LOCUS       NM_005529              14341 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens heparan sulfate proteoglycan 2 (HSPG2), transcript
            variant 2, mRNA.
ACCESSION   NM_005529
VERSION     NM_005529.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14341)
  AUTHORS   Farshadyeganeh,P., Yamada,T., Ohashi,H., Nishimura,G., Fujita,H.,
            Oishi,Y., Nunode,M., Ishikawa,S., Murotsuki,J., Yamashita,Y.,
            Ikegawa,S., Ogi,T., Arikawa-Hirasawa,E. and Ohno,K.
  TITLE     Dyssegmental dysplasia Rolland-Desbuquois type is caused by
            pathogenic variants in HSPG2 - a founder haplotype shared in five
            patients
  JOURNAL   J Hum Genet 69 (6), 235-244 (2024)
   PUBMED   38424183
  REMARK    GeneRIF: Dyssegmental dysplasia Rolland-Desbuquois type is caused
            by pathogenic variants in HSPG2 - a founder haplotype shared in
            five patients.
REFERENCE   2  (bases 1 to 14341)
  AUTHORS   Johnson,B.B., Cosson,M.V., Tsansizi,L.I., Holmes,T.L., Gilmore,T.,
            Hampton,K., Song,O.R., Vo,N.T.N., Nasir,A., Chabronova,A.,
            Denning,C., Peffers,M.J., Merry,C.L.R., Whitelock,J., Troeberg,L.,
            Rushworth,S.A., Bernardo,A.S. and Smith,J.G.W.
  TITLE     Perlecan (HSPG2) promotes structural, contractile, and metabolic
            development of human cardiomyocytes
  JOURNAL   Cell Rep 43 (1), 113668 (2024)
   PUBMED   38198277
  REMARK    GeneRIF: Perlecan (HSPG2) promotes structural, contractile, and
            metabolic development of human cardiomyocytes.
REFERENCE   3  (bases 1 to 14341)
  AUTHORS   Kim,J.J., Hong,Y.M., Yun,S.W., Lee,K.Y., Yoon,K.L., Han,M.K.,
            Kim,G.B., Kil,H.R., Song,M.S., Lee,H.D., Ha,K.S., Jun,H.O.,
            Yu,J.J., Jang,G.Y. and Lee,J.K.
  CONSRTM   Korean Kawasaki Disease Genetics Consortium
  TITLE     Identification of B-cell-related HSPG2 and CDSN as susceptibility
            loci for Kawasaki disease
  JOURNAL   Hum Immunol 84 (10), 567-570 (2023)
   PUBMED   37453912
  REMARK    GeneRIF: Identification of B-cell-related HSPG2 and CDSN as
            susceptibility loci for Kawasaki disease.
REFERENCE   4  (bases 1 to 14341)
  AUTHORS   Zhao,X.X., Xie,W.Q., Xiao,W.F., Li,H.Z., Naranmandakh,S.,
            Bruyere,O., Reginster,J.Y. and Li,Y.S.
  TITLE     Perlecan: Roles in osteoarthritis and potential treating target
  JOURNAL   Life Sci 312, 121190 (2023)
   PUBMED   36379311
  REMARK    GeneRIF: Perlecan: Roles in osteoarthritis and potential treating
            target.
            Review article
REFERENCE   5  (bases 1 to 14341)
  AUTHORS   Murdoch,A.D., Dodge,G.R., Cohen,I., Tuan,R.S. and Iozzo,R.V.
  TITLE     Primary structure of the human heparan sulfate proteoglycan from
            basement membrane (HSPG2/perlecan). A chimeric molecule with
            multiple domains homologous to the low density lipoprotein
            receptor, laminin, neural cell adhesion molecules, and epidermal
            growth factor
  JOURNAL   J Biol Chem 267 (12), 8544-8557 (1992)
   PUBMED   1569102
REFERENCE   6  (bases 1 to 14341)
  AUTHORS   Kallunki,P. and Tryggvason,K.
  TITLE     Human basement membrane heparan sulfate proteoglycan core protein:
            a 467-kD protein containing multiple domains resembling elements of
            the low density lipoprotein receptor, laminin, neural cell adhesion
            molecules, and epidermal growth factor
  JOURNAL   J Cell Biol 116 (2), 559-571 (1992)
   PUBMED   1730768
REFERENCE   7  (bases 1 to 14341)
  AUTHORS   Kallunki,P., Eddy,R.L., Byers,M.G., Kestila,M., Shows,T.B. and
            Tryggvason,K.
  TITLE     Cloning of human heparan sulfate proteoglycan core protein,
            assignment of the gene (HSPG2) to 1p36.1----p35 and identification
            of a BamHI restriction fragment length polymorphism
  JOURNAL   Genomics 11 (2), 389-396 (1991)
   PUBMED   1685141
REFERENCE   8  (bases 1 to 14341)
  AUTHORS   Dodge,G.R., Kovalszky,I., Chu,M.L., Hassell,J.R., McBride,O.W.,
            Yi,H.F. and Iozzo,R.V.
  TITLE     Heparan sulfate proteoglycan of human colon: partial molecular
            cloning, cellular expression, and mapping of the gene (HSPG2) to
            the short arm of human chromosome 1
  JOURNAL   Genomics 10 (3), 673-680 (1991)
   PUBMED   1679749
REFERENCE   9  (bases 1 to 14341)
  AUTHORS   Heremans,A., van der Schueren,B., de Cock,B., Paulsson,M.,
            Cassiman,J.J., van den Berghe,H. and David,G.
  TITLE     Matrix-associated heparan sulfate proteoglycan: core
            protein-specific monoclonal antibodies decorate the pericellular
            matrix of connective tissue cells and the stromal side of basement
            membranes
  JOURNAL   J Cell Biol 109 (6 Pt 1), 3199-3211 (1989)
   PUBMED   2687294
REFERENCE   10 (bases 1 to 14341)
  AUTHORS   Sage,H., Vernon,R.B., Funk,S.E., Everitt,E.A. and Angello,J.
  TITLE     SPARC, a secreted protein associated with cellular proliferation,
            inhibits cell spreading in vitro and exhibits Ca+2-dependent
            binding to the extracellular matrix
  JOURNAL   J Cell Biol 109 (1), 341-356 (1989)
   PUBMED   2745554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590556.20, X62515.1,
            M85289.1, AL590103.12, BE273742.1, BC033152.1 and AA450342.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005529.6.
            
            Summary: This gene encodes the perlecan protein, which consists of
            a core protein to which three long chains of glycosaminoglycans
            (heparan sulfate or chondroitin sulfate) are attached. The perlecan
            protein is a large multidomain proteoglycan that binds to and
            cross-links many extracellular matrix components and cell-surface
            molecules. It has been shown that this protein interacts with
            laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and
            transthyretin, etc., and it plays essential roles in multiple
            biological activities. Perlecan is a key component of the vascular
            extracellular matrix, where it helps to maintain the endothelial
            barrier function. It is a potent inhibitor of smooth muscle cell
            proliferation and is thus thought to help maintain vascular
            homeostasis. It can also promote growth factor (e.g., FGF2)
            activity and thus stimulate endothelial growth and re-generation.
            It is a major component of basement membranes, where it is involved
            in the stabilization of other molecules as well as being involved
            with glomerular permeability to macromolecules and cell adhesion.
            Mutations in this gene cause Schwartz-Jampel syndrome type 1,
            Silverman-Handmaker type of dyssegmental dysplasia, and tardive
            dyskinesia. Alternative splicing of this gene results in multiple
            transcript variants. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1,
            resulting in an isoform (b) that is 1 aa shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374695.8/ ENSP00000363827.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AL590556.20        41128-41283         c
            157-265             X62515.1           104-212
            266-416             M85289.1           253-403
            417-417             AL590103.12        167750-167750       c
            418-836             X62515.1           365-783
            837-1841            M85289.1           824-1828
            1842-2004           X62515.1           1795-1957
            2005-2005           AL590103.12        157877-157877       c
            2006-2201           M85289.1           1993-2188
            2202-2202           AL590103.12        157584-157584       c
            2203-2386           M85289.1           2190-2373
            2387-2387           AL590103.12        157291-157291       c
            2388-3989           M85289.1           2375-3976
            3990-4600           X62515.1           3943-4553
            4601-4601           AL590103.12        142096-142096       c
            4602-6005           M85289.1           4589-5992
            6006-6241           X62515.1           5959-6194
            6242-6246           M85289.1           6229-6233
            6247-6370           X62515.1           6200-6323
            6371-8669           M85289.1           6358-8656
            8670-9031           X62515.1           8623-8984
            9032-10372          M85289.1           9019-10359
            10373-10418         X62515.1           10326-10371
            10419-13142         M85289.1           10406-13129
            13143-13201         BE273742.1         577-635
            13202-14339         BC033152.1         1688-2825
            14340-14341         AA450342.1         42-43               c
FEATURES             Location/Qualifiers
     source          1..14341
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..14341
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /note="heparan sulfate proteoglycan 2"
                     /db_xref="GeneID:3339"
                     /db_xref="HGNC:HGNC:5273"
                     /db_xref="MIM:142461"
     exon            1..156
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..13269
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; perlecan proteoglycan; endorepellin (domain V
                     region); basement membrane-specific heparan sulfate
                     proteoglycan core protein"
                     /codon_start=1
                     /product="basement membrane-specific heparan sulfate
                     proteoglycan core protein isoform b precursor"
                     /protein_id="NP_005520.4"
                     /db_xref="CCDS:CCDS30625.1"
                     /db_xref="GeneID:3339"
                     /db_xref="HGNC:HGNC:5273"
                     /db_xref="MIM:142461"
                     /translation="MGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTAS
                     QMRWTHSYLSDDEDMLADSISGDDLGSGDLGSGDFQMVYFRALVNFTRSIEYSPQLED
                     AGSREFREVSEAVVDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQ
                     IQEMLLRVISSGSVASYVTSPQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYR
                     CDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLL
                     PGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGN
                     GHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEES
                     DCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSH
                     PRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDG
                     HFYLEHSAACLPCFCFGITSVCQSTRRFRDQIRLRFDQPDDFKGVNVTMPAQPGTPPL
                     SSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYNVRYELAR
                     GMLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGRPVQRAEL
                     LQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHATSHGRAHSVEECRCPIGYSGL
                     SCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAG
                     FFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAP
                     GYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGSFHLS
                     TRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAASTHTTNEGIFSPT
                     PGELGFSSFHRLLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPGSTPLHGQPLV
                     VLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQPATREHLLMALAGIDTLL
                     IRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTR
                     TPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQ
                     DCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQP
                     CQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPD
                     GCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPE
                     GAQLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQ
                     ITGNNIMLVASQPALQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIR
                     ATFSSVPLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTG
                     SGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDC
                     QPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQC
                     LPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRH
                     QGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVR
                     PGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTG
                     SNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWT
                     GGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRV
                     QVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAIT
                     TADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVV
                     AGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITV
                     SVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGG
                     SLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVR
                     IESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADA
                     GQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVV
                     PGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLV
                     TIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPAR
                     HQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRI
                     ESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSG
                     EYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVA
                     RQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVIS
                     VSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSH
                     HQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPP
                     IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPA
                     DSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDL
                     NCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQE
                     ASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN
                     QELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLP
                     EGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAK
                     PSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCS
                     ATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATII
                     LHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELL
                     HFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQL
                     ETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYIC
                     QAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK
                     VGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQ
                     EVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYV
                     CTATNRQGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSAD
                     GMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGH
                     FHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSS
                     GFIGCVRELRIQGEEIVFHDLNLTAHGISHCPTCRDRPCQNGGQCHDSESSSYVCVCP
                     AGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTP
                     SLSGAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGH
                     LEFRYELGSGLAVLRSAEPLALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGL
                     NLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYD
                     SSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGT
                     RCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFS
                     RSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSG
                     EARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGG
                     APDVATLTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRAQAGANTRPCPS"
     exon            157..292
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..337
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            338..447
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..506
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..667
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..796
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1051
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1171
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1303
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1448
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1600
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1747
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1911
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2091
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2288
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2436
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2564
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2651
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2710
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2778
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2919
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3096
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3276
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3395
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3507
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3621
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..3749
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3750..3836
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..3886
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3887..3981
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3982..4122
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4123..4314
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4315..4407
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4408..4488
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4489..4719
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4720..4833
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4834..4961
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            4962..5048
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5049..5107
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5108..5275
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5276..5386
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5387..5487
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5488..5668
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5669..5794
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5795..5947
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            5948..6090
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6091..6226
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6227..6381
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6382..6532
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6533..6684
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6685..6817
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6818..6963
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            6964..7099
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7100..7251
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7252..7387
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7388..7539
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7540..7678
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7679..7830
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7831..7966
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            7967..8118
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            8119..8257
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            8258..8409
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            8410..8557
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            8558..8709
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            8710..8851
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            8852..9003
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            9004..9145
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            9146..9286
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            9287..9421
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            9422..9606
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            9607..9802
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            9803..9982
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            9983..10243
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            10244..10448
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            10449..10546
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            10547..10813
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            10814..10923
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            10924..11071
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11072..11188
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11189..11300
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11301..11445
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11446..11545
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11546..11655
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11656..11764
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11765..11863
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            11864..12085
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            12086..12330
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            12331..12502
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            12503..12625
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            12626..12682
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            12683..12758
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            12759..12837
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            12838..12908
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            12909..12992
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            12993..13096
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     exon            13097..14341
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14319..14324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /note="hexamer: AATAAA"
     polyA_site      14341
                     /gene="HSPG2"
                     /gene_synonym="HSPG; PLC; PRCAN; SJA; SJS; SJS1"
                     /note="major polyA site"
ORIGIN      
        1 gctgtcccga gctggccggc gagcgggcgg ctgcgggcgg cgcggagcgg gcggcgcgga
       61 gcgagcgagc gagagagcgg cgcgggccgg gccatggggt ggcgggcggc gggcgcgctg
      121 ctgctggcgc tgctgctgca cgggcggctg ctggcggtga cccatgggct gagggcatac
      181 gatggcttgt ctctgcctga ggacatagag accgtcacag caagccaaat gcgctggaca
      241 cattcgtacc tttctgatga tgaggacatg ctggctgaca gcatctcagg agacgacctg
      301 ggcagtgggg acctgggcag cggggacttc cagatggttt atttccgagc cctggtgaat
      361 ttcactcgct ccatcgagta cagccctcag ctggaggatg caggctccag agagttccga
      421 gaggtgtccg aggctgtggt agacacgctg gagtcggagt acttgaaaat tcccggagac
      481 caggttgtca gtgtggtgtt catcaaggag ctggatggct gggtttttgt ggagctggat
      541 gtgggctcgg aagggaatgc ggatggggct cagattcagg agatgctgct cagggtcatc
      601 tccagcggct ctgtggcctc ctacgtcacc tctccccagg gattccagtt ccgacgcctg
      661 ggcacagtgc cccagttccc aagagcctgc acggaggccg agtttgcctg ccacagctac
      721 aatgagtgtg tggccctgga gtatcgctgt gaccggcggc ccgactgcag ggacatgtct
      781 gatgagctca attgtgagga gccagtcctg ggtatcagcc ccacattctc tctccttgtg
      841 gagacgacat ctttaccgcc ccggccagag acaaccatca tgcgacagcc accagtcacc
      901 cacgctcctc agcccctgct tcccggttcc gtcaggcccc tgccctgtgg gccccaggag
      961 gccgcatgcc gcaatgggca ctgcatcccc agagactacc tctgcgacgg acaggaggac
     1021 tgcgaggacg gcagcgatga gctagactgt ggccccccgc caccctgtga gcccaacgag
     1081 ttcccctgcg ggaatggaca ttgtgccctc aagctgtggc gctgcgatgg tgactttgac
     1141 tgtgaggacc gaactgatga agccaactgc cccaccaagc gtcctgagga agtgtgcggg
     1201 cccacacagt tccgatgcgt ctctaccaac atgtgcatcc cagccagctt ccactgtgac
     1261 gaggagagcg actgtcctga ccggagcgac gagtttggct gcatgccccc ccaggtggtg
     1321 acacctcccc gggagtccat ccaggcttcc cggggccaga cagtgacctt cacctgcgtg
     1381 gccattggcg tccccacccc catcatcaat tggaggctca actggggcca catcccctct
     1441 catcccaggg tgacagtgac cagcgagggt ggccgtggca cactgatcat ccgtgatgtg
     1501 aaggagtcag accagggtgc ctacacctgt gaggccatga acgcccgggg catggtgttt
     1561 ggcattcctg acggtgtcct tgagctcgtc ccacaacgag gcccctgccc tgacggccac
     1621 ttctacctgg agcacagcgc cgcctgcctg ccctgcttct gctttggcat caccagcgtg
     1681 tgccagagca cccgccgctt ccgggaccag atcaggctgc gctttgacca acccgatgac
     1741 ttcaagggtg tgaatgtgac aatgcctgcg cagcccggca cgccacccct ctcctccacg
     1801 cagctgcaga tcgacccatc cctgcacgag ttccagctag tcgacctgtc ccgccgcttc
     1861 ctcgtccacg actccttctg ggctctgcct gaacagttcc tgggcaacaa ggtggactcc
     1921 tatggcggct ccctgcgtta caacgtgcgc tacgagttgg cccgtggcat gctggagcca
     1981 gtgcagcggc cggacgtggt cctcatgggt gccgggtacc gcctcctctc ccgaggccac
     2041 acacccaccc aacctggtgc tctgaaccag cgccaggtcc agttctctga ggagcactgg
     2101 gtccatgagt ctggccggcc ggtgcagcgc gcggagctgc tgcaggtgct gcagagcctg
     2161 gaggccgtgc tcatccagac cgtgtacaac accaagatgg ccagcgtggg acttagcgac
     2221 atcgccatgg ataccaccgt cacccatgcc accagccatg gccgtgccca cagtgtggag
     2281 gagtgcagat gccccattgg ctattctggc ttgtcctgcg agagctgtga tgcccacttc
     2341 actcgggtgc ctggtgggcc ctacctgggc acctgctctg gttgcaattg caatggccat
     2401 gccagctcct gtgaccctgt gtatggccac tgcctgaatt gccagcacaa cacggagggg
     2461 ccacagtgca acaagtgcaa ggctggcttc tttggggacg ccatgaaggc cacggccact
     2521 tcctgccggc cctgcccttg cccatacatc gatgcctccc gcagattctc agacacttgc
     2581 ttcctggaca cggatggcca agccacatgt gacgcctgtg ccccaggcta cactggccgc
     2641 cgctgtgaga gctgtgcccc cggatacgag ggcaacccca tccagcccgg cgggaagtgc
     2701 aggcccgtca accaggagat tgtgcgctgt gacgagcgtg gcagcatggg gacctccggg
     2761 gaggcctgcc gctgtaagaa caatgtggtg gggcgcttgt gcaatgaatg tgctgacggc
     2821 tctttccacc tgagtacccg aaaccccgat ggctgcctca agtgcttctg catgggtgtc
     2881 agtcgccact gcaccagctc ttcatggagc cgtgcccagt tgcatggggc ctctgaggag
     2941 cctggtcact tcagcctgac caacgccgca agcacccaca ccaccaacga gggcatcttc
     3001 tcccccacgc ccggggaact gggattctcc tccttccaca gactcttatc tggaccctac
     3061 ttctggagcc tcccttcacg cttcctgggg gacaaggtga cctcctatgg aggagagctg
     3121 cgcttcacag tgacccagag gtcccagccg ggctccacac ccctgcacgg gcagccgttg
     3181 gtggtgctgc aaggtaacaa catcatccta gagcaccatg tggcccagga gcccagcccc
     3241 ggccagccca gcaccttcat tgtgcctttc cgggagcaag catggcagcg gcccgatggg
     3301 cagccagcca cacgggagca cctgctgatg gcactggcag gcatcgacac cctcctgatc
     3361 cgagcatcct acgcccagca gcccgctgag agcagggtct ctggcatcag catggacgtg
     3421 gctgtgcccg aggaaaccgg ccaggacccc gcgctggaag tggaacagtg ctcctgccca
     3481 cccgggtacc gtgggccgtc ctgccaggac tgtgacacag gctacacacg cacgcccagt
     3541 ggcctctacc tgggtacctg tgaacgctgc agctgccatg gccactcaga ggcctgcgag
     3601 ccagaaacag gtgcctgcca gggctgccag catcacacgg agggccctcg gtgtgagcag
     3661 tgccagccag gatactacgg ggacgcccag cgggggacac cacaggactg ccagctgtgc
     3721 ccctgctacg gagaccctgc tgccggccag gctgcccaca cttgttttct ggacacagac
     3781 ggccacccca cctgtgatgc gtgctcccca ggccacagtg ggcgtcactg tgagaggtgc
     3841 gcccctggct actatggcaa ccccagccag ggccagccat gccagagaga cagccaggtg
     3901 ccagggccca taggctgcaa ctgtgacccc caaggcagcg tcagcagcca gtgtgatgct
     3961 gctggtcagt gccagtgcaa ggcccaggtg gaaggcctca cttgcagcca ctgccggccc
     4021 caccacttcc acctgagtgc cagcaaccca gacggctgcc tgccctgctt ctgtatgggc
     4081 atcacccagc agtgcgccag ctctgcctac acacgccacc tgatctccac ccactttgcc
     4141 cctggggact tccaaggctt tgccctggtg aacccacagc gaaacagccg cctgacagga
     4201 gaattcactg tggaacccgt gcccgagggt gcccagctct cttttggcaa ctttgcccaa
     4261 ctcggccatg agtccttcta ctggcagctg ccggagacat accagggaga caaggtggcg
     4321 gcctacggtg ggaagttgcg atacaccctc tcctacacag caggcccaca gggcagccca
     4381 ctctctgacc ccgatgtgca gatcacgggc aacaacatca tgctagtggc ctcccagcca
     4441 gcgctgcagg gccctgagag gaggagctac gagatcatgt tccgagagga attctggcgc
     4501 cggcccgatg ggcagccggc cacacgcgag cacctcctga tggcactggc cgacctggat
     4561 gagctcctga tccgggccac gttctcctcc gtgccgctgg cggccagcat cagcgcagtc
     4621 agcctggagg tcgcccagcc ggggccctca aacagacccc gcgccctcga ggtggaggag
     4681 tgccgctgcc cgccaggcta catcggtctg tcctgccagg actgtgcccc cggctacacg
     4741 cgcaccggga gtgggctcta cctcggccac tgcgagctat gtgaatgcaa tggccactca
     4801 gacctgtgcc acccagagac tggggcctgc tcgcaatgcc agcacaacgc cgcaggggag
     4861 ttctgcgagc tttgtgcccc tggctactac ggagatgcca cagccgggac gcctgaggac
     4921 tgccagccct gtgcctgccc actgaccaac ccagagaaca tgttttcccg cacctgtgag
     4981 agcctgggag ccggcgggta ccgctgcacg gcctgcgaac ccggctacac tggccagtac
     5041 tgtgagcagt gtggcccagg ttacgtgggt aaccccagtg tgcaaggggg ccagtgcctg
     5101 ccagagacaa accaagcccc actggtggtc gaggtccatc ctgctcgaag catagtgccc
     5161 caaggtggct cccactccct gcggtgtcag gtcagtggga gcccacccca ctacttctat
     5221 tggtcccgtg aggatgggcg gcctgtgccc agcggcaccc agcagcgaca tcaaggctcc
     5281 gagctccact tccccagcgt ccagccctcg gatgctgggg tctacatttg cacctgccgt
     5341 aatctccacc aatccaatac cagccgggca gagctgctgg tcactgaggc tccaagcaag
     5401 cccatcacag tgactgtgga ggagcagcgg agccagagcg tgcgccccgg agctgacgtc
     5461 accttcatct gcacagccaa aagcaagtcc ccagcctata ccctggtgtg gacccgcctg
     5521 cacaacggga aactgcccac ccgagccatg gatttcaatg gcatcctgac cattcgcaac
     5581 gtccagctga gtgatgcagg cacctacgtg tgcaccggct ccaacatgtt tgccatggac
     5641 cagggcacag ccactctaca tgtgcaggcc tcgggcacct tgtccgcccc cgtggtctcc
     5701 atccatccgc cacagctcac agtgcagccc gggcaactgg cggagttccg ctgcagcgcc
     5761 acagggagcc ccacgcccac cctcgagtgg acagggggcc ccggcggcca gctccctgcg
     5821 aaggcacaaa tccacggcgg catcctgcgc ctgccagctg tcgagcccac ggatcaggcc
     5881 cagtacttgt gccgagccca cagcagcgct gggcagcagg tggccagggc tgtgctccac
     5941 gtgcatgggg gcggtgggcc cagagtccaa gtgagcccag agaggaccca ggtccacgca
     6001 ggccgcaccg tcaggctgta ctgcagggct gcaggcgtgc ctagcgccac catcacctgg
     6061 aggaaggaag ggggcagcct cccaccacag gcccggtcag agcgcacaga catcgcgaca
     6121 ctgctcatcc cagccatcac gactgctgac gccggcttct acctctgcgt ggccaccagc
     6181 cctgcaggca ctgcccaggc ccggatccaa gtggttgtcc tttcagcctc agatgccagc
     6241 ccaccgccgg tcaagattga gtcctcatcg ccttctgtga cagaagggca aacactcgac
     6301 ctcaactgtg tggtggcagg gtcagcccat gcccaggtca cctggtacag gcgagggggt
     6361 agcctgcctc cccacaccca ggtgcacggc tcccgtctgc ggctccccca ggtctcacca
     6421 gctgattctg gagaatatgt gtgccgtgtg gagaatggat cgggccccaa ggaggcctcc
     6481 attactgtgt ctgtgctcca cggcacccat tctggcccca gctacacccc agtgcccggc
     6541 agcacccggc ccatccgcat cgagccctcc tcctcacacg tggcggaagg gcagaccctg
     6601 gatctgaact gcgtggtgcc cgggcaggcc cacgcccagg tcacgtggca caagcgtggg
     6661 ggcagcctcc ctgcccggca ccagacccac ggctcgctgc tgcggctgca ccaggtgacc
     6721 ccggccgact caggcgagta tgtgtgccat gtggtgggca cctccggccc cctagaggcc
     6781 tcagtcctgg tcaccatcga agcctctgtc atccctggac ccatcccacc tgtcaggatc
     6841 gagtcttcat cctccacagt ggccgagggc cagaccctgg atctgagctg cgtggtggca
     6901 gggcaggccc acgcccaggt cacatggtac aagcgtgggg gcagcctccc tgcccggcac
     6961 caggttcgtg gctcccgcct gtacatcttc caggcctcac ctgccgatgc gggacagtac
     7021 gtctgccggg ccagcaacgg catggaggcc tccatcacgg tcacagtaac tgggacccag
     7081 ggggccaact tagcctaccc tgccggcagc acccagccca tccgcatcga gccctcctcc
     7141 tcgcaagtgg cggaagggca gaccctggat ctgaactgcg tggtgcccgg gcagtcccat
     7201 gcccaggtca cgtggcacaa gcgtgggggc agcctccctg tccggcacca gacccacggc
     7261 tccctgctga gactctacca agcgtccccc gccgactcgg gcgagtacgt gtgccgagtg
     7321 ttgggcagct ccgtgcctct agaggcctct gtcctggtca ccattgagcc tgcgggctca
     7381 gtgcctgcac ttggggtcac ccccacggtc cggatcgagt catcgtcttc gcaagtggcc
     7441 gaggggcaga ccctggacct gaactgcctc gttgctggtc aggcccatgc ccaggtcacg
     7501 tggcacaagc gcgggggcag cctcccggcc cggcaccagg tgcatggctc gaggctacgc
     7561 ctgctccagg tgaccccagc tgattcaggg gagtacgtgt gccgtgtggt cggcagctca
     7621 ggtacccagg aagcctcagt ccttgtcacc atccagcagc gccttagtgg ctcccactcc
     7681 cagggtgtgg cgtaccccgt ccgcatcgag tcctcctcag cctccctggc caatggacac
     7741 accctggacc tcaactgcct ggttgccagc caggctcccc acaccatcac ctggtataag
     7801 cgtggaggca gcttacccag ccggcaccag atcgtgggct cccggctgcg gatccctcag
     7861 gtgactccgg cagactcggg cgagtacgtg tgtcacgtca gtaacggtgc aggctcccgg
     7921 gagacctcgc tcatcgtcac catccagggc agcggttcct cccacgtgcc cagcgtctcc
     7981 ccaccgatca ggatcgagtc gtcttccccc acggtggtgg aagggcagac cttggatctg
     8041 aactgcgtgg tcgccaggca gccccaggct atcatcacat ggtacaagcg tgggggcagc
     8101 cttccctccc gacaccagac ccatggctcc cacctgcggt tgcaccaaat gtctgtggct
     8161 gactcgggcg agtatgtgtg ccgggccaac aacaacatcg atgccctgga ggcctccatc
     8221 gtcatctccg tctcccctag cgccggcagc ccctccgccc ctggcagctc catgcccatc
     8281 agaattgagt catcctcctc acacgtggcc gaaggggaga ccctggatct gaactgcgtg
     8341 gtccccgggc aggcccatgc ccaggtcact tggcacaagc gtgggggcag cctccccagt
     8401 caccatcaga cccgcggctc acggctgcgg ctgcaccatg tgtccccggc cgactcgggt
     8461 gaatacgtgt gccgggtgat gggcagctct ggccccctgg aggcctcagt cctggtcacc
     8521 atcgaagcct ctggctcaag tgctgtccac gtccccgccc caggtggagc cccacccatc
     8581 cgcatcgagc cctcctcctc ccgagtggca gaagggcaga ccctggatct gaagtgcgtg
     8641 gtgcccgggc aggcccacgc ccaggtcacg tggcacaagc gtggaggaaa cctccctgcc
     8701 cggcaccagg tccacggccc actgctgagg ctgaaccagg tgtccccggc tgactctggc
     8761 gagtactcgt gccaagtgac cggaagctca ggcaccctgg aggcatctgt cctggtcaca
     8821 attgagccct ccagcccagg acccattcct gctccaggac tggcccagcc catctacatc
     8881 gaggcctcct cttcacacgt gactgaaggg cagactctgg atctgaactg tgtggtgccc
     8941 gggcaggccc atgcccaggt cacgtggtac aagcgcgggg gcagcctccc cgcccggcac
     9001 cagacccatg gctcccagct gcggctccac ctcgtctccc ctgccgactc aggcgagtat
     9061 gtgtgtcgtg cagccagcgg cccaggccct gagcaagaag cctccttcac agtcaccgtc
     9121 ccgcccagtg aggggtcttc ctaccgcctt aggagcccgg tcatctccat cgacccgccc
     9181 agcagcaccg tgcagcaggg ccaggatgcc agcttcaagt gcctcatcca tgacggggca
     9241 gcccccatca gcctcgagtg gaagacccgg aaccaggagc tggaggacaa cgtccacatc
     9301 agtcccaatg gctccatcat caccatcgtg ggcacccggc ccagcaacca cggtacctac
     9361 cgctgcgtgg cctccaatgc ctacggtgtg gcccagagtg tggtgaacct cagtgtgcac
     9421 gggcccccta cagtgtccgt gctccccgag ggccccgtgt gggtgaaagt gggaaaggct
     9481 gtcaccctgg agtgtgtcag tgccggggag ccccgctcct ctgctcgttg gacccggatc
     9541 agcagcaccc ctgccaagtt ggagcagcgg acatatgggc tcatggacag ccacgcggtg
     9601 ctgcagattt catcagctaa accatcagat gcgggcactt atgtgtgcct tgctcagaat
     9661 gcactaggca cagcacagaa gcaggtggag gtgatcgtgg acacgggcgc catggcccca
     9721 ggggcccctc aggtccaagc tgaagaagct gagctgactg tggaggctgg acacacggcc
     9781 accttgcgct gctcagccac aggcagcccc gcgcccacca tccactggtc caagctgcgt
     9841 tccccactgc cctggcagca ccggctggaa ggtgacacac tcatcatacc ccgggtagcc
     9901 cagcaggact cgggccagta catctgcaat gccactagcc ctgctgggca cgctgaggcc
     9961 accatcatcc tgcacgtgga gagcccacca tatgccacca cggtcccaga gcacgcttcg
    10021 gtgcaggcag gggagacggt gcagctccag tgcctggctc acgggacacc cccactcacc
    10081 ttccagtgga gccgcgtggg cagcagcctt cctgggaggg cgaccgccag gaacgagctg
    10141 ctgcactttg agcgtgcagc ccctgaggac tcaggccgct accgctgccg ggtcaccaac
    10201 aaggtgggct cagccgaggc ctttgcccag ctgctcgtcc aaggccctcc cggctctctc
    10261 cctgccacct ccatcccagc agggtccacg cccaccgtgc aggtcacgcc tcagctagag
    10321 accaagagca ttggggccag cgttgagttc cactgtgctg tgcccagcga ccggggtacc
    10381 cagctccgtt ggttcaagga agggggtcag ctgcctccgg gtcacagcgt gcaggatggg
    10441 gtgctccgaa tccagaactt ggaccagagc tgccaaggga cgtatatatg ccaggcccat
    10501 ggaccttggg ggaaggccca ggccagtgcc cagctggtta tccaagccct gccctcggtg
    10561 ctcatcaaca tccggacctc tgtgcagacc gtggtggttg gccacgccgt ggagttcgaa
    10621 tgcctggcac tgggtgaccc caagcctcag gtgacatgga gcaaagttgg agggcacctg
    10681 cggccaggca ttgtgcagag cggaggtgtc gtcaggatcg cccacgtaga gctggctgat
    10741 gcgggacagt atcgctgcac tgccaccaac gcagctggca ccacacaatc ccacgtcctg
    10801 ctgcttgtgc aagccttgcc ccagatctca atgccccaag aagtccgtgt gcctgctggt
    10861 tctgcagctg tcttcccctg catagcctca ggctacccca ctcctgacat cagctggagc
    10921 aagctggatg gcagcctgcc acctgacagc cgcctggaga acaacatgct gatgctgccc
    10981 tcagtccgac cccaggacgc aggtacctac gtctgcaccg ccactaaccg ccagggcaag
    11041 gtcaaagcct ttgcccacct gcaggtgcca gagcgggtgg tgccctactt cacgcagacc
    11101 ccctactcct tcctaccgct gcccaccatc aaggatgcct acaggaagtt cgagatcaag
    11161 atcaccttcc ggcccgactc agccgatggg atgctgctgt acaatgggca gaagcgagtc
    11221 ccagggagcc ccaccaacct ggccaaccgg cagcccgact tcatctcctt cggcctcgtg
    11281 gggggaaggc ccgagttccg gttcgatgca ggctcaggca tggccaccat ccgccatccc
    11341 acaccactgg ccctgggcca tttccacacc gtgaccctgc tgcgcagcct cacccagggc
    11401 tccctgattg tgggtgacct ggccccggtc aatgggacct cccagggcaa gttccagggc
    11461 ctggatctga acgaggaact ctacctgggt ggctatcctg actatggtgc catccccaag
    11521 gcggggctga gcagcggctt cataggctgt gtccgggagc tgcgcatcca gggcgaggag
    11581 atcgtcttcc atgacctcaa cctcacggcg cacggcatct cccactgccc cacctgtcgg
    11641 gaccggccct gccagaatgg cggtcagtgc catgactctg agagcagcag ctacgtgtgc
    11701 gtctgcccag ctggcttcac cgggagccgc tgtgagcact cgcaggccct gcactgccat
    11761 ccagaggcct gtgggcccga cgccacctgt gtgaaccggc ctgacggtcg aggctacacc
    11821 tgccgctgcc acctgggccg ctcggggttg cggtgtgagg aaggtgtgac agtgaccacc
    11881 ccctcgctgt cgggtgctgg ctcctacctg gcactgcccg ccctcaccaa cacacaccac
    11941 gagctacgcc tggacgtgga gttcaagcca ctcgcccctg acggggtcct gctgttcagc
    12001 ggggggaaga gcgggcctgt ggaggacttc gtgtccctgg cgatggtggg cggccacctg
    12061 gagttccgct atgagttggg gtcagggctg gccgttctgc ggagcgccga gccgctggcc
    12121 ctgggccgct ggcaccgtgt gtctgcagag cgtctcaaca aggacggcag cctgcgggtg
    12181 aatggtggac gccctgtgct gcgctcctcg cccggcaaga gccagggcct caacctgcac
    12241 accctgctct acctgggggg tgtggagcct tccgtgccac tgtccccggc caccaacatg
    12301 agcgctcact tccgcggctg tgtgggcgag gtgtcagtga atggcaaacg gctggacctc
    12361 acctacagtt tcctaggcag ccagggcatc gggcaatgct atgatagctc cccatgtgag
    12421 cgccagcctt gccaacatgg tgccacgtgc atgcccgctg gcgagtatga gttccagtgc
    12481 ctgtgtcgag atggattcaa aggagacctg tgtgagcacg aggagaaccc ctgccagctc
    12541 cgtgaaccct gtctgcatgg gggcacctgc cagggcaccc gctgcctctg cctccctggc
    12601 ttctctggcc cacgctgcca acaaggctct ggacatggca tagcagagtc cgactggcat
    12661 cttgaaggca gcgggggcaa tgatgcccct gggcagtacg gagcctattt ccacgatgat
    12721 ggcttcctcg ccttccctgg ccatgtcttc tccaggagcc tgcccgaggt gcccgagacc
    12781 atcgagctgg aggttcggac cagcacagcc agtggcctcc tgctctggca gggtgtggag
    12841 gtgggagagg ccggccaagg caaggacttc atcagcctcg ggcttcaaga cgggcacctt
    12901 gtcttcaggt accagctggg tagtggggag gcccgcctgg tctctgagga ccccatcaat
    12961 gacggcgagt ggcaccgggt gacagcactg cgggagggcc gcagaggttc catccaagtc
    13021 gacggtgagg agctggtcag cggccggtcc ccaggtccca acgtggcagt caacgccaag
    13081 ggcagcgtct acatcggcgg agcccctgac gtggccacgc tgaccggggg cagattctcc
    13141 tcaggcatca caggctgtgt caagaacctg gtgctgcact cggcccgacc cggcgccccg
    13201 cccccacagc ccctggacct gcagcaccgc gcccaggccg gggccaacac acgcccctgc
    13261 ccctcgtagg cacctgcctg ccccacacgg actcccgggc cacgccccag cccgacaatg
    13321 tcgagtatat tattattaat attattatga atttttgtaa gaaaccgagg cgatgccacg
    13381 ctttgctgct accgccctgg gctggactgg aggtgggcat gccaccctca cacacacagc
    13441 tgggcaaagc cacaaggctg gccagcaagg caggttggat gggagtgggc acctcagaaa
    13501 gtcaccagga cttggggtca ggaacagtgg ctgggtgggc ccagaactgc ccccactgtc
    13561 cccctaccca ccgatggagc ccccagatag agctgggtgg cctgtttctg cagcccttgg
    13621 gcagttctca ctcctaggag agccaacctc ggcttgtggg ctggtgcccc acagctacct
    13681 gagacgggca tcgcaggagt ctctgccacc cactcaggat tgggaattgt ctttagtgcc
    13741 ggctgtggag caaaaggcag ctcacccctg ggcaggcggt ccccatcccc accagctcgt
    13801 ttttcagcac ccccacccac ctccacccag cccctggcac ctcctctggc agactccccc
    13861 tcctaccacg tcctcctggc ctgcattccc accccctcct gccagcacac agcctggggt
    13921 ccctccctca ggggctgtaa gggaaggccc accccaactc ttaccaggag ctgctacagg
    13981 cagagcccag cactgatagg gccccgccca ccgggccccg cccaccccag gccacatccc
    14041 cacccatctg gaagtgaagg cccagggact cctccaacag acaacggacg gacggatgcc
    14101 gctggtgctc aggaagagct agtgccttag gtgggggaag gcaggactca cgactgagag
    14161 agagaggagg gggatatgac caccctgccc catctgcagg agcctgaaga tccagctcaa
    14221 gtgccatcct gccagtggcc cccagactgt ggggttggga cgcctggcct ctgtgtccta
    14281 gaagggaccc tcctgtggtc tttgtcttga tttttcttaa taaacggtgc tatccccgcc
    14341 a
//
