LOCUS       NM_006948               3945 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens heat shock protein family A (Hsp70) member 13
            (HSPA13), mRNA.
ACCESSION   NM_006948
VERSION     NM_006948.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3945)
  AUTHORS   Espinoza,M.F., Nguyen,K.K., Sycks,M.M., Lyu,Z., Quanrud,G.M.,
            Montoya,M.R. and Genereux,J.C.
  TITLE     Heat shock protein Hspa13 regulates endoplasmic reticulum and
            cytosolic proteostasis through modulation of protein translocation
  JOURNAL   J Biol Chem 298 (12), 102597 (2022)
   PUBMED   36244454
  REMARK    GeneRIF: Heat shock protein Hspa13 regulates endoplasmic reticulum
            and cytosolic proteostasis through modulation of protein
            translocation.
REFERENCE   2  (bases 1 to 3945)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3945)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3945)
  AUTHORS   Bakhos-Douaihy,D., Seaayfan,E., Demaretz,S., Komhoff,M. and
            Laghmani,K.
  TITLE     Differential Effects of STCH and Stress-Inducible Hsp70 on the
            Stability and Maturation of NKCC2
  JOURNAL   Int J Mol Sci 22 (4), 2207 (2021)
   PUBMED   33672238
  REMARK    GeneRIF: Differential Effects of STCH and Stress-Inducible Hsp70 on
            the Stability and Maturation of NKCC2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3945)
  AUTHORS   He,Y., Xu,R., Zhai,B., Fang,Y., Hou,C., Xing,C., Xiao,H., Chen,G.,
            Wang,X., Ma,N., Han,G. and Wang,R.
  TITLE     Hspa13 Promotes Plasma Cell Production and Antibody Secretion
  JOURNAL   Front Immunol 11, 913 (2020)
   PUBMED   32547538
  REMARK    GeneRIF: Hspa13 Promotes Plasma Cell Production and Antibody
            Secretion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3945)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3945)
  AUTHORS   Chouchane,L., Danguir,J., Beji,C., Bouassida,K., Camoin,L.,
            Sfar,H., Gabbouj,S. and Strosberg,A.D.
  TITLE     Genetic variation in the stress protein hsp70-2 gene is highly
            associated with obesity
  JOURNAL   Int J Obes Relat Metab Disord 25 (4), 462-466 (2001)
   PUBMED   11319647
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3945)
  AUTHORS   Kaye,F.J., Modi,S., Ivanovska,I., Koonin,E.V., Thress,K., Kubo,A.,
            Kornbluth,S. and Rose,M.D.
  TITLE     A family of ubiquitin-like proteins binds the ATPase domain of
            Hsp70-like Stch
  JOURNAL   FEBS Lett 467 (2-3), 348-355 (2000)
   PUBMED   10675567
REFERENCE   9  (bases 1 to 3945)
  AUTHORS   Brodsky,G., Otterson,G.A., Parry,B.B., Hart,I., Patterson,D. and
            Kaye,F.J.
  TITLE     Localization of STCH to human chromosome 21q11.1
  JOURNAL   Genomics 30 (3), 627-628 (1995)
   PUBMED   8825657
REFERENCE   10 (bases 1 to 3945)
  AUTHORS   Otterson,G.A., Flynn,G.C., Kratzke,R.A., Coxon,A., Johnston,P.G.
            and Kaye,F.J.
  TITLE     Stch encodes the 'ATPase core' of a microsomal stress 70 protein
  JOURNAL   EMBO J 13 (5), 1216-1225 (1994)
   PUBMED   8131751
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI548162.1, U04735.1,
            BC036370.2, CA392315.1, AA018751.1, CF141775.1, BE467288.1,
            AI912654.1 and AA767266.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006948.4.
            
            Summary: The protein encoded by this gene is a member of the heat
            shock protein 70 family and is found associated with microsomes.
            Members of this protein family play a role in the processing of
            cytosolic and secretory proteins, as well as in the removal of
            denatured or incorrectly-folded proteins. The encoded protein
            contains an ATPase domain and has been shown to associate with a
            ubiquitin-like protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036370.2, HM005612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285667.4/ ENSP00000285667.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BI548162.1         71-122
            53-1755             U04735.1           62-1764
            1756-2111           BC036370.2         1760-2115
            2112-2219           U04735.1           2120-2227
            2220-2256           BC036370.2         2224-2260
            2257-2506           CA392315.1         239-488
            2507-2718           AA018751.1         242-453
            2719-3137           CF141775.1         64-482
            3138-3646           BE467288.1         1-509               c
            3647-3936           AI912654.1         12-301              c
            3937-3945           AA767266.1         15-23               c
FEATURES             Location/Qualifiers
     source          1..3945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q11.2"
     gene            1..3945
                     /gene="HSPA13"
                     /gene_synonym="STCH"
                     /note="heat shock protein family A (Hsp70) member 13"
                     /db_xref="GeneID:6782"
                     /db_xref="HGNC:HGNC:11375"
                     /db_xref="MIM:601100"
     exon            1..52
                     /gene="HSPA13"
                     /gene_synonym="STCH"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1443
                     /gene="HSPA13"
                     /gene_synonym="STCH"
                     /note="stress 70 protein chaperone, microsome-associated,
                     60kDa; microsomal stress 70 protein ATPase core; heat
                     shock 70 kDa protein 13; stress-70 protein chaperone
                     microsome-associated 60 kDa protein; heat shock protein
                     70kDa family, member 13; testis secretory sperm-binding
                     protein Li 199a; heat shock protein family A member 13"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 13 precursor"
                     /protein_id="NP_008879.3"
                     /db_xref="CCDS:CCDS13567.1"
                     /db_xref="GeneID:6782"
                     /db_xref="HGNC:HGNC:11375"
                     /db_xref="MIM:601100"
                     /translation="MAREMTILGSAVLTLLLAGYLAQQYLPLPTPKVIGIDLGTTYCS
                     VGVFFPGTGKVKVIPDENGHISIPSMVSFTDNDVYVGYESVELADSNPQNTIYDAKRF
                     IGKIFTAEELEAEIGRYPFKVLNKNGMVEFSVTSNETITVSPEYVGSRLLLKLKEMAE
                     AYLGMPVANAVISVPAEFDLKQRNSTIEAANLAGLKILRVINEPTAAAMAYGLHKADV
                     FHVLVIDLGGGTLDVSLLNKQGGMFLTRAMSGNNKLGGQDFNQRLLQYLYKQIYQTYG
                     FVPSRKEEIHRLRQAVEMVKLNLTLHQSAQLSVLLTVEEQDRKEPHSSDTELPKDKLS
                     SADDHRVNSGFGRGLSDKKSGESQVLFETEISRKLFDTLNEDLFQKILVPIQQVLKEG
                     HLEKTEIDEVVLVGGSTRIPRIRQVIQEFFGKDPNTSVDPDLAVVTGVAIQAGIDGGS
                     WPLQVSALEIPNKHLQKTNFN"
     exon            53..393
                     /gene="HSPA13"
                     /gene_synonym="STCH"
                     /inference="alignment:Splign:2.1.0"
     exon            394..607
                     /gene="HSPA13"
                     /gene_synonym="STCH"
                     /inference="alignment:Splign:2.1.0"
     exon            608..775
                     /gene="HSPA13"
                     /gene_synonym="STCH"
                     /inference="alignment:Splign:2.1.0"
     exon            776..3945
                     /gene="HSPA13"
                     /gene_synonym="STCH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3914..3919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA13"
                     /gene_synonym="STCH"
                     /note="hexamer: AATAAA"
     polyA_site      3945
                     /gene="HSPA13"
                     /gene_synonym="STCH"
                     /note="major polyA site"
ORIGIN      
        1 atcacaagcc tgttcggcgg gactgtgatg gccagagaga tgacgatctt aggatcggct
       61 gttttgactc tcctgttggc cggctatttg gcacaacagt atttaccatt gcctactcct
      121 aaagtgattg gtattgatct tggcaccacc tattgttctg ttggggtgtt ttttcctggc
      181 acaggaaaag taaaggtgat tccagatgaa aatgggcata tcagcatacc cagcatggtg
      241 tcttttactg acaatgatgt atatgtggga tatgaaagcg tagagctggc agattcaaat
      301 cctcaaaaca caatatatga tgccaaaaga ttcataggca agatttttac cgcagaagag
      361 ttggaggctg aaattggcag atacccattt aaggttttaa acaaaaatgg aatggttgag
      421 ttttctgtga caagtaatga gaccatcaca gtgtccccag aatatgttgg ctctcgacta
      481 ttgttgaagt taaaggaaat ggcagaggca tatcttggaa tgccagttgc caatgctgtc
      541 atttctgtac cagcagaatt tgatctaaaa cagagaaatt caacaattga agctgctaac
      601 cttgcaggac tgaagatttt gagggtaata aatgaaccca cagcagcagc tatggcctat
      661 ggtctccaca aggctgacgt cttccacgtc ttggtgatag acttgggcgg aggaactcta
      721 gatgtgtctt tactgaataa acaaggaggg atgtttctaa cccgagcaat gtctggaaac
      781 aataaacttg gaggacagga cttcaatcag agattgcttc agtacttata taaacagatc
      841 tatcaaacat atggcttcgt gccctctagg aaagaggaaa tccacagatt gagacaagct
      901 gtggaaatgg tcaaattaaa tctgactctt catcaatctg ctcagttgtc agtattacta
      961 acggtggagg agcaggacag gaaggaacct cacagtagtg acactgaact gccaaaagac
     1021 aaactttcct cagcagatga ccatcgcgtg aacagtgggt ttggacgtgg cctttctgat
     1081 aagaaaagtg gagaaagtca ggttttattt gaaacagaaa tatcacggaa actctttgat
     1141 acccttaatg aagacctctt tcagaaaata ctggtaccca ttcagcaagt attgaaagaa
     1201 ggccacctgg aaaagactga gattgatgag gtggttttag ttgggggctc cactcgtatt
     1261 cctcggatcc gtcaagtcat tcaagagttc tttggaaaag atcccaacac atctgtagac
     1321 cctgacctag cagtagtaac gggagtggct atccaagcag ggattgatgg aggctcttgg
     1381 cctctccaag tcagtgcttt agaaattccc aataagcatt tacaaaaaac caacttcaac
     1441 tgaattctgc agaaataatg gttatttgtg aacttgtctg atgatctctt cccatttatc
     1501 agattacctt ttccacaaaa gaaagtctct aaaatatcac agatttacct agagggcaac
     1561 atttagatac aggaaaattt tacatagtgt tttgtcttag gattagacgt gaccagattg
     1621 atcctgtttg attttggaga gatcctattc taacaaatac tctaaaatga taaaattgag
     1681 gtacaactct cttaaaagag tatggataac tatattttct ggattctgga ggttgataac
     1741 catatgcact taacattata ttctataaac attaagtagt gccagttatg agattcccag
     1801 ttcttactaa attgtattag caggagctgg taattacttg tattatcaca tgtaactaat
     1861 aatttgaact atacttgaag gaccgtgttg atgtcaggta tttacagtgg ttggaagata
     1921 gcagtattat tagcataagc tgcatacgta atattcagta actgccatat tatataacaa
     1981 atttacattc acaaattcag tatcctgtta agtgtcatat tcttgtaatc tgcattctcc
     2041 aggagtttta tgtgtttaat agatgaattt attttatttc taaaggtatt caaatgtttc
     2101 agcaccatat aatagaaata cccaattata ttctagttcc tttatgtcct gtacatcatt
     2161 ctctgcttgg atttccatta ttctgtttgg ttagagaata aaattggtaa ttgcatttga
     2221 agaatgtgtt aatgtcataa taaagccatg attgctatct tatttttgtt atccgagacc
     2281 tttgcaaaca ttggcaaata gcatcaatta cctactgtat ttgtttcttt gtttatattt
     2341 tcagtaagcc ctggggaata tagcatggaa ttgagctact aaatggtttt ggttccgttt
     2401 tacggagatt tttcctcata tttagttttg aatgaggaaa atgtgctcaa ttataaaagc
     2461 tgtgttattg ttttctatta ttatttttaa ataatcacac ttggactctt ttcaaacatt
     2521 aggttagttt gtaatgaaag caaaaaattt gtgaatactg gaagtaacgt ggaaatctaa
     2581 tgtggaagcc attgtggcaa ggtttctaca aatcggcatt tggagcagag ttgtttgttt
     2641 ttgttgtttg tttcctttaa gaaaaaccac agggaccaag aaagaaaata taacagtttg
     2701 atttctgtca tacccattgt atttgaagat atatggatac agattatata tatatataca
     2761 tattttcctt aatagaggaa tgcttcatat tattcaaaaa ttatatcctg atcacctttt
     2821 tttgtttttt attgtaaagt atctctgctt tatccattgc tgaattcgat aggatgttga
     2881 aatgctggtc accaaaaaag gaaactgagc aaattcattt caacaacatc aaaacttcag
     2941 cttctcatag taaaaagctg aatgttacta atatttttca tatctaaaaa aaaattctta
     3001 gcaatgaaat tgctgttaaa acacaaattt caatcaaata cttttgtgta tagaaaatat
     3061 gtatagtagg tagatagaaa agtataaaat gtttgttgaa gtatcttatt ttagaatgaa
     3121 tggagaaatg ccaaagatga atccttcact gcattatgaa aatatttcac atgttctctt
     3181 ggactttata taaatctgta atagatttta gaattgaaaa attctttgtg aaggtcttct
     3241 aaaagtgttc caatttatct caaaatctcc atatatagga tcagcttaaa acataaagaa
     3301 aaccttgaat ttctcaaatg tttgagatgt tcaagacagt ctcttaatcc gttaatgctt
     3361 ttggaaacaa ttgacaaaat agggcaggca gctcatctca tgtcctgaag ttggaattta
     3421 aataattcct atttgcaaat tagaatgaca gtgttggaat ttggaggcag tagttgagca
     3481 tattctctag tatatagcta cacctttaat aaaatgaagg aatgtcttca atcatatttt
     3541 agtgggctat ttataaatag tcttgaagtc aatttagttt atttatttaa aagataatgc
     3601 atcctgaaag ggatcattta tgaataacaa tctgaagtct tttcataaaa aaaattaata
     3661 aactttagtt gtacatttag ccagtgttat ttgaagtatg taacttttaa aatattaagt
     3721 gtcttgtatg attagaatat gtgaatgagt aacttatttt gtatcaggaa tgttttggta
     3781 ctgtgttttc actcaaacca ctgacttaac agatactgct gtgtataaca tgtactaaat
     3841 attacagtta ttgtgcataa cagattgttc ctcttatatt tgtgtgtata caggcaattc
     3901 atgttttaat gtaaataaat accattttgc agtttgtttt ttaaa
//
