LOCUS       NM_144617               1460 bp    mRNA    linear   PRI 17-FEB-2025
DEFINITION  Homo sapiens heat shock protein family B (small) member 6 (HSPB6),
            mRNA.
ACCESSION   NM_144617
VERSION     NM_144617.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1460)
  AUTHORS   Miao,Y., Zhong,Y., Li,Y., Qin,H., Yang,L., Cao,G., Tang,Y., Yu,T.,
            Fan,D., Lu,Y., Peng,J. and Huang,K.
  TITLE     Inhibition of HSP20 Ameliorates Steatotic Liver Disease by
            Stimulating ERK2-Dependent Autophagy
  JOURNAL   Diabetes 73 (6), 909-925 (2024)
   PUBMED   38466834
  REMARK    GeneRIF: Inhibition of HSP20 Ameliorates Steatotic Liver Disease by
            Stimulating ERK2-Dependent Autophagy.
REFERENCE   2  (bases 1 to 1460)
  AUTHORS   Gao,S., Zhang,K., Zhou,C., Song,J., Gu,Y., Cao,F., Wang,J., Xie,E.,
            Yu,C. and Qiu,J.
  TITLE     HSPB6 Deficiency Promotes the Development of Aortic Dissection and
            Rupture
  JOURNAL   Lab Invest 104 (3), 100326 (2024)
   PUBMED   38237739
  REMARK    GeneRIF: HSPB6 Deficiency Promotes the Development of Aortic
            Dissection and Rupture.
REFERENCE   3  (bases 1 to 1460)
  AUTHORS   Guo,L., Xiao,K., Xie,Y., Yang,Z., Lei,J. and Cai,L.
  TITLE     Overexpression of HSPB6 inhibits osteosarcoma progress through the
            ERK signaling pathway
  JOURNAL   Clin Exp Med 23 (8), 5389-5398 (2023)
   PUBMED   37861934
  REMARK    GeneRIF: Overexpression of HSPB6 inhibits osteosarcoma progress
            through the ERK signaling pathway.
REFERENCE   4  (bases 1 to 1460)
  AUTHORS   Wu,Y., Zhao,J., Tian,Y. and Jin,H.
  TITLE     Cellular functions of heat shock protein 20 (HSPB6) in cancer: A
            review
  JOURNAL   Cell Signal 112, 110928 (2023)
   PUBMED   37844714
  REMARK    GeneRIF: Cellular functions of heat shock protein 20 (HSPB6) in
            cancer: A review.
            Review article
REFERENCE   5  (bases 1 to 1460)
  AUTHORS   Almutairi,B.O., Almutairi,M.H., Alrefaei,A.F., Alkahtani,S. and
            Alarifi,S.
  TITLE     HSPB6 Is Depleted in Colon Cancer Patients and Its Expression Is
            Induced by 5-aza-2'-Deoxycytidine In Vitro
  JOURNAL   Medicina (Kaunas) 59 (5), 996 (2023)
   PUBMED   37241227
  REMARK    GeneRIF: HSPB6 Is Depleted in Colon Cancer Patients and Its
            Expression Is Induced by 5-aza-2'-Deoxycytidine In Vitro.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1460)
  AUTHORS   Fontaine,J.M., Sun,X., Benndorf,R. and Welsh,M.J.
  TITLE     Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and
            HSPB3
  JOURNAL   Biochem Biophys Res Commun 337 (3), 1006-1011 (2005)
   PUBMED   16225851
  REMARK    GeneRIF: Our results suggest that a variety of oligomers composed
            of different proportions of different sHSPs may form in cell types
            expressing multiple sHSPs.
REFERENCE   7  (bases 1 to 1460)
  AUTHORS   Bukach,O.V., Seit-Nebi,A.S., Marston,S.B. and Gusev,N.B.
  TITLE     Some properties of human small heat shock protein Hsp20 (HspB6)
  JOURNAL   Eur J Biochem 271 (2), 291-302 (2004)
   PUBMED   14717697
REFERENCE   8  (bases 1 to 1460)
  AUTHORS   Tessier,D.J., Komalavilas,P., Panitch,A., Joshi,L. and Brophy,C.M.
  TITLE     The small heat shock protein (HSP) 20 is dynamically associated
            with the actin cross-linking protein actinin
  JOURNAL   J Surg Res 111 (1), 152-157 (2003)
   PUBMED   12842460
REFERENCE   9  (bases 1 to 1460)
  AUTHORS   Kappe,G., Franck,E., Verschuure,P., Boelens,W.C., Leunissen,J.A.
            and de Jong,W.W.
  TITLE     The human genome encodes 10 alpha-crystallin-related small heat
            shock proteins: HspB1-10
  JOURNAL   Cell Stress Chaperones 8 (1), 53-61 (2003)
   PUBMED   12820654
REFERENCE   10 (bases 1 to 1460)
  AUTHORS   Kato,K., Goto,S., Inaguma,Y., Hasegawa,K., Morishita,R. and
            Asano,T.
  TITLE     Purification and characterization of a 20-kDa protein that is
            highly homologous to alpha B crystallin
  JOURNAL   J Biol Chem 269 (21), 15302-15309 (1994)
   PUBMED   8195168
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK056951.1, BC068046.1 and
            AK026458.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_144617.2.
            
            Summary: This locus encodes a heat shock protein. The encoded
            protein likely plays a role in smooth muscle relaxation. [provided
            by RefSeq, Jan 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056951.1, SRR3476690.1067911.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000004982.6/ ENSP00000004982.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AK056951.1         1-80
            81-1457             BC068046.1         69-1445
            1458-1460           AK026458.1         740-742
FEATURES             Location/Qualifiers
     source          1..1460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1460
                     /gene="HSPB6"
                     /gene_synonym="HEL55; Hsp20; PPP1R91"
                     /note="heat shock protein family B (small) member 6"
                     /db_xref="GeneID:126393"
                     /db_xref="HGNC:HGNC:26511"
                     /db_xref="MIM:610695"
     exon            1..219
                     /gene="HSPB6"
                     /gene_synonym="HEL55; Hsp20; PPP1R91"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..504
                     /gene="HSPB6"
                     /gene_synonym="HEL55; Hsp20; PPP1R91"
                     /note="heat shock 20 kDa-like protein p20; epididymis
                     luminal protein 55; protein phosphatase 1, regulatory
                     subunit 91; heat shock protein, alpha-crystallin-related,
                     B6; heat shock protein family B (small) member B6;
                     epididymis secretory sperm binding protein; heat shock
                     protein family B member 6"
                     /codon_start=1
                     /product="heat shock protein beta-6"
                     /protein_id="NP_653218.1"
                     /db_xref="CCDS:CCDS12475.1"
                     /db_xref="GeneID:126393"
                     /db_xref="HGNC:HGNC:26511"
                     /db_xref="MIM:610695"
                     /translation="MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAA
                     LCPTTLAPYYLRAPSVALPVAQVPTDPGHFSVLLDVKHFSPEEIAVKVVGEHVEVHAR
                     HEERPDEHGFVAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK
                     "
     exon            220..342
                     /gene="HSPB6"
                     /gene_synonym="HEL55; Hsp20; PPP1R91"
                     /inference="alignment:Splign:2.1.0"
     exon            343..1460
                     /gene="HSPB6"
                     /gene_synonym="HEL55; Hsp20; PPP1R91"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1436..1441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPB6"
                     /gene_synonym="HEL55; Hsp20; PPP1R91"
                     /note="hexamer: AATAAA"
     polyA_site      1460
                     /gene="HSPB6"
                     /gene_synonym="HEL55; Hsp20; PPP1R91"
                     /note="major polyA site"
ORIGIN      
        1 actgcaacgc ggaggagcag gatggagatc cctgtgcctg tgcagccgtc ttggctgcgc
       61 cgcgcctcgg ccccgttgcc cggactttcg gcgcccggac gcctctttga ccagcgcttc
      121 ggcgaggggc tgctggaggc cgagctggct gcgctctgcc ccaccacgct cgccccctac
      181 tacctgcgcg cacccagcgt ggcgctgccc gtcgcccagg tgccgacgga ccccggccac
      241 ttttcggtgc tgctagacgt gaagcacttc tcgccggagg aaattgctgt caaggtggtg
      301 ggcgaacacg tggaggtgca cgcgcgccac gaggagcgcc cggatgagca cggattcgtc
      361 gcgcgcgagt tccaccgtcg ctaccgcctg ccgcctggcg tggatccggc tgccgtgacg
      421 tccgcgctgt cccccgaggg cgtcctgtcc atccaggccg caccagcgtc ggcccaggcc
      481 ccaccgccag ccgcagccaa gtaggagggg gctgggccgc gcccgcaccc cgggagcctc
      541 ctcaggctcc ctctattaaa gccgatctga ctccgcccag ccagatgtcc cgagtgcgcc
      601 aaggactgtc ctctcaccca ctcctggatt ctgccctgac ctccatcctg gacactgcct
      661 tgataacata gacccttcca ctgacaccct cgctctcaca ccccctccag ctttccgacc
      721 ccacaccgac aactccccgg cttccagacc ctaccagcac taccctaacc ctcagccgac
      781 agtctcagcc ccaccgaccc actttcttgg catatagccc cacttaagac ccctcctcta
      841 cttccttctg agtcctctac aaagacatcc gggtactaca tttccatccc ttccctattt
      901 tgacaccaaa ttatggtgta gacagccctc ccccaacccc aggccagtca ggcacaatcc
      961 ccccaccccc caaacgtcct ggactgcaca gacctcccac tccagaccat ccaggcctgg
     1021 ttcccaagac ccgatccttc ccctgcaacc agacagtcta caactgcccc ctccagccca
     1081 ttttctgccg tgaaacccca gccagccaca ccagactctg gaaccctttt tcgactgccc
     1141 caactcttgg acaccaggcc aactagaaca cccaacacca aactgtacag actctcccac
     1201 cccaacctcc ccagactctg cacggatgtc ctaggccccc tccccaactc taaccagacc
     1261 ccatccccct aagtcccttt gtcttgaccc ccaagtcttc aaccagatat cctcggcaac
     1321 ccacctccca ccctcctcct cttctccttc aagacccaac tgagcacccg ctctgattcc
     1381 ccacagcctt tctccctgcc accactccct tagtctttcc caggcttact ctcccaataa
     1441 atgtgctaga gctctgccaa
//
