LOCUS       NM_001374675            1702 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens heat shock transcription factor 4 (HSF4), transcript
            variant 4, mRNA.
ACCESSION   NM_001374675
VERSION     NM_001374675.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1702)
  AUTHORS   Liu,J., Yue,K., Yang,J., Bi,C., Zhang,Y. and Zhang,W.
  TITLE     miR-330-5p Suppress Cell Growth and Invasion via Disrupting
            HSF4-mediated MACC1/STAT3 Pathway in Colorectal Cancer
  JOURNAL   Front Biosci (Landmark Ed) 29 (2), 53 (2024)
   PUBMED   38420805
  REMARK    GeneRIF: miR-330-5p Suppress Cell Growth and Invasion via
            Disrupting HSF4-mediated MACC1/STAT3 Pathway in Colorectal Cancer.
REFERENCE   2  (bases 1 to 1702)
  AUTHORS   Berry,V., Ionides,A., Pontikos,N., Moore,A.T., Quinlan,R.A. and
            Michaelides,M.
  TITLE     Variants in PAX6, PITX3 and HSF4 causing autosomal dominant
            congenital cataracts
  JOURNAL   Eye (Lond) 36 (8), 1694-1701 (2022)
   PUBMED   34345029
  REMARK    GeneRIF: Variants in PAX6, PITX3 and HSF4 causing autosomal
            dominant congenital cataracts.
REFERENCE   3  (bases 1 to 1702)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1702)
  AUTHORS   Cao,Z., Zhu,Y., Liu,L., Wu,S., Liu,B., Zhuang,J., Tong,Y., Chen,X.,
            Xie,Y., Nie,K., Lu,C., Ma,X. and Yang,J.
  TITLE     Novel mutations in HSF4 cause congenital cataracts in Chinese
            families
  JOURNAL   BMC Med Genet 19 (1), 150 (2018)
   PUBMED   30143024
  REMARK    GeneRIF: The results expand the spectrum of HSF4 mutations causing
            congenital cataracts.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1702)
  AUTHORS   Liao,S., Qu,Z., Li,L., Zhou,B., Gao,M., Huang,M. and Li,D.
  TITLE     HSF4 transcriptional regulates HMOX-1 expression in HLECs
  JOURNAL   Gene 655, 30-34 (2018)
   PUBMED   29454088
  REMARK    GeneRIF: HMOX-1, an anti-oxidase, is a bona fide transcriptional
            target gene of HSF4 in HLECs (human lens epithelial cells). HSF4
            directly binds to the HSE element in HMOX-1 promoter to mediate its
            mRNA transcription and protein accumulation.
REFERENCE   6  (bases 1 to 1702)
  AUTHORS   Somasundaram,T. and Bhat,S.P.
  TITLE     Developmentally dictated expression of heat shock factors:
            exclusive expression of HSF4 in the postnatal lens and its specific
            interaction with alphaB-crystallin heat shock promoter
  JOURNAL   J Biol Chem 279 (43), 44497-44503 (2004)
   PUBMED   15308659
  REMARK    GeneRIF: HSF4 binds to alphaB-crystallin, Hsp70, and Hsp82
            promoters and has a role in interacting with the canonical heat
            shock element of the alphaB-crystallin gene
REFERENCE   7  (bases 1 to 1702)
  AUTHORS   Smaoui,N., Beltaief,O., BenHamed,S., M'Rad,R., Maazoul,F.,
            Ouertani,A., Chaabouni,H. and Hejtmancik,J.F.
  TITLE     A homozygous splice mutation in the HSF4 gene is associated with an
            autosomal recessive congenital cataract
  JOURNAL   Invest Ophthalmol Vis Sci 45 (8), 2716-2721 (2004)
   PUBMED   15277496
  REMARK    GeneRIF: This is the first report describing association of an
            autosomal recessive cataract with the HSF4 locus on 16q21-q22.1 and
            the first description of HSF4 splice variants
REFERENCE   8  (bases 1 to 1702)
  AUTHORS   Bu,L., Jin,Y., Shi,Y., Chu,R., Ban,A., Eiberg,H., Andres,L.,
            Jiang,H., Zheng,G., Qian,M., Cui,B., Xia,Y., Liu,J., Hu,L.,
            Zhao,G., Hayden,M.R. and Kong,X.
  TITLE     Mutant DNA-binding domain of HSF4 is associated with autosomal
            dominant lamellar and Marner cataract
  JOURNAL   Nat Genet 31 (3), 276-278 (2002)
   PUBMED   12089525
  REMARK    GeneRIF: Mutant DNA-binding domain of HSF4 is associated with
            autosomal dominant lamellar and Marner cataract. . We suggest that
            HSF4 is critical to lens development.
REFERENCE   9  (bases 1 to 1702)
  AUTHORS   Tanabe,M., Sasai,N., Nagata,K., Liu,X.D., Liu,P.C., Thiele,D.J. and
            Nakai,A.
  TITLE     The mammalian HSF4 gene generates both an activator and a repressor
            of heat shock genes by alternative splicing
  JOURNAL   J Biol Chem 274 (39), 27845-27856 (1999)
   PUBMED   10488131
REFERENCE   10 (bases 1 to 1702)
  AUTHORS   Nakai,A., Tanabe,M., Kawazoe,Y., Inazawa,J., Morimoto,R.I. and
            Nagata,K.
  TITLE     HSF4, a new member of the human heat shock factor family which
            lacks properties of a transcriptional activator
  JOURNAL   Mol Cell Biol 17 (1), 469-481 (1997)
   PUBMED   8972228
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK293631.1, AB029348.1,
            D87673.1 and AC074143.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Heat-shock transcription factors (HSFs) activate
            heat-shock response genes under conditions of heat or other
            stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which
            is shared among all vertebrate HSFs and has been suggested to be
            involved in the negative regulation of DNA binding activity. Two
            alternatively spliced transcripts encoding distinct isoforms and
            possessing different transcriptional activity have been described.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.25814.1, AB029348.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000521374.6/ ENSP00000430947.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AK293631.1         65-132
            69-1575             AB029348.1         9-1515
            1576-1611           D87673.1           1426-1461
            1612-1620           AC074143.5         138487-138495
            1621-1702           D87673.1           1468-1549
FEATURES             Location/Qualifiers
     source          1..1702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1702
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /note="heat shock transcription factor 4"
                     /db_xref="GeneID:3299"
                     /db_xref="HGNC:HGNC:5227"
                     /db_xref="MIM:602438"
     exon            1..190
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1546
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /note="isoform b is encoded by transcript variant 4; heat
                     shock factor protein 4; HSF 4; hHSF4; HSTF 4"
                     /codon_start=1
                     /product="heat shock factor protein 4 isoform b"
                     /protein_id="NP_001361604.1"
                     /db_xref="CCDS:CCDS42175.1"
                     /db_xref="GeneID:3299"
                     /db_xref="HGNC:HGNC:5227"
                     /db_xref="MIM:602438"
                     /translation="MQEAPAALPTEPGPSPVPAFLGKLWALVGDPGTDHLIRWSPSGT
                     SFLVSDQSRFAKEVLPQYFKHSNMASFVRQLNMYGFRKVVSIEQGGLLRPERDHVEFQ
                     HPSFVRGREQLLERVRRKVPALRGDDGRWRPEDLGRLLGEVQALRGVQESTEARLREL
                     RQQNEILWREVVTLRQSHGQQHRVIGKLIQCLFGPLQAGPSNAGGKRKLSLMLDEGSS
                     CPTPAKFNTCPLPGALLQDPYFIQSPLPETNLGLSPHRARGPIISDIPEDSPSPEGTR
                     LSPSSDGRREKGLALLKEEPASPGGDGEAGLALAPNECDFCVTAPPPLPVAVVQAILE
                     GKGSFSPEGPRNAQQPEPGDPREIPDRGPLGLESGDRSPESLLPPMLLQPPQESVEPA
                     GPLDVLGPSLQGREWTLMDLDMELSLMQPLVPERGEPELAVKGLNSPSPGKDPTLGAP
                     LLLDVQAALGGPALGLPGALTIYSTPESRTASYLGPEASPSP"
     exon            191..299
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            300..427
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            428..552
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            553..628
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            629..693
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            694..796
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            797..921
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1149
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1255
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1321
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1391
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1702
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1683..1688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /note="hexamer: CATAAA"
     polyA_site      1702
                     /gene="HSF4"
                     /gene_synonym="CTM; CTRCT5"
                     /note="major polyA site"
ORIGIN      
        1 actttccgcg gctttgacga gcccgcagcg gccgggcccg agcgcagagc cgggccgaga
       61 ctgcaccatg caggaagcgc cagctgcgct gcccacggag ccaggcccca gccccgtgcc
      121 tgccttcctc ggcaagctat gggcgctggt gggggaccca ggcacagacc acctgatccg
      181 ctggagcccg agcgggacca gtttcctcgt aagcgaccag agccgtttcg ccaaggaagt
      241 gctgccccag tatttcaagc atagcaacat ggcgagcttc gtgcgccaac tcaacatgta
      301 cggttttcgg aaggtggtga gcatcgagca gggcggcctg cttaggccgg agcgcgacca
      361 cgtcgagttc cagcacccga gcttcgtgcg cggccgcgag cagctactgg agcgcgtgcg
      421 gcgcaaggtg cccgcgctgc gcggcgacga cggccgctgg cgcccggagg acctgggtcg
      481 actactgggc gaggtgcagg ctttgcgggg agtgcaggag agcaccgagg cgcggctgcg
      541 ggagctcagg cagcagaacg agatcttgtg gcgggaggtg gtgacacttc ggcagagcca
      601 cggtcagcag caccgggtca ttggcaagct gatccagtgt ctctttgggc cacttcaggc
      661 ggggccgagc aatgcaggag gcaagagaaa gctgtccctg atgctggatg aggggagctc
      721 atgcccaaca cctgccaagt tcaacacctg ccctctacct ggtgcccttc tgcaggaccc
      781 ctacttcatc cagtcgcctc tcccagagac aaatttgggc cttagccctc acagggccag
      841 gggccccatc atctctgaca tcccagaaga ctctccatcc cctgagggga ccaggctttc
      901 tccctccagt gatggcagga gggagaaggg cctggcactg ctcaaagaag agccggccag
      961 tccagggggg gatggcgagg ccgggctggc cctggcccca aacgagtgtg acttctgcgt
     1021 gacagccccc ccgccactgc ctgtggctgt ggtgcaggcc atcctggaag ggaaagggag
     1081 cttcagcccc gaggggccca ggaatgccca acagcctgaa ccaggggatc ccagggagat
     1141 acctgacagg gggcctctgg gcctggaaag cggggacagg agcccagaga gtctgctgcc
     1201 tccgatgctg cttcagcccc ctcaagaaag tgtggaacct gcagggcctc tagatgtgct
     1261 gggccccagt ctccaagggc gagaatggac cctgatggac ttggacatgg agctgtcctt
     1321 gatgcagccc ttggttccag agcggggtga gcctgagctg gcggtcaagg ggttaaattc
     1381 tccaagccca gggaaggacc ccacgctcgg ggccccactc ctgctggatg tccaggcggc
     1441 cttgggaggc ccagccctgg gcctgcctgg ggctttaacc atttatagca ctcctgagag
     1501 ccggactgcc tcctacttgg gcccggaagc cagtccctcc ccctaagacc ccgcgcctct
     1561 gaaggggctt ggaaccagtc cgccgctgca catccttctt ggcttcctgg cgccccctat
     1621 cgggggtgag cgaagccccc actactaaat ggcctctctc cactaccccg actatccctg
     1681 cacataaact ccgttttttt tt
//
