LOCUS       NM_052970               3133 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens heat shock protein family A (Hsp70) member 12B
            (HSPA12B), transcript variant 1, mRNA.
ACCESSION   NM_052970
VERSION     NM_052970.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3133)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3133)
  AUTHORS   Tu,F., Wang,X., Zhang,X., Ha,T., Wang,Y., Fan,M., Yang,K.,
            Gill,P.S., Ozment,T.R., Dai,Y., Liu,L., Williams,D.L. and Li,C.
  TITLE     Novel Role of Endothelial Derived Exosomal HSPA12B in Regulating
            Macrophage Inflammatory Responses in Polymicrobial Sepsis
  JOURNAL   Front Immunol 11, 825 (2020)
   PUBMED   32457753
  REMARK    GeneRIF: Novel Role of Endothelial Derived Exosomal HSPA12B in
            Regulating Macrophage Inflammatory Responses in Polymicrobial
            Sepsis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3133)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3133)
  AUTHORS   Zhang,X., Chen,Y., Wang,L., Kang,Q., Yu,G., Wan,X., Wang,J. and
            Zhu,K.
  TITLE     MiR-4505 aggravates lipopolysaccharide-induced vascular endothelial
            injury by targeting heat shock protein A12B
  JOURNAL   Mol Med Rep 17 (1), 1389-1395 (2018)
   PUBMED   29115487
  REMARK    GeneRIF: miR4505 downregulates the expression of HSPA12B and
            aggravates the LPSinduced vascular endothelial cell injury.
REFERENCE   5  (bases 1 to 3133)
  AUTHORS   Kong,Q., Dai,L., Wang,Y., Zhang,X., Li,C., Jiang,S., Li,Y., Ding,Z.
            and Liu,L.
  TITLE     HSPA12B Attenuated Acute Myocardial Ischemia/reperfusion Injury via
            Maintaining Endothelial Integrity in a PI3K/Akt/mTOR-dependent
            Mechanism
  JOURNAL   Sci Rep 6, 33636 (2016)
   PUBMED   27644317
  REMARK    GeneRIF: HSPA12B overexpression attenuated acute myocardial I/R
            injury. This protective action of HSPA12B was mediated, at least in
            part, through activation of PI3K/Akt/mTOR signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3133)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3133)
  AUTHORS   Starr,J.M., Shiels,P.G., Harris,S.E., Pattie,A., Pearce,M.S.,
            Relton,C.L. and Deary,I.J.
  TITLE     Oxidative stress, telomere length and biomarkers of physical aging
            in a cohort aged 79 years from the 1932 Scottish Mental Survey
  JOURNAL   Mech Ageing Dev 129 (12), 745-751 (2008)
   PUBMED   18977241
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3133)
  AUTHORS   Harris,S.E., Fox,H., Wright,A.F., Hayward,C., Starr,J.M.,
            Whalley,L.J. and Deary,I.J.
  TITLE     A genetic association analysis of cognitive ability and cognitive
            ageing using 325 markers for 109 genes associated with oxidative
            stress or cognition
  JOURNAL   BMC Genet 8, 43 (2007)
   PUBMED   17601350
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3133)
  AUTHORS   Han,Z., Truong,Q.A., Park,S. and Breslow,J.L.
  TITLE     Two Hsp70 family members expressed in atherosclerotic lesions
  JOURNAL   Proc Natl Acad Sci U S A 100 (3), 1256-1261 (2003)
   PUBMED   12552099
REFERENCE   10 (bases 1 to 3133)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109804.41, BC117284.1 and
            BC110881.1.
            
            On Nov 23, 2018 this sequence version replaced NM_052970.4.
            
            Summary: The protein encoded by this gene contains an atypical heat
            shock protein 70 (Hsp70) ATPase domain and is therefore a distant
            member of the mammalian Hsp70 family. This gene may be involved in
            susceptibility to atherosclerosis. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110881.1, AK056712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254963.7/ ENSP00000254963.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AL109804.41        57271-57357
            88-2712             BC117284.1         1-2625
            2713-3133           BC110881.1         2677-3097
FEATURES             Location/Qualifiers
     source          1..3133
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..3133
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /note="heat shock protein family A (Hsp70) member 12B"
                     /db_xref="GeneID:116835"
                     /db_xref="HGNC:HGNC:16193"
                     /db_xref="MIM:610702"
     exon            1..110
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            111..170
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2188
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /note="isoform 1 is encoded by transcript variant 1; heat
                     shock 70 kDa protein 12B; heat shock protein family A
                     member 12B"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 12B isoform 1"
                     /protein_id="NP_443202.3"
                     /db_xref="CCDS:CCDS13061.1"
                     /db_xref="GeneID:116835"
                     /db_xref="HGNC:HGNC:16193"
                     /db_xref="MIM:610702"
                     /translation="MLAVPEMGLQGLYIGSSPERSPVPSPPGSPRTQESCGIAPLTPS
                     QSPKPEVRAPQQASFSVVVAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQK
                     TPTCLLLTPEGAFHSFGYTARDYYHDLDPEEARDWLYFEKFKMKIHSATDLTLKTQLE
                     AVNGKTMPALEVFAHALRFFREHALQELREQSPSLPEKDTVRWVLTVPAIWKQPAKQF
                     MREAAYLAGLVSRENAEQLLIALEPEAASVYCRKLRLHQLLDLSGRAPGGGRLGERRS
                     IDSSFRQAREQLRRSRHSRTFLVESGVGELWAEMQAGDRYVVADCGGGTVDLTVHQLE
                     QPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDFIATFKRQRPAAWVDLTIAFE
                     ARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSSVNFVKWSSQGMLRMSC
                     EAMNELFQPTVSGIIQHIEALLARPEVQGVKLLFLVGGFAESAVLQHAVQAALGARGL
                     RVVVPHDVGLTILKGAVLFGQAPGVVRVRRSPLTYGVGVLNRFVPGRHPPEKLLVRDG
                     RRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAEDARFITDPGV
                     RKCGALSLELEPADCGQDTAGAPPGRREIRAAMQFGDTEIKVTAVDVSTNRSVRASID
                     FLSN"
     exon            171..268
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            269..393
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            394..580
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            581..685
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            686..802
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            803..977
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1064
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1169
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1428
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1532
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..3133
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3108..3113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /note="hexamer: AATAAA"
     polyA_site      3133
                     /gene="HSPA12B"
                     /gene_synonym="C20orf60"
                     /note="major polyA site"
ORIGIN      
        1 agggccgggc gcacgtcgag ggctgcggcc gccgcagcgg gcacggccaa cgagctgcgg
       61 gcccgggatc gcggcggctg gacggggctg gagctgtcgg gagggcggag ctacagggcc
      121 tgcaaggatg ttggctgtcc cggagatggg cctgcagggg ctgtacatcg gctccagccc
      181 ggagcggtcc ccagtgccta gcccacccgg ctccccgagg acccaggaaa gctgcggcat
      241 tgcccccctc acaccctcgc agtctccaaa acccgaggtc cgagcccccc agcaggcctc
      301 cttctctgtg gtggtggcca ttgacttcgg caccacgtct agtggctatg ctttcagctt
      361 tgccagtgac cctgaggcca tccacatgat gaggaaatgg gagggcggag acccgggcgt
      421 ggcccaccag aagaccccga cctgcctgct gctgactccg gagggcgcct tccacagctt
      481 tggctacacc gcccgcgatt actaccatga cctggacccc gaagaggcgc gggactggct
      541 ctacttcgag aagttcaaga tgaagatcca cagcgccacg gatctcacct tgaagaccca
      601 gctagaggca gtaaatggaa agacgatgcc cgccctggag gtgttcgccc atgccctgcg
      661 cttcttcagg gagcacgccc ttcaggagct gagggagcag agcccatcgc tgccagagaa
      721 ggacactgtg cgctgggtgt tgacggtgcc tgccatctgg aaacagccag ccaagcagtt
      781 catgcgggag gctgcctacc tggctggact agtgtcccga gagaatgcag agcagctact
      841 catcgccctg gagcccgagg ccgcctcggt atactgccgc aagctgcgcc tgcaccagct
      901 cctggacctg agtggccggg ccccaggtgg tgggcgcctg ggtgagcgcc gctccatcga
      961 ctccagcttc cgtcaggctc gggagcagct gcgaaggtcc cgccacagcc gcacgttcct
     1021 ggtggagtca ggcgtaggag agctgtgggc agagatgcaa gcaggagacc gctacgtggt
     1081 ggccgactgc ggcggaggca ccgtggacct gacggtgcac cagctggagc agccccatgg
     1141 caccctcaag gagctctaca aggcatctgg gggcccttat ggcgcggtgg gcgtggacct
     1201 ggccttcgag cagctgctgt gccgcatctt cggcgaggac ttcatcgcca ccttcaaaag
     1261 gcaacggccg gcagcctggg tagatctgac catcgccttc gaggctcgca agcgcactgc
     1321 tggcccacac cgtgcagggg cgctcaacat ctcgctgccc ttctccttca ttgacttcta
     1381 ccgcaagcag cggggccaca acgtggagac cgctctgcgc aggagcagcg tgaacttcgt
     1441 gaagtggtcc tcacagggga tgctccgaat gtcttgtgaa gccatgaacg agctctttca
     1501 gcccaccgtc agcgggatca tccagcacat agaggccctg ctggcacggc cggaggtgca
     1561 gggtgtgaag ctgctgttcc tagtgggcgg cttcgccgag tcagcggtgc tgcagcacgc
     1621 ggtgcaggcg gcgctgggcg cccgcggtct gcgtgtcgtg gtcccgcacg acgtgggcct
     1681 caccatcctc aaaggcgcgg tgctgttcgg ccaggcgccg ggcgtggtgc gggtccgccg
     1741 ctcgccgctc acctatggcg tgggcgtgct caaccgcttt gtgcctgggc gccacccgcc
     1801 cgaaaagctg ctggttcgcg acggccgccg ctggtgcacc gacgtcttcg agcgcttcgt
     1861 ggccgccgag cagtcggtgg ccctgggcga ggaggtgcgg cgcagctact gcccggcgcg
     1921 tcccggccag cggcgcgtac tcatcaacct gtactgctgc gcggcagagg atgcgcgctt
     1981 catcaccgac cccggcgtgc gcaaatgcgg cgcgctcagc ctcgagcttg agcccgccga
     2041 ctgcggccag gacaccgccg gcgcgcctcc cggccgccgc gagatccgcg ccgccatgca
     2101 gtttggcgac accgaaatta aggtcaccgc cgtcgacgtc agcaccaatc gctccgtgcg
     2161 cgcgtccatc gactttcttt ccaactgagg gcgcgccggc gcggtgccag cgccgtctgc
     2221 ccggccccgc cctctttcgg ttcaggggcc tgcggagcgg gttggggcgg gggaaacgat
     2281 agttctgcag tctgcgcctt tccacgccct ccagccccgg gggagataag gtcatgggag
     2341 agtgggtggg gacacaccca gagactggct ttgggattgg gcactggtcc gctgactgcc
     2401 aggctgaagg gacccgccaa ggactgaacg ggtaagagaa gaggtttgca agacagagcg
     2461 cgcagcccgg caaggggcat gtgaccccga aggaagaacg caacagaaga gtcctggtct
     2521 gaacttggcc gagtaggggt gggggtggga tggcaggagg agccgcagga ggaaggaggt
     2581 tgtgcagggt ctggacctgc agggctgaag ttcactcatc gaccgactca gccccaaccg
     2641 ggagccaggc agaaaaaccc tgtgccgtag gaaagtgact ggaagtggac tccagaggga
     2701 caggtgtggt ggcacagtcc tggtgtggtg ctgaccaccc aaatatgact gtgaattgtg
     2761 gaaagggcag tagatctcta atgtggaggt gggaacatta ttgtggtgga ggcaattatg
     2821 agggtagcat ttctttcgag acaaaacacc cgtctgggaa ggccccaagg tcagcttatg
     2881 aaggacccca cttgcacccc accccagcca tggaagagca gctggagggt ggatggggag
     2941 gccagaggga gcaatgaggg gtggtcccag ctctgctatt gactcggtat gcctttagga
     3001 cattctctta ccgctcatgg gcctcagttt cctaaagtgt gaaatgtcag gcacttccct
     3061 ctaactggca tgcaacagcc ccacctgcct gagagccctg aggtgacaat aaaacattta
     3121 tgctcaaggg gaa
//
