LOCUS       NM_001080439            4118 bp    mRNA    linear   PRI 31-MAY-2024
DEFINITION  Homo sapiens heat shock transcription factor 5 (HSF5), mRNA.
ACCESSION   NM_001080439 NM_173792 XM_064190
VERSION     NM_001080439.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4118)
  AUTHORS   Aizemaiti,R., Wu,Z., Tang,J., Yan,H. and Lv,X.
  TITLE     Heat shock factor 5 correlated with immune infiltration serves as a
            prognostic biomarker in lung adenocarcinoma
  JOURNAL   Int J Med Sci 18 (2), 448-458 (2021)
   PUBMED   33390814
  REMARK    GeneRIF: Heat shock factor 5 correlated with immune infiltration
            serves as a prognostic biomarker in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4118)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 4118)
  AUTHORS   Anderson,D., Holt,B.J., Pennell,C.E., Holt,P.G., Hart,P.H. and
            Blackwell,J.M.
  TITLE     Genome-wide association study of vitamin D levels in children:
            replication in the Western Australian Pregnancy Cohort (Raine)
            study
  JOURNAL   Genes Immun 15 (8), 578-583 (2014)
   PUBMED   25208829
REFERENCE   4  (bases 1 to 4118)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005666.1, BI459434.1 and BC033017.1.
            
            On May 17, 2019 this sequence version replaced NM_001080439.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033017.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323777.8/ ENSP00000313243.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC005666.1         66551-66557         c
            8-47                BI459434.1         6-45
            48-4118             BC033017.1         5-4075
FEATURES             Location/Qualifiers
     source          1..4118
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..4118
                     /gene="HSF5"
                     /gene_synonym="HSF 5; HSTF 5"
                     /note="heat shock transcription factor 5"
                     /db_xref="GeneID:124535"
                     /db_xref="HGNC:HGNC:26862"
                     /db_xref="MIM:620843"
     exon            1..684
                     /gene="HSF5"
                     /gene_synonym="HSF 5; HSTF 5"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1925
                     /gene="HSF5"
                     /gene_synonym="HSF 5; HSTF 5"
                     /note="heat shock transcription factor family member 5"
                     /codon_start=1
                     /product="heat shock factor protein 5"
                     /protein_id="NP_001073908.2"
                     /db_xref="CCDS:CCDS32690.1"
                     /db_xref="GeneID:124535"
                     /db_xref="HGNC:HGNC:26862"
                     /db_xref="MIM:620843"
                     /translation="MEALLSTPINPNNFPAKLWRLVNSPRYRSIRWDGRGEGLLIDQP
                     LFEAELLSPPGPGGGGGTAGAGAEPELFKTTSFTSFIRQLNLYGFRKVVLGGPGGGKP
                     AGNGPLHHFHNPHFRRDQPQLLVHLKRLTSANKAKLAAGLEVPCRPPNRFQRLLITSA
                     SAATAPLQHQQPPPPAGPRPEPHGPVAVGQFHRSFRRDSLSPYSCVSTPSHDHSTYPL
                     KGLDRTPVPHRIWQNSLGMHPGQVETSPTFSDKGVPFPVLQRFPTEVTYTLQPSTTSV
                     HVQQGPQTMVSSSQKYSNYTPSAQYSQAYYPTAVLQCCSPTHMDALSSCVTPTASSYA
                     HCNYFQNPSMQSSYPVEFLPSNWPCSTTDENTKTEVNLEAVFQIVDELHSSPKLEMVK
                     VEPVENQCPTSPSYRGQHILANSNNSNPCSASQASQLEPLTPVGSDIMSFVVGTEQAV
                     ACSLPQSPEYIYTIHTAQPVENSTIQESAAIQQAHVKLKEHLNHNPSPSSVVFVQEGP
                     PFSTHQVDANIKCQTSSRENILPSEQMGFLISEMGPASKPSEDTGLATPARYREHRSN
                     SQQGKSPDLHLLVDVACKQERFPKEEELKE"
     exon            685..1059
                     /gene="HSF5"
                     /gene_synonym="HSF 5; HSTF 5"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1154
                     /gene="HSF5"
                     /gene_synonym="HSF 5; HSTF 5"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1676
                     /gene="HSF5"
                     /gene_synonym="HSF 5; HSTF 5"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1854
                     /gene="HSF5"
                     /gene_synonym="HSF 5; HSTF 5"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..4118
                     /gene="HSF5"
                     /gene_synonym="HSF 5; HSTF 5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4095..4100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSF5"
                     /gene_synonym="HSF 5; HSTF 5"
                     /note="hexamer: AATAAA"
     polyA_site      4118
                     /gene="HSF5"
                     /gene_synonym="HSF 5; HSTF 5"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgccaac ggtccctggt acgcggcgga tgggcgccgg caggagcggg cagggcgagg
       61 cgaaggccgg ggagggatcg agaacggtgt gggagagcta ggctcggggg gcgaggcccc
      121 ggcccggcgg ggcgatggag gcgctgctct ccacccccat caaccccaac aacttccccg
      181 ccaagctgtg gcgcctggtg aacagcccgc gctaccgctc catccgctgg gacggccgcg
      241 gcgaggggct gcttatcgat cagccgctct tcgaggccga gctgctcagc ccgcccgggc
      301 cggggggcgg tggcgggact gcgggggccg gggccgagcc cgagctcttc aaaaccacca
      361 gcttcaccag cttcatccgc cagctcaacc tctacggctt ccgcaaggtg gtgctgggcg
      421 ggccgggggg cggcaaaccg gcaggcaatg ggccgctcca tcacttccac aacccgcact
      481 tccgccgcga ccagccacag ctgctcgtgc acctcaagcg cctcaccagc gccaacaagg
      541 ccaagctggc ggccggcctg gaggtgccct gccgcccgcc caaccgcttc cagcggctgc
      601 tcatcacctc ggcctccgcc gccaccgcgc cactgcagca ccagcagccg ccgccgcccg
      661 cggggccccg gcccgagccg cacggaccag tggctgtagg acaatttcac cggtcatttc
      721 gtcgagatag tttgtctcct tactcctgtg tatcaactcc atcccacgac cacagtactt
      781 accctctgaa aggtttagat cggaccccag ttcctcatag aatatggcag aactcccttg
      841 gaatgcatcc tggacaagtg gagacatctc ccacattttc agataaaggg gttccgtttc
      901 ctgtactcca gaggtttcca actgaggtta cctatacact gcagcccagc accacatctg
      961 tacatgttca acaaggtcct caaacaatgg tcagctcctc ccaaaaatac agtaactaca
     1021 caccctcagc acagtactcg caagcctact atccaacagc tgtgctacag tgctgttctc
     1081 ctacccacat ggatgctcta agtagttgtg tcactcccac tgcctcttcc tatgcacact
     1141 gcaactactt ccagaatcct tcaatgcagt cctcctatcc agttgaattt ttgccttcca
     1201 attggccctg cagtactact gatgaaaata caaagacaga agtaaaccta gaggctgtct
     1261 ttcagatagt tgatgagttg cattcctccc ctaaattgga gatggtaaag gtggagcctg
     1321 ttgagaatca gtgcccaaca tctccgtctt acagaggcca acacatttta gctaattcta
     1381 acaacagcaa tccatgttct gcaagtcagg ctagccagct ggagccactt actcctgtag
     1441 gctcagatat tatgtctttt gtggttggaa cagaacaagc agttgcctgc tctctaccac
     1501 agtcacctga gtacatctat accatccaca cagctcagcc tgttgaaaat agcacaatac
     1561 aggaatctgc agccatccag caagctcatg tcaaactgaa ggagcaccta aatcataatc
     1621 catctccatc ttcagtagta tttgtgcagg aagggccacc attcagcaca caccaggtgg
     1681 atgccaacat aaaatgccag accagttcac gtgagaatat cttgccgtca gaacagatgg
     1741 gattcctcat ttcagaaatg gggcctgcta gcaagcctag tgaagacaca ggtttagcca
     1801 ctccagccag atacagagag cacagaagca actcacaaca aggaaagtcc cctgatcttc
     1861 atctgctggt ggacgtggcc tgcaagcagg agcgctttcc aaaggaggaa gaattaaaag
     1921 agtgaggaat ggatgacaaa tgtgacattg tgcactagct gtagctggag gcagactagc
     1981 cttgcacatg acaaactgtt gggatttttt cagttctgtt aaggaaaaaa aagtattttt
     2041 tgtttcgtta attgagaatt ttgttaattg agaattggga atttgtatgt actacagtgg
     2101 ttcagttcag attatctgcc ttgacaaact actgaacatc tagcagccac gttttttggc
     2161 tgcccagatc ccttttaaat gaaaagttct gaccttctgt tatagtcaag gagcatctaa
     2221 aaactgctcc atctatggta ctaagaataa tctgtgtgtg tgctgatttg ttgtcttgcc
     2281 actcaaactg tagtcagcac aactttagtg gggaattcag tctctctgat tcaagtcaca
     2341 gtgtgatcct tttagaggag attgtgtgag aaacaaaggc atgtgaggtc accagcatca
     2401 caggtctaaa tgcatcagga attccaggga agaaactctg gagaagagct aattttctaa
     2461 gtgattaacc aggaaattct cttacttcct aacccagcat tctgttttaa gagcaaggca
     2521 tccggacttg gaccatctat cacacttaac agcccctgat tcttttatat taatggaagc
     2581 attcttctat tttcatatct ttctttaatt ttaatgatac attatcataa atggtaaaaa
     2641 gattttatta atatatcact tatttaaatg tctttaaaga aagtatttaa cttgtttaat
     2701 ataattgtat ttataaatgc tgatagattt aaaggtttta aagttttata tttttattat
     2761 tgcaggatag aaggataaag gatgcatgtg tagtattttt attttgaaag gaaaatgtac
     2821 aatgtgtgaa caaaaacatt aagagattta atatactatt ttcttatttt agatttttac
     2881 attcaataag tataaattct catctatata aggtattgtg tgcaaatttg ggaaaaaact
     2941 gattagcagc catttagtag aagctatgcc tctgattttt aaagaatggt ttcaatctgg
     3001 tttaagcttc tgagagaatt ttggataatg ggatagatgg taacattttt ttcttatccc
     3061 tgttacagga ttctagattt gtgcagtagg attgtgggac tgtgttttag gagagaagga
     3121 tgtcttggat gtccagtttc tgtggttaat cccttacttg cttatccagt gacagcaaga
     3181 aactttctga tttaaagtct ttcaattgac caaaactttc ttattggatt ctgtttcagt
     3241 tctcctatta agcactgcag aaacgaaagg aaagcctagg aatatgaaac taattaaaaa
     3301 ggcacttggt gatatgacat agtactatgc tagccgttgt ggatgtaaca gttcatttct
     3361 tatactgcat tgtgccttcc caatgatgtc aaaccctaga aatattacag agatctactt
     3421 ttctggaaaa gggtgagctc tgtattgatc tgcagtgact ctgtttagat attaaagtag
     3481 gttctgaaaa gcgacctgtg tggtccctct gattagacta gttaatgtct atgtgatggg
     3541 catttattta tctttattag caaggtttaa aagagcaaat tatcaagaca cctatatctt
     3601 ttggccagac tatataatat tttgtcagag tatgtgaaga ggagacccaa tttccaaatg
     3661 aaggaacttt gctttttctc tgtcatgttg aagagctaat atactgtgta gattttcccc
     3721 taaatatggc tttcttagct ttatagatgt tgagataata tcttttgagg aacacatgtc
     3781 aagcaggaac cttggcatag atttggtttc agttgtttta aggcttaatt aatgaaatgc
     3841 cttaatcagc tttccaaaca tttttatata tgaatacagc agaccaagga gctggatctc
     3901 ctgctatcct tacacgcctt gtatctatca actaaagctg tcattaatga cttgggcaaa
     3961 atggcaagag gtataataaa gtcttcctgt gaattagcca gtagggtctg acacaactag
     4021 tcaactaaca aggttcctga ctagtacctc agtatttcag caccttaagc actgataaat
     4081 ttcaatcagt caacaataaa gtgagtgttc caactaga
//
