LOCUS       NM_004134               4404 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens heat shock protein family A (Hsp70) member 9 (HSPA9),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_004134
VERSION     NM_004134.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4404)
  AUTHORS   Chen,X., Wu,Q., Gong,W., Ju,S., Fan,J., Gao,X., Liu,X., Lei,X.,
            Liu,S., Ming,X., Wang,Q., Fu,M., Song,Y., Wang,Y. and Zhan,Q.
  TITLE     GRP75 triggers white adipose tissue browning to promote
            cancer-associated cachexia
  JOURNAL   Signal Transduct Target Ther 9 (1), 253 (2024)
   PUBMED   39327432
  REMARK    GeneRIF: GRP75 triggers white adipose tissue browning to promote
            cancer-associated cachexia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4404)
  AUTHORS   Han,B., Zhen,F., Sun,Y., Sun,B., Wang,H.Y., Liu,W., Huang,J.,
            Liang,X., Wang,Y.R., Chen,X.S., Li,S.J. and Hu,J.
  TITLE     Tumor suppressor KEAP1 promotes HSPA9 degradation, controlling
            mitochondrial biogenesis in breast cancer
  JOURNAL   Cell Rep 43 (7), 114507 (2024)
   PUBMED   39003742
  REMARK    GeneRIF: Tumor suppressor KEAP1 promotes HSPA9 degradation,
            controlling mitochondrial biogenesis in breast cancer.
REFERENCE   3  (bases 1 to 4404)
  AUTHORS   Chen,W., Song,Y.S., Lee,H.S., Lin,C.W., Lee,J., Kang,Y.E.,
            Kim,S.K., Kim,S.Y., Park,Y.J. and Park,J.I.
  TITLE     Estrogen-related receptor alpha promotes thyroid tumor cell
            survival via a tumor subtype-specific regulation of target gene
            networks
  JOURNAL   Oncogene 43 (31), 2431-2446 (2024)
   PUBMED   38937602
  REMARK    GeneRIF: Estrogen-related receptor alpha promotes thyroid tumor
            cell survival via a tumor subtype-specific regulation of target
            gene networks.
REFERENCE   4  (bases 1 to 4404)
  AUTHORS   Zhu,W., Rao,J., Zhang,L.H., Xue,K.M., Li,L., Li,J.J., Chen,Q.Z. and
            Fu,R.
  TITLE     OMA1 competitively binds to HSPA9 to promote mitophagy and activate
            the cGAS-STING pathway to mediate GBM immune escape
  JOURNAL   J Immunother Cancer 12 (4), e008718 (2024)
   PUBMED   38604814
  REMARK    GeneRIF: OMA1 competitively binds to HSPA9 to promote mitophagy and
            activate the cGAS-STING pathway to mediate GBM immune escape.
            Erratum:[J Immunother Cancer. 2024 Nov 20;12(11):e008718corr1. doi:
            10.1136/jitc-2023-008718corr1.. PMID: 39572161]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4404)
  AUTHORS   Mizukoshi,E., Suzuki,M., Loupatov,A., Uruno,T., Hayashi,H.,
            Misono,T., Kaul,S.C., Wadhwa,R. and Imamura,T.
  TITLE     Fibroblast growth factor-1 interacts with the glucose-regulated
            protein GRP75/mortalin
  JOURNAL   Biochem J 343 Pt 2 (Pt 2), 461-466 (1999)
   PUBMED   10510314
REFERENCE   6  (bases 1 to 4404)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
REFERENCE   7  (bases 1 to 4404)
  AUTHORS   Kaul,S.C., Wadhwa,R., Matsuda,Y., Hensler,P.J., Pereira-Smith,O.M.,
            Komatsu,Y. and Mitsui,Y.
  TITLE     Mouse and human chromosomal assignments of mortalin, a novel member
            of the murine hsp70 family of proteins
  JOURNAL   FEBS Lett 361 (2-3), 269-272 (1995)
   PUBMED   7698336
REFERENCE   8  (bases 1 to 4404)
  AUTHORS   Bhattacharyya,T., Karnezis,A.N., Murphy,S.P., Hoang,T.,
            Freeman,B.C., Phillips,B. and Morimoto,R.I.
  TITLE     Cloning and subcellular localization of human mitochondrial hsp70
  JOURNAL   J Biol Chem 270 (4), 1705-1710 (1995)
   PUBMED   7829505
REFERENCE   9  (bases 1 to 4404)
  AUTHORS   Dahlseid,J.N., Lill,R., Green,J.M., Xu,X., Qiu,Y. and Pierce,S.K.
  TITLE     PBP74, a new member of the mammalian 70-kDa heat shock protein
            family, is a mitochondrial protein
  JOURNAL   Mol Biol Cell 5 (11), 1265-1275 (1994)
   PUBMED   7865888
REFERENCE   10 (bases 1 to 4404)
  AUTHORS   Domanico,S.Z., DeNagel,D.C., Dahlseid,J.N., Green,J.M. and
            Pierce,S.K.
  TITLE     Cloning of the gene encoding peptide-binding protein 74 shows that
            it is a new member of the heat shock protein 70 family
  JOURNAL   Mol Cell Biol 13 (6), 3598-3610 (1993)
   PUBMED   7684501
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315177.1, AC011385.6 and
            AK225488.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004134.6.
            
            Summary: This gene encodes a member of the heat shock protein 70
            gene family. The encoded protein is primarily localized to the
            mitochondria but is also found in the endoplasmic reticulum, plasma
            membrane and cytoplasmic vesicles. This protein is a heat-shock
            cognate protein. This protein plays a role in cell proliferation,
            stress response and maintenance of the mitochondria. A pseudogene
            of this gene is found on chromosome 2.[provided by RefSeq, May
            2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.23784.1,
                                           SRR1660809.221280.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000297185.9/
                                                  ENSP00000297185.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-609               AK315177.1         17-625
            610-610             AC011385.6         79577-79577
            611-838             AK315177.1         627-854
            839-839             AC011385.6         81386-81386
            840-2123            AK315177.1         856-2139
            2124-2825           AK225488.1         1699-2400
            2826-4404           AC011385.6         93176-94754
FEATURES             Location/Qualifiers
     source          1..4404
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..4404
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /note="heat shock protein family A (Hsp70) member 9"
                     /db_xref="GeneID:3313"
                     /db_xref="HGNC:HGNC:5244"
                     /db_xref="MIM:600548"
     exon            1..164
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2123
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /note="p66-mortalin; peptide-binding protein 74; mortalin,
                     perinuclear; heat shock 70kD protein 9B; stress-70
                     protein, mitochondrial; mortalin-2; epididymis secretory
                     sperm binding protein Li 124m; catecholamine-regulated
                     protein 40; 75 kDa glucose-regulated protein; heat shock
                     70kDa protein 9 (mortalin); mortalin2; heat shock protein
                     family A member 9"
                     /codon_start=1
                     /product="stress-70 protein, mitochondrial precursor"
                     /protein_id="NP_004125.3"
                     /db_xref="CCDS:CCDS4208.1"
                     /db_xref="GeneID:3313"
                     /db_xref="HGNC:HGNC:5244"
                     /db_xref="MIM:600548"
                     /translation="MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRR
                     DYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVG
                     MPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKL
                     YSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLR
                     VINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGE
                     DFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTM
                     DSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRM
                     PKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETL
                     GGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGI
                     PPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAE
                     KYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLAR
                     KDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ"
     exon            165..223
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            224..311
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            312..493
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            494..618
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            619..692
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            693..799
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            800..962
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1055
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1265
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1493
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1598
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1716
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1811
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1904
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2045
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..4404
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2803..2808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /note="hexamer: AATAAA"
     polyA_site      2825
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /note="major polyA site"
     regulatory      3250..3255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /note="hexamer: AATAAA"
     polyA_site      3278
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
     regulatory      4375..4380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
                     /note="hexamer: CATAAA"
     polyA_site      4404
                     /gene="HSPA9"
                     /gene_synonym="CRP40; CSA; EVPLS; GRP-75; GRP75;
                     HEL-S-124m; HSPA9B; MOT; MOT2; MTHSP75; PBP74; SAAN;
                     SIDBA4"
ORIGIN      
        1 agaagcgctg ccgccaccgc atcgcgcagc tctttgccgt cggagcgctt gtttgctgcc
       61 tcgtactcct ccatttatcc gccatgataa gtgccagccg agctgcagca gcccgtctcg
      121 tgggcgccgc agcctcccgg ggccctacgg ccgcccgcca ccaggatagc tggaatggcc
      181 ttagtcatga ggcttttaga cttgtttcaa ggcgggatta tgcatcagaa gcaatcaagg
      241 gagcagttgt tggtattgat ttgggtacta ccaactcctg cgtggcagtt atggaaggta
      301 aacaagcaaa ggtgctggag aatgccgaag gtgccagaac caccccttca gttgtggcct
      361 ttacagcaga tggtgagcga cttgttggaa tgccggccaa gcgacaggct gtcaccaacc
      421 caaacaatac attttatgct accaagcgtc tcattggccg gcgatatgat gatcctgaag
      481 tacagaaaga cattaaaaat gttcccttta aaattgtccg tgcctccaat ggtgatgcct
      541 gggttgaggc tcatgggaaa ttgtattctc cgagtcagat tggagcattt gtgttgatga
      601 agatgaaaga gactgcagaa aattacttgg ggcacacagc aaaaaatgct gtgatcacag
      661 tcccagctta tttcaatgac tcgcagagac aggccactaa agatgctggc cagatatctg
      721 gactgaatgt gcttcgggtg attaatgagc ccacagctgc tgctcttgcc tatggtctag
      781 acaaatcaga agacaaagtc attgctgtat atgatttagg tggtggaact tttgatattt
      841 ctatcctgga aattcagaaa ggagtatttg aggtgaaatc cacaaatggg gataccttct
      901 taggtgggga agactttgac caggccttgc tacggcacat tgtgaaggag ttcaagagag
      961 agacaggggt tgatttgact aaagacaaca tggcacttca gagggtacgg gaagctgctg
     1021 aaaaggctaa atgtgaactc tcctcatctg tgcagactga catcaatttg ccctatctta
     1081 caatggattc ttctggaccc aagcatttga atatgaagtt gacccgtgct caatttgaag
     1141 ggattgtcac tgatctaatc agaaggacta tcgctccatg ccaaaaagct atgcaagatg
     1201 cagaagtcag caagagtgac ataggagaag tgattcttgt gggtggcatg actaggatgc
     1261 ccaaggttca gcagactgta caggatcttt ttggcagagc cccaagtaaa gctgtcaatc
     1321 ctgatgaggc tgtggccatt ggagctgcca ttcagggagg tgtgttggcc ggcgatgtca
     1381 cggatgtgct gctccttgat gtcactcccc tgtctctggg tattgaaact ctaggaggtg
     1441 tctttaccaa acttattaat aggaatacca ctattccaac caagaagagc caggtattct
     1501 ctactgccgc tgatggtcaa acgcaagtgg aaattaaagt gtgtcagggt gaaagagaga
     1561 tggctggaga caacaaactc cttggacagt ttactttgat tggaattcca ccagcccctc
     1621 gtggagttcc tcagattgaa gttacatttg acattgatgc caatgggata gtacatgttt
     1681 ctgctaaaga taaaggcaca ggacgtgagc agcagattgt aatccagtct tctggtggat
     1741 taagcaaaga tgatattgaa aatatggtta aaaatgcaga gaaatatgct gaagaagacc
     1801 ggcgaaagaa ggaacgagtt gaagcagtta atatggctga aggaatcatt cacgacacag
     1861 aaaccaagat ggaagaattc aaggaccaat tacctgctga tgagtgcaac aagctgaaag
     1921 aagagatttc caaaatgagg gagctcctgg ctagaaaaga cagcgaaaca ggagaaaata
     1981 ttagacaggc agcatcctct cttcagcagg catcactgaa gctgttcgaa atggcataca
     2041 aaaagatggc atctgagcga gaaggctctg gaagttctgg cactggggaa caaaaggaag
     2101 atcaaaagga ggaaaaacag taataatagc agaaattttg aagccagaag gacaacatat
     2161 gaagcttagg agtgaagaga cttcctgagc agaaatgggc gaacttcagt ctttttactg
     2221 tgtttttgca gtattctata tataatttcc ttaatttgta aatttagtga ccattagcta
     2281 gtgatcattt aatggacagt gattctaaca gtataaagtt cacaatattc tatgtcccta
     2341 gcctgtcatt tttcagctgc atgtaaaagg aggtaggatg aattgatcat tataaagatt
     2401 taactatttt atgctgaagt gaccatattt tcaaggggtg aaaccatctc gcacacagca
     2461 atgaaggtag tcatccatag acttgaaatg agaccacata tggggatgag atccttctag
     2521 ttagcctagt actgctgtac tggcctgtat gtacatgggg tccttcaact gaggccttgc
     2581 aagtcaagct ggctgtgcca tgtttgtaga tggggcagag gaatctagaa caatgggaaa
     2641 cttagctatt tatattaggt acagctatta aaacaaggta ggaatgaggc tagaccttta
     2701 acttccctaa ggcatacttt tctagctacc ttctgccctg tgtctggcac ctacatcctt
     2761 gatgattgtt ctcttaccca ttctggaatt tttttttttt taaataaata cagaaagcat
     2821 cttgatctct tgtttgtgag gggtgatgcc ctgagattta gcttcaagaa tatgccatgg
     2881 ctcatgcttc ccatatttcc caaagaggga aatacaggat ttgctaacac tggttaaaaa
     2941 tgcaaattca agatttggaa gggctgttat aatgaaataa tgagcagtat cagcatgtgc
     3001 aaatcttgtt tgaaggattt tattttctcc ccttagacct ttggtacatt tagaatcttg
     3061 aaagtttcta gatctctaac atgaaagttt ctagatctct aacatgaaag tttttagatc
     3121 tctaacatga aaaccaaggt ggctattttc aggttgcttt cagctccaag tagaaataac
     3181 cagaattggc ttacattaaa gaaactgcat ctagaaataa gtcctaagat actatttcta
     3241 tggctcaaaa ataaaaggaa cccagatttc tttccctatt tctgcttttc tgtcctcagt
     3301 gtactggctt gtcccaaatt ctctgatgta gttctaataa ttatcatgtg ctgacaacct
     3361 gagcagaaag gcaactacat ctttattcaa tgttaagatt tcccaaaagt cttccagcac
     3421 atttccctta tgtttcatgg atgaatgtca tatgccatgt tcaaaagagt ctgttatcaa
     3481 gatgggctta gaatatcaga cacaatggct ccttttataa tgttttgtaa tatgtagaaa
     3541 tgagattact gtatttccaa aaatcagtat aagaaatcaa tttaatttgc aagtatgaag
     3601 gaagtgattt agacaacatt tttggaagat tcagtgcttg ttaacaccca tgtaaaagat
     3661 tcttgggatt cgtgaaaaat tctaggctca ggtttccaac cacatgaaca ctcaatggga
     3721 acattgtagg attatgaagg attgttatat ggtgtgttgg aaaataactt ttagcatttt
     3781 tggttggccc ttgcccactg cctctactgt ctcctaaaga taactttaaa agccctccag
     3841 gatttccaaa gtactccagt tgagaactac tggcttaatg ctagtcaaga ttcatccttg
     3901 ggatcagaga gaggagccaa atgcccaagc aaaatatata tttgagttct attaggaggg
     3961 agaagttgct tgggtatggg tggacacagt atttcagtca cctatcagta aagctaatag
     4021 cataaatagc aagaaggtat atggagattt cctacagcca ataggatata tatctagaat
     4081 aagatttact gtaagaaaga aactggctca caattatgga accgaggtcc cacccacagt
     4141 ccactgctgg gaaagctgtt ggggtaaaat ttcagtgacc aggaacacag tggtgtccta
     4201 gtccgaggtt agaagaatat ggatgtctta gctctggcag ttctatatag gcccttaact
     4261 gattagatga tgtccactca catcaaagca gagcaatctc caattcaata ctaatctctt
     4321 ctggagagag acaaatgttt aacccgttaa atggcatcaa tggctaaact gacacataaa
     4381 attaactatc acaaaaggca aaaa
//
