LOCUS       NM_002155               2355 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens heat shock protein family A (Hsp70) member 6 (HSPA6),
            mRNA.
ACCESSION   NM_002155 XM_001134322
VERSION     NM_002155.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Zhu,X., Chen,X., Shen,X., Liu,Y., Fu,W., Wang,B., Zhao,L., Yang,F.,
            Mo,N., Zhong,G., Jiang,S. and Yang,Z.
  TITLE     PP4R1 accelerates the malignant progression of NSCLC via
            up-regulating HSPA6 expression and HSPA6-mediated ER stress
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (1), 119588 (2024)
   PUBMED   37739270
  REMARK    GeneRIF: PP4R1 accelerates the malignant progression of NSCLC via
            up-regulating HSPA6 expression and HSPA6-mediated ER stress.
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Guo,R., Guo,Y.Z., Zhou,Q., Li,G., Du,Z., Shi,Y. and Xing,Q.
  TITLE     ROR2 deficit may induce the tetralogy of Fallot via down-regulating
            of beta-catenin/SOX3/HSPA6 in vitro and in vivo
  JOURNAL   J Cell Mol Med 27 (22), 3539-3552 (2023)
   PUBMED   37749917
  REMARK    GeneRIF: ROR2 deficit may induce the tetralogy of Fallot via
            down-regulating of beta-catenin/SOX3/HSPA6 in vitro and in vivo.
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Huang,X., Wang,Z., Zhang,J., Ni,X., Bai,G., Cao,J., Zhang,C.,
            Han,Z. and Liu,T.
  TITLE     BARX1 promotes osteosarcoma cell proliferation and invasion by
            regulating HSPA6 expression
  JOURNAL   J Orthop Surg Res 18 (1), 211 (2023)
   PUBMED   36927457
  REMARK    GeneRIF: BARX1 promotes osteosarcoma cell proliferation and
            invasion by regulating HSPA6 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2355)
  AUTHORS   Song,B., Shen,S., Fu,S. and Fu,J.
  TITLE     HSPA6 and its role in cancers and other diseases
  JOURNAL   Mol Biol Rep 49 (11), 10565-10577 (2022)
   PUBMED   35666422
  REMARK    GeneRIF: HSPA6 and its role in cancers and other diseases.
            Review article
REFERENCE   5  (bases 1 to 2355)
  AUTHORS   Vavilova,J.D., Boyko,A.A., Troyanova,N.I., Ponomareva,N.V.,
            Fokin,V.F., Fedotova,E.Y., Streltsova,M.A., Kust,S.A.,
            Grechikhina,M.V., Shustova,O.A., Azhikina,T.L., Kovalenko,E.I. and
            Sapozhnikov,A.M.
  TITLE     Alterations in Proteostasis System Components in Peripheral Blood
            Mononuclear Cells in Parkinson Disease: Focusing on the HSP70 and
            p62 Levels
  JOURNAL   Biomolecules 12 (4), 493 (2022)
   PUBMED   35454081
  REMARK    GeneRIF: Alterations in Proteostasis System Components in
            Peripheral Blood Mononuclear Cells in Parkinson Disease: Focusing
            on the HSP70 and p62 Levels.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2355)
  AUTHORS   Mercier,P.A., Winegarden,N.A. and Westwood,J.T.
  TITLE     Human heat shock factor 1 is predominantly a nuclear protein before
            and after heat stress
  JOURNAL   J Cell Sci 112 (Pt 16), 2765-2774 (1999)
   PUBMED   10413683
REFERENCE   7  (bases 1 to 2355)
  AUTHORS   Rensing,S.A. and Maier,U.G.
  TITLE     Phylogenetic analysis of the stress-70 protein family
  JOURNAL   J Mol Evol 39 (1), 80-86 (1994)
   PUBMED   7545947
REFERENCE   8  (bases 1 to 2355)
  AUTHORS   Leung,T.K., Hall,C., Rajendran,M., Spurr,N.K. and Lim,L.
  TITLE     The human heat-shock genes HSPA6 and HSPA7 are both expressed and
            localize to chromosome 1
  JOURNAL   Genomics 12 (1), 74-79 (1992)
   PUBMED   1346391
REFERENCE   9  (bases 1 to 2355)
  AUTHORS   Leung,T.K., Rajendran,M.Y., Monfries,C., Hall,C. and Lim,L.
  TITLE     The human heat-shock protein family. Expression of a novel
            heat-inducible HSP70 (HSP70B') and isolation of its cDNA and
            genomic DNA
  JOURNAL   Biochem J 267 (1), 125-132 (1990)
   PUBMED   2327978
REFERENCE   10 (bases 1 to 2355)
  AUTHORS   Schiller,P., Amin,J., Ananthan,J., Brown,M.E., Scott,W.A. and
            Voellmy,R.
  TITLE     Cis-acting elements involved in the regulated expression of a human
            HSP70 gene
  JOURNAL   J Mol Biol 203 (1), 97-105 (1988)
   PUBMED   3184191
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093925.1, BC035665.1, AL590385.23 and CD366171.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002155.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7346977.931148.1,
                                        SRR1803613.132626.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309758.6/ ENSP00000310219.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK093925.1         1-10
            11-1147             BC035665.1         1-1137
            1148-1148           AL590385.23        82346-82346
            1149-1555           BC035665.1         1139-1545
            1556-1556           AL590385.23        82754-82754
            1557-2200           BC035665.1         1547-2190
            2201-2355           CD366171.1         16-170              c
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..2355
                     /gene="HSPA6"
                     /gene_synonym="HSP70B'"
                     /note="heat shock protein family A (Hsp70) member 6"
                     /db_xref="GeneID:3310"
                     /db_xref="HGNC:HGNC:5239"
                     /db_xref="MIM:140555"
     exon            1..2355
                     /gene="HSPA6"
                     /gene_synonym="HSP70B'"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2051
                     /gene="HSPA6"
                     /gene_synonym="HSP70B'"
                     /note="heat shock 70kD protein 6 (HSP70B'); heat shock 70
                     kDa protein B'; heat shock 70kDa protein 6 (HSP70B');
                     epididymis secretory sperm binding protein; heat shock
                     protein family A member 6"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 6"
                     /protein_id="NP_002146.2"
                     /db_xref="CCDS:CCDS1231.1"
                     /db_xref="GeneID:3310"
                     /db_xref="HGNC:HGNC:5239"
                     /db_xref="MIM:140555"
                     /translation="MQAPRELAVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYV
                     AFTDTERLVGDAAKSQAALNPHNTVFDAKRLIGRKFADTTVQSDMKHWPFRVVSEGGK
                     PKVRVCYRGEDKTFYPEEISSMVLSKMKETAEAYLGQPVKHAVITVPAYFNDSQRQAT
                     KDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVLIFDLGGGTFDVSVLSIDAGV
                     FEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRALRRLRTACERAKRTL
                     SSSTQATLEIDSLFEGVDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIH
                     DVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQD
                     LLLLDVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERA
                     MTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITND
                     KGRLSKEEVERMVHEAEQYKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPE
                     EDRRKMQDKCREVLAWLEHNQLAEKEEYEHQKRELEQICRPIFSRLYGGPGVPGGSSC
                     GTQARQGDPSTGPIIEEVD"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA6"
                     /gene_synonym="HSP70B'"
                     /note="hexamer: AATAAA"
     polyA_site      2257
                     /gene="HSPA6"
                     /gene_synonym="HSP70B'"
                     /note="major polyA site"
     regulatory      2336..2341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA6"
                     /gene_synonym="HSP70B'"
                     /note="hexamer: AATATA"
     polyA_site      2355
                     /gene="HSPA6"
                     /gene_synonym="HSP70B'"
                     /note="major polyA site"
ORIGIN      
        1 agatccgagc cgggctggct gcagagaaac cgcagggaga gcctcactgc tgagcgcccc
       61 tcgacggcgg agcggcagca gcctccgtgg cctccagcat ccgacaagaa gcttcagcca
      121 tgcaggcccc acgggagctc gcggtgggca tcgacctggg caccacctac tcgtgcgtgg
      181 gcgtgtttca gcagggccgc gtggagatcc tggccaacga ccagggcaac cgcaccacgc
      241 ccagctacgt ggccttcacc gacaccgagc ggctggtcgg ggacgcggcc aagagccagg
      301 cggccctgaa cccccacaac accgtgttcg atgccaagcg gctgatcggg cgcaagttcg
      361 cggacaccac ggtgcagtcg gacatgaagc actggccctt ccgggtggtg agcgagggcg
      421 gcaagcccaa ggtgcgcgta tgctaccgcg gggaggacaa gacgttctac cccgaggaga
      481 tctcgtccat ggtgctgagc aagatgaagg agacggccga ggcgtacctg ggccagcccg
      541 tgaagcacgc agtgatcacc gtgcccgcct atttcaatga ctcgcagcgc caggccacca
      601 aggacgcggg ggccatcgcg gggctcaacg tgttgcggat catcaatgag cccacggcag
      661 ctgccatcgc ctatgggctg gaccggcggg gcgcgggaga gcgcaacgtg ctcatttttg
      721 acctgggtgg gggcaccttc gatgtgtcgg ttctctccat tgacgctggt gtctttgagg
      781 tgaaagccac tgctggagat acccacctgg gaggagagga cttcgacaac cggctcgtga
      841 accacttcat ggaagaattc cggcggaagc atgggaagga cctgagcggg aacaagcgtg
      901 ccctgcgcag gctgcgcaca gcctgtgagc gcgccaagcg caccctgtcc tccagcaccc
      961 aggccaccct ggagatagac tccctgttcg agggcgtgga cttctacacg tccatcactc
     1021 gtgcccgctt tgaggaactg tgctcagacc tcttccgcag caccctggag ccggtggaga
     1081 aggccctgcg ggatgccaag ctggacaagg cccagattca tgacgtcgtc ctggtggggg
     1141 gctccacacg catccccaag gtgcagaagt tgctgcagga cttcttcaac ggcaaggagc
     1201 tgaacaagag catcaaccct gatgaggctg tggcctatgg ggctgctgtg caggcggccg
     1261 tgttgatggg ggacaaatgt gagaaagtgc aggatctcct gctgctggat gtggctcccc
     1321 tgtctctggg gctggagaca gcaggtgggg tgatgaccac gctgatccag aggaacgcca
     1381 ctatccccac caagcagacc cagactttca ccacctactc ggacaaccag cctggggtct
     1441 tcatccaggt gtatgagggt gagagggcca tgaccaagga caacaacctg ctggggcgtt
     1501 ttgaactcag tggcatccct cctgccccac gtggagtccc ccagatagag gtgacttttg
     1561 acattgatgc taatggcatc ctgagcgtga cagccactga caggagcaca ggtaaggcta
     1621 acaagatcac catcaccaat gacaagggcc ggctgagcaa ggaggaggtg gagaggatgg
     1681 ttcatgaagc cgagcagtac aaggctgagg atgaggccca gagggacaga gtggctgcca
     1741 aaaactcgct ggaggcccat gtcttccatg tgaaaggttc tttgcaagag gaaagcctta
     1801 gggacaagat tcccgaagag gacaggcgca aaatgcaaga caagtgtcgg gaagtccttg
     1861 cctggctgga gcacaaccag ctggcagaga aggaggagta tgagcatcag aagagggagc
     1921 tggagcaaat ctgtcgcccc atcttctcca ggctctatgg ggggcctggt gtccctgggg
     1981 gcagcagttg tggcactcaa gcccgccagg gggaccccag caccggcccc atcattgagg
     2041 aggttgattg aatggccctt cgtgataagt cagctgtgac tgtcagggct atgctatggg
     2101 ccttctagac tgtcttctat gatcctgccc ttcagagatg aactttccct ccaaagctag
     2161 aactttcttc ccaggataac tgaagtcttt tgactttttg cggggagggc ggttcatcct
     2221 cttctgcttc aaataaaaag tcattaattt attaaaactt gtgtggcact ttaacattgc
     2281 tttcacctat attttgtgta ctttgttact tgcatgtatg aattttgtta tgtaaaatat
     2341 agttatagac ctaaa
//
