LOCUS       NM_005346               2517 bp    mRNA    linear   PRI 16-JUN-2024
DEFINITION  Homo sapiens heat shock protein family A (Hsp70) member 1B
            (HSPA1B), mRNA.
ACCESSION   NM_005346
VERSION     NM_005346.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2517)
  AUTHORS   Guo,S., Luo,X., Yin,X., Yang,Y. and Yang,L.
  TITLE     Interaction of HSP70-2 gene polymorphism with body mass index and
            alcohol consumption on the prognosis of Uyghur patients with
            ischemic heart failure
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 52 (1), 101-109 (2023)
   PUBMED   37283123
  REMARK    GeneRIF: Interaction of HSP70-2 gene polymorphism with body mass
            index and alcohol consumption on the prognosis of Uyghur patients
            with ischemic heart failure.
REFERENCE   2  (bases 1 to 2517)
  AUTHORS   Ochoa-Ramirez,L.A., Diaz-Camacho,S.P., Mellado-Corrales,S.N.,
            Munoz-Estrada,V.F., Rios-Tostado,J.J., Sanchez-Zazueta,J.G. and
            Velarde-Felix,J.S.
  TITLE     Analysis of the heat shock protein 70 (HSP70) genetic variants in
            nonsegmental vitiligo patients
  JOURNAL   Int J Dermatol 62 (2), 225-230 (2023)
   PUBMED   36345598
  REMARK    GeneRIF: Analysis of the heat shock protein 70 (HSP70) genetic
            variants in nonsegmental vitiligo patients.
REFERENCE   3  (bases 1 to 2517)
  AUTHORS   Faisal,S., Abdelaal,S., Jeraiby,M.A., Toaimah,F.H.S., Kattan,S.W.,
            Abdel-Gawad,A.R., Riad,E., Toraih,E.A., Fawzy,M.S. and Ibrahim,A.
  TITLE     Diagnostic and Prognostic Risk Assessment of Heat Shock Protein
            HSPA1B rs2763979 Gene Variant in Asthma
  JOURNAL   Genes (Basel) 13 (12), 2391 (2022)
   PUBMED   36553658
  REMARK    GeneRIF: Diagnostic and Prognostic Risk Assessment of Heat Shock
            Protein HSPA1B rs2763979 Gene Variant in Asthma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2517)
  AUTHORS   Alele,F.O., Otto,J.R., Malau-Aduli,B.S. and Malau-Aduli,A.E.O.
  TITLE     Next Generation Sequencing of Genotype Variants and Genetic
            Association between Heat Shock Proteins HSPA1B Single Nucleotide
            Polymorphism at the g.31829044 Locus and Heat Tolerance: A Pilot
            Quasi-Experimental Study
  JOURNAL   Biomolecules 12 (10), 1465 (2022)
   PUBMED   36291674
  REMARK    GeneRIF: Next Generation Sequencing of Genotype Variants and
            Genetic Association between Heat Shock Proteins HSPA1B Single
            Nucleotide Polymorphism at the g.31829044 Locus and Heat Tolerance:
            A Pilot Quasi-Experimental Study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2517)
  AUTHORS   Chernyak,Y.I. and Kudaeva,I.V.
  TITLE     Analysis of HSPA1B (+1267A>G) Genetic Polymorphism in Patients with
            Vibration Disease in Combination with Metabolic Syndrome
  JOURNAL   Bull Exp Biol Med 171 (3), 375-378 (2021)
   PUBMED   34292443
  REMARK    GeneRIF: Analysis of HSPA1B (+1267A>G) Genetic Polymorphism in
            Patients with Vibration Disease in Combination with Metabolic
            Syndrome.
REFERENCE   6  (bases 1 to 2517)
  AUTHORS   Grosz,M.D., Womack,J.E. and Skow,L.C.
  TITLE     Syntenic conservation of HSP70 genes in cattle and humans
  JOURNAL   Genomics 14 (4), 863-868 (1992)
   PUBMED   1478667
REFERENCE   7  (bases 1 to 2517)
  AUTHORS   Milner,C.M. and Campbell,R.D.
  TITLE     Structure and expression of the three MHC-linked HSP70 genes
  JOURNAL   Immunogenetics 32 (4), 242-251 (1990)
   PUBMED   1700760
REFERENCE   8  (bases 1 to 2517)
  AUTHORS   Sargent,C.A., Dunham,I., Trowsdale,J. and Campbell,R.D.
  TITLE     Human major histocompatibility complex contains genes for the major
            heat shock protein HSP70
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 1968-1972 (1989)
   PUBMED   2538825
REFERENCE   9  (bases 1 to 2517)
  AUTHORS   Goate,A.M., Cooper,D.N., Hall,C., Leung,T.K., Solomon,E. and Lim,L.
  TITLE     Localization of a human heat-shock HSP 70 gene sequence to
            chromosome 6 and detection of two other loci by somatic-cell hybrid
            and restriction fragment length polymorphism analysis
  JOURNAL   Hum Genet 75 (2), 123-128 (1987)
   PUBMED   2880793
REFERENCE   10 (bases 1 to 2517)
  AUTHORS   Wu,B., Hunt,C. and Morimoto,R.
  TITLE     Structure and expression of the human gene encoding major heat
            shock protein HSP70
  JOURNAL   Mol Cell Biol 5 (2), 330-341 (1985)
   PUBMED   2858050
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL671762.10.
            
            On Aug 31, 2019 this sequence version replaced NM_005346.5.
            
            Summary: This intronless gene encodes a 70kDa heat shock protein
            which is a member of the heat shock protein 70 family. In
            conjuction with other heat shock proteins, this protein stabilizes
            existing proteins against aggregation and mediates the folding of
            newly translated proteins in the cytosol and in organelles. It is
            also involved in the ubiquitin-proteasome pathway through
            interaction with the AU-rich element RNA-binding protein 1. The
            gene is located in the major histocompatibility complex class III
            region, in a cluster with two closely related genes which encode
            similar proteins. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC063507.1, SRR7346977.1145010.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375650.5/ ENSP00000364801.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2517              AL671762.10        35586-38102
FEATURES             Location/Qualifiers
     source          1..2517
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..2517
                     /gene="HSPA1B"
                     /gene_synonym="HSP70-1; HSP70-1B; HSP70-2; HSP70.1;
                     HSP70.2; HSP72; HSPA1; HSX70"
                     /note="heat shock protein family A (Hsp70) member 1B"
                     /db_xref="GeneID:3304"
                     /db_xref="HGNC:HGNC:5233"
                     /db_xref="MIM:603012"
     exon            1..2517
                     /gene="HSPA1B"
                     /gene_synonym="HSP70-1; HSP70-1B; HSP70-2; HSP70.1;
                     HSP70.2; HSP72; HSPA1; HSX70"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..2139
                     /gene="HSPA1B"
                     /gene_synonym="HSP70-1; HSP70-1B; HSP70-2; HSP70.1;
                     HSP70.2; HSP72; HSPA1; HSX70"
                     /note="heat shock 70kD protein 1B; heat shock 70 kDa
                     protein 1A/1B; HSP70-1/HSP70-2; HSP70.1/HSP70.2; heat
                     shock 70kDa protein 1B; heat shock 70 kDa protein 2; heat
                     shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A;
                     heat shock protein family A member 1B"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 1B"
                     /protein_id="NP_005337.2"
                     /db_xref="CCDS:CCDS34415.1"
                     /db_xref="GeneID:3304"
                     /db_xref="HGNC:HGNC:5233"
                     /db_xref="MIM:603012"
                     /translation="MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAF
                     TDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPK
                     VQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKD
                     AGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFE
                     VKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSS
                     STQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDL
                     VLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLL
                     LLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMT
                     KDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKG
                     RLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEAD
                     KKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGA
                     QGPKGGSGSGPTIEEVD"
     regulatory      2500..2505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA1B"
                     /gene_synonym="HSP70-1; HSP70-1B; HSP70-2; HSP70.1;
                     HSP70.2; HSP72; HSPA1; HSX70"
                     /note="hexamer: AATAAA"
     polyA_site      2517
                     /gene="HSPA1B"
                     /gene_synonym="HSP70-1; HSP70-1B; HSP70-2; HSP70.1;
                     HSP70.2; HSP72; HSPA1; HSX70"
                     /note="major polyA site"
ORIGIN      
        1 aaacggccag cctgaggagc tgctgcgagg gtccgcttcg tctttcgaga gtgactcccg
       61 cggtcccaag gctttccaga gcgaacctgt gcggctgcag gcaccggcgt gttgagtttc
      121 cggcgttccg aaggactgag ctcttgtcgc ggatcccgtc cgccgtttcc agcccccagt
      181 ctcagagcgg agcccacaga gcagggcacc ggcatggcca aagccgcggc gatcggcatc
      241 gacctgggca ccacctactc ctgcgtgggg gtgttccaac acggcaaggt ggagatcatc
      301 gccaacgacc agggcaaccg caccaccccc agctacgtgg ccttcacgga caccgagcgg
      361 ctcatcgggg atgcggccaa gaaccaggtg gcgctgaacc cgcagaacac cgtgtttgac
      421 gcgaagcggc tgattggccg caagttcggc gacccggtgg tgcagtcgga catgaagcac
      481 tggcctttcc aggtgatcaa cgacggagac aagcccaagg tgcaggtgag ctacaagggg
      541 gagaccaagg cattctaccc cgaggagatc tcgtccatgg tgctgaccaa gatgaaggag
      601 atcgccgagg cgtacctggg ctacccggtg accaacgcgg tgatcaccgt gccggcctac
      661 ttcaacgact cgcagcgcca ggccaccaag gatgcgggtg tgatcgcggg gctcaacgtg
      721 ctgcggatca tcaacgagcc cacggccgcc gccatcgcct acggcctgga cagaacgggc
      781 aagggggagc gcaacgtgct catctttgac ctgggcgggg gcaccttcga cgtgtccatc
      841 ctgacgatcg acgacggcat cttcgaggtg aaggccacgg ccggggacac ccacctgggt
      901 ggggaggact ttgacaacag gctggtgaac cacttcgtgg aggagttcaa gagaaaacac
      961 aagaaggaca tcagccagaa caagcgagcc gtgaggcggc tgcgcaccgc ctgcgagagg
     1021 gccaagagga ccctgtcgtc cagcacccag gccagcctgg agatcgactc cctgtttgag
     1081 ggcatcgact tctacacgtc catcaccagg gcgaggttcg aggagctgtg ctccgacctg
     1141 ttccgaagca ccctggagcc cgtggagaag gctctgcgcg acgccaagct ggacaaggcc
     1201 cagattcacg acctggtcct ggtcgggggc tccacccgca tccccaaggt gcagaagctg
     1261 ctgcaggact tcttcaacgg gcgcgacctg aacaagagca tcaaccccga cgaggctgtg
     1321 gcctacgggg cggcggtgca ggcggccatc ctgatggggg acaagtccga gaacgtgcag
     1381 gacctgctgc tgctggacgt ggctcccctg tcgctggggc tggagacggc cggaggcgtg
     1441 atgactgccc tgatcaagcg caactccacc atccccacca agcagacgca gatcttcacc
     1501 acctactccg acaaccaacc cggggtgctg atccaggtgt acgagggcga gagggccatg
     1561 acgaaagaca acaatctgtt ggggcgcttc gagctgagcg gcatccctcc ggcccccagg
     1621 ggcgtgcccc agatcgaggt gaccttcgac atcgatgcca acggcatcct gaacgtcacg
     1681 gccacggaca agagcaccgg caaggccaac aagatcacca tcaccaacga caagggccgc
     1741 ctgagcaagg aggagatcga gcgcatggtg caggaggcgg agaagtacaa agcggaggac
     1801 gaggtgcagc gcgagagggt gtcagccaag aacgccctgg agtcctacgc cttcaacatg
     1861 aagagcgccg tggaggatga ggggctcaag ggcaagatca gcgaggcgga caagaagaag
     1921 gttctggaca agtgtcaaga ggtcatctcg tggctggacg ccaacacctt ggccgagaag
     1981 gacgagtttg agcacaagag gaaggagctg gagcaggtgt gtaaccccat catcagcgga
     2041 ctgtaccagg gtgccggtgg tcccgggcct ggcggcttcg gggctcaggg tcccaaggga
     2101 gggtctgggt caggccctac cattgaggag gtggattagg ggcctttgtt ctttagtatg
     2161 tttgtctttg aggtggactg ttgggactca aggactttgc tgctgttttc ctatgtcatt
     2221 tctgcttcag ctctttgctg cttcacttct ttgtaaagtt gtaacctgat ggtaattagc
     2281 tggcttcatt atttttgtag tacaaccgat atgttcatta gaattctttg catttaatgt
     2341 tgatactgta agggtgtttc gttcccttta aatgaatcaa cactgccacc ttctgtacga
     2401 gtttgtttgt tttttttttt tttttttttt tttgcttggc gaaaacacta caaaggctgg
     2461 gaatgtatgt ttttataatt tgtttattta aatatgaaaa ataaaatgtt aaacttt
//
