LOCUS       NM_006644               5244 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens heat shock protein family H (Hsp110) member 1 (HSPH1),
            transcript variant 1, mRNA.
ACCESSION   NM_006644
VERSION     NM_006644.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5244)
  AUTHORS   Wu,X., Zhu,Y., Hu,C., Du,X., Xue,W., Chen,Y., Dong,L. and Pan,J.
  TITLE     Extracellular vesicles related gene HSPH1 exerts anti-tumor effects
            in prostate cancer via promoting the stress response of CD8 + T
            cells
  JOURNAL   Cell Oncol (Dordr) 47 (3), 1059-1064 (2024)
   PUBMED   38165608
  REMARK    GeneRIF: Extracellular vesicles related gene HSPH1 exerts
            anti-tumor effects in prostate cancer via promoting the stress
            response of CD8 + T cells.
REFERENCE   2  (bases 1 to 5244)
  AUTHORS   Teshima,H., Watanabe,H., Yasutake,R., Ikeda,Y., Yonezu,Y.,
            Okamoto,N., Kakihana,A., Yuki,R., Nakayama,Y. and Saito,Y.
  TITLE     Functional differences between Hsp105/110 family proteins in cell
            proliferation, cell division, and drug sensitivity
  JOURNAL   J Cell Biochem 122 (12), 1958-1967 (2021)
   PUBMED   34617313
  REMARK    GeneRIF: Functional differences between Hsp105/110 family proteins
            in cell proliferation, cell division, and drug sensitivity.
REFERENCE   3  (bases 1 to 5244)
  AUTHORS   Chen,K.J., Li,F.Z., Ye,Q., Jia,M. and Fang,S.
  TITLE     HSP105 expression in cutaneous malignant melanoma: Correlation with
            clinicopathological characteristics
  JOURNAL   PLoS One 16 (10), e0258053 (2021)
   PUBMED   34618840
  REMARK    GeneRIF: HSP105 expression in cutaneous malignant melanoma:
            Correlation with clinicopathological characteristics.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5244)
  AUTHORS   Li,Y., Zhang,N., Zhang,L., Song,Y., Liu,J., Yu,J. and Yang,M.
  TITLE     Oncogene HSPH1 modulated by the rs2280059 genetic variant
            diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma
  JOURNAL   Carcinogenesis 41 (9), 1195-1202 (2020)
   PUBMED   32815538
  REMARK    GeneRIF: Oncogene HSPH1 modulated by the rs2280059 genetic variant
            diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma.
REFERENCE   5  (bases 1 to 5244)
  AUTHORS   Arvanitidou,S., Martinelli-Klay,C.P., Samson,J., Lobrinus,J.A.,
            Dulguerov,N. and Lombardi,T.
  TITLE     HSP105 expression in oral squamous cell carcinoma: Correlation with
            clinicopathological features and outcomes
  JOURNAL   J Oral Pathol Med 49 (7), 665-671 (2020)
   PUBMED   32128880
  REMARK    GeneRIF: HSP105 expression in oral squamous cell carcinoma:
            Correlation with clinicopathological features and outcomes.
REFERENCE   6  (bases 1 to 5244)
  AUTHORS   Hylander,B.L., Chen,X., Graf,P.C. and Subjeck,J.R.
  TITLE     The distribution and localization of hsp110 in brain
  JOURNAL   Brain Res 869 (1-2), 49-55 (2000)
   PUBMED   10865058
REFERENCE   7  (bases 1 to 5244)
  AUTHORS   Ishihara,K., Yasuda,K. and Hatayama,T.
  TITLE     Phosphorylation of the 105-kDa heat shock proteins, HSP105alpha and
            HSP105beta, by casein kinase II
  JOURNAL   Biochem Biophys Res Commun 270 (3), 927-931 (2000)
   PUBMED   10772927
REFERENCE   8  (bases 1 to 5244)
  AUTHORS   Ishihara,K., Yasuda,K. and Hatayama,T.
  TITLE     Molecular cloning, expression and localization of human 105 kDa
            heat shock protein, hsp105
  JOURNAL   Biochim Biophys Acta 1444 (1), 138-142 (1999)
   PUBMED   9931472
REFERENCE   9  (bases 1 to 5244)
  AUTHORS   Hatayama,T., Yasuda,K. and Yasuda,K.
  TITLE     Association of HSP105 with HSC70 in high molecular mass complexes
            in mouse FM3A cells
  JOURNAL   Biochem Biophys Res Commun 248 (2), 395-401 (1998)
   PUBMED   9675148
REFERENCE   10 (bases 1 to 5244)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD251908.1, BC037553.1 and
            AL137142.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_006644.3.
            
            Summary: This gene encodes a member of the heat shock protein 70
            family of proteins. The encoded protein functions as a nucleotide
            exchange factor for the molecular chaperone heat shock cognate 71
            kDa protein (Hsc70). In addition, this protein plays a distinct but
            related role as a holdase that inhibits the aggregation of
            misfolded proteins, including the cystic fibrosis transmembrane
            conductance regulator (CFTR) protein. Elevated expression of this
            protein has been observed in numerous human cancers. [provided by
            RefSeq, Mar 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1, also known as Hsp105alpha.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86956.1, SRR11853563.8865.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320027.10/ ENSP00000318687.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               CD251908.1         77-521
            446-3592            BC037553.1         465-3611
            3593-5244           AL137142.20        36021-37672         c
FEATURES             Location/Qualifiers
     source          1..5244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.3"
     gene            1..5244
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /note="heat shock protein family H (Hsp110) member 1"
                     /db_xref="GeneID:10808"
                     /db_xref="HGNC:HGNC:16969"
                     /db_xref="MIM:610703"
     exon            1..429
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..2899
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /note="isoform 1 is encoded by transcript variant 1; heat
                     shock protein 105 kDa; antigen NY-CO-25; heat shock
                     protein family H member 1; heat shock 105kDa/110kDa
                     protein 1"
                     /codon_start=1
                     /product="heat shock protein 105 kDa isoform 1"
                     /protein_id="NP_006635.2"
                     /db_xref="CCDS:CCDS9340.1"
                     /db_xref="GeneID:10808"
                     /db_xref="HGNC:HGNC:16969"
                     /db_xref="MIM:610703"
                     /translation="MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSK
                     NRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIK
                     VMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAA
                     QIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKG
                     KLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKL
                     MSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVED
                     VSAVEIVGGATRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPAFKVREF
                     SVTDAVPFPISLIWNHDSEDTEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQ
                     GVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEM
                     SSEADMECLNQRPPENPDTDKNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENK
                     IPDADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLLNMYIETEGKMIMQ
                     DKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQDHQNFLRLLTETEDWLYEEGED
                     QAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRNKDEKY
                     NHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIKELNNTCEP
                     VVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPPHQNGECYPNEKNSVNMD
                     LD"
     exon            430..487
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            488..628
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            629..751
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            752..851
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            852..985
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1230
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1459
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1566
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1700
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1906
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2038
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2176
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2302
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2410
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..2530
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2692
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..5244
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3561..3566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /note="hexamer: AATAAA"
     polyA_site      3592
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /note="major polyA site"
     regulatory      3786..3791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /note="hexamer: AATAAA"
     polyA_site      3814
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
     regulatory      4910..4915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /note="hexamer: ATTAAA"
     polyA_site      4937
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
     regulatory      5154..5159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /note="hexamer: AATAAA"
     regulatory      5172..5177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
                     /note="hexamer: ATTAAA"
     polyA_site      5177
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
     polyA_site      5196
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
     polyA_site      5244
                     /gene="HSPH1"
                     /gene_synonym="HSP105; HSP105A; HSP105B; NY-CO-25"
ORIGIN      
        1 gggtcggtag ttcagcgccg gcgccggtgt gcgagccgcg gcagagtgag gcaggcaacc
       61 cgaggtgcgg agcgacctgc ggaggctgag ccccgctttc tcccagggtt tcttatcagc
      121 cagccgccgc tgtccccggg ggagtaggag gctcctgaca ggccgcggct gtctgtgtgt
      181 ccttctgagt gtcagaggaa cggccagacc ccgcgggccg gagcagaacg cggccagggc
      241 agaaagcggc ggcaggagaa gcaggcaggg ggccggagga cgcagaccga gacccgaggc
      301 ggaggcggac cgcgagccgg ccatgtcggt ggtggggttg gacgtgggct cgcagagctg
      361 ctacatcgcg gtagcccggg ccgggggcat cgagaccatc gccaatgagt tcagcgaccg
      421 gtgcaccccg tcagtcatat catttggatc aaaaaataga acaatcggag ttgcagccaa
      481 aaatcagcaa atcactcatg caaacaatac ggtgtctaac ttcaaaagat ttcatggccg
      541 agcattcaat gaccccttca ttcaaaagga gaaggaaaac ttgagttacg atttggttcc
      601 attgaaaaat ggtggagttg gaataaaggt aatgtacatg ggtgaagaac atctatttag
      661 tgtggagcag ataacagcca tgttgttgac taagctgaag gaaactgctg aaaacagcct
      721 caagaaacca gtaacagatt gtgttatttc agtcccctcc ttctttacag atgctgagag
      781 gcgatctgtg ttagatgctg cacagattgt tggcctaaac tgtttaagac ttatgaatga
      841 catgacagct gttgctttga attacggaat ttataagcag gatctcccaa gcctggatga
      901 gaaacctcgg atagtggttt ttgttgatat gggacattca gcttttcaag tgtctgcttg
      961 tgcttttaac aagggaaaat tgaaggtact gggaacagct tttgatcctt tcttaggagg
     1021 aaaaaacttc gatgaaaagt tagtggaaca tttttgtgca gaatttaaaa ctaagtacaa
     1081 gttggatgca aaatccaaaa tacgagcact cctacgtctg tatcaggaat gtgaaaaact
     1141 gaaaaagcta atgagctcta acagcacaga ccttccactg aatatcgaat gctttatgaa
     1201 tgataaagat gtttccggaa agatgaacag gtcacaattt gaagaactct gtgctgaact
     1261 tctgcaaaag atagaagtac ccctttattc actgttggaa caaactcatc tcaaagtaga
     1321 agatgtgagt gcagttgaga ttgttggagg cgctacacga attccagctg tgaaggaaag
     1381 aattgccaaa ttctttggaa aagatattag cacaacactc aatgcagatg aagcagtagc
     1441 cagaggatgt gcattacagt gtgcaatact ttccccggca tttaaagtta gagaattttc
     1501 cgtcacagat gcagttcctt ttccaatatc tctgatctgg aaccatgatt cagaagatac
     1561 tgaaggtgtt catgaagtct ttagtcgaaa ccatgctgct cctttctcca aagttctcac
     1621 ctttctgaga agggggcctt ttgagctaga agctttctat tctgatcccc aaggagttcc
     1681 atatccagaa gcaaaaatag gccgctttgt agttcagaat gtttctgcac agaaagatgg
     1741 agaaaaatct agagtaaaag tcaaagtgcg agtcaacacc catggcattt tcaccatctc
     1801 tacggcatct atggtggaga aagtcccaac tgaggagaat gaaatgtctt ctgaagctga
     1861 catggagtgt ctgaatcaga gaccaccaga aaacccagac actgataaaa atgtccagca
     1921 agacaacagt gaagctggaa cacagcccca ggtacaaact gatgctcaac aaacctcaca
     1981 gtctccccct tcacctgaac ttacctcaga agaaaacaaa atcccagatg ctgacaaagc
     2041 aaatgaaaaa aaagttgacc agcctccaga agctaaaaag cccaaaataa aggtggtgaa
     2101 tgttgagctg cctattgaag ccaacttggt ctggcagtta gggaaagacc ttcttaacat
     2161 gtatattgag acagagggta agatgataat gcaagataaa ttggaaaaag aaaggaatga
     2221 tgctaaaaat gcagttgagg aatatgtgta tgagttcaga gacaagctgt gtggaccata
     2281 tgaaaaattt atatgtgagc aggatcatca aaattttttg agactcctca cagaaactga
     2341 agactggctg tatgaagaag gagaggacca agctaaacaa gcatatgttg acaagttgga
     2401 agaattaatg aaaattggca ctccagttaa agttcggttt caggaagctg aagaacggcc
     2461 aaaaatgttt gaagaactag gacagaggct gcagcattat gccaagatag cagctgactt
     2521 cagaaataag gatgagaaat acaaccatat tgatgagtct gaaatgaaaa aagtggagaa
     2581 gtctgttaat gaagtgatgg aatggatgaa taatgtcatg aatgctcagg ctaaaaagag
     2641 tcttgatcag gatccagttg tacgtgctca ggaaattaaa acaaaaatca aggaattgaa
     2701 caacacatgt gaacccgttg taacacaacc gaaaccaaaa attgaatcac ccaaactgga
     2761 aagaactcca aatggcccaa atattgataa aaaggaagaa gatttagaag acaaaaacaa
     2821 ttttggtgct gaacctccac atcagaatgg tgaatgttac cctaatgaga aaaattctgt
     2881 taatatggac ttggactaga taaccttaaa ttggcctatt ccttcaatta ataaaatatt
     2941 tttgccatag tatgtgactc tacataacat actgaaacta tttatatttt cttttttaag
     3001 gatatttaga aattttgtgt attatatgga aaaagaaaaa aagcttaagt ctgtagtctt
     3061 tatgatccta aaagggaaaa ttgccttggt aactttcaga ttcctgtgga attgtgaatt
     3121 catactaagc tttctgtgca gtctcaccat ttgcatcact gaggatgaaa ctgacttttg
     3181 tcttttggag aaaaaaaact gtactgcttg ttcaagaggg ctgtgattaa aatctttaag
     3241 catttgttcc tgccaaggta gttttcttgc attttgctct ccattcagca tgtgtgtggg
     3301 tgtggatgtt tataaacaag actaagtctg acttcataag ggctttctaa aaccatttct
     3361 gtccaagaga aaatgacttt ttgctttgat attaaaaatt caatgagtaa aacaaaagct
     3421 agtcaaatgt gttagcagca tgcagaacaa aaactttaaa ctttctctct cactatacag
     3481 tatattgtca tgtgaaagtg tggaatggaa gaaatgtcga tcctgttgta actgattgtg
     3541 aacactttta tgagctttaa aataaagttc atcttatggt gtcatttcta aactgttgat
     3601 tttgtcacta atttaaaaaa tgagatgagg gagaatatga attattctag cagaaatgaa
     3661 gttagtgtcc agtttttctt ttttactgct tatgttctct cttttctaag tgaaaatgtt
     3721 tttctcctga cagaaaaata gcatatgttt attacattaa agcattttaa aaatactata
     3781 aagtgaataa aacttaaaat cttgccaccc agaagaaaac attgttaaca cttcgttata
     3841 catccttgga gccttttacc cctaatgatg ggggtatatt tgtgtgagtg tctatgttat
     3901 agtgctgtag gctgttttta aaaactctgt gccagggaaa ttagtaaata cagtcaagtg
     3961 ttgtaactgc ataaatgtag tgagttcatt ataaagacgt acttaaaaat accaatcttg
     4021 ctattggtag atttaggtgt ttctcatttt tgctgttcta aataatgctg caatgaatct
     4081 atctggttgt tttgtaagca caaaattgaa gtagtgttgg aggtagggga gaagacacat
     4141 gcacttagga taggtgacaa ccagctcctc actagggtgc aacagtttat tctttttttt
     4201 tttttggtag agctggggtt tcgctatgtt gcccaagttc gtcttgaact cctgggctca
     4261 agcaatctgt ctgcctcagc ctcccaaagt gctgggatta catggtgtga gccaccatgc
     4321 ccagccattt atgatcttga tgagggccaa ctttccctct tccacaaggg attaatctta
     4381 gaactatagc caatttatta taagtactat ttagctactc tgtgctccac acatcacgga
     4441 gtaatatctt caaactatga ggtttagtaa cacttgactg ctgaggttta tttcctcagc
     4501 tctgatgctt cctgggtgaa gatgtaagtt attaaattaa ctcaaatttt aaagctaaca
     4561 cttcattcca tctagaccag gtagctcgtc atttgtacgt ctgataggtg cttcaacatc
     4621 tcagaattgg cttatttttc atgcattgca tattgtactc atttgtaata ttggaatgta
     4681 aaatgttctt actaagaatc tttatgtcag ctattcaaca tttccctact ttataatttc
     4741 tagctgcttt accatttagc aactttaaat ttttatgcag ttaatatgtt tctttggttt
     4801 ttatgttttc tgaatgtctt taatgcacat taatgtatac ttagtagata cacatttaca
     4861 cattgagaag tgaagatagg tttgtgttct gtgtacaatt aggacatcca ttaaaaaaga
     4921 tttttaaaaa ctgtgaatgg gaaaacatgt ttttcctcct gtcctaaaat agaacctgat
     4981 gacgggaggg agcatcagtc agtctggcct aaatcagtgt actgcgcttt tggatgcggg
     5041 caaaagtatt gtcatgttga ttactttata ataacgtatt aatatcattg gctcaaacag
     5101 ttgtgatata tacctagtaa tcatcgagga tctcaaagat atgcaccagt ttgaataaat
     5161 gctgtttaaa gattaaattt tacaattcat tttaaattgt cattttgtga caatatttct
     5221 aaacaacgtc catttttaat aaca
//
