LOCUS       NM_007031               1900 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens heat shock transcription factor 2 binding protein
            (HSF2BP), mRNA.
ACCESSION   NM_007031
VERSION     NM_007031.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1900)
  AUTHORS   Pendlebury,D.F., Zhang,J., Agrawal,R., Shibuya,H. and Nandakumar,J.
  TITLE     Structure of a meiosis-specific complex central to BRCA2
            localization at recombination sites
  JOURNAL   Nat Struct Mol Biol 28 (8), 671-680 (2021)
   PUBMED   34373645
  REMARK    GeneRIF: Structure of a meiosis-specific complex central to BRCA2
            localization at recombination sites.
REFERENCE   2  (bases 1 to 1900)
  AUTHORS   Ghouil,R., Miron,S., Koornneef,L., Veerman,J., Paul,M.W., Le
            Du,M.H., Sleddens-Linkels,E., van Rossum-Fikkert,S.E., van Loon,Y.,
            Felipe-Medina,N., Pendas,A.M., Maas,A., Essers,J., Legrand,P.,
            Baarends,W.M., Kanaar,R., Zinn-Justin,S. and Zelensky,A.N.
  TITLE     BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers
            does not impact meiotic recombination
  JOURNAL   Nat Commun 12 (1), 4605 (2021)
   PUBMED   34326328
  REMARK    GeneRIF: BRCA2 binding through a cryptic repeated motif to HSF2BP
            oligomers does not impact meiotic recombination.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1900)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1900)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1900)
  AUTHORS   Sato,K., Brandsma,I., van Rossum-Fikkert,S.E., Verkaik,N.,
            Oostra,A.B., Dorsman,J.C., van Gent,D.C., Knipscheer,P., Kanaar,R.
            and Zelensky,A.N.
  TITLE     HSF2BP negatively regulates homologous recombination in DNA
            interstrand crosslink repair
  JOURNAL   Nucleic Acids Res 48 (5), 2442-2456 (2020)
   PUBMED   31960047
  REMARK    GeneRIF: Naturally occurring elevated production of HSF2BP in
            tumors may be a source of cancer-promoting genomic instability and
            also a targetable vulnerability.
REFERENCE   6  (bases 1 to 1900)
  AUTHORS   Kottyan,L.C., Davis,B.P., Sherrill,J.D., Liu,K., Rochman,M.,
            Kaufman,K., Weirauch,M.T., Vaughn,S., Lazaro,S., Rupert,A.M.,
            Kohram,M., Stucke,E.M., Kemme,K.A., Magnusen,A., He,H.,
            Dexheimer,P., Chehade,M., Wood,R.A., Pesek,R.D., Vickery,B.P.,
            Fleischer,D.M., Lindbad,R., Sampson,H.A., Mukkada,V.A.,
            Putnam,P.E., Abonia,J.P., Martin,L.J., Harley,J.B. and
            Rothenberg,M.E.
  TITLE     Genome-wide association analysis of eosinophilic esophagitis
            provides insight into the tissue specificity of this allergic
            disease
  JOURNAL   Nat Genet 46 (8), 895-900 (2014)
   PUBMED   25017104
REFERENCE   7  (bases 1 to 1900)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   8  (bases 1 to 1900)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   9  (bases 1 to 1900)
  AUTHORS   Hu,Y.H., Warnatz,H.J., Vanhecke,D., Wagner,F., Fiebitz,A.,
            Thamm,S., Kahlem,P., Lehrach,H., Yaspo,M.L. and Janitz,M.
  TITLE     Cell array-based intracellular localization screening reveals novel
            functional features of human chromosome 21 proteins
  JOURNAL   BMC Genomics 7, 155 (2006)
   PUBMED   16780588
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1900)
  AUTHORS   Yoshima,T., Yura,T. and Yanagi,H.
  TITLE     Novel testis-specific protein that interacts with heat shock factor
            2
  JOURNAL   Gene 214 (1-2), 139-146 (1998)
   PUBMED   9651507
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB007131.1 and AP001050.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007031.1.
            
            Summary: HSF2 binding protein (HSF2BP) associates with HSF2. The
            interaction occurs between the trimerization domain of HSF2 and the
            amino terminal hydrophilic region of HSF2BP that comprises two
            leucine zipper motifs. HSF2BP may therefore be involved in
            modulating HSF2 activation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007131.1, BC000153.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291560.7/ ENSP00000291560.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1894              AB007131.1         6-1899
            1895-1900           AP001050.1         39721-39726         c
FEATURES             Location/Qualifiers
     source          1..1900
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..1900
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /note="heat shock transcription factor 2 binding protein"
                     /db_xref="GeneID:11077"
                     /db_xref="HGNC:HGNC:5226"
                     /db_xref="MIM:604554"
     exon            1..103
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /inference="alignment:Splign:2.1.0"
     exon            104..363
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1332
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /note="meiotic localizer of BRCA2"
                     /codon_start=1
                     /product="heat shock factor 2-binding protein"
                     /protein_id="NP_008962.1"
                     /db_xref="CCDS:CCDS13697.1"
                     /db_xref="GeneID:11077"
                     /db_xref="HGNC:HGNC:5226"
                     /db_xref="MIM:604554"
                     /translation="MGEAGAAEEACRHMGTKEEFVKVRKKDLERLTTEVMQIRDFLPR
                     ILNGEVLESFQKLKIVEKNLERKEQELEQLKMDCEHFKARLETVQADNIREKKEKLAL
                     RQQLNEAKQQLLQQAEYCTEMGAAACTLLWGVSSSEEVVKAILGGDKALKFFSITGQT
                     MESFVKSLDGDVQELDSDESQFVFALAGIVTNVAAIACGREFLVNSSRVLLDTILQLL
                     GDLKPGQCTKLKVLMLMSLYNVSINLKGLKYISESPGFIPLLWWLLSDPDAEVCLHVL
                     RLVQSVVLEPEVFSKSASEFRSSLPLQRILAMSKSRNPRLQTAAQELLEDLRTLEHNV
                     "
     exon            364..514
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /inference="alignment:Splign:2.1.0"
     exon            515..618
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /inference="alignment:Splign:2.1.0"
     exon            619..768
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /inference="alignment:Splign:2.1.0"
     exon            769..901
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1019
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1123
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1900
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1870..1875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /note="hexamer: AATAAA"
     polyA_site      1900
                     /gene="HSF2BP"
                     /gene_synonym="MEILB2; POF19"
                     /note="major polyA site"
ORIGIN      
        1 gagcgcggca gtggccctgg cagctggcgg agcggcccag cccgtgtgca cgtggcgccg
       61 gcgctgcctt tcggttgcca aaattcaggc tgtagacggc gagataacaa gtttaaaacc
      121 ccggctaagc cagaagagcc aaagagggac ctcgccaagg ccactcctcg ctctctaggc
      181 cgagaatact gcgcaaattc tgggaggttt gggcctggcg gctctccgtt cccgaccccc
      241 ggcgtggatt cgttcccgcg ctttctggcg tgaggggtca gagggcgcgc cgacgctcag
      301 gcgaacggag cggaggcggc agcggccatg ggcgaagcgg gcgccgctga ggaggcctgc
      361 cggcacatgg gaactaaaga ggaatttgtt aaagtcagaa agaaggatct ggaacggctg
      421 acaactgaag tgatgcaaat acgggacttc ttacccagaa tactaaatgg ggaggtgctg
      481 gagagcttcc agaaattaaa gattgtagaa aaaaacctgg aaaggaaaga gcaagaatta
      541 gagcagctga aaatggattg tgagcacttt aaagcccgcc tggaaaccgt gcaggccgac
      601 aacataagag agaagaagga gaaactggct cttcgacagc agttgaatga agcgaagcag
      661 caactcctgc agcaggcaga gtattgtaca gaaatgggag cagcagcgtg taccctcttg
      721 tggggtgtct ccagcagtga ggaagtcgtc aaggccattt tgggaggaga taaagctttg
      781 aagtttttca gcatcactgg tcaaacaatg gagagttttg tgaagtcgtt agacggtgat
      841 gtccaggagc tggattcgga tgaaagtcag tttgttttcg ctctggctgg aattgtcacg
      901 aatgttgctg ctatagcatg tggtcgtgaa ttcttggtta attcaagccg ggtgctcttg
      961 gacaccatat tgcagcttct gggagacttg aagccaggac agtgtaccaa actcaaagtg
     1021 ctaatgctga tgtccctata caatgtaagc atcaatttga aaggcttgaa atacatcagc
     1081 gagagtccag gattcatccc tttgctgtgg tggcttttga gtgatccaga tgcagaggtg
     1141 tgccttcatg tactgaggct tgtccagtct gtggttctgg aacctgaagt cttctccaag
     1201 tcggcctctg agttccggag ctccctgccc ctgcaacgca tcctggcaat gtccaagagc
     1261 cgcaaccccc gcctgcaaac cgcagcccag gagctcctgg aagatctccg cactctggag
     1321 cataatgtgt aggtgtgctc ggccaccagg gttttggtga aaatgccggt gtcccttctc
     1381 cccagatccc tcatttgata ctccaaaacc atcaccatgt accatgtgtt agagttggca
     1441 aaatgtgatt gactagagat ggacatgaat tgatatgtat cccacataac tttgtcttgg
     1501 aagtgagagt gcttgtaggt ggttggttaa gcttgccaaa ggagaggcca tgaaagaacc
     1561 tgtccttctg gaaaagtggt ccatgtctgt gctggctgga agagggcttg cttagggcag
     1621 cttcttgctg ctcagcagac catgacctgt aggttcacct ataaaacagg gaaattgaat
     1681 aaccatctac cccattagtc agcattttct tgagatacat ttctttgaaa agcaattcat
     1741 tctctctcta gtaattgtaa ttaatccccc caaaatgcaa gtttactttt ataacctttt
     1801 ggtgaacctg ctatttcgga tgacattggg cattttagtt ctatattttt tgtgcctctt
     1861 ttatttttga ataaagaaaa tcagaagagt tgtattacga
//
