LOCUS       NM_024610               1964 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens HSPB1 associated protein 1 (HSPBAP1), transcript
            variant 1, mRNA.
ACCESSION   NM_024610
VERSION     NM_024610.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1964)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1964)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1964)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1964)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1964)
  AUTHORS   Saeed,K., Ostling,P., Bjorkman,M., Mirtti,T., Alanen,K.,
            Vesterinen,T., Sankila,A., Lundin,J., Lundin,M., Rannikko,A.,
            Nordling,S., Mpindi,J.P., Kohonen,P., Iljin,K., Kallioniemi,O. and
            Rantala,J.K.
  TITLE     Androgen receptor-interacting protein HSPBAP1 facilitates growth of
            prostate cancer cells in androgen-deficient conditions
  JOURNAL   Int J Cancer 136 (11), 2535-2545 (2015)
   PUBMED   25359680
  REMARK    GeneRIF: Data suggest a novel role and a possible link for HSPBAP1
            in promoting prostate cancer cell survival in androgen-deficient
            conditions by maintaining a basal level of androgen
            receptor-mediated transcription.
REFERENCE   6  (bases 1 to 1964)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   7  (bases 1 to 1964)
  AUTHORS   Xi,Z.Q., Sun,J.J., Wang,X.F., Li,M.W., Liu,X.Z., Wang,L.Y., Zhu,X.,
            Xiao,F., Li,J.M., Gong,Y. and Guan,L.F.
  TITLE     HSPBAP1 is found extensively in the anterior temporal neocortex of
            patients with intractable epilepsy
  JOURNAL   Synapse 61 (9), 741-747 (2007)
   PUBMED   17568411
  REMARK    GeneRIF: HSPBAP1 is found extensively in the anterior temporal
            neocortex of patients with intractable epilepsy.
REFERENCE   8  (bases 1 to 1964)
  AUTHORS   Jiang,M., Ma,Y., Cheng,H., Ni,X., Guo,L., Xie,Y. and Mao,Y.
  TITLE     Molecular cloning and characterization of a novel human gene
            (HSPBAP1) from human fetal brain
  JOURNAL   Cytogenet Cell Genet 95 (1-2), 48-51 (2001)
   PUBMED   11978969
  REMARK    GeneRIF: Molecular cloning and characterization of a novel human
            gene (HSPBAP1) from human fetal brain
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC048348.25, AK289410.1,
            BI912690.1, BC011897.2 and BU630355.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024610.5.
            
            Summary: This gene encodes a protein that binds to one of the small
            heat shock proteins, specifically hsp27. Hsp27 is involved with
            cell growth and differentiation. This encoded protein was found to
            be abnormally expressed in patients with intractable epilepsy,
            although how brain function is affected remains unknown. [provided
            by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.464148.1,
                                           SRR1660805.173231.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306103.3/ ENSP00000302562.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC048348.25        5249-5260
            13-47               AK289410.1         1-35
            48-62               BI912690.1         16-30
            63-1960             BC011897.2         35-1932
            1961-1964           BU630355.1         21-24               c
FEATURES             Location/Qualifiers
     source          1..1964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..1964
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /note="HSPB1 associated protein 1"
                     /db_xref="GeneID:79663"
                     /db_xref="HGNC:HGNC:16389"
                     /db_xref="MIM:608263"
     exon            1..215
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1618
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein associating with small stress protein PASS1; 27
                     kDa heat shock protein-associated protein 1; HSPB (heat
                     shock 27kDa) associated protein 1"
                     /codon_start=1
                     /product="HSPB1-associated protein 1 isoform 1"
                     /protein_id="NP_078886.2"
                     /db_xref="CCDS:CCDS3017.1"
                     /db_xref="GeneID:79663"
                     /db_xref="HGNC:HGNC:16389"
                     /db_xref="MIM:608263"
                     /translation="MAAGSEATTPVIVAAGAGGEEGEHVKPFKPEKAKEIIMSLQQPA
                     IFCNMVFDWPARHWNAKYLSQVLHGKQIRFRMGMKSMSTVPQFETTCNYVEATLEEFL
                     TWNCDQSSISGPFRDYDHSKFWAYADYKYFVSLFEDKTDLFQDVKWSDFGFPGRNGQE
                     STLWIGSLGAHTPCHLDSYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFS
                     KINVVNPDLKRFPQFRKAQRHAVTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELE
                     EDHLARVEEAITRMLVCALKTAENPQNTRAWLNPTEVEETSHAVNCCYLNAAVSAFFD
                     RCRTSEVVEIQALRTDGEHMKKEELNVCNHMEVGQTGSQNLTTGTDKPEAASPFGPDL
                     VPVAQRSEEPPSERGGIFGSDGKDFVDKDGEHFGKLHCAKRQQIMSNSENAIEEQIAS
                     NTTTTPQTFISTDDLLDCLVNPQVTRIVAQLLIQGRSL"
     exon            216..401
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..583
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..720
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..892
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /inference="alignment:Splign:2.1.0"
     exon            893..976
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1087
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1964
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1684..1689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /note="hexamer: AATAAA"
     polyA_site      1709
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
     regulatory      1943..1948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /note="hexamer: AATAAA"
     polyA_site      1964
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /note="major polyA site"
ORIGIN      
        1 gtgagagccg gcgtttccgt aggagccggg cgggagtcgc cggggctcct tcctgtggtg
       61 cagcttcggg tctcggagtt tggcccctac tctgacccca ccccagctcc gctccgcctt
      121 gggttccggc agaacccgcc ttgcggtagc catggcagca ggctccgagg cgaccactcc
      181 tgtgatcgtt gcggctgggg ctggagggga ggaaggtgaa catgtcaaac cttttaagcc
      241 agagaaagca aaagaaatta tcatgtcttt acaacaacct gcaatcttct gtaacatggt
      301 gtttgattgg ccagcacgac actggaatgc taaatacctt tcgcaggtcc ttcatggcaa
      361 gcagatacga ttcagaatgg ggatgaaaag catgagcaca gttcctcagt ttgaaactac
      421 atgtaattac gtagaagcta cactcgaaga gtttctgacc tggaactgtg accagtctag
      481 tatttctgga ccatttagag attatgacca ttccaagttc tgggcttatg ctgactataa
      541 atattttgtc agtctatttg aagacaagac agatcttttc caggatgtga aatggtctga
      601 cttcgggttt cctggaagaa atggacagga aagtacattg tggattggct ccttgggagc
      661 ccacacaccc tgtcatctgg actcctatgg ttgtaacttg gtattccagg tacaaggaag
      721 gaaacgatgg catctctttc ctcctgaaga tactcctttc ctttatccaa ctagaatccc
      781 ttatgaagaa tctagtgtgt tcagtaaaat caatgttgtc aatcctgatt taaagcgttt
      841 tcctcagttc cggaaagctc aaagacatgc ggttacactg agcccaggac aggttctctt
      901 tgttcccaga cactggtggc attacgtaga atccattgat cctgtcactg tcagtataaa
      961 ctcatggatt gaactggaag aggatcacct agcccgggta gaagaggcaa tcacccgtat
     1021 gcttgtgtgt gccctgaaaa ctgcagagaa tccacaaaat accagagcct ggttaaaccc
     1081 cactgaggtt gaggaaacgt cccatgcagt caactgttgc tacttaaatg cagctgtttc
     1141 tgcatttttt gatcgctgca gaacatctga ggtagtagaa atccaagcac tgagaacaga
     1201 tggagagcac atgaaaaagg aagaattaaa tgtgtgcaac cacatggagg tgggccaaac
     1261 aggtagccag aacttgacca caggaacaga caaaccggag gcagcaagtc cctttggccc
     1321 tgatctggtc cctgtagcac agaggtccga agaaccgcct tcagaaagag gaggcatatt
     1381 tggaagtgat gggaaagact ttgtggacaa ggatggagaa cactttggaa aattgcattg
     1441 tgccaagaga caacaaataa tgagcaacag tgaaaatgca attgaggaac agattgcctc
     1501 aaatactact acgactcctc aaacattcat ttctacggat gacttgctgg actgcttggt
     1561 gaatccacaa gtaaccagga tagtggcaca acttttgata caaggaagaa gtttatgatt
     1621 caagtggaag atgactttta aaataatatt ttttaaatat atatttttaa gtagtatgac
     1681 taaaataaag atgaaccagc aaaaggtcag tttgcacatt tgtaaatgta tttatcctta
     1741 ccgaattaca tgtcagtctg ttgccacctt ctttcatgca cattcctctt tggccaaact
     1801 ggctgctctt tgtttgtaag cttttgttcc tctctcatcc catactttta gcctgtgtca
     1861 aatgtaagtc ccaagtattt ccagcaggaa gtaatgtctt cctcagcctc aaccagggac
     1921 caaccggctg cttacttttg caaataaaat tttactagaa cacg
//
