LOCUS       NM_005345               2400 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens heat shock protein family A (Hsp70) member 1A
            (HSPA1A), mRNA.
ACCESSION   NM_005345
VERSION     NM_005345.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2400)
  AUTHORS   Wang,Y., Yang,Y., Liang,C. and Zhang,H.
  TITLE     Exploring the Roles of Key Mediators IKBKE and HSPA1A in
            Alzheimer's Disease and Hepatocellular Carcinoma through
            Bioinformatics Analysis
  JOURNAL   Int J Mol Sci 25 (13), 6934 (2024)
   PUBMED   39000042
  REMARK    GeneRIF: Exploring the Roles of Key Mediators IKBKE and HSPA1A in
            Alzheimer's Disease and Hepatocellular Carcinoma through
            Bioinformatics Analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2400)
  AUTHORS   Lang,B.J., Holton,K.M., Guerrero-Gimenez,M.E., Okusha,Y.,
            Magahis,P.T., Shi,A., Neguse,M., Venkatesh,S., Nhu,A.M.,
            Gestwicki,J.E. and Calderwood,S.K.
  TITLE     Heat shock protein 72 supports extracellular matrix production in
            metastatic mammary tumors
  JOURNAL   Cell Stress Chaperones 29 (3), 456-471 (2024)
   PUBMED   38703814
  REMARK    GeneRIF: Heat shock protein 72 supports extracellular matrix
            production in metastatic mammary tumors.
REFERENCE   3  (bases 1 to 2400)
  AUTHORS   Jayashree,K., Senthilkumar,G.P., Parameswaran,S. and Vadivelan,M.
  TITLE     Association of elevated extracellular HSP72 in albuminuria with
            systemic inflammation and disease progression in type 2 diabetic
            kidney disease
  JOURNAL   Clin Biochem 121-122, 110682 (2023)
   PUBMED   37926404
  REMARK    GeneRIF: Association of elevated extracellular HSP72 in albuminuria
            with systemic inflammation and disease progression in type 2
            diabetic kidney disease.
REFERENCE   4  (bases 1 to 2400)
  AUTHORS   Schleef,M., Rozes,M., Pillot,B., Bidaux,G., Guebre-Egziabher,F.,
            Juillard,L., Baetz,D. and Lemoine,S.
  TITLE     Heat Shock Protein 70 Is Involved in the Efficiency of
            Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion
            Injury by Modulating Mitochondrial Functions
  JOURNAL   Int J Mol Sci 24 (11), 9541 (2023)
   PUBMED   37298493
  REMARK    GeneRIF: Heat Shock Protein 70 Is Involved in the Efficiency of
            Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion
            Injury by Modulating Mitochondrial Functions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2400)
  AUTHORS   Mitsis,T., Papageorgiou,L., Papakonstantinou,E., Diakou,I.,
            Pierouli,K., Dragoumani,K., Bacopoulou,F., Kino,T., Chrousos,G.P.,
            Eliopoulos,E. and Vlachakis,D.
  TITLE     A Genomic Study of the Japanese Population Focusing on the
            Glucocorticoid Receptor Interactome Highlights Distinct Genetic
            Characteristics Associated with Stress Response
  JOURNAL   Adv Exp Med Biol 1423, 101-113 (2023)
   PUBMED   37525035
  REMARK    GeneRIF: A Genomic Study of the Japanese Population Focusing on the
            Glucocorticoid Receptor Interactome Highlights Distinct Genetic
            Characteristics Associated with Stress Response.
REFERENCE   6  (bases 1 to 2400)
  AUTHORS   Grosz,M.D., Womack,J.E. and Skow,L.C.
  TITLE     Syntenic conservation of HSP70 genes in cattle and humans
  JOURNAL   Genomics 14 (4), 863-868 (1992)
   PUBMED   1478667
REFERENCE   7  (bases 1 to 2400)
  AUTHORS   Abravaya,K., Myers,M.P., Murphy,S.P. and Morimoto,R.I.
  TITLE     The human heat shock protein hsp70 interacts with HSF, the
            transcription factor that regulates heat shock gene expression
  JOURNAL   Genes Dev 6 (7), 1153-1164 (1992)
   PUBMED   1628823
REFERENCE   8  (bases 1 to 2400)
  AUTHORS   Milner,C.M. and Campbell,R.D.
  TITLE     Structure and expression of the three MHC-linked HSP70 genes
  JOURNAL   Immunogenetics 32 (4), 242-251 (1990)
   PUBMED   1700760
REFERENCE   9  (bases 1 to 2400)
  AUTHORS   Sargent,C.A., Dunham,I., Trowsdale,J. and Campbell,R.D.
  TITLE     Human major histocompatibility complex contains genes for the major
            heat shock protein HSP70
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 1968-1972 (1989)
   PUBMED   2538825
REFERENCE   10 (bases 1 to 2400)
  AUTHORS   Wu,B., Hunt,C. and Morimoto,R.
  TITLE     Structure and expression of the human gene encoding major heat
            shock protein HSP70
  JOURNAL   Mol Cell Biol 5 (2), 330-341 (1985)
   PUBMED   2858050
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK225692.1, DA256622.1,
            AK096017.1 and BC002453.2.
            
            On May 17, 2019 this sequence version replaced NM_005345.5.
            
            Summary: This intronless gene encodes a 70kDa heat shock protein
            which is a member of the heat shock protein 70 family. In
            conjuction with other heat shock proteins, this protein stabilizes
            existing proteins against aggregation and mediates the folding of
            newly translated proteins in the cytosol and in organelles. It is
            also involved in the ubiquitin-proteasome pathway through
            interaction with the AU-rich element RNA-binding protein 1. The
            gene is located in the major histocompatibility complex class III
            region, in a cluster with two closely related genes which encode
            similar proteins. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK225699.1, SRR1660803.95837.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375651.7/ ENSP00000364802.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-435               AK225692.1         1-435
            436-562             DA256622.1         436-562
            563-1908            AK225692.1         563-1908
            1909-2398           AK096017.1         1414-1903
            2399-2400           BC002453.2         2362-2363
FEATURES             Location/Qualifiers
     source          1..2400
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..2400
                     /gene="HSPA1A"
                     /gene_synonym="HEL-S-103; HSP70; HSP70-1; HSP70-1A;
                     HSP70-2; HSP70.1; HSP70.2; HSP70I; HSP72; HSPA1"
                     /note="heat shock protein family A (Hsp70) member 1A"
                     /db_xref="GeneID:3303"
                     /db_xref="HGNC:HGNC:5232"
                     /db_xref="MIM:140550"
     exon            1..2400
                     /gene="HSPA1A"
                     /gene_synonym="HEL-S-103; HSP70; HSP70-1; HSP70-1A;
                     HSP70-2; HSP70.1; HSP70.2; HSP70I; HSP72; HSPA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2140
                     /gene="HSPA1A"
                     /gene_synonym="HEL-S-103; HSP70; HSP70-1; HSP70-1A;
                     HSP70-2; HSP70.1; HSP70.2; HSP70I; HSP72; HSPA1"
                     /note="heat shock 70kD protein 1A; epididymis secretory
                     protein Li 103; heat shock 70 kDa protein 1; heat
                     shock-induced protein; dnaK-type molecular chaperone
                     HSP70-1; heat shock 70 kDa protein 1A/1B; HSP70-1/HSP70-2;
                     HSP70.1/HSP70.2; heat shock 70 kDa protein 1/2; epididymis
                     secretory sperm binding protein; heat shock 70kDa protein
                     1A; Heat shock 70 kDa protein 1B; Heat shock 70 kDa
                     protein 2; heat shock protein family A member 1A"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 1A"
                     /protein_id="NP_005336.3"
                     /db_xref="CCDS:CCDS34414.1"
                     /db_xref="GeneID:3303"
                     /db_xref="HGNC:HGNC:5232"
                     /db_xref="MIM:140550"
                     /translation="MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAF
                     TDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPK
                     VQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKD
                     AGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFE
                     VKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSS
                     STQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDL
                     VLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLL
                     LLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMT
                     KDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKG
                     RLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEAD
                     KKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGA
                     QGPKGGSGSGPTIEEVD"
     regulatory      2382..2387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA1A"
                     /gene_synonym="HEL-S-103; HSP70; HSP70-1; HSP70-1A;
                     HSP70-2; HSP70.1; HSP70.2; HSP70I; HSP72; HSPA1"
                     /note="hexamer: AATAAA"
     polyA_site      2400
                     /gene="HSPA1A"
                     /gene_synonym="HEL-S-103; HSP70; HSP70-1; HSP70-1A;
                     HSP70-2; HSP70.1; HSP70.2; HSP70I; HSP72; HSPA1"
                     /note="major polyA site"
ORIGIN      
        1 aacggctagc ctgaggagct gctgcgacag tccactacct ttttcgagag tgactcccgt
       61 tgtcccaagg cttcccagag cgaacctgtg cggctgcagg caccggcgcg tcgagtttcc
      121 ggcgtccgga aggaccgagc tcttctcgcg gatccagtgt tccgtttcca gcccccaatc
      181 tcagagcgga gccgacagag agcagggaac cggcatggcc aaagccgcgg cgatcggcat
      241 cgacctgggc accacctact cctgcgtggg ggtgttccaa cacggcaagg tggagatcat
      301 cgccaacgac cagggcaacc gcaccacccc cagctacgtg gccttcacgg acaccgagcg
      361 gctcatcggg gatgcggcca agaaccaggt ggcgctgaac ccgcagaaca ccgtgtttga
      421 cgcgaagcgg ctgattggcc gcaagttcgg cgacccggtg gtgcagtcgg acatgaagca
      481 ctggcctttc caggtgatca acgacggaga caagcccaag gtgcaggtga gctacaaggg
      541 ggagaccaag gcattctacc ccgaggagat ctcgtccatg gtgctgacca agatgaagga
      601 gatcgccgag gcgtacctgg gctacccggt gaccaacgcg gtgatcaccg tgccggccta
      661 cttcaacgac tcgcagcgcc aggccaccaa ggatgcgggt gtgatcgcgg ggctcaacgt
      721 gctgcggatc atcaacgagc ccacggccgc cgccatcgcc tacggcctgg acagaacggg
      781 caagggggag cgcaacgtgc tcatctttga cctgggcggg ggcaccttcg acgtgtccat
      841 cctgacgatc gacgacggca tcttcgaggt gaaggccacg gccggggaca cccacctggg
      901 tggggaggac tttgacaaca ggctggtgaa ccacttcgtg gaggagttca agagaaaaca
      961 caagaaggac atcagccaga acaagcgagc cgtgaggcgg ctgcgcaccg cctgcgagag
     1021 ggccaagagg accctgtcgt ccagcaccca ggccagcctg gagatcgact ccctgtttga
     1081 gggcatcgac ttctacacgt ccatcaccag ggcgaggttc gaggagctgt gctccgacct
     1141 gttccgaagc accctggagc ccgtggagaa ggctctgcgc gacgccaagc tggacaaggc
     1201 ccagattcac gacctggtcc tggtcggggg ctccacccgc atccccaagg tgcagaagct
     1261 gctgcaggac ttcttcaacg ggcgcgacct gaacaagagc atcaaccccg acgaggctgt
     1321 ggcctacggg gcggcggtgc aggcggccat cctgatgggg gacaagtccg agaacgtgca
     1381 ggacctgctg ctgctggacg tggctcccct gtcgctgggg ctggagacgg ccggaggcgt
     1441 gatgactgcc ctgatcaagc gcaactccac catccccacc aagcagacgc agatcttcac
     1501 cacctactcc gacaaccaac ccggggtgct gatccaggtg tacgagggcg agagggccat
     1561 gacgaaagac aacaatctgt tggggcgctt cgagctgagc ggcatccctc cggcccccag
     1621 gggcgtgccc cagatcgagg tgaccttcga catcgatgcc aacggcatcc tgaacgtcac
     1681 ggccacggac aagagcaccg gcaaggccaa caagatcacc atcaccaacg acaagggccg
     1741 cctgagcaag gaggagatcg agcgcatggt gcaggaggcg gagaagtaca aagcggagga
     1801 cgaggtgcag cgcgagaggg tgtcagccaa gaacgccctg gagtcctacg ccttcaacat
     1861 gaagagcgcc gtggaggatg aggggctcaa gggcaagatc agcgaggcgg acaagaagaa
     1921 ggtgctggac aagtgtcaag aggtcatctc gtggctggac gccaacacct tggccgagaa
     1981 ggacgagttt gagcacaaga ggaaggagct ggagcaggtg tgtaacccca tcatcagcgg
     2041 actgtaccag ggtgccggtg gtcccgggcc tgggggcttc ggggctcagg gtcccaaggg
     2101 agggtctggg tcaggcccca ccattgagga ggtagattag gggcctttcc aagattgctg
     2161 tttttgtttt ggagcttcaa gactttgcat ttcctagtat ttctgtttgt cagttctcaa
     2221 tttcctgtgt ttgcaatgtt gaaatttttt ggtgaagtac tgaacttgct ttttttccgg
     2281 tttctacatg cagagatgaa tttatactgc catcttacga ctatttcttc tttttaatac
     2341 acttaactca ggccattttt taagttggtt acttcaaagt aaataaactt taaaattcaa
//
