LOCUS       NM_001202485            3897 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens HSPE1-MOB4 readthrough (HSPE1-MOB4), mRNA.
ACCESSION   NM_001202485
VERSION     NM_001202485.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3897)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020550.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001202485.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring HSPE1 (heat shock 10kDa
            protein 1 (chaperonin 10)) and MOB4 (MOB family member 4, phocein)
            genes on chromosome 2. The read-through transcript produces a
            fusion protein that shares sequence identity with each individual
            gene product. [provided by RefSeq, Oct 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.225512.1,
                                           SRR1803617.63845.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 3336, 25843
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC020550.4         166131-166191       c
            62-226              AC020550.4         165332-165496       c
            227-289             AC020550.4         142884-142946       c
            290-390             AC020550.4         130940-131040       c
            391-433             AC020550.4         126417-126459       c
            434-520             AC020550.4         126133-126219       c
            521-600             AC020550.4         118155-118234       c
            601-712             AC020550.4         116184-116295       c
            713-3897            AC020550.4         112871-116055       c
FEATURES             Location/Qualifiers
     source          1..3897
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..3897
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /note="HSPE1-MOB4 readthrough"
                     /db_xref="GeneID:100529241"
                     /db_xref="HGNC:HGNC:49184"
     exon            1..61
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..844
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /codon_start=1
                     /product="HSPE1-MOB4 protein"
                     /protein_id="NP_001189414.1"
                     /db_xref="GeneID:100529241"
                     /db_xref="HGNC:HGNC:49184"
                     /translation="MAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQA
                     TVVAVGSGSKGKDFYNWPDESFDEMDSTLAVQQYIQQNIRADCSNIDKILEPPEGQDE
                     GVWKYEHLRQFCLELNGLAVKLQSECHPDTCTQMTATEQWIFLCAAHKTPKECPAIDY
                     TRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYE
                     NETFLCHRFTKFVMKYNLMSKDNLIVPILEEEVQNSVSGESEA"
     exon            62..226
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /inference="alignment:Splign:2.1.0"
     exon            227..289
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /inference="alignment:Splign:2.1.0"
     exon            290..390
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /inference="alignment:Splign:2.1.0"
     exon            391..433
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /inference="alignment:Splign:2.1.0"
     exon            434..520
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /inference="alignment:Splign:2.1.0"
     exon            521..600
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /inference="alignment:Splign:2.1.0"
     exon            601..712
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /inference="alignment:Splign:2.1.0"
     exon            713..3897
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1085..1090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /note="hexamer: AATAAA"
     polyA_site      1111
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /note="major polyA site"
     regulatory      2793..2798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /note="hexamer: CATAAA"
     polyA_site      2815
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /note="major polyA site"
     regulatory      2967..2972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /note="hexamer: CATAAA"
     polyA_site      2989
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
     regulatory      3877..3882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
                     /note="hexamer: AGTAAA"
     polyA_site      3897
                     /gene="HSPE1-MOB4"
                     /gene_synonym="HSPE1-PHOCN"
ORIGIN      
        1 gcgagtctct ttgcggcgct acactagagc agagtacgag tctgaggcgg agggagtaat
       61 ggcaggacaa gcgtttagaa agtttcttcc actctttgac cgagtattgg ttgaaaggag
      121 tgctgctgaa actgtaacca aaggaggcat tatgcttcca gaaaaatctc aaggaaaagt
      181 attgcaagca acagtagtcg ctgttggatc gggttctaaa ggaaaggatt tctataattg
      241 gcctgatgaa tcctttgatg aaatggacag tacactagct gttcaacagt atattcaaca
      301 gaacataaga gcagattgct ccaatattga caaaattctt gaaccacctg aaggccaaga
      361 tgaaggtgtg tggaagtatg aacatttaag gcagttctgc cttgagctaa atggacttgc
      421 tgtcaaactt cagagtgaat gccatccaga tacttgcact caaatgacag caactgaaca
      481 atggattttt ctttgtgcag ctcataaaac tccaaaagag tgtcctgcta tagactatac
      541 tagacacaca cttgatggtg ctgcatgtct tctgaatagc aataaatatt ttcccagcag
      601 ggttagcata aaggaatcat ctgtagcgaa actaggatca gtatgccgta ggatttacag
      661 aatattttca catgcttatt ttcatcatcg gcagatattt gatgaatatg aaaatgaaac
      721 atttttgtgt catcggttta ctaagtttgt gatgaaatac aatttgatgt ccaaggataa
      781 cctgattgta ccaattttag aagaggaagt acagaattca gtttctgggg aaagtgaagc
      841 atgaagggaa tcataggaaa aatgtactga tcatataatt aacattatgt actgtatata
      901 tcattttaga cacatcaatc atgtatccat attatagctt ctttgtttag tataggtttt
      961 tgtatgctgg gtttgccttt taaaatggga aatacttttt aagttattca taagctgtat
     1021 attcaccagt gtggcactca tggtttttaa ataagattag tattatctgt ttataatgcc
     1081 tgttaataaa agaatttaca gtttggtaaa attgctgcta aacaatcatt ggatcacaat
     1141 cctcatcaga caaacccatc tgtaaaaaaa atgagggaga gcttgaggtt tcacacaagc
     1201 catttactaa agaggtagaa atgttttcta ttggttttac cttgagttta gatatcctaa
     1261 aaaattctgt agtacgtagt tttgtcttac ctgttaactt tccccaattg agataaaagt
     1321 gttttaaaat tctgtttata gtttttgata tgcatatata attatgtgta tatctaaata
     1381 caaatgcaaa tgaagcatta gtaatactta aataatttta ctgtgctaca taaagtataa
     1441 catacttgga aaggatttac cgttctgcaa caacggactg gtacatacag gatgatcaca
     1501 atggtaaggc acataaatta ttttcccact ggaaacctgc cctgtccacc ccttctcatt
     1561 tcccttaacc ttatcttcaa actactttag ctgagaagct tttcaccaga ctgagttagt
     1621 ggtggcttat acctatttat atttgtatta attgcttaca gattatacct catattagca
     1681 attacattac actacaagaa aatgtatttg cataggctct tgcttatctt tgttttgcaa
     1741 aattgttcta cttagaaaac agtccttaaa atagtttgac tcttcctgtt agtaatatat
     1801 taatctttca tttaaccagc taggcagcat taaatagaat tgaagaaata ccatagtatt
     1861 tattttacac cccctctccc acgaagttta tgtttggatt acatgcacgt gtgagattat
     1921 ttgcaataat tcataggttc caagggtgtt gatgaatagt catacatttt tttggacttt
     1981 gttataattc attgtggtaa gaatgattga aatgcagatt taacaatctt ataatctatt
     2041 gaatgccatt tttgataaag cactggaggt cttattgcca aactgattgt aatgaggcag
     2101 taagggtgaa aacattgtac atgttgtgaa gaaagtattt aaatccaact tttgaacaga
     2161 tttaacaaac atgaggaact tttttattta gaaggataat tttgaagatg aaaatgtatt
     2221 catcttaatt gttttttcaa atttaaggga ataatttata ccatcttttc agacaagaat
     2281 gtacagcaaa aataagggga acagtagtat actgagagtg tgtgtatgta tagtgtatgc
     2341 ctttccaagc ttgccagtct ttttggcttt gaacactgcc catcagctac agtcattact
     2401 gttccccaac ccacaactat cttttaagaa gtcttagttc acagtgaaag gaatgatgac
     2461 tttgaaatta tggatttata ttaatggcac tataaaccaa tggtaatggt aatttttaaa
     2521 cttgctaaat attgagaaac taaactacta agttaataaa ttatatatag cagtgtagct
     2581 gttctctcta gatggtgtct cacaatggat ttctgttgct tgactatttt cttagtgaat
     2641 atttatacta aggtagtgac tgagatttgg tgatctggct gagtattttg aaacacattt
     2701 tgaataatat ggcttagtgt taacggggac ttaaatatga tttttttttc ttactcattt
     2761 caccttccct gtactgtatg tttggaattg atcataaaac atctccaaaa gaaaataatc
     2821 agtttgtagt cttgcttttg tattcatgtt gataatctta ctaattgtga agttgattca
     2881 ctactatact aggtaagacc taagtgaaac agttcctgtt tttccttaat actgttttca
     2941 gaattttgaa aatgtactta tatatacata aatactacta aaaaattaat gagcctggca
     3001 aaccattgat ttataaaagt aagtgttcta agaggggaac aagacagttc tgtgtgataa
     3061 ggaagttagg ctccactttt tgtttgaatt accctatgta tatccgaagg taaacttagg
     3121 cttttctttc caaaagatcg tatagtcaat tcattctttt tctcctatca catctgggaa
     3181 agtagctaac ttttaactat ttatgttccc ataagtaacc cttcttttgt gtgtatacat
     3241 ttccttttct ctgacttgag atgtcaaatt tggatttcta gaacagtttc tcagttaaat
     3301 tcttgatgac ttaacaactt ttactatcag aatacaatta gaaatccttg gtcaggcaca
     3361 ggggctcacg cctgtaatcc cagcactttg ggaagccaag gcagacagat cacctgaggt
     3421 caggagttcg agaccagcct gaccaacatg gagaaaccct gtctctacta aaaatacaaa
     3481 aattagccgg gcgtggtgct actcgtgagg ctgaggcagg agaatcgctt gaacccggga
     3541 ggtggaggtt gcggtgagct gagatcgtgc cattgcactc cagcctgggt aacgagcaaa
     3601 actccgtctc aaaaactccg tctcaaaaaa aaaaaatcct tgattacatt gttagtaagg
     3661 actgtgttac gattataaac acatttattg gttgatgtca aattcactgt aatagtagaa
     3721 ctaagttttt tatgtgagta ctttgcccta ctgtctatat gatgacatct tttttgagca
     3781 gctaaatttt aaattgtata tactttattt tgtgaatcct tgttgaatgt gctaaaggtt
     3841 tctttgtgta gttcttccat gctatgcgaa tattttagta aaagtagttg attttta
//
