LOCUS       NM_001130106            1799 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens HSPA (Hsp70) binding protein 1 (HSPBP1), transcript
            variant 2, mRNA.
ACCESSION   NM_001130106
VERSION     NM_001130106.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1799)
  AUTHORS   Youn,C.K., Lee,J.H., Hariharasudhan,G., Kim,H.B., Kim,J., Lee,S.,
            Lim,S.C., Yoon,S.P., Park,S.G., Chang,I.Y. and You,H.J.
  TITLE     HspBP1 is a dual function regulatory protein that controls both DNA
            repair and apoptosis in breast cancer cells
  JOURNAL   Cell Death Dis 13 (4), 309 (2022)
   PUBMED   35387978
  REMARK    GeneRIF: HspBP1 is a dual function regulatory protein that controls
            both DNA repair and apoptosis in breast cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1799)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1799)
  AUTHORS   Yang,Y.X., Huang,J.P., Li,S.N., Li,J., Ling,T., Xie,T. and Xu,L.G.
  TITLE     HSPBP1 facilitates cellular RLR-mediated antiviral response by
            inhibiting the K48-linked ubiquitination of RIG-I
  JOURNAL   Mol Immunol 134, 62-71 (2021)
   PUBMED   33713958
  REMARK    GeneRIF: HSPBP1 facilitates cellular RLR-mediated antiviral
            response by inhibiting the K48-linked ubiquitination of RIG-I.
REFERENCE   4  (bases 1 to 1799)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1799)
  AUTHORS   Mahboubi,H., Moujaber,O., Kodiha,M. and Stochaj,U.
  TITLE     The Co-Chaperone HspBP1 Is a Novel Component of Stress Granules
            that Regulates Their Formation
  JOURNAL   Cells 9 (4), 825 (2020)
   PUBMED   32235396
  REMARK    GeneRIF: The Co-Chaperone HspBP1 Is a Novel Component of Stress
            Granules that Regulates Their Formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1799)
  AUTHORS   McLellan,C.A., Raynes,D.A. and Guerriero,V.
  TITLE     HspBP1, an Hsp70 cochaperone, has two structural domains and is
            capable of altering the conformation of the Hsp70 ATPase domain
  JOURNAL   J Biol Chem 278 (21), 19017-19022 (2003)
   PUBMED   12651857
REFERENCE   7  (bases 1 to 1799)
  AUTHORS   Kabani,M., McLellan,C., Raynes,D.A., Guerriero,V. and Brodsky,J.L.
  TITLE     HspBP1, a homologue of the yeast Fes1 and Sls1 proteins, is an
            Hsc70 nucleotide exchange factor
  JOURNAL   FEBS Lett 531 (2), 339-342 (2002)
   PUBMED   12417338
REFERENCE   8  (bases 1 to 1799)
  AUTHORS   Raynes,D.A. and Guerriero,V.
  TITLE     Isolation and characterization of isoforms of HspBP1, inhibitors of
            Hsp70
  JOURNAL   Biochim Biophys Acta 1490 (1-2), 203-207 (2000)
   PUBMED   10786638
REFERENCE   9  (bases 1 to 1799)
  AUTHORS   Raynes,D.A. and Guerriero,V. Jr.
  TITLE     Inhibition of Hsp70 ATPase activity and protein renaturation by a
            novel Hsp70-binding protein
  JOURNAL   J Biol Chem 273 (49), 32883-32888 (1998)
   PUBMED   9830037
  REMARK    GeneRIF: The cochaperone HspBP1 binds to and inhibits Hsp70
            activity.
REFERENCE   10 (bases 1 to 1799)
  AUTHORS   Zou,J., Guo,Y., Guettouche,T., Smith,D.F. and Voellmy,R.
  TITLE     Repression of heat shock transcription factor HSF1 activation by
            HSP90 (HSP90 complex) that forms a stress-sensitive complex with
            HSF1
  JOURNAL   Cell 94 (4), 471-480 (1998)
   PUBMED   9727490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM853303.1, AF217996.1, AB020592.1 and BU630679.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001130106.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream start codon, compared to variant 3. Variants 1 and 2
            encode the same isoform (2), which has a shorter N-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF217996.1, SRR14038194.581328.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BM853303.1         1-23
            24-169              AF217996.1         1-146
            170-1683            AB020592.1         1-1514
            1684-1799           BU630679.1         18-133              c
FEATURES             Location/Qualifiers
     source          1..1799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1799
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /note="HSPA (Hsp70) binding protein 1"
                     /db_xref="GeneID:23640"
                     /db_xref="HGNC:HGNC:24989"
                     /db_xref="MIM:612939"
     exon            1..166
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..240
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            241..544
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1414
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /note="isoform 2 is encoded by transcript variant 2; hsp70
                     interacting protein; hsp70-binding protein 1; HSPA (heat
                     shock 70kDa) binding protein, cytoplasmic cochaperone 1;
                     heat shock protein-binding protein 1"
                     /codon_start=1
                     /product="hsp70-binding protein 1 isoform 2"
                     /protein_id="NP_001123578.1"
                     /db_xref="CCDS:CCDS33111.1"
                     /db_xref="GeneID:23640"
                     /db_xref="HGNC:HGNC:24989"
                     /db_xref="MIM:612939"
                     /translation="MSDEGSRGSRLPLALPPASQGCSSGGGGGGSSAGGSGNSRPPRN
                     LQGLLQMAITAGSEEPDPPPEPMSEERRQWLQEAMSAAFRGQREEVEQMKSCLRVLSQ
                     PMPPTAGEAEQAADQQEREGALELLADLCENMDNAADFCQLSGMHLLVGRYLEAGAAG
                     LRWRAAQLIGTCSQNVAAIQEQVLGLGALRKLLRLLDRDACDTVRVKALFAISCLVRE
                     QEAGLLQFLRLDGFSVLMRAMQQQVQKLKVKSAFLLQNLLVGHPEHKGTLCSMGMVQQ
                     LVALVRTEHSPFHEHVLGALCSLVTDFPQGVRECREPELGLEELLRHRCQLLQQHEEY
                     QEELEFCEKLLQTCFSSPADDSMDR"
     exon            545..749
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            750..974
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1130
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1227
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1339
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1799
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /note="hexamer: AATAAA"
     polyA_site      1683
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /note="major polyA site"
     regulatory      1773..1778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
                     /note="hexamer: AATAAA"
     polyA_site      1799
                     /gene="HSPBP1"
                     /gene_synonym="FES1"
ORIGIN      
        1 gcaaaagtat cgggggcggg actcgctgag gtgcgaaaac tgggccaggg gcagggcttt
       61 gaccagctac ttgagcgtga aggggcggcg cccgcacgaa ggggcgtccc agcttggagg
      121 cggggcccgg atgggagggg cggggccgag tgcagtatcc cgccagatgg cggcgcccag
      181 cagagtcagg tgcggacgac tttgtctgta ggagcagcgg cggcttgagg acccggggag
      241 accctcaaga atcgacccat caggacgcca gagctgcttc agcggtgacc accttctccc
      301 tctaacacat tcttcccttc ttcacaaacg gcccatgtca gacgaaggct caagggggag
      361 ccgcctgccc ctggcgctgc ccccggcctc ccagggttgc tcttcagggg gcggcggcgg
      421 cggctcctcg gctgggggct cgggcaattc ccggccccca cgcaacctcc aaggcttgct
      481 gcagatggcc atcaccgcgg gctctgaaga gccagaccct cctccagaac cgatgagtga
      541 ggagaggcgt cagtggctgc aggaggccat gtcggctgcc ttccgaggcc agcgggagga
      601 ggtggagcag atgaagagct gcctccgagt gctgtcacag cccatgcccc ccactgctgg
      661 ggaggccgag caggcggccg accagcaaga gcgagagggg gccctggagc tgctggccga
      721 cctgtgtgag aacatggaca atgccgcaga cttctgccag ctgtctggca tgcacctgct
      781 ggtgggccgg tacctggagg cgggggctgc gggactgcgg tggcgggcgg cacagctcat
      841 cggcacgtgc agtcagaacg tggcagccat ccaggagcag gtgctgggcc tgggtgccct
      901 gcgtaagctg ctgcggctgc tggaccgcga cgcctgcgac acggtgcgcg tcaaggccct
      961 cttcgccatc tcctgtctgg tccgagagca ggaggctggg ctgctgcagt tcctccgcct
     1021 ggacggcttc tctgtgttga tgagggccat gcagcagcag gtgcagaagc tcaaggtcaa
     1081 atcagcattc ctgctgcaga acctgctggt gggccaccct gaacacaaag ggaccctgtg
     1141 ctccatgggg atggtccagc agctggtggc cctggtgcgg acagagcaca gccccttcca
     1201 cgagcacgtg cttggagccc tgtgcagcct ggtgacagac tttccgcagg gtgtgcgcga
     1261 gtgtcgggag ccggaactgg gcctggagga gctcctccgc caccgctgtc agctgctgca
     1321 gcagcatgag gagtaccagg aggagctgga gttctgtgaa aagctgctac agacctgttt
     1381 ctccagccca gcggacgaca gcatggatcg gtgaaaccag gtggcttctt gcccccttct
     1441 ccgtgggaac cccaggcctc ttgcctccct ccccacctac aaggccctct cccaagggat
     1501 cgcagggcct aggtgcctgg acccagggtg tgccagcccg tctctgtgca gtccctggaa
     1561 ggggcgctga gaaaggcacc agctccttgg accccacctc ccatgctctc actctcatcc
     1621 ccgttctctt gtccacacag ctcttccaat aaaggtgttt ctcttcctcc ttctcctcct
     1681 tcactgccgc ctttgtcatc tcctttggag ggtgcatggg ggacgggagg aggggcacgg
     1741 gtttaaggga cttggggagc cactggaaga ataataaaag tgttgctctt tatcatcta
//
