LOCUS       NM_002154               4774 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens heat shock protein family A (Hsp70) member 4 (HSPA4),
            mRNA.
ACCESSION   NM_002154
VERSION     NM_002154.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4774)
  AUTHORS   Tu,Z., Jin,P., Wang,Q., Feng,Y., Chu,X., Fu,L., Hou,S. and Li,W.
  TITLE     Dynamically changed HSP70 after reperfusion following cerebral
            infarction in human and rats: correlation with p38 MAPK
  JOURNAL   Neuroreport 35 (7), 439-446 (2024)
   PUBMED   38597327
  REMARK    GeneRIF: Dynamically changed HSP70 after reperfusion following
            cerebral infarction in human and rats: correlation with p38 MAPK.
REFERENCE   2  (bases 1 to 4774)
  AUTHORS   Leone,S., Srivastava,A., Herrero-Ruiz,A., Hummel,B., Tittel,L.,
            Campalastri,R., Aprile-Garcia,F., Tan,J.H., Rawat,P., Andersson,P.,
            Willis,A.E. and Sawarkar,R.
  TITLE     HSP70 binds to specific non-coding RNA and regulates human RNA
            polymerase III
  JOURNAL   Mol Cell 84 (4), 687-701 (2024)
   PUBMED   38266641
  REMARK    GeneRIF: HSP70 binds to specific non-coding RNA and regulates human
            RNA polymerase III.
REFERENCE   3  (bases 1 to 4774)
  AUTHORS   de Lemos Muller,C.H., Schroeder,H.T., Farinha,J.B., Lopez,P.,
            Reischak-Oliveira,A., Pinto,R.S., de Bittencourt Junior,P.I.H. and
            Krause,M.
  TITLE     Effects of resistance training on heat shock response (HSR), HSP70
            expression, oxidative stress, inflammation, and metabolism in
            middle-aged people
  JOURNAL   J Physiol Biochem 80 (1), 161-173 (2024)
   PUBMED   37930617
  REMARK    GeneRIF: Effects of resistance training on heat shock response
            (HSR), HSP70 expression, oxidative stress, inflammation, and
            metabolism in middle-aged people.
REFERENCE   4  (bases 1 to 4774)
  AUTHORS   Tagaeva,R., Efimova,S., Ischenko,A., Zhakhov,A., Shevtsov,M. and
            Ostroumova,O.
  TITLE     A new look at Hsp70 activity in phosphatidylserine-enriched
            membranes: chaperone-induced quasi-interdigitated lipid phase
  JOURNAL   Sci Rep 13 (1), 19233 (2023)
   PUBMED   37932471
  REMARK    GeneRIF: A new look at Hsp70 activity in
            phosphatidylserine-enriched membranes: chaperone-induced
            quasi-interdigitated lipid phase.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4774)
  AUTHORS   Yurinskaya,M.M., Garbuz,D.G., Evgen'ev,M.B. and Vinokurov,M.G.
  TITLE     [The Protective Action of Hsp70 and Hydrogen Sulfide Donors in
            THP-1 Macrophages in the Lipopolysaccharide-Induced Inflammatory
            Response by Modulating Endocytosis]
  JOURNAL   Mol Biol (Mosk) 57 (6), 1017-1027 (2023)
   PUBMED   38062957
  REMARK    GeneRIF: [The Protective Action of Hsp70 and Hydrogen Sulfide
            Donors in THP-1 Macrophages in the Lipopolysaccharide-Induced
            Inflammatory Response by Modulating Endocytosis].
REFERENCE   6  (bases 1 to 4774)
  AUTHORS   Naylor,D.J., Stines,A.P., Hoogenraad,N.J. and Hoj,P.B.
  TITLE     Evidence for the existence of distinct mammalian cytosolic,
            microsomal, and two mitochondrial GrpE-like proteins, the
            Co-chaperones of specific Hsp70 members
  JOURNAL   J Biol Chem 273 (33), 21169-21177 (1998)
   PUBMED   9694873
REFERENCE   7  (bases 1 to 4774)
  AUTHORS   Kaneko,Y., Kimura,T., Kishishita,M., Noda,Y. and Fujita,J.
  TITLE     Cloning of apg-2 encoding a novel member of heat shock protein 110
            family
  JOURNAL   Gene 189 (1), 19-24 (1997)
   PUBMED   9161406
REFERENCE   8  (bases 1 to 4774)
  AUTHORS   Schulte,A.M., Fischer,S., Sachse,G.E., Hafner,S., Stelck,S. and
            Gassen,H.G.
  TITLE     Identification and characterization of a novel hsc70-like gene in
            the human lung tumor cell line HS24
  JOURNAL   DNA Cell Biol 16 (3), 257-268 (1997)
   PUBMED   9115634
REFERENCE   9  (bases 1 to 4774)
  AUTHORS   Bruner,K.L., Derfoul,A., Robertson,N.M., Guerriero,G.,
            Fernandes-Alnemri,T., Alnemri,E.S. and Litwack,G.
  TITLE     The unliganded mineralocorticoid receptor is associated with heat
            shock proteins 70 and 90 and the immunophilin FKBP-52
  JOURNAL   Recept Signal Transduct 7 (2), 85-98 (1997)
   PUBMED   9392437
REFERENCE   10 (bases 1 to 4774)
  AUTHORS   Fathallah,D.M., Cherif,D., Dellagi,K. and Arnaout,M.A.
  TITLE     Molecular cloning of a novel human hsp70 from a B cell line and its
            assignment to chromosome 5
  JOURNAL   J Immunol 151 (2), 810-813 (1993)
   PUBMED   8335910
  REMARK    Erratum:[J Immunol 1993 Dec 1;151(11):6616]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG723797.1, AB023420.1, BQ431980.1, BU686725.1, CF145856.1,
            BU171424.1 and AC113410.2.
            
            On Nov 23, 2018 this sequence version replaced NM_002154.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.187453.1,
                                           SRR1803615.67299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304858.7/ ENSP00000302961.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               BG723797.1         52-446
            396-2101            AB023420.1         436-2141
            2102-2765           BQ431980.1         81-744
            2766-2917           BU686725.1         272-423
            2918-2947           CF145856.1         485-514
            2948-3022           BU686725.1         454-528
            3023-3342           BU171424.1         422-741
            3343-4774           AC113410.2         8856-10287          c
FEATURES             Location/Qualifiers
     source          1..4774
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..4774
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /note="heat shock protein family A (Hsp70) member 4"
                     /db_xref="GeneID:3308"
                     /db_xref="HGNC:HGNC:5237"
                     /db_xref="MIM:601113"
     exon            1..345
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..2761
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /note="heat shock 70kD protein 4; hsp70 RY; heat shock
                     protein, 110 kDa; heat shock 70-related protein APG-2;
                     epididymis secretory sperm binding protein Li 5a; heat
                     shock protein family H member 2"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 4"
                     /protein_id="NP_002145.3"
                     /db_xref="CCDS:CCDS4166.1"
                     /db_xref="GeneID:3308"
                     /db_xref="HGNC:HGNC:5237"
                     /db_xref="MIM:601113"
                     /translation="MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPK
                     NRSIGAAAKSQVISNAKNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIK
                     VTYMEEERNFTTEQVTAMLLSKLKETAESVLKKPVVDCVVSVPCFYTDAERRSVMDAT
                     QIAGLNCLRLMNETTAVALAYGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRG
                     KLKVLATAFDTTLGGRKFDEVLVNHFCEEFGKKYKLDIKSKIRALLRLSQECEKLKKL
                     MSANASDLPLSIECFMNDVDVSGTMNRGKFLEMCNDLLARVEPPLRSVLEQTKLKKED
                     IYAVEIVGGATRIPAVKEKISKFFGKELSTTLNADEAVTRGCALQCAILSPAFKVREF
                     SITDVVPYPISLRWNSPAEEGSSDCEVFSKNHAAPFSKVLTFYRKEPFTLEAYYSSPQ
                     DLPYPDPAIAQFSVQKVTPQSDGSSSKVKVKVRVNVHGIFSVSSASLVEVHKSEENEE
                     PMETDQNAKEEEKMQVDQEEPHVEEQQQQTPAENKAESEEMETSQAGSKDKKMDQPPQ
                     AKKAKVKTSTVDLPIENQLLWQIDREMLNLYIENEGKMIMQDKLEKERNDAKNAVEEY
                     VYEMRDKLSGEYEKFVSEDDRNSFTLKLEDTENWLYEDGEDQPKQVYVDKLAELKNLG
                     QPIKIRFQESEERPKLFEELGKQIQQYMKIISSFKNKEDQYDHLDAADMTKVEKSTNE
                     AMEWMNNKLNLQNKQSLTMDPVVKSKEIEAKIKELTSTCSPIISKPKPKVEPPKEEQK
                     NAEQNGPVDGQGDNPGPQAAEQGTDTAVPSDSDKKLPEMDID"
     exon            346..403
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            404..544
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            545..667
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            668..767
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            768..901
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1146
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1223
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1375
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1482
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1616
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1798
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1888
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2041
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2167
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2275
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2395
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2557
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..4774
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2779..2784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /note="hexamer: ATTAAA"
     polyA_site      2802
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /note="major polyA site"
     regulatory      4752..4757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /note="hexamer: AATAAA"
     polyA_site      4774
                     /gene="HSPA4"
                     /gene_synonym="APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY;
                     HSPH2; RY"
                     /note="major polyA site"
ORIGIN      
        1 gagatcttct ccgcccccgc taccggcgcc tcctctgcgg ccactgagcc ggagccggcc
       61 tgagcagcgc tctcggttgc agtacccact ggaaggactt aggcgctcgc gtggacaccg
      121 caagcccctc agtagcctcg gcccaagagg cctgctttcc actcgctagc cccgccgggg
      181 gtccgtgtcc tgtctcggtg gccggacccg ggcccgagcc cgagcagtag ccggcgccat
      241 gtcggtggtg ggcatagacc tgggcttcca gagctgctac gtcgctgtgg cccgcgccgg
      301 cggcatcgag actatcgcta atgagtatag cgaccgctgc acgccggctt gcatttcttt
      361 tggtcctaag aatcgttcaa ttggagcagc agctaaaagc caggtaattt ctaatgcaaa
      421 gaacacagtc caaggattta aaagattcca tggccgagca ttctctgatc catttgtgga
      481 ggcagaaaaa tctaaccttg catatgatat tgtgcagttg cctacaggat taacaggtat
      541 aaaggtgaca tatatggagg aagagcgaaa ttttaccact gagcaagtga ctgccatgct
      601 tttgtccaaa ctgaaggaga cagccgaaag tgttcttaag aagcctgtag ttgactgtgt
      661 tgtttcggtt ccttgtttct atactgatgc agaaagacga tcagtgatgg atgcaacaca
      721 gattgctggt cttaattgct tgcgattaat gaatgaaacc actgcagttg ctcttgcata
      781 tggaatctat aagcaggatc ttcctgcctt agaagagaaa ccaagaaatg tagtttttgt
      841 agacatgggc cactctgctt atcaagtttc tgtatgtgca tttaatagag gaaaactgaa
      901 agttctggcc actgcatttg acacgacatt gggaggtaga aaatttgatg aagtgttagt
      961 aaatcacttc tgtgaagaat ttgggaagaa atacaagcta gacattaagt ccaaaatccg
     1021 tgcattatta cgactctctc aggagtgtga gaaactcaag aaattgatga gtgcaaatgc
     1081 ttcagatctc cctttgagca ttgaatgttt tatgaatgat gttgatgtat ctggaactat
     1141 gaatagaggc aaatttctgg agatgtgcaa tgatctctta gctagagtgg agccaccact
     1201 tcgtagtgtt ttggaacaaa ccaagttaaa gaaagaagat atttatgcag tggagatagt
     1261 tggtggtgct acacgaatcc ctgcggtaaa agagaagatc agcaaatttt tcggtaaaga
     1321 acttagtaca acattaaatg ctgatgaagc tgtcactcga ggctgtgcat tgcagtgtgc
     1381 catcttatcg cctgctttca aagtcagaga attttctatc actgatgtag taccatatcc
     1441 aatatctctg agatggaatt ctccagctga agaagggtca agtgactgtg aagtcttttc
     1501 caaaaatcat gctgctcctt tctctaaagt tcttacattt tatagaaagg aacctttcac
     1561 tcttgaggcc tactacagct ctcctcagga tttgccctat ccagatcctg ctatagctca
     1621 gttttcagtt cagaaagtca ctcctcagtc tgatggctcc agttcaaaag tgaaagtcaa
     1681 agttcgagta aatgtccatg gcattttcag tgtgtccagt gcatctttag tggaggttca
     1741 caagtctgag gaaaatgagg agccaatgga aacagatcag aatgcaaagg aggaagagaa
     1801 gatgcaagtg gaccaggagg aaccacatgt tgaagagcaa cagcagcaga caccagcaga
     1861 aaataaggca gagtctgaag aaatggagac ctctcaagct ggatccaagg ataaaaagat
     1921 ggaccaacca ccccaagcca agaaggcaaa agtgaagacc agtactgtgg acctgccaat
     1981 cgagaatcag ctattatggc agatagacag agagatgctc aacttgtaca ttgaaaatga
     2041 gggtaagatg atcatgcagg ataaactgga gaaggagcgg aatgatgcta agaacgcagt
     2101 ggaggaatat gtgtatgaaa tgagagacaa gcttagtggt gaatatgaga agtttgtgag
     2161 tgaagatgat cgtaacagtt ttactttgaa actggaagat actgaaaatt ggttgtatga
     2221 ggatggagaa gaccagccaa agcaagttta tgttgataag ttggctgaat taaaaaatct
     2281 aggtcaacct attaagatac gtttccagga atctgaagaa cgaccaaaat tatttgaaga
     2341 actagggaaa cagatccaac agtatatgaa aataatcagc tctttcaaaa acaaggagga
     2401 ccagtatgat catttggatg ctgctgacat gacaaaggta gaaaaaagca caaatgaagc
     2461 aatggagtgg atgaataaca agctaaatct gcagaacaag cagagtttga ccatggatcc
     2521 agttgtcaag tcaaaagaga ttgaagctaa aattaaggag ctgacaagta cttgtagccc
     2581 tataatttca aagcccaaac ccaaagtgga acctccaaaa gaggaacaaa aaaatgcaga
     2641 gcagaatgga ccagtggatg gacaaggaga caacccaggc ccccaggctg ctgagcaggg
     2701 tacagacaca gctgtgcctt cggattcaga caagaagctt cctgaaatgg acattgattg
     2761 attccaacac ttgtttctat taaaacagac tattataaag ctttaagttg tcaactttgt
     2821 tctaaatatc aactagcgca agtgaatact gaagatttct tagtcagttt ttaggggatt
     2881 ttcggggagg ggaaataggt aatgtatgga gcattttcac ttctaaatag ttagatacag
     2941 aaattaagtg cattgtatct ttttcataat ggtactattt agaagcccag ttagtcttac
     3001 tgagcttatg cttcactcct ttatgtttaa ccatgtgtct acaagaataa gtttgttttg
     3061 gaaagttgag ctatagctac agctctagct atccagcaga cttttcatta tgacttacat
     3121 ggcaggagct ctaattatgc tttaaaaatc tgttgtggag attgctttaa atgctccctg
     3181 cctggtgtgg ggatggggtc cccctctttg tgagggctgg agcatggcac ggcatggatt
     3241 aacacggcag aggaacaaag gtgtgctctg agcttcttca tatttcacct tcaccctcac
     3301 ctgtgttctc ttccctctct cccaataaaa gggctcccat tataaatgcc atgtacttct
     3361 cttgggaaaa tagaccccct tgcctagagt aagttgttaa ctgagggctt taaacctgga
     3421 ggctcttcct gaaagtatgt tcatgaatac cccaagcatc aaggtctaaa taattttcag
     3481 aagattagaa ttgggtagat atactgttgg atatagccat ggtaaattta actgaggaat
     3541 taaatccttg ttaattttgg tgtaaagatt tgtatcctgg cctgtttatt caggtgggag
     3601 atgttctgta taattttgag gtatagcttg aactcctaga acaagagtta aaagttcttt
     3661 ttagctcatt cacaatcact tgtgtgttaa gtgttaatat ctgtcatgaa cctgccaatt
     3721 tgtacgtgtt aagcagctga cagatgatgc aaaaaaaact aagatacact ggattgtact
     3781 ggatgagtct gaaattagtg ttaaagaagt gtggtgcctg atgttataac aacacctcat
     3841 tcttaactgt gtggccaatg tcaggtatac caaagcattc ctctgactgc tttttggggc
     3901 agtgttgaca ggagtgaggc attttggaaa ctccaaggga agcctgtgtt tgaggccaga
     3961 gttggtacct gctttaagaa actgttacag ggcttgttgg taatgttttg aatctttgta
     4021 aaaattgata ttctgtataa cagagtgcct ctctgttact tttggcctat gttgttagaa
     4081 ataagatgct atcttgcata gttagaatta agcgtttgtc catctctaga taacattgaa
     4141 aagtttgagt gttacaggct ctaaagtgca atggagaaca attgcttagg aggaggaagg
     4201 ggaaagtata cttatgttgg tgtgtaagca tgcatggagg cctcgaggca ccacaacaag
     4261 gccaggttct tagcacatcc tctgttctct acctgtcatg cttcaagagt tccagctggc
     4321 ctgctgtgaa gccagtagct attttaaaag tgctggctgc aggattaagc caacccttta
     4381 caactggccc agaccgtaat ggccatttct tcttaaaaaa aaaaaaattt tttttttttt
     4441 tttttttttt tttttttttt tttttggtgt gtgtgtgtgt gtgtgtgggg aagggtgtgg
     4501 gtgctgggat gggggtgaat ttcaagttga aacacgatga tgtggtctgc ttgctctctg
     4561 cttagacagg ctttaagacc aattggattt tcatggaggc caggacagag agtggtaatt
     4621 gatggcttgt gtacagacaa gcatttatcc aggttgcgtt atccaaactg atttgttaaa
     4681 gctccaggtc acgttcttac actaagaaaa tcattcagta aacatgagac aagtttagga
     4741 aaaactaata aaataaacct gtcttaaact tgaa
//
