LOCUS       NM_005527               2762 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens heat shock protein family A (Hsp70) member 1 like
            (HSPA1L), mRNA.
ACCESSION   NM_005527
VERSION     NM_005527.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2762)
  AUTHORS   Ochoa-Ramirez,L.A., Diaz-Camacho,S.P., Mellado-Corrales,S.N.,
            Munoz-Estrada,V.F., Rios-Tostado,J.J., Sanchez-Zazueta,J.G. and
            Velarde-Felix,J.S.
  TITLE     Analysis of the heat shock protein 70 (HSP70) genetic variants in
            nonsegmental vitiligo patients
  JOURNAL   Int J Dermatol 62 (2), 225-230 (2023)
   PUBMED   36345598
  REMARK    GeneRIF: Analysis of the heat shock protein 70 (HSP70) genetic
            variants in nonsegmental vitiligo patients.
REFERENCE   2  (bases 1 to 2762)
  AUTHORS   Liu,X., Teng,Z., Wang,Z., Zhu,P., Song,Z. and Liu,F.
  TITLE     Expressions of HSPA1L and HSPA9 are associated with poor sperm
            quality of low-motility spermatozoa in fertile men
  JOURNAL   Andrologia 54 (2), e14321 (2022)
   PUBMED   34796524
  REMARK    GeneRIF: Expressions of HSPA1L and HSPA9 are associated with poor
            sperm quality of low-motility spermatozoa in fertile men.
REFERENCE   3  (bases 1 to 2762)
  AUTHORS   Huusko,J.M., Tiensuu,H., Haapalainen,A.M., Pasanen,A.,
            Tissarinen,P., Karjalainen,M.K., Zhang,G., Christensen,K.,
            Ryckman,K.K., Jacobsson,B., Murray,J.C., Kingsmore,S.F.,
            Hallman,M., Muglia,L.J. and Ramet,M.
  TITLE     Integrative genetic, genomic and transcriptomic analysis of heat
            shock protein and nuclear hormone receptor gene associations with
            spontaneous preterm birth
  JOURNAL   Sci Rep 11 (1), 17115 (2021)
   PUBMED   34429451
  REMARK    GeneRIF: Integrative genetic, genomic and transcriptomic analysis
            of heat shock protein and nuclear hormone receptor gene
            associations with spontaneous preterm birth.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2762)
  AUTHORS   Nakatsuka,A., Yamaguchi,S., Eguchi,J., Kakuta,S., Iwakura,Y.,
            Sugiyama,H. and Wada,J.
  TITLE     A Vaspin-HSPA1L complex protects proximal tubular cells from
            organelle stress in diabetic kidney disease
  JOURNAL   Commun Biol 4 (1), 373 (2021)
   PUBMED   33742129
  REMARK    GeneRIF: A Vaspin-HSPA1L complex protects proximal tubular cells
            from organelle stress in diabetic kidney disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2762)
  AUTHORS   Choi,S.I., Lee,J.H., Kim,R.K., Jung,U., Kahm,Y.J., Cho,E.W. and
            Kim,I.G.
  TITLE     HSPA1L Enhances Cancer Stem Cell-Like Properties by Activating
            IGF1Rbeta and Regulating beta-Catenin Transcription
  JOURNAL   Int J Mol Sci 21 (18), 6957 (2020)
   PUBMED   32971893
  REMARK    GeneRIF: HSPA1L Enhances Cancer Stem Cell-Like Properties by
            Activating IGF1Rbeta and Regulating beta-Catenin Transcription.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2762)
  AUTHORS   Milner,C.M. and Campbell,R.D.
  TITLE     Polymorphic analysis of the three MHC-linked HSP70 genes
  JOURNAL   Immunogenetics 36 (6), 357-362 (1992)
   PUBMED   1356099
REFERENCE   7  (bases 1 to 2762)
  AUTHORS   Milner,C.M. and Campbell,R.D.
  TITLE     Structure and expression of the three MHC-linked HSP70 genes
  JOURNAL   Immunogenetics 32 (4), 242-251 (1990)
   PUBMED   1700760
REFERENCE   8  (bases 1 to 2762)
  AUTHORS   Sargent,C.A., Dunham,I., Trowsdale,J. and Campbell,R.D.
  TITLE     Human major histocompatibility complex contains genes for the major
            heat shock protein HSP70
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 1968-1972 (1989)
   PUBMED   2538825
REFERENCE   9  (bases 1 to 2762)
  AUTHORS   Harrison,G.S., Drabkin,H.A., Kao,F.T., Hartz,J., Hart,I.M.,
            Chu,E.H., Wu,B.J. and Morimoto,R.I.
  TITLE     Chromosomal location of human genes encoding major heat-shock
            protein HSP70
  JOURNAL   Somat Cell Mol Genet 13 (2), 119-130 (1987)
   PUBMED   3470951
REFERENCE   10 (bases 1 to 2762)
  AUTHORS   Goate,A.M., Cooper,D.N., Hall,C., Leung,T.K., Solomon,E. and Lim,L.
  TITLE     Localization of a human heat-shock HSP 70 gene sequence to
            chromosome 6 and detection of two other loci by somatic-cell hybrid
            and restriction fragment length polymorphism analysis
  JOURNAL   Hum Genet 75 (2), 123-128 (1987)
   PUBMED   2880793
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL671762.10, BG717447.1,
            D85730.1, BC034483.1, M59829.1, CA443193.1 and BX115051.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 28, 2018 this sequence version replaced NM_005527.3.
            
            Summary: This gene encodes a 70kDa heat shock protein. In
            conjunction with other heat shock proteins, this protein stabilizes
            existing proteins against aggregation and mediates the folding of
            newly translated proteins in the cytosol and in organelles. The
            gene is located in the major histocompatibility complex class III
            region, in a cluster with two closely related genes which also
            encode isoforms of the 70kDa heat shock protein. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK295416.1, SRR1803615.268463.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000375654.5/
                                                ENSP00000364805.4
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AL671762.10        22907-23131         c
            226-273             BG717447.1         14-61
            274-357             D85730.1           1-84
            358-1650            BC034483.1         110-1402
            1651-1885           D85730.1           1378-1612
            1886-1964           M59829.1           2437-2515
            1965-2286           D85730.1           1692-2013
            2287-2391           M59829.1           2838-2942
            2392-2644           D85730.1           2119-2371
            2645-2759           CA443193.1         16-130              c
            2760-2762           BX115051.1         14-16               c
FEATURES             Location/Qualifiers
     source          1..2762
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..2762
                     /gene="HSPA1L"
                     /gene_synonym="HSP70-1L; HSP70-HOM; HSP70T; hum70t"
                     /note="heat shock protein family A (Hsp70) member 1 like"
                     /db_xref="GeneID:3305"
                     /db_xref="HGNC:HGNC:5234"
                     /db_xref="MIM:140559"
     exon            1..395
                     /gene="HSPA1L"
                     /gene_synonym="HSP70-1L; HSP70-HOM; HSP70T; hum70t"
                     /inference="alignment:Splign:2.1.0"
     exon            396..2762
                     /gene="HSPA1L"
                     /gene_synonym="HSP70-1L; HSP70-HOM; HSP70T; hum70t"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..2334
                     /gene="HSPA1L"
                     /gene_synonym="HSP70-1L; HSP70-HOM; HSP70T; hum70t"
                     /note="heat shock 70kD protein-like 1; heat shock 10kDa
                     protein 1-like; epididymis secretory sperm binding
                     protein; heat shock 70 kDa protein 1L; heat shock 70 kDa
                     protein 1-Hom; heat shock 70kDa protein 1-like; heat shock
                     protein family A member 1L"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 1-like"
                     /protein_id="NP_005518.3"
                     /db_xref="CCDS:CCDS34413.1"
                     /db_xref="GeneID:3305"
                     /db_xref="HGNC:HGNC:5234"
                     /db_xref="MIM:140559"
                     /translation="MATAKGIAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYV
                     AFTDTERLIGDAAKNQVAMNPQNTVFDAKRLIGRKFNDPVVQADMKLWPFQVINEGGK
                     PKVLVSYKGENKAFYPEEISSMVLTKLKETAEAFLGHPVTNAVITVPAYFNDSQRQAT
                     KDAGVIAGLNVLRIINEPTAAAIAYGLDKGGQGERHVLIFDLGGGTFDVSILTIDDGI
                     FEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTL
                     SSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKALRDAKMDKAKIH
                     DIVLVGGSTRIPKVQRLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQD
                     LLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERA
                     MTKDNNLLGRFDLTGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKVNKITITND
                     KGRLSKEEIERMVLDAEKYKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISE
                     SDKNKILDKCNELLSWLEVNQLAEKDEFDHKRKELEQMCNPIITKLYQGGCTGPACGT
                     GYVPGRPATGPTIEEVD"
     regulatory      2626..2631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA1L"
                     /gene_synonym="HSP70-1L; HSP70-HOM; HSP70T; hum70t"
                     /note="hexamer: AGTAAA"
     polyA_site      2648
                     /gene="HSPA1L"
                     /gene_synonym="HSP70-1L; HSP70-HOM; HSP70T; hum70t"
                     /note="major polyA site"
     regulatory      2740..2745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA1L"
                     /gene_synonym="HSP70-1L; HSP70-HOM; HSP70T; hum70t"
                     /note="hexamer: ATTAAA"
     polyA_site      2762
                     /gene="HSPA1L"
                     /gene_synonym="HSP70-1L; HSP70-HOM; HSP70T; hum70t"
                     /note="major polyA site"
ORIGIN      
        1 gttggtctcc atggcgatgc tgaccgcctg cgcttcagcg cctaattgac aggaagggtc
       61 ggcgctgggc ttttaattgt gggggcttgc tgggcctgcg cagttgtggg cagggggctg
      121 gtgcggggag cgggttacgc gcgtccaggg gagggtgggg gcgtttgtgt tgacaccgcc
      181 cggccacgtt acaatggaga tactgtctct gacctcatgg gccagtttgg aaaaagatta
      241 ctgagttgga gccgtctcaa atttgcaggg agggacgggg tggggggtgg ggggaccccg
      301 gttgtgcagt ttgatattga gggagccccc acctactcgc tggggctgcg taatctggac
      361 gtttccaaac tgaagcgaag gcgtcgggag actaggcctc agagaaccat ggctactgcc
      421 aagggaatcg ccataggcat cgacctgggc accacctact cctgtgtggg ggtgttccag
      481 cacggcaagg tggagatcat cgccaacgac cagggcaacc gcaccacccc cagctacgtg
      541 gccttcacag acaccgagcg gctcattggg gatgcggcca agaaccaggt agcaatgaat
      601 ccccagaaca ctgtttttga tgctaaacgt ctgatcggca ggaaatttaa tgatcctgtt
      661 gtacaagcag atatgaaact ttggcctttt caagtgatta atgaaggagg caagcccaaa
      721 gtccttgtgt cctacaaagg ggagaataaa gctttctacc ctgaggaaat ctcttcgatg
      781 gtattgacta agttgaagga gactgctgag gcctttttgg gccaccctgt caccaatgca
      841 gtgattaccg tgccagccta tttcaatgac tctcaacgtc aggctactaa ggatgcaggt
      901 gtgattgctg gacttaatgt gctaagaatc atcaatgagc ccacggctgc tgccattgcc
      961 tatggtttag ataaaggagg tcaaggagaa cgacatgtcc tgatttttga tctgggtgga
     1021 ggcacatttg atgtgtcaat tctgaccata gatgatggga tttttgaggt aaaggccact
     1081 gctggggaca ctcacctggg tggggaggac tttgacaaca ggcttgtgag ccacttcgtg
     1141 gaggagttca agaggaaaca caaaaaggac atcagccaga acaagcgagc cgtgaggcgg
     1201 ctgcgcaccg cctgcgagag ggccaagagg accctgtcgt ccagcaccca ggccaaccta
     1261 gaaattgatt cactttatga aggcattgac ttctatacat ccatcaccag agctcgattt
     1321 gaagagttgt gtgcagacct gtttaggggt accctggagc ctgtagaaaa agcgcttcgg
     1381 gatgccaaga tggataaggc taaaatccat gacattgttt tagtaggggg ctccacccgc
     1441 atccccaagg tgcagcggct gcttcaggac tacttcaatg gacgtgatct caacaagagc
     1501 atcaaccctg atgaggccgt agcatatggg gctgcggtac aagcagccat cctgatgggg
     1561 gacaagtctg agaaggtaca ggacctgctg ctgctggacg tggctcccct gtccctgggg
     1621 ctggagacgg ctgggggcgt gatgactgcc ctgataaagc gcaactccac catccccacc
     1681 aagcagacac agattttcac cacctactct gacaaccaac ccggggtgct gatccaggtg
     1741 tatgagggcg agagggccat gacaaaggac aacaacctgc tggggcggtt tgacctgact
     1801 ggaatccctc cagcacccag gggagttcct cagatcgagg tgacgtttga cattgatgcc
     1861 aatggtattc tcaatgtcac agccacggac aagagcaccg gcaaggtgaa caagatcacc
     1921 atcaccaatg acaagggccg cctgagcaag gaggagattg agcgcatggt tctggatgct
     1981 gagaaatata aagctgaaga tgaggtccag agggagaaaa ttgctgcaaa gaatgcctta
     2041 gaatcctatg cttttaacat gaagagtgtt gtgagtgatg aaggtttgaa gggcaagatt
     2101 agtgagtctg ataaaaataa aatattggat aaatgcaacg agctcctttc gtggctggag
     2161 gtcaatcaac tggcagagaa agatgagttt gatcataaga gaaaggaatt ggagcagatg
     2221 tgtaacccta tcatcacaaa actctaccaa ggaggatgca ctgggcctgc ctgcggaaca
     2281 gggtatgtgc ctggaaggcc tgccacaggc cccacaattg aagaagtaga ttaattcttt
     2341 ttagaactga agcatcctag gatgcctcta catgtatttc attcccctca tcttcaaaca
     2401 tcattattat tcttgaccag acctgaatct aagttaccat cccttggaaa ttctggagaa
     2461 ggagtctcat gcaccaccta tcacactccc tcacatcctg tttctgactt tggaatggac
     2521 tcaggaaaac taggcccctc tttaaaccgt gtgatgtatt tgaatgtctg ttatttccag
     2581 ccaccctaac attcttcttc ctgtgtggat gcttatttgt caatcagtaa atttgttcgt
     2641 aaagaaaatt acttctggta tttaggctgt gaatgtacct tgaaggggag agttcatgga
     2701 gagagcatgt gttctctgat tgtgaggtca ctgtgaatga ttaaattggt aagggtaaag
     2761 ta
//
