LOCUS       NM_021979               2497 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens heat shock protein family A (Hsp70) member 2 (HSPA2),
            transcript variant 1, mRNA.
ACCESSION   NM_021979
VERSION     NM_021979.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2497)
  AUTHORS   Sojka,D.R., Gogler,A., Kania,D., Vydra,N., Wiecha,K.,
            Adamiec-Organisciok,M., Wilk,A., Chumak,V., Matysniak,D. and
            Scieglinska,D.
  TITLE     The human testis-enriched HSPA2 interacts with HIF-1alpha in
            epidermal keratinocytes, yet HIF-1alpha stability and
            HIF-1-dependent gene expression rely on the HSPA (HSP70) activity
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (5), 119735 (2024)
   PUBMED   38641179
  REMARK    GeneRIF: The human testis-enriched HSPA2 interacts with HIF-1alpha
            in epidermal keratinocytes, yet HIF-1alpha stability and
            HIF-1-dependent gene expression rely on the HSPA (HSP70) activity.
REFERENCE   2  (bases 1 to 2497)
  AUTHORS   Dong,Y., Li,T., Ma,Z., Zhou,C., Wang,X. and Li,J.
  TITLE     HSPA1A, HSPA2, and HSPA8 Are Potential Molecular Biomarkers for
            Prognosis among HSP70 Family in Alzheimer's Disease
  JOURNAL   Dis Markers 2022, 9480398 (2022)
   PUBMED   36246562
  REMARK    GeneRIF: HSPA1A, HSPA2, and HSPA8 Are Potential Molecular
            Biomarkers for Prognosis among HSP70 Family in Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2497)
  AUTHORS   Zhai,L.L., Qiao,P.P., Sun,Y.S., Ju,T.F. and Tang,Z.G.
  TITLE     Tumorigenic and immunological roles of Heat shock protein A2 in
            pancreatic cancer: a bioinformatics analysis
  JOURNAL   Rev Assoc Med Bras (1992) 68 (4), 470-475 (2022)
   PUBMED   35649069
  REMARK    GeneRIF: Tumorigenic and immunological roles of Heat shock protein
            A2 in pancreatic cancer: a bioinformatics analysis.
REFERENCE   4  (bases 1 to 2497)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2497)
  AUTHORS   Nowicka-Bauer,K., Malcher,A., Wloczkowska,O., Kamieniczna,M.,
            Olszewska,M. and Kurpisz,M.K.
  TITLE     Evaluation of seminal plasma HSPA2 protein as a biomarker of human
            spermatogenesis status
  JOURNAL   Reprod Biol 22 (1), 100597 (2022)
   PUBMED   34959194
  REMARK    GeneRIF: Evaluation of seminal plasma HSPA2 protein as a biomarker
            of human spermatogenesis status.
REFERENCE   6  (bases 1 to 2497)
  AUTHORS   Allen,J.W., Dix,D.J., Collins,B.W., Merrick,B.A., He,C.,
            Selkirk,J.K., Poorman-Allen,P., Dresser,M.E. and Eddy,E.M.
  TITLE     HSP70-2 is part of the synaptonemal complex in mouse and hamster
            spermatocytes
  JOURNAL   Chromosoma 104 (6), 414-421 (1996)
   PUBMED   8601336
REFERENCE   7  (bases 1 to 2497)
  AUTHORS   Roux,A.F., Nguyen,V.T., Squire,J.A. and Cox,D.W.
  TITLE     A heat shock gene at 14q22: mapping and expression
  JOURNAL   Hum Mol Genet 3 (10), 1819-1822 (1994)
   PUBMED   7849706
REFERENCE   8  (bases 1 to 2497)
  AUTHORS   Bonnycastle,L.L., Yu,C.E., Hunt,C.R., Trask,B.J., Clancy,K.P.,
            Weber,J.L., Patterson,D. and Schellenberg,G.D.
  TITLE     Cloning, sequencing, and mapping of the human chromosome 14 heat
            shock protein gene (HSPA2)
  JOURNAL   Genomics 23 (1), 85-93 (1994)
   PUBMED   7829106
REFERENCE   9  (bases 1 to 2497)
  AUTHORS   Schwab,C.G., Bozak,C.K., Whitehouse,N.L. and Olson,V.M.
  TITLE     Amino acid limitation and flow to the duodenum at four stages of
            lactation. 2. Extent of lysine limitation
  JOURNAL   J Dairy Sci 75 (12), 3503-3518 (1992)
   PUBMED   1474216
REFERENCE   10 (bases 1 to 2497)
  AUTHORS   Dworniczak,B. and Mirault,M.E.
  TITLE     Structure and expression of a human gene coding for a 71 kd heat
            shock 'cognate' protein
  JOURNAL   Nucleic Acids Res 15 (13), 5181-5197 (1987)
   PUBMED   3037489
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB042367.1, CN356507.1, CD300159.1, BC036107.1 and BC001752.1.
            
            On Aug 14, 2020 this sequence version replaced NM_021979.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: GQ891480.1, BC036107.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247207.7/ ENSP00000247207.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               DB042367.1         249-550
            303-479             CN356507.1         359-535
            480-1058            CD300159.1         171-749
            1059-1698           BC036107.1         1058-1697
            1699-2497           BC001752.1         1666-2464
FEATURES             Location/Qualifiers
     source          1..2497
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.3"
     gene            1..2497
                     /gene="HSPA2"
                     /gene_synonym="HSP70-2; HSP70-3"
                     /note="heat shock protein family A (Hsp70) member 2"
                     /db_xref="GeneID:3306"
                     /db_xref="HGNC:HGNC:5235"
                     /db_xref="MIM:140560"
     exon            1..2497
                     /gene="HSPA2"
                     /gene_synonym="HSP70-2; HSP70-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2029
                     /gene="HSPA2"
                     /gene_synonym="HSP70-2; HSP70-3"
                     /note="heat shock 70kD protein 2; heat shock 70kDa protein
                     2; epididymis secretory sperm binding protein; heat shock
                     protein family A member 2"
                     /codon_start=1
                     /product="heat shock-related 70 kDa protein 2"
                     /protein_id="NP_068814.2"
                     /db_xref="CCDS:CCDS9766.1"
                     /db_xref="GeneID:3306"
                     /db_xref="HGNC:HGNC:5235"
                     /db_xref="MIM:140560"
                     /translation="MSARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVA
                     FTDTERLIGDAAKNQVAMNPTNTIFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKP
                     KVQVEYKGETKTFFPEEISSMVLTKMKEIAEAYLGGKVHSAVITVPAYFNDSQRQATK
                     DAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLIFDLGGGTFDVSILTIEDG
                     IFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVRRLRTACERAKRT
                     LSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKLDKGQI
                     QEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQ
                     DLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGER
                     AMTKDNNLLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITN
                     DKGRLSKDDIDRMVQEAERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKIS
                     EQDKNKILDKCQEVINWLDRNQMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGSGG
                     GGSGASGGPTIEEVD"
     regulatory      2474..2479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA2"
                     /gene_synonym="HSP70-2; HSP70-3"
                     /note="hexamer: AGTAAA"
     polyA_site      2497
                     /gene="HSPA2"
                     /gene_synonym="HSP70-2; HSP70-3"
                     /note="major polyA site"
ORIGIN      
        1 gagttgctgg tagtgcccgt ggtgcttggt tcgaggtggc cgttagttga ctccgcggag
       61 ttcatctccc tggttttccc gtcctaacgt cgctcgcctt tcagtcagga tgtctgcccg
      121 tggcccggct atcggcatcg acctgggcac cacctattcg tgcgtcgggg tcttccaaca
      181 tggcaaggtg gagatcatcg ccaacgacca gggcaatcgc accaccccca gctacgtggc
      241 cttcacggac accgagcgcc tcatcggcga cgccgccaag aaccaggtgg ccatgaaccc
      301 caccaacacc atcttcgacg ccaagaggct gattggacgg aaattcgagg atgccacagt
      361 gcagtcggat atgaaacact ggccgttccg ggtggtgagc gagggaggca agcccaaagt
      421 gcaagtagag tacaaggggg agaccaagac cttcttccca gaggagatat cctccatggt
      481 cctcacgaag atgaaggaga tcgcggaagc ctacctgggg ggcaaggtgc acagcgcggt
      541 cataacggtc ccggcctatt tcaacgactc gcagcgccag gccaccaagg acgcaggcac
      601 catcacgggg ctcaatgtgc tgcgcatcat caacgagccc acggcggcgg ccatcgccta
      661 cggcctggac aagaagggct gcgcgggcgg cgagaagaac gtgctcatct ttgacctggg
      721 cggtggcact ttcgacgtgt ccatcctgac catcgaggat ggcatcttcg aggtgaagtc
      781 cacggccggc gacacccacc tgggcggtga ggacttcgac aaccgcatgg tgagccacct
      841 ggcggaggag ttcaagcgca agcacaagaa ggacattggg cccaacaagc gcgccgtgag
      901 gcggctgcgc accgcttgcg agcgcgccaa gcgcaccctg agctcgtcca cgcaggcgag
      961 catcgagatc gactcgctct acgagggcgt ggacttctat acgtccatca cgcgcgcccg
     1021 cttcgaggag ctcaatgccg acctctttcg cgggaccctg gagccggtgg agaaggcgct
     1081 gcgcgacgcc aagctggaca agggccagat ccaggagatc gtgctggtgg gcggctccac
     1141 tcgtatcccc aagatccaga agctgctgca ggatttcttc aacggcaagg agctgaacaa
     1201 gagcatcaac cccgacgagg cggtggccta tggcgccgcg gtgcaggcgg ccatcctcat
     1261 cggcgacaaa tcagagaatg tgcaggacct gctgctactc gacgtgaccc cgttgtcgct
     1321 gggcatcgag acagctggcg gtgtcatgac cccactcatc aagaggaaca ccacgatccc
     1381 caccaagcag acgcagacct tcaccaccta ctcggacaac cagagcagcg tactggtgca
     1441 ggtatacgag ggcgaacggg ccatgaccaa ggacaataac ctgctgggca agttcgacct
     1501 gaccgggatt ccccctgcgc ctcgcggggt cccccaaatc gaggttacct tcgacattga
     1561 cgccaatggc atccttaacg ttaccgccgc cgacaagagc accggtaagg aaaacaaaat
     1621 caccatcacc aatgacaaag gtcgtctgag caaggacgac attgaccgga tggtgcagga
     1681 ggcggagcgg tacaaatcgg aagatgaggc gaatcgcgac cgagtcgcgg ccaaaaacgc
     1741 cctggagtcc tatacctaca acatcaagca gacggtggaa gacgagaaac tgaggggcaa
     1801 gattagcgag caggacaaaa acaagatcct cgacaagtgt caggaggtga tcaactggct
     1861 cgaccgaaac cagatggcag agaaagatga gtatgaacac aagcagaaag agctcgaaag
     1921 agtttgcaac cccatcatca gcaaacttta ccaaggtggt cctggcggcg gcagcggcgg
     1981 cggcggttca ggagcctccg ggggacccac catcgaagaa gtggactaag cttgcactca
     2041 agtcagcgta aacctctttg cctttctctc tctctctttt tttttgtttg tttctttgaa
     2101 atgtccttgt gccaagtacg agatctattg ttggaagtct ttggtatatg caaatgaaag
     2161 gagaggtgca acaacttagt ttaattataa aagttccaaa gtttgttttt taaaaacatt
     2221 attcgaggtt tctctttaat gcattttgcg tgtttgctga cttgagcatt tttgattagt
     2281 tcgtgcatgg agatttgttt gagatgagaa accttaagtt tgcacacctg ttctgtagaa
     2341 gcttggaaac agtaaaatat ataggagctt aaattgttta tttttatgta ctactttaaa
     2401 actaaactga acattgcagt aatgttaagg acaggtatac tttttgcaaa caaatgcata
     2461 aatgcaaatg taaagtaaag ctgaaattga tctcaaa
//
