LOCUS       NM_001164415            1966 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens heat shock transcription factor family, X-linked 2
            (HSFX2), mRNA.
ACCESSION   NM_001164415 XM_001713713
VERSION     NM_001164415.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Katsura,Y. and Satta,Y.
  TITLE     No evidence for a second evolutionary stratum during the early
            evolution of mammalian sex chromosomes
  JOURNAL   PLoS One 7 (10), e45488 (2012)
   PUBMED   23094017
  REMARK    Erratum:[PLoS One. 2014;9(5):e97169]
REFERENCE   4  (bases 1 to 1966)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   5  (bases 1 to 1966)
  AUTHORS   Shinka,T., Sato,Y., Chen,G., Naroda,T., Kinoshita,K., Unemi,Y.,
            Tsuji,K., Toida,K., Iwamoto,T. and Nakahori,Y.
  TITLE     Molecular characterization of heat shock-like factor encoded on the
            human Y chromosome, and implications for male infertility
  JOURNAL   Biol Reprod 71 (1), 297-306 (2004)
   PUBMED   15044259
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244197.3 and BC021706.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001164415.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021706.2, SRR14038195.2382973.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000598963.3/ ENSP00000469223.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-598               AC244197.3         115401-115998       c
            599-1963            BC021706.2         4-1368
            1964-1966           AC244197.3         113196-113198       c
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1966
                     /gene="HSFX2"
                     /note="heat shock transcription factor family, X-linked 2"
                     /db_xref="GeneID:100130086"
                     /db_xref="HGNC:HGNC:32701"
     exon            1..1178
                     /gene="HSFX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             615..1886
                     /gene="HSFX2"
                     /codon_start=1
                     /product="heat shock transcription factor, X-linked"
                     /protein_id="NP_001157887.1"
                     /db_xref="CCDS:CCDS48179.1"
                     /db_xref="GeneID:100130086"
                     /db_xref="HGNC:HGNC:32701"
                     /translation="MEDKRSLSMARCEERNSRGQDHGLERVPFPPQLQSETYLHPADP
                     SPAWDDPGSTGSPNLRLLTEEIAFQPLAEEASFRRPHPDGDVPPQGEDNLLSLPFPQK
                     LWRLVSSNQFSSIWWDDSGACRVINQKLFEKEILKRDVAHKVFATTSIKSFFRQLNLY
                     GFRKRRQCTFRTFTRIFSAKRLVSILNKLEFYCHPYFQRDSPHLLVRMKRRVGVKSAP
                     RHQEEDKPEAAGSCLAPADTEQQDHTSPNENDQVTPQHREPAGPNTQIRSGSAPPATP
                     VMVPDSAVASDNSPVTQPAGEWSEGSQAHVTPVAAVPGPAALPFLYVPGSPTQMNSYG
                     PVVALPTASRSTLAMDTTGLPAPGMLPFCHLWVPVTLVAAGAAQPAASMVMFPHLPAL
                     HHHCPHSHRTSQYMPASDGPQAYPDYADQST"
     exon            1179..1966
                     /gene="HSFX2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcctccga ctccccactg gactgcatgg cgacggcgtg tggtggggca gtcagctaag
       61 ccatttgcct aaggggctgt cgggcatctg cgtgctgggg accgacagtg tgggtgtgtt
      121 aggaggatct gtatggagca cattgctgcc tctggctagg acagggtgga aagggtggcg
      181 tggctacagc ctgacccatg ggcaccgtcc taccctttgt tctgtgcttc cgagtgtcag
      241 tcatgtgctg gggtctgtgg gcccatgact cagacggtga gctctgacct tcctgagcca
      301 gggctttgct gtagttgtgc ctggctcagg agctctagga caaggggacc gctccaggtc
      361 tgcatctacg gtgtggcagg gcccctcggc actcttgtgc actagtgtca tctttcccat
      421 tgaaatgact gtgaggacca gaatgtgcac atgcagatgg gcagctactt gtctgccttg
      481 gccctttatt acacaacttg ctgggggtgg agatgccacc ccccggcagt cagagcccct
      541 ttatgatgtc atggggctgg ttacatgact gccaaggggt gctgctggcc acactgcact
      601 agcaagtttg ccagatggag gacaagcgat cattgagtat ggctcgctgt gaagaaagaa
      661 attcgagggg acaggatcat ggcttggaaa gggtgccttt ccctccccag ttgcagtcag
      721 agacctacct tcacccagca gatccttccc ctgcctggga cgacccgggg tccactggga
      781 gccctaactt gaggctgctg acagaagaaa tcgctttcca acctctggcc gaggaagctt
      841 cgttcagaag gccgcaccct gacggtgacg tcccgcccca gggagaagat aatctcctct
      901 ccctcccctt tccacagaaa ctgtggagac tggtcagcag caaccagttt tcgtccatct
      961 ggtgggatga cagtggggct tgtagagtga tcaatcaaaa actctttgaa aaggagattc
     1021 tcaaaaggga cgtcgcacac aaagtgtttg ccacaacttc gataaagagc ttcttccgcc
     1081 agctaaactt gtatggcttc cgaaaacggc gtcaatgcac tttcaggacc ttcacccgca
     1141 ttttctccgc aaaaaggctg gtctccatct tgaataagtt agagttctac tgccatcctt
     1201 actttcaaag agactcccct cacctcctcg tgaggatgaa gagaagagtg ggtgtcaagt
     1261 ctgcaccaag acatcaggag gaggacaagc cagaagctgc tggatcctgt ctggcaccag
     1321 cagacactga gcaacaagat cacacgtctc cgaatgagaa tgaccaggtc acaccgcaac
     1381 accgggaacc ggccggtccc aacacccaaa tcaggagtgg ctctgctcca ccagcaactc
     1441 ctgtgatggt gcctgattcc gccgtggcga gtgacaacag tccagtgacc cagccggccg
     1501 gcgagtggtc agagggcagc caggctcacg tcactccggt ggccgctgtc cctgggcctg
     1561 cagcgctgcc cttcctctat gtccctggat ctcccactca gatgaattct tacgggcctg
     1621 tggtggccct tcccacagcg tcccgtagta cccttgccat ggacaccaca ggacttcctg
     1681 cacctggcat gctgcccttt tgccatctct gggtaccggt gaccctagtg gctgctgggg
     1741 ctgcacagcc tgctgcctcc atggtcatgt tcccccatct cccagctctg caccaccatt
     1801 gcccccacag ccaccgcacg tcacagtaca tgccagctag cgatgggccc caggcgtacc
     1861 cagactacgc agaccagagc acatagaggg cagcatttgg gcagaatatg tgctggtcaa
     1921 taaatgtgtc agaaaatgag taattttctg actgcacaaa aaagtc
//
