LOCUS       NM_005348               3228 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens heat shock protein 90 alpha family class A member 1
            (HSP90AA1), transcript variant 2, mRNA.
ACCESSION   NM_005348
VERSION     NM_005348.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3228)
  AUTHORS   Xu,X., Huang,Y., Yang,F., Sun,X., Lin,R., Feng,J., Yang,M.,
            Shao,J., Liu,X., Zhou,T., Xie,S. and Yang,Y.
  TITLE     NudCL2 is required for cytokinesis by stabilizing RCC2 with Hsp90
            at the midbody
  JOURNAL   Protein Cell 15 (10), 766-782 (2024)
   PUBMED   38801297
  REMARK    GeneRIF: NudCL2 is required for cytokinesis by stabilizing RCC2
            with Hsp90 at the midbody.
REFERENCE   2  (bases 1 to 3228)
  AUTHORS   Zhang,C., Chen,X., Liu,R. and Zhao,G.
  TITLE     HSP90 Inhibition Attenuated Isoflurane-Induced Neurotoxicity in
            Mice and Human Neuroglioma Cells
  JOURNAL   Neurochem Res 49 (3), 706-717 (2024)
   PUBMED   38055149
  REMARK    GeneRIF: HSP90 Inhibition Attenuated Isoflurane-Induced
            Neurotoxicity in Mice and Human Neuroglioma Cells.
REFERENCE   3  (bases 1 to 3228)
  AUTHORS   Mansour,H.M., Mohamed,A.F., Khattab,M.M. and El-Khatib,A.S.
  TITLE     Heat Shock Protein 90 in Parkinson's Disease: Profile of a Serial
            Killer
  JOURNAL   Neuroscience 537, 32-46 (2024)
   PUBMED   38040085
  REMARK    GeneRIF: Heat Shock Protein 90 in Parkinson's Disease: Profile of a
            Serial Killer.
            Review article
REFERENCE   4  (bases 1 to 3228)
  AUTHORS   Iqbal,M., Lewis,S.L., Padhye,S. and Jinwal,U.K.
  TITLE     Updates on Abeta Processing by Hsp90, BRICHOS, and Newly Reported
            Distinctive Chaperones
  JOURNAL   Biomolecules 14 (1), 16 (2023)
   PUBMED   38254616
  REMARK    GeneRIF: Updates on Abeta Processing by Hsp90, BRICHOS, and Newly
            Reported Distinctive Chaperones.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3228)
  AUTHORS   Zhang,Z., Sun,D., Tang,H., Ren,J., Yin,S. and Yang,K.
  TITLE     PER2 binding to HSP90 enhances immune response against oral
            squamous cell carcinoma by inhibiting IKK/NF-kappaB pathway and
            PD-L1 expression
  JOURNAL   J Immunother Cancer 11 (11) (2023)
   PUBMED   37914384
  REMARK    GeneRIF: PER2 binding to HSP90 enhances immune response against
            oral squamous cell carcinoma by inhibiting IKK/NF-kappaB pathway
            and PD-L1 expression.
REFERENCE   6  (bases 1 to 3228)
  AUTHORS   Shaknovich,R., Shue,G. and Kohtz,D.S.
  TITLE     Conformational activation of a basic helix-loop-helix protein
            (MyoD1) by the C-terminal region of murine HSP90 (HSP84)
  JOURNAL   Mol Cell Biol 12 (11), 5059-5068 (1992)
   PUBMED   1406681
REFERENCE   7  (bases 1 to 3228)
  AUTHORS   Nemoto,T., Ohara-Nemoto,Y. and Ota,M.
  TITLE     Association of the 90-kDa heat shock protein does not affect the
            ligand-binding ability of androgen receptor
  JOURNAL   J Steroid Biochem Mol Biol 42 (8), 803-812 (1992)
   PUBMED   1525041
REFERENCE   8  (bases 1 to 3228)
  AUTHORS   Hutchison,K.A., Brott,B.K., De Leon,J.H., Perdew,G.H., Jove,R. and
            Pratt,W.B.
  TITLE     Reconstitution of the multiprotein complex of pp60src, hsp90, and
            p50 in a cell-free system
  JOURNAL   J Biol Chem 267 (5), 2902-2908 (1992)
   PUBMED   1310678
REFERENCE   9  (bases 1 to 3228)
  AUTHORS   Ozawa,K., Murakami,Y., Eki,T., Soeda,E. and Yokoyama,K.
  TITLE     Mapping of the gene family for human heat-shock protein 90 alpha to
            chromosomes 1, 4, 11, and 14
  JOURNAL   Genomics 12 (2), 214-220 (1992)
   PUBMED   1740332
REFERENCE   10 (bases 1 to 3228)
  AUTHORS   Yamazaki,M., Tashiro,H., Yokoyama,K. and Soeda,E.
  TITLE     Molecular cloning of cDNA encoding a human heat-shock protein whose
            expression is induced by adenovirus type 12 E1A in HeLa cells
  JOURNAL   Agric Biol Chem 54 (12), 3163-3170 (1990)
   PUBMED   1368637
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC303876.1, AJ890083.1 and
            AI250920.1.
            
            On Jun 2, 2019 this sequence version replaced NM_005348.3.
            
            Summary: The protein encoded by this gene is an inducible molecular
            chaperone that functions as a homodimer. The encoded protein aids
            in the proper folding of specific target proteins by use of an
            ATPase activity that is modulated by co-chaperones. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.275136.1,
                                           SRR1803613.103948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216281.13/ ENSP00000216281.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               DC303876.1         132-310
            180-3201            AJ890083.1         161-3182
            3202-3228           AI250920.1         8-34                c
FEATURES             Location/Qualifiers
     source          1..3228
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.31"
     gene            1..3228
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /note="heat shock protein 90 alpha family class A member
                     1"
                     /db_xref="GeneID:3320"
                     /db_xref="HGNC:HGNC:5253"
                     /db_xref="MIM:140571"
     exon            1..59
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2258
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /EC_number="3.6.4.10"
                     /note="isoform 2 is encoded by transcript variant 2; heat
                     shock 90kD protein 1, alpha; heat shock 90kDa protein 1,
                     alpha; heat shock protein HSP 90-alpha; heat shock 90kD
                     protein 1, alpha-like 4; heat shock 90kD protein,
                     alpha-like 4; HSP 86; heat shock 86 kDa; renal carcinoma
                     antigen NY-REN-38; epididymis luminal secretory protein
                     52; LPS-associated protein 2;
                     lipopolysaccharide-associated protein 2; epididymis
                     secretory sperm binding protein Li 65p; heat shock protein
                     90kDa alpha (cytosolic), class A member 1; heat shock
                     protein 90kDa alpha family class A member 1; heat shock
                     protein family C member 1"
                     /codon_start=1
                     /product="heat shock protein HSP 90-alpha isoform 2"
                     /protein_id="NP_005339.3"
                     /db_xref="CCDS:CCDS9967.1"
                     /db_xref="GeneID:3320"
                     /db_xref="HGNC:HGNC:5253"
                     /db_xref="MIM:140571"
                     /translation="MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIF
                     LRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKAD
                     LINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQY
                     AWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPI
                     TLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKK
                     KKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQ
                     LEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSE
                     DLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH
                     EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFV
                     ERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKT
                     KFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNST
                     MGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQ
                     THANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD"
     exon            60..221
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            222..588
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            589..722
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            723..1040
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1206
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1397
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1545
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1814
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..2148
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..3228
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2903..2908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /note="hexamer: AATACA"
     polyA_site      2922
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /note="major polyA site"
     regulatory      3205..3210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
                     /note="hexamer: AATACA"
     polyA_site      3228
                     /gene="HSP90AA1"
                     /gene_synonym="EL52; HEL-S-65p; Hsp103; HSP86; Hsp89;
                     HSP89A; Hsp90; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1;
                     HSPCAL4; HSPN; LAP-2; LAP2"
ORIGIN      
        1 agttgcttca gcgtcccggt gtggctgtgc cgttggtcct gtgcggtcac ttagccaaga
       61 tgcctgagga aacccagacc caagaccaac cgatggagga ggaggaggtt gagacgttcg
      121 cctttcaggc agaaattgcc cagttgatgt cattgatcat caatactttc tactcgaaca
      181 aagagatctt tctgagagag ctcatttcaa attcatcaga tgcattggac aaaatccggt
      241 atgaaagctt gacagatccc agtaaattag actctgggaa agagctgcat attaacctta
      301 taccgaacaa acaagatcga actctcacta ttgtggatac tggaattgga atgaccaagg
      361 ctgacttgat caataacctt ggtactatcg ccaagtctgg gaccaaagcg ttcatggaag
      421 ctttgcaggc tggtgcagat atctctatga ttggccagtt cggtgttggt ttttattctg
      481 cttatttggt tgctgagaaa gtaactgtga tcaccaaaca taacgatgat gagcagtacg
      541 cttgggagtc ctcagcaggg ggatcattca cagtgaggac agacacaggt gaacctatgg
      601 gtcgtggaac aaaagttatc ctacacctga aagaagacca aactgagtac ttggaggaac
      661 gaagaataaa ggagattgtg aagaaacatt ctcagtttat tggatatccc attactcttt
      721 ttgtggagaa ggaacgtgat aaagaagtaa gcgatgatga ggctgaagaa aaggaagaca
      781 aagaagaaga aaaagaaaaa gaagagaaag agtcggaaga caaacctgaa attgaagatg
      841 ttggttctga tgaggaagaa gaaaagaagg atggtgacaa gaagaagaag aagaagatta
      901 aggaaaagta catcgatcaa gaagagctca acaaaacaaa gcccatctgg accagaaatc
      961 ccgacgatat tactaatgag gagtacggag aattctataa gagcttgacc aatgactggg
     1021 aagatcactt ggcagtgaag catttttcag ttgaaggaca gttggaattc agagcccttc
     1081 tatttgtccc acgacgtgct ccttttgatc tgtttgaaaa cagaaagaaa aagaacaaca
     1141 tcaaattgta tgtacgcaga gttttcatca tggataactg tgaggagcta atccctgaat
     1201 atctgaactt cattagaggg gtggtagact cggaggatct ccctctaaac atatcccgtg
     1261 agatgttgca acaaagcaaa attttgaaag ttatcaggaa gaatttggtc aaaaaatgct
     1321 tagaactctt tactgaactg gcggaagata aagagaacta caagaaattc tatgagcagt
     1381 tctctaaaaa cataaagctt ggaatacacg aagactctca aaatcggaag aagctttcag
     1441 agctgttaag gtactacaca tctgcctctg gtgatgagat ggtttctctc aaggactact
     1501 gcaccagaat gaaggagaac cagaaacata tctattatat cacaggtgag accaaggacc
     1561 aggtagctaa ctcagccttt gtggaacgtc ttcggaaaca tggcttagaa gtgatctata
     1621 tgattgagcc cattgatgag tactgtgtcc aacagctgaa ggaatttgag gggaagactt
     1681 tagtgtcagt caccaaagaa ggcctggaac ttccagagga tgaagaagag aaaaagaagc
     1741 aggaagagaa aaaaacaaag tttgagaacc tctgcaaaat catgaaagac atattggaga
     1801 aaaaagttga aaaggtggtt gtgtcaaacc gattggtgac atctccatgc tgtattgtca
     1861 caagcacata tggctggaca gcaaacatgg agagaatcat gaaagctcaa gccctaagag
     1921 acaactcaac aatgggttac atggcagcaa agaaacacct ggagataaac cctgaccatt
     1981 ccattattga gaccttaagg caaaaggcag aggctgataa gaacgacaag tctgtgaagg
     2041 atctggtcat cttgctttat gaaactgcgc tcctgtcttc tggcttcagt ctggaagatc
     2101 cccagacaca tgctaacagg atctacagga tgatcaaact tggtctgggt attgatgaag
     2161 atgaccctac tgctgatgat accagtgctg ctgtaactga agaaatgcca ccccttgaag
     2221 gagatgacga cacatcacgc atggaagaag tagactaatc tctggctgag ggatgactta
     2281 cctgttcagt actctacaat tcctctgata atatattttc aaggatgttt ttctttattt
     2341 ttgttaatat taaaaagtct gtatggcatg acaactactt taaggggaag ataagatttc
     2401 tgtctactaa gtgatgctgt gataccttag gcactaaagc agagctagta atgctttttg
     2461 agtttcatgt tggtttattt tcacagattg gggtaacgtg cactgtaaga cgtatgtaac
     2521 atgatgttaa ctttgtggtc taaagtgttt agctgtcaag ccggatgcct aagtagacca
     2581 aatcttgtta ttgaagtgtt ctgagctgta tcttgatgtt tagaaaagta ttcgttacat
     2641 cttgtaggat ctactttttg aacttttcat tccctgtagt tgacaattct gcatgtacta
     2701 gtcctctaga aataggttaa actgaagcaa cttgatggaa ggatctctcc acagggcttg
     2761 ttttccaaag aaaagtattg tttggaggag caaagttaaa agcctaccta agcatatcgt
     2821 aaagctgttc aaaaataact cagacccagt cttgtggatg gaaatgtagt gctcgagtca
     2881 cattctgctt aaagttgtaa caaatacaga tgagttaaaa gatattgtgt gacagtgtct
     2941 tatttagggg gaaaggggag tatctggatg acagttagtg ccaaaatgta aaacatgagg
     3001 cgctagcagg agatggttaa acactagctg ctccaagggt tgacatggtc ttcccagcat
     3061 gtactcagca ggtgtggggt ggagcacacg taggcacaga aaacaggaat gcagacaaca
     3121 tgcatcccct gcgtccatga gttacatgtg ttctcttagt gtccacgttg ttttgatgtt
     3181 attcatggaa taccttctgt gttaaataca gtcacttaat tccttggc
//
