LOCUS       NP_078886                488 aa            linear   PRI 19-SEP-2024
DEFINITION  HSPB1-associated protein 1 isoform 1 [Homo sapiens].
ACCESSION   NP_078886
VERSION     NP_078886.2
DBSOURCE    REFSEQ: accession NM_024610.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 488)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 488)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (residues 1 to 488)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 488)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (residues 1 to 488)
  AUTHORS   Saeed,K., Ostling,P., Bjorkman,M., Mirtti,T., Alanen,K.,
            Vesterinen,T., Sankila,A., Lundin,J., Lundin,M., Rannikko,A.,
            Nordling,S., Mpindi,J.P., Kohonen,P., Iljin,K., Kallioniemi,O. and
            Rantala,J.K.
  TITLE     Androgen receptor-interacting protein HSPBAP1 facilitates growth of
            prostate cancer cells in androgen-deficient conditions
  JOURNAL   Int J Cancer 136 (11), 2535-2545 (2015)
   PUBMED   25359680
  REMARK    GeneRIF: Data suggest a novel role and a possible link for HSPBAP1
            in promoting prostate cancer cell survival in androgen-deficient
            conditions by maintaining a basal level of androgen
            receptor-mediated transcription.
REFERENCE   6  (residues 1 to 488)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   7  (residues 1 to 488)
  AUTHORS   Xi,Z.Q., Sun,J.J., Wang,X.F., Li,M.W., Liu,X.Z., Wang,L.Y., Zhu,X.,
            Xiao,F., Li,J.M., Gong,Y. and Guan,L.F.
  TITLE     HSPBAP1 is found extensively in the anterior temporal neocortex of
            patients with intractable epilepsy
  JOURNAL   Synapse 61 (9), 741-747 (2007)
   PUBMED   17568411
  REMARK    GeneRIF: HSPBAP1 is found extensively in the anterior temporal
            neocortex of patients with intractable epilepsy.
REFERENCE   8  (residues 1 to 488)
  AUTHORS   Jiang,M., Ma,Y., Cheng,H., Ni,X., Guo,L., Xie,Y. and Mao,Y.
  TITLE     Molecular cloning and characterization of a novel human gene
            (HSPBAP1) from human fetal brain
  JOURNAL   Cytogenet Cell Genet 95 (1-2), 48-51 (2001)
   PUBMED   11978969
  REMARK    GeneRIF: Molecular cloning and characterization of a novel human
            gene (HSPBAP1) from human fetal brain
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC048348.25, AK289410.1,
            BI912690.1, BC011897.2 and BU630355.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 3, 2002 this sequence version replaced NP_078886.1.
            
            Summary: This gene encodes a protein that binds to one of the small
            heat shock proteins, specifically hsp27. Hsp27 is involved with
            cell growth and differentiation. This encoded protein was found to
            be abnormally expressed in patients with intractable epilepsy,
            although how brain function is affected remains unknown. [provided
            by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.464148.1,
                                           SRR1660805.173231.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306103.3/ ENSP00000302562.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     Protein         1..488
                     /product="HSPB1-associated protein 1 isoform 1"
                     /note="protein associating with small stress protein
                     PASS1; 27 kDa heat shock protein-associated protein 1;
                     HSPB (heat shock 27kDa) associated protein 1"
                     /calculated_mol_wt=55036
     Region          37..272
                     /region_name="Cupin_8"
                     /note="Cupin-like domain; pfam13621"
                     /db_xref="CDD:463936"
     Region          88..208
                     /region_name="Interaction with HSPB1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96EW2.1)"
     Region          369..415
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96EW2.1)"
     CDS             1..488
                     /gene="HSPBAP1"
                     /gene_synonym="PASS1"
                     /coded_by="NM_024610.6:152..1618"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS3017.1"
                     /db_xref="GeneID:79663"
                     /db_xref="HGNC:HGNC:16389"
                     /db_xref="MIM:608263"
ORIGIN      
        1 maagseattp vivaagagge egehvkpfkp ekakeiimsl qqpaifcnmv fdwparhwna
       61 kylsqvlhgk qirfrmgmks mstvpqfett cnyveatlee fltwncdqss isgpfrdydh
      121 skfwayadyk yfvslfedkt dlfqdvkwsd fgfpgrngqe stlwigslga htpchldsyg
      181 cnlvfqvqgr krwhlfpped tpflyptrip yeessvfski nvvnpdlkrf pqfrkaqrha
      241 vtlspgqvlf vprhwwhyve sidpvtvsin swieleedhl arveeaitrm lvcalktaen
      301 pqntrawlnp teveetshav nccylnaavs affdrcrtse vveiqalrtd gehmkkeeln
      361 vcnhmevgqt gsqnlttgtd kpeaaspfgp dlvpvaqrse eppserggif gsdgkdfvdk
      421 dgehfgklhc akrqqimsns enaieeqias nttttpqtfi stddlldclv npqvtrivaq
      481 lliqgrsl
//
