LOCUS       NM_025015               5714 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens heat shock protein family A (Hsp70) member 12A
            (HSPA12A), transcript variant 2, mRNA.
ACCESSION   NM_025015 XM_048898 XM_945467
VERSION     NM_025015.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5714)
  AUTHORS   Li,J., Shen,S. and Shen,H.
  TITLE     Heat-shock protein A12A attenuates oxygen-glucose
            deprivation/reoxygenation-induced human brain microvascular
            endothelial cell dysfunction via PGC-1alpha/SIRT3 pathway
  JOURNAL   Drug Dev Res 85 (1), e22130 (2024)
   PUBMED   37942840
  REMARK    GeneRIF: Heat-shock protein A12A attenuates oxygen-glucose
            deprivation/reoxygenation-induced human brain microvascular
            endothelial cell dysfunction via PGC-1alpha/SIRT3 pathway.
REFERENCE   2  (bases 1 to 5714)
  AUTHORS   Lu,Z., Fan,L., Zhang,F., Huang,C., Cai,Y., Chen,C., Li,G.,
            Zhang,M., Huang,J., Ning,C., Li,Y., Wang,W., Geng,H., Liu,Y.,
            Chen,S., Li,H., Yang,S., Zhang,H., Tian,W., Ye,T., Liu,J., Yang,X.,
            Xu,B., Zhu,Y., Zhong,R., Li,H., Tian,J., Li,B. and Miao,X.
  TITLE     HSPA12A was identified as a key driver in colorectal cancer GWAS
            loci 10q26.12 and modulated by an enhancer-promoter interaction
  JOURNAL   Arch Toxicol 97 (7), 2015-2028 (2023)
   PUBMED   37245169
  REMARK    GeneRIF: HSPA12A was identified as a key driver in colorectal
            cancer GWAS loci 10q26.12 and modulated by an enhancer-promoter
            interaction.
REFERENCE   3  (bases 1 to 5714)
  AUTHORS   Pan,Y.J., Huo,F.C., Kang,M.J., Liu,B.W., Wu,M.D. and Pei,D.S.
  TITLE     Alternative splicing of HSPA12A pre-RNA by SRSF11 contributes to
            metastasis potential of colorectal cancer
  JOURNAL   Clin Transl Med 12 (11), e1113 (2022)
   PUBMED   36394206
  REMARK    GeneRIF: Alternative splicing of HSPA12A pre-RNA by SRSF11
            contributes to metastasis potential of colorectal cancer.
REFERENCE   4  (bases 1 to 5714)
  AUTHORS   Min,X., Cheng,H., Cao,X., Chen,Z., Zhang,X., Li,Y., Mao,Q., Xue,B.,
            Fang,L., Liu,L. and Ding,Z.
  TITLE     Heat shock protein A12A activates migration of hepatocellular
            carcinoma cells in a monocarboxylate transporter 4-dependent manner
  JOURNAL   Cell Stress Chaperones 27 (1), 83-95 (2022)
   PUBMED   35050463
  REMARK    GeneRIF: Heat shock protein A12A activates migration of
            hepatocellular carcinoma cells in a monocarboxylate transporter
            4-dependent manner.
REFERENCE   5  (bases 1 to 5714)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5714)
  AUTHORS   Starr,J.M., Shiels,P.G., Harris,S.E., Pattie,A., Pearce,M.S.,
            Relton,C.L. and Deary,I.J.
  TITLE     Oxidative stress, telomere length and biomarkers of physical aging
            in a cohort aged 79 years from the 1932 Scottish Mental Survey
  JOURNAL   Mech Ageing Dev 129 (12), 745-751 (2008)
   PUBMED   18977241
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5714)
  AUTHORS   Larson,M.G., Atwood,L.D., Benjamin,E.J., Cupples,L.A.,
            D'Agostino,R.B. Sr., Fox,C.S., Govindaraju,D.R., Guo,C.Y.,
            Heard-Costa,N.L., Hwang,S.J., Murabito,J.M., Newton-Cheh,C.,
            O'Donnell,C.J., Seshadri,S., Vasan,R.S., Wang,T.J., Wolf,P.A. and
            Levy,D.
  TITLE     Framingham Heart Study 100K project: genome-wide associations for
            cardiovascular disease outcomes
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S5 (2007)
   PUBMED   17903304
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5714)
  AUTHORS   Harris,S.E., Fox,H., Wright,A.F., Hayward,C., Starr,J.M.,
            Whalley,L.J. and Deary,I.J.
  TITLE     A genetic association analysis of cognitive ability and cognitive
            ageing using 325 markers for 109 genes associated with oxidative
            stress or cognition
  JOURNAL   BMC Genet 8, 43 (2007)
   PUBMED   17601350
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5714)
  AUTHORS   Pongrac,J.L., Middleton,F.A., Peng,L., Lewis,D.A., Levitt,P. and
            Mirnics,K.
  TITLE     Heat shock protein 12A shows reduced expression in the prefrontal
            cortex of subjects with schizophrenia
  JOURNAL   Biol Psychiatry 56 (12), 943-950 (2004)
   PUBMED   15601604
  REMARK    GeneRIF: We found that HSPA12A is expressed in the human brain and
            shows a neuron- and region-specific transcript distribution, with
            strongest expression in the frontal and occipital cortical regions.
            HSPA12A Mrna was significantly reduced in schizophrenia.
REFERENCE   10 (bases 1 to 5714)
  AUTHORS   Han,Z., Truong,Q.A., Park,S. and Breslow,J.L.
  TITLE     Two Hsp70 family members expressed in atherosclerotic lesions
  JOURNAL   Proc Natl Acad Sci U S A 100 (3), 1256-1261 (2003)
   PUBMED   12552099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB007877.1 and BU738372.1.
            
            On Jun 2, 2019 this sequence version replaced NM_025015.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007877.1, SRR18074969.1138755.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369209.8/ ENSP00000358211.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5706              AB007877.1         9-5714
            5707-5714           BU738372.1         18-25               c
FEATURES             Location/Qualifiers
     source          1..5714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..5714
                     /gene="HSPA12A"
                     /note="heat shock protein family A (Hsp70) member 12A"
                     /db_xref="GeneID:259217"
                     /db_xref="HGNC:HGNC:19022"
                     /db_xref="MIM:610701"
     exon            1..137
                     /gene="HSPA12A"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2125
                     /gene="HSPA12A"
                     /note="isoform 2 is encoded by transcript variant 2; heat
                     shock 70kD protein 12A; heat shock 70kDa protein 12A; heat
                     shock protein family A member 12A"
                     /codon_start=1
                     /product="heat shock 70 kDa protein 12A isoform 2"
                     /protein_id="NP_079291.2"
                     /db_xref="CCDS:CCDS41569.1"
                     /db_xref="GeneID:259217"
                     /db_xref="HGNC:HGNC:19022"
                     /db_xref="MIM:610701"
                     /translation="MADKEAGGSDGPRETAPTSAYSSPARSLGDTGITPLSPSHIVND
                     TDSNVSEQQSFLVVVAVDFGTTSSGYAYSFTKEPECIHVMRRWEGGDPGVSNQKTPTT
                     ILLTPERKFHSFGYAARDFYHDLDPNEAKQWLYLEKFKMKLHTTGDLTMDTDLTAANG
                     KKVKALEIFAYALQYFKEQALKELSDQAGSEFENSDVRWVITVPAIWKQPAKQFMRQA
                     AYQAGLASPENSEQLIIALEPEAASIYCRKLRLHQMIELSSKAAVNGYSGSDTVGAGF
                     TQAKEHIRRNRQSRTFLVENVIGEIWSELEEGDKYVVVDSGGGTVDLTVHQIRLPEGH
                     LKELYKATGGPYGSLGVDYEFEKLLYKIFGEDFIEQFKIKRPAAWVDLMIAFESRKRA
                     AAPDRTNPLNITLPFSFIDYYKKFRGHSVEHALRKSNVDFVKWSSQGMLRMSPDAMNA
                     LFKPTIDSIIEHLRDLFQKPEVSTVKFLFLVGGFAEAPLLQQAVQAAFGDQCRIIIPQ
                     DVGLTILKGAVLFGLDPAVIKVRRSPLTYGVGVLNRYVEGKHPPEKLLVKDGTRWCTD
                     VFDKFISADQSVALGELVKRSYTPAKPSQLVIVINIYSSEHDNVSFITDPGVKKCGTL
                     RLDLTGTSGTAVPARREIQTLMQFGDTEIKATAIDIATSKSVKVGIDFLNY"
     exon            138..223
                     /gene="HSPA12A"
                     /inference="alignment:Splign:2.1.0"
     exon            224..351
                     /gene="HSPA12A"
                     /inference="alignment:Splign:2.1.0"
     exon            352..538
                     /gene="HSPA12A"
                     /inference="alignment:Splign:2.1.0"
     exon            539..643
                     /gene="HSPA12A"
                     /inference="alignment:Splign:2.1.0"
     exon            644..760
                     /gene="HSPA12A"
                     /inference="alignment:Splign:2.1.0"
     exon            761..932
                     /gene="HSPA12A"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1019
                     /gene="HSPA12A"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1124
                     /gene="HSPA12A"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1383
                     /gene="HSPA12A"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1487
                     /gene="HSPA12A"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..5714
                     /gene="HSPA12A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5691..5696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSPA12A"
                     /note="hexamer: AATAAA"
     polyA_site      5714
                     /gene="HSPA12A"
                     /note="major polyA site"
ORIGIN      
        1 agacacggcc cgagcgccgc cgcggacgcg gacagagacc cgcacgggca cgggcgctgc
       61 gctggaggct cccctcgcgg tccggggctg cgcgaccatg gcggacaagg aggccggcgg
      121 cagcgacggg ccccgagaaa cggctcccac atctgcatat tcatctccag cccggagtct
      181 tggggacaca ggaataacgc ctctgtcccc ctcccatatt gtgaacgaca ctgactccaa
      241 cgtctcagaa cagcagtcat ttctcgtggt ggtggccgtc gactttggga ccacatccag
      301 tggctatgcc tacagcttca ccaaggagcc ggaatgcatc catgtgatga ggcgatggga
      361 gggaggtgac cctggtgtgt ccaatcagaa gactccaacc accatcttgc tgactcccga
      421 gaggaagttc cacagcttcg ggtatgccgc cagggacttt taccatgacc tggatcccaa
      481 tgaggccaag cagtggctgt acctggagaa gttcaagatg aagctgcaca ccactgggga
      541 cctcaccatg gatacagacc tgacggcagc aaatggcaag aaagtcaaag cccttgaaat
      601 ctttgcttat gccctgcagt actttaagga gcaggcgctg aaggagctga gtgaccaggc
      661 gggttcggag ttcgagaact ctgatgtcag atgggtcatc acggtgcctg ccatctggaa
      721 gcagccggcc aagcagttca tgagacaagc tgcctaccag gcaggcctgg cctcccccga
      781 gaactcggag cagctcatca ttgccttgga gcctgaggca gcctctatct actgccgaaa
      841 gctgcggcta caccagatga ttgagctgag cagcaaggca gccgtcaatg ggtacagcgg
      901 cagtgacaca gtaggagctg ggtttacaca ggctaaggaa cacatacggc gtaatcggca
      961 gagtcggacc tttttggtgg agaatgtcat aggagaaatc tggtccgagc tggaggaagg
     1021 tgataagtat gtggttgtgg acagtggcgg tggcaccgta gacctgacag tccatcagat
     1081 ccggttaccg gagggacacc ttaaggaact gtataaagca acaggcggac cctatggatc
     1141 tttaggagta gattatgagt tcgaaaaact tctgtataaa atatttggag aggattttat
     1201 tgaacaattc aaaatcaaac gccctgcagc ctgggttgac ttaatgattg cgtttgagtc
     1261 tcgcaaaagg gcggctgccc cagacagaac taacccgctg aacatcaccc tgcccttctc
     1321 cttcattgac tactacaaga agttccgcgg gcacagtgtg gagcacgcct tgcggaaaag
     1381 caatgtggat tttgtgaagt ggtcctcgca ggggatgctg cggatgagtc cagatgccat
     1441 gaacgccctt tttaagccga ccatcgatag catcattgag catctccggg acctgtttca
     1501 gaagcccgag gtgtccaccg tcaagttcct ctttctggtg ggcggctttg ccgaggcgcc
     1561 cctgctgcag caggcggtgc aggctgcttt tggggaccag tgccggatca tcatccccca
     1621 ggacgtgggc ctcaccatcc tcaagggtgc cgtcctcttt ggcctggacc ccgcggtcat
     1681 caaggtgcgc cggtcgccgc tcacctacgg ggtaggcgtg ctgaaccgct acgtggaggg
     1741 caagcacccg cctgagaagc tgctggtgaa ggatggcact cggtggtgca ccgacgtctt
     1801 tgacaagttc atctctgccg accagtctgt ggctctgggt gagctggtca agcgtagcta
     1861 caccccggcc aagccctccc agctggtcat tgtcatcaac atctacagct ctgagcacga
     1921 caacgtcagc ttcatcactg atcccggggt gaagaagtgt ggcacgctcc gcctggatct
     1981 cacagggacc agtggcactg cggtgcccgc ccggagggag atccagaccc ttatgcagtt
     2041 cggggacacc gagatcaaag ccacagccat tgatatagcc acttcgaaga gtgtcaaagt
     2101 tgggatcgac ttcttaaatt actaaccctc ccgccccgct gcctgtcccc ttggactcaa
     2161 cttatctgca tctgctgacc tcaaccttga ctgttctttc cctaaccttg accctcacca
     2221 ttgcccatgt gaatttcagc agggaagatg agaacaatca gggctagaaa taattagtga
     2281 cttttgaggg cacactggag tcagaaaaac agaaattaag attaaggttt aggcatagaa
     2341 aattaaagga tcctggagga gcagctagtt ttcataggta caaaagtggt gaaatggcca
     2401 cggagaaggg aatcagtaca tttctgcagc agtggttgcg ctgctttgaa cagatctccg
     2461 ttatgtagaa tttaggatgc cctattgctg tctttctaga tttaaaatga gatctttgaa
     2521 ccaggaggag atcttcatct gagacttgtc tttctaaatt ttttggatgg ccatcaatat
     2581 aaaatgccac ccatctgcag ttaatttctt ttcctcatca tgtgattaaa agtggtgatt
     2641 cagtgggaac tgggaatgtt tttagctggt ggtagaaggc tgcctacact gggcactgtt
     2701 ttagattctc atatcattta aacagcaagg aggttcaggg aagaataacc gtagccttgg
     2761 gtaatccact agggcttttg tgagtaggag agctgatacc tcacattctt agcaggtgaa
     2821 aacttgccat gatggaaaca gatagtgaag agttactgac gtatcccaaa ttatatgctg
     2881 tgacataaat tcccagcatg cccagccctg atttctgagt tcataagtaa ttctagtgaa
     2941 ccttagtagg aattctgggt aagaaaatga ggttgccatt ggtcttgttt gcatcaccaa
     3001 gaccagacat ccagaagagc ccctcacctt gaaaagcaga cagattttaa attaaccccc
     3061 tccttcccac tcaccttcat ctccctaaga gttttggcca tttaattcca cattttgaaa
     3121 ggaatacatt ggtgaaattt gggaagagaa tctgtgctat gcaatgtttc attaaaatct
     3181 tcagtttttc aagtctctct aaaaataatt tgtagatcta tacttgatgt attaagtcag
     3241 ttttttttca cagcgggcct gtggctcgcc tgcatcagaa ttgcctgggt gcgtgttcag
     3301 aacaggttcc tggatctgag ccctttttaa ctgaggccga ctcttggaga ggggcaccag
     3361 aatctgcatt tgtagtgtat accacatcgt ggttcaactg aaattggaga aatactaacc
     3421 tgagattttg ttgaagttca cacacagatc acagcccgcc ctctgcaggt gtcccctttg
     3481 ggctccttta ggaagagggc ttccatgaga aggtgacccc ataccttgcc ctcttggtca
     3541 atgggattgg ggctccacct ggcttggaga tggccctttt aaccctcaca ggaagggcca
     3601 ggggaggaaa aaaattgcaa gaaagcgaca ccaagaacgg agctgactga ggaaccaact
     3661 ggagggtctt cactctctcc ttccccagtg tacaaaacca gttttctgca acattcagga
     3721 gccaaatgag gaaaaagaat caagaatctg actcacagcc catctgatct gttcaaagct
     3781 gtcttttcca cctgctgaaa ttcattaaat cactggaggc atgcataatg aatggagaat
     3841 gagtgaactt ccaatgcaac ttggattcac aaacccatta tcatagccaa tatgcagatt
     3901 ttaaacagca tttcacattt catttgacca tgtcttcttt ttcgcatcgc ctgctgcaga
     3961 attccctact agaatgtgaa acaacgaaca aaccacagaa cttagagtgt gctggttagt
     4021 cacataactt agtagcagga ttgtgtatcc aggcacaaag gtgtctttgc taatgttctc
     4081 ttgctacctg ccctgcttca aacgctaaat ggtatgggtc tttctttgtt gccagccata
     4141 ttctacaaat aagacttttc aatatagtta tgagtaatat aattttatgt acatataatg
     4201 ttagaatatt gtacagaatc ttggtttcta cgatgcgctt ttcttgtttc aaaaagagga
     4261 aaatgcttga tttttgttga tgatactttt gttactgtcc ttaattttcc atagtttggt
     4321 ttcttaattg tgctcactaa gcatcgatct gtgctgatgc caagctatgg actatgtacg
     4381 caagaccgag caatagacag aggtgcctag ggtccaaaca cactgaacgc acgtggaccg
     4441 cctggatcag gagcctcatc agacccttct ccatgcacat ccttcccaaa cagtcacaga
     4501 ttccattgaa aggagcagat tctatcagtt cttctgtgca gactttaaga gctgaacgtt
     4561 ctggttctgg aagccatgtg actgcgcaga acaacctaag aaaccctttg tgtcctgagg
     4621 ggtcgttgac ctctccttcc gggtcggagc agtcactctg agggcaaagc gtggtccact
     4681 gtgtgtgatg ttttcaggat gctagggtca aagaaagaaa ccaagtggta cataagccca
     4741 gcttttctgc tgggctaagt gtaagtgtga gtaacatggt caagcccctc ttttttgggc
     4801 taatgtaaag cctttcctgc cttgcattaa tgctatctcc ctgtgtactg tttctcttaa
     4861 atgagcagat agaaatctgc agtgttggca gataggtgat ggagaggatg ataattttat
     4921 cttctggcca cagagctgca gccccagttg tcagagtcct taaatgaaac ccccaaatcc
     4981 atccctcctt ccctaccccc actggaatat tctagaataa gagcactgga taagtacact
     5041 tgaacacatt tttctaacct tagaaaatac ctacaaggcc tgttgtcttg acccattact
     5101 caattgtccc tggcatatta tctgatcttc acgtttcttg gaagcagaat catcaaggct
     5161 ttcctttgta actgcccttt ccgtacacag caggcatgaa taaatgctga gtaacagaca
     5221 agttacagac aggaggggaa agaggaggaa ccatacaact gtttttgcaa aatgatggct
     5281 gagtccagat tatagaggtt gccttaccct tagaatgtta tttagaccaa gtttagcttt
     5341 tagagtccag gtctggttaa ttgccagggt agcaaagaat cgcatgcacc aatgtaaaca
     5401 ggagtcagaa tgcattatta gtcaaagatc gaatttcaca ttgtagagat gtatagctgt
     5461 gattaagctg catatgtatg ctgggaaacg gcttgagtgg atggctaata taaaagttgt
     5521 tggccataat gccacacctc tcatctgctt gaaatatgga ccagtattct aaaatatcag
     5581 ctactggggt ctcattcact acaagataaa ttcaaacttc acagaacttt gcagcagttc
     5641 accaccagac gggactgtgt ctgcaaactc tcttgtcttc acagacgcct aataaagcaa
     5701 aactctgaat ctca
//
