoreductase HTATIP2;
                     HIV-1 TAT-interactive protein 2; 30 kDa HIV-1
                     TAT-interacting protein; HIV-1 Tat interactive protein 2,
                     30kDa"
                     /codon_start=1
                     /product="oxidoreductase HTATIP2 isoform b"
                     /protein_id="NP_001091992.1"
                     /db_xref="CCDS:CCDS7852.1"
                     /db_xref="GeneID:10553"
                     /db_xref="HGNC:HGNC:16637"
                     /db_xref="MIM:605628"
                     /translation="MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLF
                     SKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAGAE
                     GFVRVDRDYVLKSAELAKAGGCKHFNLLSSKGADKSSNFLYLQVKGEVEAKVEELKFD
                     RYSVFRPGVLLCDRQESRPGEWLVRKFFGSLPDSWASGHSVPVVTVVRAMLNNVVRPR
                     DKQMELLENKAIHDLGKAHGSLKP"
     exon            720..827
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
                     /inference="alignment:Splign:2.1.0"
     exon            828..965
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1027
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1830
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1456..1461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
                     /note="hexamer: AATAAA"
     polyA_site      1483
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
     regulatory      1800..1805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
                     /note="hexamer: AATAAA"
     regulatory      1808..1813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
                     /note="hexamer: AATAAA"
     polyA_site      1823
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
                     /note="major polyA site"
     polyA_site      1830
                     /gene="HTATIP2"
                     /gene_synonym="CC3; SDR44U1; TIP30"
                     /note="major polyA site"
ORIGIN      
        1 agcgtcgccg cgaggccacc cggaagacca agccgggtag gcgctgtctc cgtcgcctcc
       61 aacccccccg gtccgaccag ggaaggtggg atgctctgat ggccgggcct gcggcgctga
      121 gcgcggcggc ggcggctgct ctggcggccg ccctgctcct gctgcgtcgt gaggacccgg
      181 ggccgggggc tggccccagg taacccctcc gcgtatggga ccgagctggg ccaggtctcc
      241 tggccgggcc ggggataccg tggggtatgc ccagtgatgc cagcagcttg tggcacctgg
      301 gcgcaccctc cagctcgggc cccttccgat gggtctgctg gctcaggtgc gggcgatggc
      361 cggggagccg cgccccgcac gtgactcagc actttcccca gagcccggac tgcggagaac
      421 aatatcctcc tccctaacag ataaacagcc cttgttcctc gggataagga ctggcagtcc
      481 cctgacaccc taagaccggc atctgtcgat gttatttccc cagcatggcc gaaacagaag
      541 ccctgtcgaa gcttcgggaa gacttcagga tgcagaataa atccgtcttt attttgggcg
      601 ccagcggaga aaccggcaga gtgctcttaa aggaaatcct ggagcagggc ctgttttcca
      661 aagtcacgct cattggccgg aggaagctca ccttcgacga ggaagcttat aaaaatgtga
      721 atcaagaagt ggtggacttt gaaaagttgg atgactacgc ctctgccttt caaggtcatg
      781 atgttggatt ctgttgcctg ggtaccacca gagggaaagc tggggcggag ggatttgttc
      841 gtgttgaccg agattatgtg ctgaagtctg cagagctggc aaaagctgga gggtgcaaac
      901 atttcaactt gctatcctct aaaggagctg ataaatcaag caatttttta tatctacaag
      961 ttaagggaga agtagaagcc aaggttgaag aattaaaatt tgatcgttac tctgtattta
     1021 ggcctggagt tctgttatgt gataggcaag aatctcgccc aggtgaatgg ctggttagaa
     1081 agttctttgg ctccttacca gactcttggg ccagtgggca ttctgtgcct gtggtgaccg
     1141 tggttagagc aatgctgaac aatgtggtga gaccaagaga caagcagatg gaactgctgg
     1201 agaacaaggc catccatgac ctggggaaag cgcatggctc tctcaagcca tgaccacatt
     1261 ggagaaatgg tttttattgt caaccttaac acccatcacc aaatcggtaa tttcagggtc
     1321 taaaaaaagt cagcatgttt taactttgtt gttttactat cctcaggcat ccattccaat
     1381 caagaaatga tggtgctctg catcagtggt tcagagcctg gttatacata tagatcactc
     1441 agggagcttt ggaaaaataa agatttgtca gccctatctc aaacttgaat caaaatttct
     1501 ggggtgtggg cacaataatc tgtaattttc tttgtttata cttcccctga tgccactggt
     1561 tccgatgcca ctggctgggg ggcctgcttt gaaatgcttg tctgcagagt cacagcagcc
     1621 atgaaaacct tatgaccgtg caaatgagct ctgctctaaa attgttgaca ttcatgtctc
     1681 tgagttacaa aagtgctaat tcactacatg taattgtgta agtaaacatt gtgcctttac
     1741 tacttcttta tgtaatagaa gttatatacc taagcttata taatacatgg ggaggattaa
     1801 ataaaggaat aaagatgaat ggacaactcc
//
