LOCUS       NP_036399                359 aa            linear   PRI 27-APR-2025
DEFINITION  hsp70-binding protein 1 isoform 2 [Homo sapiens].
ACCESSION   NP_036399 XP_001128038
VERSION     NP_036399.3
DBSOURCE    REFSEQ: accession NM_012267.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 359)
  AUTHORS   Youn,C.K., Lee,J.H., Hariharasudhan,G., Kim,H.B., Kim,J., Lee,S.,
            Lim,S.C., Yoon,S.P., Park,S.G., Chang,I.Y. and You,H.J.
  TITLE     HspBP1 is a dual function regulatory protein that controls both DNA
            repair and apoptosis in breast cancer cells
  JOURNAL   Cell Death Dis 13 (4), 309 (2022)
   PUBMED   35387978
  REMARK    GeneRIF: HspBP1 is a dual function regulatory protein that controls
            both DNA repair and apoptosis in breast cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 359)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (residues 1 to 359)
  AUTHORS   Yang,Y.X., Huang,J.P., Li,S.N., Li,J., Ling,T., Xie,T. and Xu,L.G.
  TITLE     HSPBP1 facilitates cellular RLR-mediated antiviral response by
            inhibiting the K48-linked ubiquitination of RIG-I
  JOURNAL   Mol Immunol 134, 62-71 (2021)
   PUBMED   33713958
  REMARK    GeneRIF: HSPBP1 facilitates cellular RLR-mediated antiviral
            response by inhibiting the K48-linked ubiquitination of RIG-I.
REFERENCE   4  (residues 1 to 359)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (residues 1 to 359)
  AUTHORS   Mahboubi,H., Moujaber,O., Kodiha,M. and Stochaj,U.
  TITLE     The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules
            that Regulates Their Formation
  JOURNAL   Cells 9 (4), 825 (2020)
   PUBMED   32235396
  REMARK    GeneRIF: The Co-Chaperone HspBP1 Is a Novel Component of Stress
            Granules that Regulates Their Formation.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 359)
  AUTHORS   McLellan,C.A., Raynes,D.A. and Guerriero,V.
  TITLE     HspBP1, an Hsp70 cochaperone, has two structural domains and is
            capable of altering the conformation of the Hsp70 ATPase domain
  JOURNAL   J Biol Chem 278 (21), 19017-19022 (2003)
   PUBMED   12651857
REFERENCE   7  (residues 1 to 359)
  AUTHORS   Kabani,M., McLellan,C., Raynes,D.A., Guerriero,V. and Brodsky,J.L.
  TITLE     HspBP1, a homologue of the yeast Fes1 and Sls1 proteins, is an
            Hsc70 nucleotide exchange factor
  JOURNAL   FEBS Lett 531 (2), 339-342 (2002)
   PUBMED   12417338
REFERENCE   8  (residues 1 to 359)
  AUTHORS   Raynes,D.A. and Guerriero,V.
  TITLE     Isolation and characterization of isoforms of HspBP1, inhibitors of
            Hsp70
  JOURNAL   Biochim Biophys Acta 1490 (1-2), 203-207 (2000)
   PUBMED   10786638
REFERENCE   9  (residues 1 to 359)
  AUTHORS   Raynes,D.A. and Guerriero,V. Jr.
  TITLE     Inhibition of Hsp70 ATPase activity and protein renaturation by a
            novel Hsp70-binding protein
  JOURNAL   J Biol Chem 273 (49), 32883-32888 (1998)
   PUBMED   9830037
  REMARK    GeneRIF: The cochaperone HspBP1 binds to and inhibits Hsp70
            activity.
REFERENCE   10 (residues 1 to 359)
  AUTHORS   Zou,J., Guo,Y., Guettouche,T., Smith,D.F. and Voellmy,R.
  TITLE     Repression of heat shock transcription factor HSF1 activation by
            HSP90 (HSP90 complex) that forms a stress-sensitive complex with
            HSF1
  JOURNAL   Cell 94 (4), 471-480 (1998)
   PUBMED   9727490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM853303.1, AB020592.1 and BU630679.1.
            
            On or before Sep 20, 2006 this sequence version replaced
            XP_001128038.1, NP_036399.2.
            
            Transcript Variant: This variant (1) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream start codon, compared to variant 3. Variants 1 and 2
            encode the same isoform (2), which has a shorter N-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.146349.1, AK075293.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000433386.7/ ENSP00000398244.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..359
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     Protein         1..359
                     /product="hsp70-binding protein 1 isoform 2"
                     /note="hsp70 interacting protein; hsp70-binding protein 1;
                     HSPA (heat shock 70kDa) binding protein, cytoplasmic
                     cochaperone 1; heat shock protein-binding protein 1"
                     /calculated_mol_wt=39172
     Region          1..71
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZL4.2)"
     Region          45..139
                     /region_name="Fes1"
                     /note="Nucleotide exchange factor Fes1; pfam08609"
                     /db_xref="CDD:462534"
     Region          88..130
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(121,125,129,163,167,171,206,210,214)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          132..174
                     /region_name="ARM 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZL4.2)"
     Region          137..174
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          177..217
                     /region_name="ARM 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZL4.2)"
     Region          180..215
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          220..259
                     /region_name="ARM 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZL4.2)"
     Region          233..257
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          262..301
                     /region_name="ARM 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZL4.2)"
     Region          265..301
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            351
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9NZL4.2)"
     Site            356
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9NZL4.2)"
     CDS             1..359
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /coded_by="NM_012267.5:171..1250"
                     /note="isoform 2 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS33111.1"
                     /db_xref="GeneID:23640"
                     /db_xref="HGNC:HGNC:24989"
                     /db_xref="MIM:612939"
ORIGIN      
        1 msdegsrgsr lplalppasq gcssgggggg ssaggsgnsr pprnlqgllq maitagseep
       61 dpppepmsee rrqwlqeams aafrgqreev eqmksclrvl sqpmpptage aeqaadqqer
      121 egalelladl cenmdnaadf cqlsgmhllv gryleagaag lrwraaqlig tcsqnvaaiq
      181 eqvlglgalr kllrlldrda cdtvrvkalf aisclvreqe agllqflrld gfsvlmramq
      241 qqvqklkvks afllqnllvg hpehkgtlcs mgmvqqlval vrtehspfhe hvlgalcslv
      301 tdfpqgvrec repelgleel lrhrcqllqq heeyqeelef cekllqtcfs spaddsmdr
//
