LOCUS       NM_001540                777 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens heat shock protein family B (small) member 1 (HSPB1),
            mRNA.
ACCESSION   NM_001540
VERSION     NM_001540.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 777)
  AUTHORS   Meng,J., Fang,J., Bao,Y., Chen,H., Hu,X., Wang,Z., Li,M., Cheng,Q.,
            Dong,Y., Yang,X., Zou,Y., Zhao,D., Tang,J., Zhang,W. and Chen,C.
  TITLE     The biphasic role of Hspb1 on ferroptotic cell death in Parkinson's
            disease
  JOURNAL   Theranostics 14 (12), 4643-4666 (2024)
   PUBMED   39239519
  REMARK    GeneRIF: The biphasic role of Hspb1 on ferroptotic cell death in
            Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 777)
  AUTHORS   Tieliwaerdi,A., Aini,A., Amuti,M., Aierken,Y., Nijiati,M. and
            Luo,B.
  TITLE     STUB1 promotes the degradation of HSPB1 and induces ferroptosis in
            lung cancer cells
  JOURNAL   Environ Toxicol 39 (8), 4156-4170 (2024)
   PUBMED   38661247
  REMARK    GeneRIF: STUB1 promotes the degradation of HSPB1 and induces
            ferroptosis in lung cancer cells.
REFERENCE   3  (bases 1 to 777)
  AUTHORS   Xu,Z.Y., Han,J., Yang,K., Zhang,G.M., Jiao,M.N., Liang,S.X.,
            Yan,Y.B. and Chen,W.
  TITLE     HSP27 promotes vasculogenic mimicry formation in human salivary
            adenoid cystic carcinoma via the AKT-MMP-2/9 pathway
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol 137 (5), 515-528 (2024)
   PUBMED   38553306
  REMARK    GeneRIF: HSP27 promotes vasculogenic mimicry formation in human
            salivary adenoid cystic carcinoma via the AKT-MMP-2/9 pathway.
REFERENCE   4  (bases 1 to 777)
  AUTHORS   Homa,K. and Zur-Wyrozumska,K.
  TITLE     HSPB1 mutation causing distal Hereditary Motor Neuropathy type 2B
            in a Polish family
  JOURNAL   Folia Med Cracov 63 (4), 57-61 (2023)
   PUBMED   38578345
  REMARK    GeneRIF: HSPB1 mutation causing distal Hereditary Motor Neuropathy
            type 2B in a Polish family.
REFERENCE   5  (bases 1 to 777)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Hereditary Neuropathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301532
REFERENCE   6  (bases 1 to 777)
  AUTHORS   Bird,T.D.
  TITLE     Charcot-Marie-Tooth Neuropathy Type 2 - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301462
REFERENCE   7  (bases 1 to 777)
  AUTHORS   Stokoe,D., Engel,K., Campbell,D.G., Cohen,P. and Gaestel,M.
  TITLE     Identification of MAPKAP kinase 2 as a major enzyme responsible for
            the phosphorylation of the small mammalian heat shock proteins
  JOURNAL   FEBS Lett 313 (3), 307-313 (1992)
   PUBMED   1332886
REFERENCE   8  (bases 1 to 777)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   9  (bases 1 to 777)
  AUTHORS   Kato,K., Shinohara,H., Goto,S., Inaguma,Y., Morishita,R. and
            Asano,T.
  TITLE     Copurification of small heat shock protein with alpha B crystallin
            from human skeletal muscle
  JOURNAL   J Biol Chem 267 (11), 7718-7725 (1992)
   PUBMED   1560006
REFERENCE   10 (bases 1 to 777)
  AUTHORS   Landry,J., Lambert,H., Zhou,M., Lavoie,J.N., Hickey,E., Weber,L.A.
            and Anderson,C.W.
  TITLE     Human HSP27 is phosphorylated at serines 78 and 82 by heat shock
            and mitogen-activated kinases that recognize the same amino acid
            motif as S6 kinase II
  JOURNAL   J Biol Chem 267 (2), 794-803 (1992)
   PUBMED   1730670
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP231480.1 and BC012768.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001540.4.
            
            Summary: This gene encodes a member of the small heat shock protein
            (HSP20) family of proteins. In response to environmental stress,
            the encoded protein translocates from the cytoplasm to the nucleus
            and functions as a molecular chaperone that promotes the correct
            folding of other proteins. This protein plays an important role in
            the differentiation of a wide variety of cell types. Expression of
            this gene is correlated with poor clinical outcome in multiple
            human cancers, and the encoded protein may promote cancer cell
            proliferation and metastasis, while protecting cancer cells from
            apoptosis. Mutations in this gene have been identified in human
            patients with Charcot-Marie-Tooth disease and distal hereditary
            motor neuropathy. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012292.1, X54079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248553.7/ ENSP00000248553.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BP231480.1         116-133
            19-777              BC012768.2         1-759
FEATURES             Location/Qualifiers
     source          1..777
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..777
                     /gene="HSPB1"
                     /gene_synonym="CMT2F; HEL-S-102; HMN2B; HMND3; HS.76067;
                     Hsp25; HSP27; HSP28; SRP27"
                     /note="heat shock protein family B (small) member 1"
                     /db_xref="GeneID:3315"
                     /db_xref="HGNC:HGNC:5246"
                     /db_xref="MIM:602195"
     exon            1..404
                     /gene="HSPB1"
                     /gene_synonym="CMT2F; HEL-S-102; HMN2B; HMND3; HS.76067;
                     Hsp25; HSP27; HSP28; SRP27"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..658
                     /gene="HSPB1"
                     /gene_synonym="CMT2F; HEL-S-102; HMN2B; HMND3; HS.76067;
                     Hsp25; HSP27; HSP28; SRP27"
                     /note="heat shock 27kD protein 1; stress-responsive
                     protein 27; epididymis secretory protein Li 102;
                     estrogen-regulated 24 kDa protein; 28 kDa heat shock
                     protein; heat shock 27 kDa protein; heat shock 27kDa
                     protein 1; heat shock protein family B member 1"
                     /codon_start=1
                     /product="heat shock protein beta-1"
                     /protein_id="NP_001531.1"
                     /db_xref="CCDS:CCDS5583.1"
                     /db_xref="GeneID:3315"
                     /db_xref="HGNC:HGNC:5246"
                     /db_xref="MIM:602195"
                     /translation="MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQ
                     WLGGSSWPGYVRPLPPAAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVN
                     HFAPDELTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPE
                     GTLTVEAPMPKLATQSNEITIPVTFESRAQLGGPEAAKSDETAAK"
     exon            405..468
                     /gene="HSPB1"
                     /gene_synonym="CMT2F; HEL-S-102; HMN2B; HMND3; HS.76067;
                     Hsp25; HSP27; HSP28; SRP27"
                     /inference="alignment:Splign:2.1.0"
     exon            469..777
                     /gene="HSPB1"
                     /gene_synonym="CMT2F; HEL-S-102; HMN2B; HMND3; HS.76067;
                     Hsp25; HSP27; HSP28; SRP27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      756..761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPB1"
                     /gene_synonym="CMT2F; HEL-S-102; HMN2B; HMND3; HS.76067;
                     Hsp25; HSP27; HSP28; SRP27"
                     /note="hexamer: AATAAA"
     polyA_site      777
                     /gene="HSPB1"
                     /gene_synonym="CMT2F; HEL-S-102; HMN2B; HMND3; HS.76067;
                     Hsp25; HSP27; HSP28; SRP27"
                     /note="major polyA site"
ORIGIN      
        1 gcacttttct gagcagacgt ccagagcaga gtcagccagc atgaccgagc gccgcgtccc
       61 cttctcgctc ctgcggggcc ccagctggga ccccttccgc gactggtacc cgcatagccg
      121 cctcttcgac caggccttcg ggctgccccg gctgccggag gagtggtcgc agtggttagg
      181 cggcagcagc tggccaggct acgtgcgccc cctgcccccc gccgccatcg agagccccgc
      241 agtggccgcg cccgcctaca gccgcgcgct cagccggcaa ctcagcagcg gggtctcgga
      301 gatccggcac actgcggacc gctggcgcgt gtccctggat gtcaaccact tcgccccgga
      361 cgagctgacg gtcaagacca aggatggcgt ggtggagatc accggcaagc acgaggagcg
      421 gcaggacgag catggctaca tctcccggtg cttcacgcgg aaatacacgc tgccccccgg
      481 tgtggacccc acccaagttt cctcctccct gtcccctgag ggcacactga ccgtggaggc
      541 ccccatgccc aagctagcca cgcagtccaa cgagatcacc atcccagtca ccttcgagtc
      601 gcgggcccag cttgggggcc cagaagctgc aaaatccgat gagactgccg ccaagtaaag
      661 ccttagcccg gatgcccacc cctgctgccg ccactggctg tgcctccccc gccacctgtg
      721 tgttcttttg atacatttat cttctgtttt tctcaaataa agttcaaagc aaccacc
//
