LOCUS       NM_007355               2555 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens heat shock protein 90 alpha family class B member 1
            (HSP90AB1), transcript variant 2, mRNA.
ACCESSION   NM_007355 XR_108652 XR_112882 XR_113895
VERSION     NM_007355.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2555)
  AUTHORS   Spel,L., Hou,C., Theodoropoulou,K., Zaffalon,L., Wang,Z.,
            Bertoni,A., Volpi,S., Hofer,M., Gattorno,M. and Martinon,F.
  TITLE     HSP90beta controls NLRP3 autoactivation
  JOURNAL   Sci Adv 10 (9), eadj6289 (2024)
   PUBMED   38416826
  REMARK    GeneRIF: HSP90beta controls NLRP3 autoactivation.
REFERENCE   2  (bases 1 to 2555)
  AUTHORS   Sharma,S. and Kumar,P.
  TITLE     Dissecting the functional significance of HSP90AB1 and other heat
            shock proteins in countering glioblastomas and ependymomas using
            omics analysis and drug prediction using virtual screening
  JOURNAL   Neuropeptides 102, 102383 (2023)
   PUBMED   37729687
  REMARK    GeneRIF: Dissecting the functional significance of HSP90AB1 and
            other heat shock proteins in countering glioblastomas and
            ependymomas using omics analysis and drug prediction using virtual
            screening.
REFERENCE   3  (bases 1 to 2555)
  AUTHORS   Teng,F., Wang,Y., Liu,M., Tian,S., Stjepanovic,G. and Su,M.Y.
  TITLE     Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric
            metabolic enzyme
  JOURNAL   Structure 31 (11), 1431-1440 (2023)
   PUBMED   37788672
REFERENCE   4  (bases 1 to 2555)
  AUTHORS   Fu,J.L., Zheng,S.Y., Wang,Y., Hu,X.B., Xiao,Y., Wang,J.M.,
            Zhang,L., Wang,L., Nie,Q., Hou,M., Bai,Y.Y., Gan,Y.W., Liang,X.M.,
            Xie,L.L. and Li,D.W.
  TITLE     HSP90beta prevents aging-related cataract formation through
            regulation of the charged multivesicular body protein (CHMP4B) and
            p53
  JOURNAL   Proc Natl Acad Sci U S A 120 (31), e2221522120 (2023)
   PUBMED   37487085
  REMARK    GeneRIF: HSP90beta prevents aging-related cataract formation
            through regulation of the charged multivesicular body protein
            (CHMP4B) and p53.
REFERENCE   5  (bases 1 to 2555)
  AUTHORS   Huang,M., Chen,L., Guo,Y., Ruan,Y. and Xu,H.
  TITLE     PARP1 negatively regulates transcription of BLM through its
            interaction with HSP90AB1 in prostate cancer
  JOURNAL   J Transl Med 21 (1), 445 (2023)
   PUBMED   37415147
  REMARK    GeneRIF: PARP1 negatively regulates transcription of BLM through
            its interaction with HSP90AB1 in prostate cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2555)
  AUTHORS   Tang,P.Z., Gannon,M.J., Andrew,A. and Miller,D.
  TITLE     Evidence for oestrogenic regulation of heat shock protein
            expression in human endometrium and steroid-responsive cell lines
  JOURNAL   Eur J Endocrinol 133 (5), 598-605 (1995)
   PUBMED   7581991
REFERENCE   7  (bases 1 to 2555)
  AUTHORS   Rebbe,N.F., Hickman,W.S., Ley,T.J., Stafford,D.W. and Hickman,S.
  TITLE     Nucleotide sequence and regulation of a human 90-kDa heat shock
            protein gene
  JOURNAL   J Biol Chem 264 (25), 15006-15011 (1989)
   PUBMED   2768249
REFERENCE   8  (bases 1 to 2555)
  AUTHORS   Lees-Miller,S.P. and Anderson,C.W.
  TITLE     Two human 90-kDa heat shock proteins are phosphorylated in vivo at
            conserved serines that are phosphorylated in vitro by casein kinase
            II
  JOURNAL   J Biol Chem 264 (5), 2431-2437 (1989)
   PUBMED   2492519
REFERENCE   9  (bases 1 to 2555)
  AUTHORS   Hoffmann,T. and Hovemann,B.
  TITLE     Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related
            genes encode formerly identified tumour-specific transplantation
            antigens
  JOURNAL   Gene 74 (2), 491-501 (1988)
   PUBMED   2469626
REFERENCE   10 (bases 1 to 2555)
  AUTHORS   Rebbe,N.F., Ware,J., Bertina,R.M., Modrich,P. and Stafford,D.W.
  TITLE     Nucleotide sequence of a cDNA for a member of the human 90-kDa
            heat-shock protein family
  JOURNAL   Gene 53 (2-3), 235-245 (1987)
   PUBMED   3301534
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC340766.1, BC004928.1 and
            BE539681.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007355.3.
            
            Summary: This gene encodes a member of the heat shock protein 90
            family; these proteins are involved in signal transduction, protein
            folding and degradation and morphological evolution. This gene
            encodes the constitutive form of the cytosolic 90 kDa heat-shock
            protein and is thought to play a role in gastric apoptosis and
            inflammation. Alternative splicing results in multiple transcript
            variants. Pseudogenes have been identified on multiple chromosomes.
            [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode
            the same protein (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016753.2, SRR1803617.119933.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371646.10/ ENSP00000360709.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DC340766.1         77-87
            12-2549             BC004928.1         1-2538
            2550-2555           BE539681.1         391-396
FEATURES             Location/Qualifiers
     source          1..2555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..2555
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /note="heat shock protein 90 alpha family class B member
                     1"
                     /db_xref="GeneID:3326"
                     /db_xref="HGNC:HGNC:5258"
                     /db_xref="MIM:140572"
     exon            1..95
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2270
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /note="isoform a is encoded by transcript variant 2; heat
                     shock 90kD protein 1, beta; heat shock protein HSP
                     90-beta; heat shock 84 kDa; HSP90-beta; heat shock protein
                     90 kDa; heat shock protein 90kDa alpha (cytosolic), class
                     B member 1; heat shock protein 90kDa alpha family class B
                     member 1; heat shock protein family C member 3"
                     /codon_start=1
                     /product="heat shock protein HSP 90-beta isoform a"
                     /protein_id="NP_031381.2"
                     /db_xref="CCDS:CCDS4909.1"
                     /db_xref="GeneID:3326"
                     /db_xref="HGNC:HGNC:5258"
                     /db_xref="MIM:140572"
                     /translation="MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELI
                     SNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNL
                     GTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESS
                     AGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLE
                     KEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKY
                     IDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF
                     IPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISR
                     EMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRR
                     LSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGF
                     EVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKL
                     MKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKK
                     HLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR
                     MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD"
     exon            96..242
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /inference="alignment:Splign:2.1.0"
     exon            243..449
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /inference="alignment:Splign:2.1.0"
     exon            450..609
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /inference="alignment:Splign:2.1.0"
     exon            610..743
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /inference="alignment:Splign:2.1.0"
     exon            744..1052
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1218
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1409
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1557
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1826
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2160
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2555
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2530..2535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /note="hexamer: AATAAA"
     polyA_site      2555
                     /gene="HSP90AB1"
                     /gene_synonym="D6S182; HSP84; HSP90B; HSPC2; HSPCB"
                     /note="major polyA site"
ORIGIN      
        1 ctctcgagtc actccggcgc agtgttggga ctgtctgggt atcggaaagc aagcctacgt
       61 tgctcactat tacgtataat ccttttcttt tcaagatgcc tgaggaagtg caccatggag
      121 aggaggaggt ggagactttt gcctttcagg cagaaattgc ccaactcatg tccctcatca
      181 tcaatacctt ctattccaac aaggagattt tccttcggga gttgatctct aatgcttctg
      241 atgccttgga caagattcgc tatgagagcc tgacagaccc ttcgaagttg gacagtggta
      301 aagagctgaa aattgacatc atccccaacc ctcaggaacg taccctgact ttggtagaca
      361 caggcattgg catgaccaaa gctgatctca taaataattt gggaaccatt gccaagtctg
      421 gtactaaagc attcatggag gctcttcagg ctggtgcaga catctccatg attgggcagt
      481 ttggtgttgg cttttattct gcctacttgg tggcagagaa agtggttgtg atcacaaagc
      541 acaacgatga tgaacagtat gcttgggagt cttctgctgg aggttccttc actgtgcgtg
      601 ctgaccatgg tgagcccatt ggcaggggta ccaaagtgat cctccatctt aaagaagatc
      661 agacagagta cctagaagag aggcgggtca aagaagtagt gaagaagcat tctcagttca
      721 taggctatcc catcaccctt tatttggaga aggaacgaga gaaggaaatt agtgatgatg
      781 aggcagagga agagaaaggt gagaaagaag aggaagataa agatgatgaa gaaaaaccca
      841 agatcgaaga tgtgggttca gatgaggagg atgacagcgg taaggataag aagaagaaaa
      901 ctaagaagat caaagagaaa tacattgatc aggaagaact aaacaagacc aagcctattt
      961 ggaccagaaa ccctgatgac atcacccaag aggagtatgg agaattctac aagagcctca
     1021 ctaatgactg ggaagaccac ttggcagtca agcacttttc tgtagaaggt cagttggaat
     1081 tcagggcatt gctatttatt cctcgtcggg ctccctttga cctttttgag aacaagaaga
     1141 aaaagaacaa catcaaactc tatgtccgcc gtgtgttcat catggacagc tgtgatgagt
     1201 tgataccaga gtatctcaat tttatccgtg gtgtggttga ctctgaggat ctgcccctga
     1261 acatctcccg agaaatgctc cagcagagca aaatcttgaa agtcattcgc aaaaacattg
     1321 ttaagaagtg ccttgagctc ttctctgagc tggcagaaga caaggagaat tacaagaaat
     1381 tctatgaggc attctctaaa aatctcaagc ttggaatcca cgaagactcc actaaccgcc
     1441 gccgcctgtc tgagctgctg cgctatcata cctcccagtc tggagatgag atgacatctc
     1501 tgtcagagta tgtttctcgc atgaaggaga cacagaagtc catctattac atcactggtg
     1561 agagcaaaga gcaggtggcc aactcagctt ttgtggagcg agtgcggaaa cggggcttcg
     1621 aggtggtata tatgaccgag cccattgacg agtactgtgt gcagcagctc aaggaatttg
     1681 atgggaagag cctggtctca gttaccaagg agggtctgga gctgcctgag gatgaggagg
     1741 agaagaagaa gatggaagag agcaaggcaa agtttgagaa cctctgcaag ctcatgaaag
     1801 aaatcttaga taagaaggtt gagaaggtga caatctccaa tagacttgtg tcttcacctt
     1861 gctgcattgt gaccagcacc tacggctgga cagccaatat ggagcggatc atgaaagccc
     1921 aggcacttcg ggacaactcc accatgggct atatgatggc caaaaagcac ctggagatca
     1981 accctgacca ccccattgtg gagacgctgc ggcagaaggc tgaggccgac aagaatgata
     2041 aggcagttaa ggacctggtg gtgctgctgt ttgaaaccgc cctgctatct tctggctttt
     2101 cccttgagga tccccagacc cactccaacc gcatctatcg catgatcaag ctaggtctag
     2161 gtattgatga agatgaagtg gcagcagagg aacccaatgc tgcagttcct gatgagatcc
     2221 cccctctcga gggcgatgag gatgcgtctc gcatggaaga agtcgattag gttaggagtt
     2281 catagttgga aaacttgtgc ccttgtatag tgtccccatg ggctcccact gcagcctcga
     2341 gtgcccctgt cccacctggc tccccctgct ggtgtctagt gtttttttcc ctctcctgtc
     2401 cttgtgttga aggcagtaaa ctaagggtgt caagccccat tccctctcta ctcttgacag
     2461 caggattgga tgttgtgtat tgtggtttat tttattttct tcattttgtt ctgaaattaa
     2521 agtatgcaaa ataaagaata tgccgttttt ataca
//
