LOCUS       NM_006308                679 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens heat shock protein family B (small) member 3 (HSPB3),
            mRNA.
ACCESSION   NM_006308
VERSION     NM_006308.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 679)
  AUTHORS   Han,J.E., Kang,K.H., Kim,H., Hong,Y.B., Choi,B.O. and Koh,H.
  TITLE     PINK1 and Parkin rescue motor defects and mitochondria dysfunction
            induced by a patient-derived HSPB3 mutant in Drosophila models
  JOURNAL   Biochem Biophys Res Commun 682, 71-76 (2023)
   PUBMED   37804589
  REMARK    GeneRIF: PINK1 and Parkin rescue motor defects and mitochondria
            dysfunction induced by a patient-derived HSPB3 mutant in Drosophila
            models.
REFERENCE   2  (bases 1 to 679)
  AUTHORS   Gianniou,D.D., Sklirou,A.D., Papadimitriou,M.A., Pilala,K.M.,
            Stravodimos,K., Avgeris,M., Scorilas,A. and Trougakos,I.P.
  TITLE     Evaluation of the Small Heat Shock Protein Family Members HSPB2 and
            HSPB3 in Bladder Cancer Prognosis and Progression
  JOURNAL   Int J Mol Sci 24 (3), 2609 (2023)
   PUBMED   36768927
  REMARK    GeneRIF: Evaluation of the Small Heat Shock Protein Family Members
            HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 679)
  AUTHORS   Tiago,T., Hummel,B., Morelli,F.F., Basile,V., Vinet,J., Galli,V.,
            Mediani,L., Antoniani,F., Pomella,S., Cassandri,M., Garone,M.G.,
            Silvestri,B., Cimino,M., Cenacchi,G., Costa,R., Mouly,V., Poser,I.,
            Yeger-Lotem,E., Rosa,A., Alberti,S., Rota,R., Ben-Zvi,A.,
            Sawarkar,R. and Carra,S.
  TITLE     Small heat-shock protein HSPB3 promotes myogenesis by regulating
            the lamin B receptor
  JOURNAL   Cell Death Dis 12 (5), 452 (2021)
   PUBMED   33958580
  REMARK    GeneRIF: Small heat-shock protein HSPB3 promotes myogenesis by
            regulating the lamin B receptor.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 679)
  AUTHORS   Kalioraki,M.A., Artemaki,P.I., Sklirou,A.D., Kontos,C.K.,
            Adamopoulos,P.G., Papadopoulos,I.N., Trougakos,I.P. and Scorilas,A.
  TITLE     Heat shock protein beta 3 (HSPB3) is an unfavorable molecular
            biomarker in colorectal adenocarcinoma
  JOURNAL   Mol Carcinog 59 (1), 116-125 (2020)
   PUBMED   31709619
  REMARK    GeneRIF: High HSPB3 expression is associated with poor relapse-free
            survival (RFS) and overall survival (OS) of patients with
            colorectal adenocarcinoma.
REFERENCE   5  (bases 1 to 679)
  AUTHORS   Kolb,S.J., Snyder,P.J., Poi,E.J., Renard,E.A., Bartlett,A., Gu,S.,
            Sutton,S., Arnold,W.D., Freimer,M.L., Lawson,V.H., Kissel,J.T. and
            Prior,T.W.
  TITLE     Mutant small heat shock protein B3 causes motor neuropathy: utility
            of a candidate gene approach
  JOURNAL   Neurology 74 (6), 502-506 (2010)
   PUBMED   20142617
  REMARK    GeneRIF: an HSPB3 mutation associated with an axonal motor
            neuropathy
REFERENCE   6  (bases 1 to 679)
  AUTHORS   Vos,M.J., Kanon,B. and Kampinga,H.H.
  TITLE     HSPB7 is a SC35 speckle resident small heat shock protein
  JOURNAL   Biochim Biophys Acta 1793 (8), 1343-1353 (2009)
   PUBMED   19464326
  REMARK    Erratum:[Biochim Biophys Acta. 2009 Dec;1793(12):1929-30]
REFERENCE   7  (bases 1 to 679)
  AUTHORS   Fontaine,J.M., Sun,X., Benndorf,R. and Welsh,M.J.
  TITLE     Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and
            HSPB3
  JOURNAL   Biochem Biophys Res Commun 337 (3), 1006-1011 (2005)
   PUBMED   16225851
  REMARK    GeneRIF: Our results suggest that a variety of oligomers composed
            of different proportions of different sHSPs may form in cell types
            expressing multiple sHSPs.
REFERENCE   8  (bases 1 to 679)
  AUTHORS   Sugiyama,Y., Suzuki,A., Kishikawa,M., Akutsu,R., Hirose,T.,
            Waye,M.M., Tsui,S.K., Yoshida,S. and Ohno,S.
  TITLE     Muscle develops a specific form of small heat shock protein complex
            composed of MKBP/HSPB2 and HSPB3 during myogenic differentiation
  JOURNAL   J Biol Chem 275 (2), 1095-1104 (2000)
   PUBMED   10625651
REFERENCE   9  (bases 1 to 679)
  AUTHORS   Boelens,W.C., Van Boekel,M.A. and De Jong,W.W.
  TITLE     HspB3, the most deviating of the six known human small heat shock
            proteins
  JOURNAL   Biochim Biophys Acta 1388 (2), 513-516 (1998)
   PUBMED   9858786
REFERENCE   10 (bases 1 to 679)
  AUTHORS   Lam,W.Y., Wing Tsui,S.K., Law,P.T., Luk,S.C., Fung,K.P., Lee,C.Y.
            and Waye,M.M.
  TITLE     Isolation and characterization of a human heart cDNA encoding a new
            member of the small heat shock protein family--HSPL27
  JOURNAL   Biochim Biophys Acta 1314 (1-2), 120-124 (1996)
   PUBMED   8972725
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U15590.1, BX106905.1 and
            N74672.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006308.2.
            
            Summary: This gene encodes a muscle-specific small heat shock
            protein. A mutation in this gene is the cause of autosomal dominant
            distal hereditary motor neuropathy type 2C.[provided by RefSeq, Sep
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR5189655.146331.1, SRR5189655.40478.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302005.3/ ENSP00000303394.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-372               U15590.1           85-456
            373-530             BX106905.1         456-613
            531-679             N74672.1           11-159              c
FEATURES             Location/Qualifiers
     source          1..679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..679
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HMND4; HSPL27"
                     /note="heat shock protein family B (small) member 3"
                     /db_xref="GeneID:8988"
                     /db_xref="HGNC:HGNC:5248"
                     /db_xref="MIM:604624"
     exon            1..679
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HMND4; HSPL27"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..544
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HMND4; HSPL27"
                     /note="protein 3; HSP 17; heat shock 17 kDa protein; heat
                     shock 27kDa protein 3; heat shock protein family B member
                     3"
                     /codon_start=1
                     /product="heat shock protein beta-3"
                     /protein_id="NP_006299.1"
                     /db_xref="CCDS:CCDS3961.1"
                     /db_xref="GeneID:8988"
                     /db_xref="HGNC:HGNC:5248"
                     /db_xref="MIM:604624"
                     /translation="MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVD
                     LRKTRAAQSPPVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGT
                     RMDEHGFISRSFTRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK"
     regulatory      659..664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HMND4; HSPL27"
                     /note="hexamer: ATTAAA"
     polyA_site      679
                     /gene="HSPB3"
                     /gene_synonym="DHMN2C; HMN2C; HMND4; HSPL27"
                     /note="major polyA site"
ORIGIN      
        1 agtcagtagg caactgcagg ggctcgccac tgactgaagg cagtggaagg ttggcagaag
       61 gaggctgttc aaggctgttt ttgccttcac tatggcaaaa atcattttga ggcacctcat
      121 agagattcca gtgcgttacc aggaagagtt tgaagctcga ggtctagaag actgcaggct
      181 ggatcatgct ttatatgcac tgcctgggcc aaccatcgtg gacctgagga aaaccagggc
      241 agcgcagtct cctccagtgg actcagcggc agagacgcca ccccgagaag gcaaatccca
      301 ctttcagatc ctgctggacg tggtccagtt cctccctgaa gacatcatca ttcagacctt
      361 cgaaggctgg ctgctgataa aagcacaaca cggaaccaga atggatgagc acggttttat
      421 ctcaagaagc ttcacccgac agtacaaact accagatggt gtggaaatca aagatttgtc
      481 tgcagtcctc tgtcatgatg gaattttggt ggtggaagta aaggatccag ttgggactaa
      541 gtgacatcgt atcggttcct gttcagatga catggggaag atgatggttc agccactggt
      601 actacgagaa tgtttgtatt acccacattt gaaatgattt gctatgattt ttatgaagat
      661 taaaaatata tacacagtt
//
