LOCUS       NM_012267               1635 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens HSPA (Hsp70) binding protein 1 (HSPBP1), transcript
            variant 1, mRNA.
ACCESSION   NM_012267 XM_001128038
VERSION     NM_012267.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1635)
  AUTHORS   Youn,C.K., Lee,J.H., Hariharasudhan,G., Kim,H.B., Kim,J., Lee,S.,
            Lim,S.C., Yoon,S.P., Park,S.G., Chang,I.Y. and You,H.J.
  TITLE     HspBP1 is a dual function regulatory protein that controls both DNA
            repair and apoptosis in breast cancer cells
  JOURNAL   Cell Death Dis 13 (4), 309 (2022)
   PUBMED   35387978
  REMARK    GeneRIF: HspBP1 is a dual function regulatory protein that controls
            both DNA repair and apoptosis in breast cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1635)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1635)
  AUTHORS   Yang,Y.X., Huang,J.P., Li,S.N., Li,J., Ling,T., Xie,T. and Xu,L.G.
  TITLE     HSPBP1 facilitates cellular RLR-mediated antiviral response by
            inhibiting the K48-linked ubiquitination of RIG-I
  JOURNAL   Mol Immunol 134, 62-71 (2021)
   PUBMED   33713958
  REMARK    GeneRIF: HSPBP1 facilitates cellular RLR-mediated antiviral
            response by inhibiting the K48-linked ubiquitination of RIG-I.
REFERENCE   4  (bases 1 to 1635)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1635)
  AUTHORS   Mahboubi,H., Moujaber,O., Kodiha,M. and Stochaj,U.
  TITLE     The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules
            that Regulates Their Formation
  JOURNAL   Cells 9 (4), 825 (2020)
   PUBMED   32235396
  REMARK    GeneRIF: The Co-Chaperone HspBP1 Is a Novel Component of Stress
            Granules that Regulates Their Formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1635)
  AUTHORS   McLellan,C.A., Raynes,D.A. and Guerriero,V.
  TITLE     HspBP1, an Hsp70 cochaperone, has two structural domains and is
            capable of altering the conformation of the Hsp70 ATPase domain
  JOURNAL   J Biol Chem 278 (21), 19017-19022 (2003)
   PUBMED   12651857
REFERENCE   7  (bases 1 to 1635)
  AUTHORS   Kabani,M., McLellan,C., Raynes,D.A., Guerriero,V. and Brodsky,J.L.
  TITLE     HspBP1, a homologue of the yeast Fes1 and Sls1 proteins, is an
            Hsc70 nucleotide exchange factor
  JOURNAL   FEBS Lett 531 (2), 339-342 (2002)
   PUBMED   12417338
REFERENCE   8  (bases 1 to 1635)
  AUTHORS   Raynes,D.A. and Guerriero,V.
  TITLE     Isolation and characterization of isoforms of HspBP1, inhibitors of
            Hsp70
  JOURNAL   Biochim Biophys Acta 1490 (1-2), 203-207 (2000)
   PUBMED   10786638
REFERENCE   9  (bases 1 to 1635)
  AUTHORS   Raynes,D.A. and Guerriero,V. Jr.
  TITLE     Inhibition of Hsp70 ATPase activity and protein renaturation by a
            novel Hsp70-binding protein
  JOURNAL   J Biol Chem 273 (49), 32883-32888 (1998)
   PUBMED   9830037
  REMARK    GeneRIF: The cochaperone HspBP1 binds to and inhibits Hsp70
            activity.
REFERENCE   10 (bases 1 to 1635)
  AUTHORS   Zou,J., Guo,Y., Guettouche,T., Smith,D.F. and Voellmy,R.
  TITLE     Repression of heat shock transcription factor HSF1 activation by
            HSP90 (HSP90 complex) that forms a stress-sensitive complex with
            HSF1
  JOURNAL   Cell 94 (4), 471-480 (1998)
   PUBMED   9727490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM853303.1, AB020592.1 and BU630679.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012267.4.
            
            Transcript Variant: This variant (1) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream start codon, compared to variant 3. Variants 1 and 2
            encode the same isoform (2), which has a shorter N-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.146349.1, AK075293.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000433386.7/ ENSP00000398244.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BM853303.1         274-278
            6-1519              AB020592.1         1-1514
            1520-1635           BU630679.1         18-133              c
FEATURES             Location/Qualifiers
     source          1..1635
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1635
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /note="HSPA (Hsp70) binding protein 1"
                     /db_xref="GeneID:23640"
                     /db_xref="HGNC:HGNC:24989"
                     /db_xref="MIM:612939"
     exon            1..76
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..380
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1250
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /note="isoform 2 is encoded by transcript variant 1; hsp70
                     interacting protein; hsp70-binding protein 1; HSPA (heat
                     shock 70kDa) binding protein, cytoplasmic cochaperone 1;
                     heat shock protein-binding protein 1"
                     /codon_start=1
                     /product="hsp70-binding protein 1 isoform 2"
                     /protein_id="NP_036399.3"
                     /db_xref="CCDS:CCDS33111.1"
                     /db_xref="GeneID:23640"
                     /db_xref="HGNC:HGNC:24989"
                     /db_xref="MIM:612939"
                     /translation="MSDEGSRGSRLPLALPPASQGCSSGGGGGGSSAGGSGNSRPPRN
                     LQGLLQMAITAGSEEPDPPPEPMSEERRQWLQEAMSAAFRGQREEVEQMKSCLRVLSQ
                     PMPPTAGEAEQAADQQEREGALELLADLCENMDNAADFCQLSGMHLLVGRYLEAGAAG
                     LRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVRE
                     QEAGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQ
                     LVALVRTEHSPFHEHVLGALCSLVTDFPQGVRECREPELGLEELLRHRCQLLQQHEEY
                     QEELEFCEKLLQTCFSSPADDSMDR"
     exon            381..585
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..810
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..966
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1063
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1175
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1635
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1484..1489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /note="hexamer: AATAAA"
     polyA_site      1519
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /note="major polyA site"
     regulatory      1609..1614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /note="hexamer: AATAAA"
     polyA_site      1635
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
ORIGIN      
        1 agatggcggc gcccagcaga gtcaggtgcg gacgactttg tctgtaggag cagcggcggc
       61 ttgaggaccc ggggagaccc tcaagaatcg acccatcagg acgccagagc tgcttcagcg
      121 gtgaccacct tctccctcta acacattctt cccttcttca caaacggccc atgtcagacg
      181 aaggctcaag ggggagccgc ctgcccctgg cgctgccccc ggcctcccag ggttgctctt
      241 cagggggcgg cggcggcggc tcctcggctg ggggctcggg caattcccgg cccccacgca
      301 acctccaagg cttgctgcag atggccatca ccgcgggctc tgaagagcca gaccctcctc
      361 cagaaccgat gagtgaggag aggcgtcagt ggctgcagga ggccatgtcg gctgccttcc
      421 gaggccagcg ggaggaggtg gagcagatga agagctgcct ccgagtgctg tcacagccca
      481 tgccccccac tgctggggag gccgagcagg cggccgacca gcaagagcga gagggggccc
      541 tggagctgct ggccgacctg tgtgagaaca tggacaatgc cgcagacttc tgccagctgt
      601 ctggcatgca cctgctggtg ggccggtacc tggaggcggg ggctgcggga ctgcggtggc
      661 gggcggcaca gctcatcggc acgtgcagtc agaacgtggc agccatccag gagcaggtgc
      721 tgggcctggg tgccctgcgt aagctgctgc ggctgctgga ccgcgacgcc tgcgacacgg
      781 tgcgcgtcaa ggccctcttc gccatctcct gtctggtccg agagcaggag gctgggctgc
      841 tgcagttcct ccgcctggac ggcttctctg tgttgatgag ggccatgcag cagcaggtgc
      901 agaagctcaa ggtcaaatca gcattcctgc tgcagaacct gctggtgggc caccctgaac
      961 acaaagggac cctgtgctcc atggggatgg tccagcagct ggtggccctg gtgcggacag
     1021 agcacagccc cttccacgag cacgtgcttg gagccctgtg cagcctggtg acagactttc
     1081 cgcagggtgt gcgcgagtgt cgggagccgg aactgggcct ggaggagctc ctccgccacc
     1141 gctgtcagct gctgcagcag catgaggagt accaggagga gctggagttc tgtgaaaagc
     1201 tgctacagac ctgtttctcc agcccagcgg acgacagcat ggatcggtga aaccaggtgg
     1261 cttcttgccc ccttctccgt gggaacccca ggcctcttgc ctccctcccc acctacaagg
     1321 ccctctccca agggatcgca gggcctaggt gcctggaccc agggtgtgcc agcccgtctc
     1381 tgtgcagtcc ctggaagggg cgctgagaaa ggcaccagct ccttggaccc cacctcccat
     1441 gctctcactc tcatccccgt tctcttgtcc acacagctct tccaataaag gtgtttctct
     1501 tcctccttct cctccttcac tgccgccttt gtcatctcct ttggagggtg catgggggac
     1561 gggaggaggg gcacgggttt aagggacttg gggagccact ggaagaataa taaaagtgtt
     1621 gctctttatc atcta
//
