LOCUS       NM_033108               1395 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens heat shock transcription factor Y-linked 1 (HSFY1),
            transcript variant 1, mRNA.
ACCESSION   NM_033108
VERSION     NM_033108.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1395)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1395)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1395)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1395)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 1395)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 1395)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1395)
  AUTHORS   Shinka,T., Sato,Y., Chen,G., Naroda,T., Kinoshita,K., Unemi,Y.,
            Tsuji,K., Toida,K., Iwamoto,T. and Nakahori,Y.
  TITLE     Molecular characterization of heat shock-like factor encoded on the
            human Y chromosome, and implications for male infertility
  JOURNAL   Biol Reprod 71 (1), 297-306 (2004)
   PUBMED   15044259
REFERENCE   8  (bases 1 to 1395)
  AUTHORS   Tessari,A., Salata,E., Ferlin,A., Bartoloni,L., Slongo,M.L. and
            Foresta,C.
  TITLE     Characterization of HSFY, a novel AZFb gene on the Y chromosome
            with a possible role in human spermatogenesis
  JOURNAL   Mol Hum Reprod 10 (4), 253-258 (2004)
   PUBMED   14985478
  REMARK    GeneRIF: Could have an important role in human spermatogenesis.
REFERENCE   9  (bases 1 to 1395)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   10 (bases 1 to 1395)
  AUTHORS   Fan,Y. and Silber,S.J.
  TITLE     Y Chromosome Infertility
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301513
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC036567.2 and BX281920.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 20, 2019 this sequence version replaced NM_033108.2.
            
            Summary: This gene encodes a member of the heat shock factor (HSF)
            family of transcriptional activators for heat shock proteins. This
            gene is a candidate gene for azoospermia, since it localizes to a
            region of chromosome Y that is sometimes deleted in infertile
            males. The genome has two identical copies of this gene within a
            palindromic region; this record represents the more centromeric
            copy. Alternative splicing results in multiple transcript variants
            encoding distinct isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1) of this protein. Isoform 1 has an HSF-type DNA-binding motif.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF332227.1, BC036567.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307393.3/ ENSP00000303599.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1388              BC036567.2         33-1420
            1389-1395           BX281920.1         50-56               c
FEATURES             Location/Qualifiers
     source          1..1395
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.222"
     gene            1..1395
                     /gene="HSFY1"
                     /gene_synonym="HSF2L; HSFY"
                     /note="heat shock transcription factor Y-linked 1"
                     /db_xref="GeneID:86614"
                     /db_xref="HGNC:HGNC:18568"
                     /db_xref="MIM:400029"
     exon            1..581
                     /gene="HSFY1"
                     /gene_synonym="HSF2L; HSFY"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1274
                     /gene="HSFY1"
                     /gene_synonym="HSF2L; HSFY"
                     /note="isoform 1 is encoded by transcript variant 1; heat
                     shock transcription factor 2-like protein; heat shock
                     transcription factor, Y-linked"
                     /codon_start=1
                     /product="heat shock transcription factor, Y-linked
                     isoform 1"
                     /protein_id="NP_149099.2"
                     /db_xref="CCDS:CCDS35475.1"
                     /db_xref="GeneID:86614"
                     /db_xref="HGNC:HGNC:18568"
                     /db_xref="MIM:400029"
                     /translation="MAHVSSETQDVSPKDELTASEASTRSPLCEHTFPGDSDLRSMIE
                     EHAFQVLSQGSLLESPSYTVCVSEPDKDDDFLSLNFPRKLWKIVESDQFKSISWDENG
                     TCIVINEELFKKEILETKAPYRIFQTDAIKSFVRQLNLYGFSKIQQNFQRSAFLATFL
                     SEEKESSVLSKLKFYYNPNFKRGYPQLLVRVKRRIGVKNASPISTLFNEDFNKKHFRA
                     GANMENHNSALAAEASEESLFSASKNLNMPLTRESSVRQIIANSSVPIRSGFPPPSPS
                     TSVGPSEQIATDQHAILNQLTTIHMHSHSTYMQARGHIVNFITTTTSQYHIISPLQNG
                     YFGLTVEPSAVPTRYPLVSVNEAPYRNMLPAGNPWLQMPTIADRSAAPHSRLALQPSP
                     LDKYHPNYN"
     exon            582..1395
                     /gene="HSFY1"
                     /gene_synonym="HSF2L; HSFY"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcatttgaa gctgcagtcc tgaaaaccat gcaggccgga agagtagata aagaaatatt
       61 tatttgagat ggcacatgtt tcttcagaaa ctcaagatgt ttcccccaaa gatgaattaa
      121 ctgcttcaga agcctccact aggtctccat tgtgtgaaca caccttccct ggggactcag
      181 acttacggtc aatgattgaa gaacatgctt ttcaggtttt gtcacaagga tccttgttag
      241 aaagtccaag ttacacagtt tgtgtctctg agccagataa agatgatgat tttctttctc
      301 tgaactttcc caggaaactt tggaaaatag tggaaagtga ccaattcaag tctatttcat
      361 gggatgagaa tggaacttgc atagtgatta atgaagaact cttcaagaaa gaaattttgg
      421 aaacaaaggc tccttacaga atatttcaaa ctgatgctat caaaagtttt gttcgacagc
      481 tcaaccttta tggatttagt aaaattcaac agaattttca aagatctgcc tttctagcca
      541 cctttctgtc agaagagaaa gaatcgtctg tcttaagcaa gttaaagttc tattataatc
      601 caaatttcaa gcgtggctat ccccaacttt tagtaagagt gaagagaaga attggtgtta
      661 aaaatgcttc acctatatct actttattca acgaagattt caacaagaag cattttagag
      721 caggggctaa catggagaat cataattctg ccttagctgc tgaagctagt gaagaaagtt
      781 tattttcagc ctctaaaaat ttaaatatgc ctctaacaag ggaatcttct gtcagacaga
      841 taattgcaaa ttcatctgtc cccattagaa gtggtttccc tcctccttca ccttcaacct
      901 cagttggacc atcagaacaa attgcaacag atcaacatgc tattttaaat cagttgacca
      961 ctattcatat gcactctcat agtacctaca tgcaagcaag gggccacatt gtgaatttta
     1021 ttacaaccac aacttctcaa taccacatca tatctccctt acaaaatggt tattttgggc
     1081 tgacagtgga accatctgct gttcccacac gatatcctct ggtatcagtc aatgaggctc
     1141 catatcgtaa catgctacca gcaggcaacc cgtggttgca aatgcctacg atcgctgata
     1201 gatcagctgc ccctcattcc aggctagctc ttcaaccatc accactggac aaatatcacc
     1261 ctaattacaa ctgatctgcc attaaaagag gaccagatta tgaatgacaa cagagactaa
     1321 catttacatt gacaaaaaac cctaaaaatt tctgcaatta tcttattgaa caataaaatt
     1381 gcatgtttac ttcta
//
