LOCUS       NM_004506               2596 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens heat shock transcription factor 2 (HSF2), transcript
            variant 1, mRNA.
ACCESSION   NM_004506
VERSION     NM_004506.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2596)
  AUTHORS   Joutsen,J., Pessa,J.C., Jokelainen,O., Sironen,R., Hartikainen,J.M.
            and Sistonen,L.
  TITLE     Comprehensive analysis of human tissues reveals unique expression
            and localization patterns of HSF1 and HSF2
  JOURNAL   Cell Stress Chaperones 29 (2), 235-271 (2024)
   PUBMED   38458311
  REMARK    GeneRIF: Comprehensive analysis of human tissues reveals unique
            expression and localization patterns of HSF1 and HSF2.
REFERENCE   2  (bases 1 to 2596)
  AUTHORS   Cao,Z., Ma,L., Cai,W., Niu,X., Yang,N., Ni,J., Wang,X., Wei,M.,
            Chen,S. and Li,Y.
  TITLE     Genome-wide association study reveals HSF2, GJA1 and TRIM36 as
            susceptibility genes for preeclampsia: a community-based population
            study in Tianjin, China
  JOURNAL   Hypertens Pregnancy 42 (1), 2256863 (2023)
   PUBMED   37735976
  REMARK    GeneRIF: Genome-wide association study reveals HSF2, GJA1 and
            TRIM36 as susceptibility genes for preeclampsia: a community-based
            population study in Tianjin, China.
REFERENCE   3  (bases 1 to 2596)
  AUTHORS   de Thonel,A., Ahlskog,J.K., Daupin,K., Dubreuil,V., Berthelet,J.,
            Chaput,C., Pires,G., Leonetti,C., Abane,R., Barris,L.C., Leray,I.,
            Aalto,A.L., Naceri,S., Cordonnier,M., Benasolo,C., Sanial,M.,
            Duchateau,A., Vihervaara,A., Puustinen,M.C., Miozzo,F.,
            Fergelot,P., Lebigot,E., Verloes,A., Gressens,P., Lacombe,D.,
            Gobbo,J., Garrido,C., Westerheide,S.D., David,L., Petitjean,M.,
            Taboureau,O., Rodrigues-Lima,F., Passemard,S., Saberan-Djoneidi,D.,
            Nguyen,L., Lancaster,M., Sistonen,L. and Mezger,V.
  TITLE     CBP-HSF2 structural and functional interplay in Rubinstein-Taybi
            neurodevelopmental disorder
  JOURNAL   Nat Commun 13 (1), 7002 (2022)
   PUBMED   36385105
  REMARK    GeneRIF: CBP-HSF2 structural and functional interplay in
            Rubinstein-Taybi neurodevelopmental disorder.
            Erratum:[Nat Commun. 2023 Sep 28;14(1):6067. doi:
            10.1038/s41467-023-41869-4.. PMID: 37770591]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2596)
  AUTHORS   Tokunaga,Y., Otsuyama,K.I., Kakuta,S. and Hayashida,N.
  TITLE     Heat Shock Transcription Factor 2 Is Significantly Involved in
            Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer,
            Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel
            Mechanisms of Several Severe Diseases
  JOURNAL   Int J Mol Sci 23 (22), 13763 (2022)
   PUBMED   36430241
  REMARK    GeneRIF: Heat Shock Transcription Factor 2 Is Significantly
            Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease,
            Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The
            Novel Mechanisms of Several Severe Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2596)
  AUTHORS   Gupta,N., Sarkar,S., Mehta,P., Sankhwar,S.N. and Rajender,S.
  TITLE     Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate
            with sperm motility in idiopathic infertility
  JOURNAL   Andrologia 54 (9), e14517 (2022)
   PUBMED   35768906
  REMARK    GeneRIF: Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes
            correlate with sperm motility in idiopathic infertility.
REFERENCE   6  (bases 1 to 2596)
  AUTHORS   Walsh,D., Li,Z., Wu,Y. and Nagata,K.
  TITLE     Heat shock and the role of the HSPs during neural plate induction
            in early mammalian CNS and brain development
  JOURNAL   Cell Mol Life Sci 53 (2), 198-211 (1997)
   PUBMED   9118008
  REMARK    Review article
REFERENCE   7  (bases 1 to 2596)
  AUTHORS   Nakai,A., Tanabe,M., Kawazoe,Y., Inazawa,J., Morimoto,R.I. and
            Nagata,K.
  TITLE     HSF4, a new member of the human heat shock factor family which
            lacks properties of a transcriptional activator
  JOURNAL   Mol Cell Biol 17 (1), 469-481 (1997)
   PUBMED   8972228
REFERENCE   8  (bases 1 to 2596)
  AUTHORS   Sheldon,L.A. and Kingston,R.E.
  TITLE     Hydrophobic coiled-coil domains regulate the subcellular
            localization of human heat shock factor 2
  JOURNAL   Genes Dev 7 (8), 1549-1558 (1993)
   PUBMED   8339932
  REMARK    Erratum:[Genes Dev 1994 Feb 1;8(3):386]
REFERENCE   9  (bases 1 to 2596)
  AUTHORS   Sarge,K.D., Zimarino,V., Holm,K., Wu,C. and Morimoto,R.I.
  TITLE     Cloning and characterization of two mouse heat shock factors with
            distinct inducible and constitutive DNA-binding ability
  JOURNAL   Genes Dev 5 (10), 1902-1911 (1991)
   PUBMED   1717345
REFERENCE   10 (bases 1 to 2596)
  AUTHORS   Schuetz,T.J., Gallo,G.J., Sheldon,L., Tempst,P. and Kingston,R.E.
  TITLE     Isolation of a cDNA for HSF2: evidence for two heat shock factor
            genes in humans
  JOURNAL   Proc Natl Acad Sci U S A 88 (16), 6911-6915 (1991)
   PUBMED   1871106
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC112323.1 and Z99129.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004506.3.
            
            Summary: The protein encoded by this gene belongs to the HSF family
            of transcription factors that bind specifically to the heat-shock
            promoter element and activate transcription. Heat shock
            transcription factors activate heat-shock response genes under
            conditions of heat or other stresses. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.110161.1,
                                           SRR1803615.38625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368455.9/ ENSP00000357440.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2437              BC112323.1         5-2441
            2438-2596           Z99129.1           30172-30330
FEATURES             Location/Qualifiers
     source          1..2596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..2596
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /note="heat shock transcription factor 2"
                     /db_xref="GeneID:3298"
                     /db_xref="HGNC:HGNC:5225"
                     /db_xref="MIM:140581"
     exon            1..179
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1697
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /note="isoform a is encoded by transcript variant 1; heat
                     shock factor protein 2"
                     /codon_start=1
                     /product="heat shock factor protein 2 isoform a"
                     /protein_id="NP_004497.1"
                     /db_xref="CCDS:CCDS5124.1"
                     /db_xref="GeneID:3298"
                     /db_xref="HGNC:HGNC:5225"
                     /db_xref="MIM:140581"
                     /translation="MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRF
                     AKEILPKYFKHNNMASFVRQLNMYGFRKVVHIDSGIVKQERDGPVEFQHPYFKQGQDD
                     LLENIKRKVSSSKPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKE
                     VSELRAKHAQQQQVIRKIVQFIVTLVQNNQLVSLKRKRPLLLNTNGAQKKNLFQHIVK
                     EPTDNHHHKVPHSRTEGLKPRERISDDIIIYDVTDDNADEENIPVIPETNEDVISDPS
                     NCSQYPDIVIVEDDNEDEYAPVIQSGEQNEPARESLSSGSDGSSPLMSSAVQLNGSSS
                     LTSEDPVTMMDSILNDNINLLGKVELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVD
                     LFTSSVQMNPTDYINNTKSENKGLETTKNNVVQPVSEEGRKSKSKPDKQLIQYTAFPL
                     LAFLDGNPASSVEQASTTASSEVLSSVDKPIEVDELLDSSLDPEPTQSKLVRLEPLTE
                     AEASEATLFYLCELAPAPLDSDMPLLDS"
     exon            180..288
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            289..416
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..541
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..617
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            618..679
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            680..767
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            768..916
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1156
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1262
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1316
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1401
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..2596
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2414..2419
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /note="hexamer: AATAAA"
     polyA_site      2437
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /note="major polyA site"
ORIGIN      
        1 gttctcgggg agctgctgcc gtagctgccg ccgccgctac caccgcgttc gggtgtagaa
       61 tttggaatcc ctgcgccgcg ttaacaatga agcagagttc gaacgtgccg gctttcctca
      121 gcaagctgtg gacgcttgtg gaggaaaccc acactaacga gttcatcacc tggagccaga
      181 atggccaaag ttttctggtc ttggatgagc aacgatttgc aaaagaaatt cttcccaaat
      241 atttcaagca caataatatg gcaagctttg tgaggcaact gaatatgtat ggtttccgta
      301 aagtagtaca tatcgactct ggaattgtaa agcaagaaag agatggtcct gtagaatttc
      361 agcatcctta cttcaaacaa ggacaggatg acttgttgga gaacattaaa aggaaggttt
      421 catcttcaaa accagaagaa aataaaattc gtcaggaaga tttaacaaaa attataagta
      481 gtgctcagaa ggttcagata aaacaggaaa ctattgagtc caggctttct gaattaaaaa
      541 gtgagaatga gtccctttgg aaggaggtgt cagaattacg agcaaagcat gcacaacagc
      601 aacaagttat tcgaaagatt gtccagttta ttgttacatt ggttcaaaat aaccaacttg
      661 tgagtttaaa acgtaaaagg cctctacttc taaacactaa tggagcccaa aagaagaacc
      721 tgtttcagca catagtcaaa gaaccaactg ataatcatca tcataaagtt ccacacagta
      781 ggactgaagg tttaaagcca agggagagga tttcagatga catcattatt tatgatgtta
      841 ctgatgataa tgcagatgaa gaaaatatcc cagttattcc agaaactaat gaggatgtta
      901 tatctgatcc ctccaactgt agccagtacc ctgatattgt catcgttgaa gatgacaatg
      961 aagatgagta tgcacctgtc attcagagtg gagagcagaa tgaaccagcc agagaatccc
     1021 taagttcagg cagtgatggc agcagccctc tcatgtctag tgctgtccag ctaaatggct
     1081 catccagtct gacctcagaa gatccagtga ccatgatgga ttccattttg aatgataaca
     1141 tcaatctttt gggaaaggtt gagctgttgg attatcttga cagtattgac tgcagtttag
     1201 aggacttcca ggccatgcta tcaggaagac aatttagcat agacccagat ctcctggttg
     1261 atcttttcac tagttctgtg cagatgaatc ccacagatta catcaataat acaaaatctg
     1321 agaataaagg attagaaact accaagaaca atgtagttca gccagtttcg gaagagggaa
     1381 gaaaatctaa atccaaacca gataagcagc ttatccagta taccgccttt ccacttcttg
     1441 cattcctcga tgggaaccct gcttcttctg ttgaacaggc gagtacaaca gcatcatcag
     1501 aagttttgtc ctctgtagat aaacccatag aagttgatga gcttctggat agcagcctag
     1561 acccagaacc aacccaaagt aagcttgttc gcctggagcc attgactgaa gctgaagcta
     1621 gtgaagctac actgttttat ttatgtgaac ttgctcctgc acctctggat agtgatatgc
     1681 cacttttaga tagctaaatc cccaggaagt ggactttaca tgtatatatt catcaaaatg
     1741 atgaactatt tattttaaag tatcatttgg tacttttttt gtaaattgct ttgttttgtt
     1801 taatcagata ctgtggaata aaagcacctt ttgcttttct cactaaccac acactcttgc
     1861 agagctttca ggtgttactc agctgcatag ttacgcagat gtaatgcaca ttattggcgt
     1921 atctttaagt tggattcaaa tggccatttt tctccaattt tggtaaattg gatatctttt
     1981 ttttacaaat acgaccatta acctcagtta aatttttgtt tgttttcctg tttgatgctg
     2041 tctatttgca ttgagtgtaa gtcatttgaa ctaatggtat aactcctaaa gctttctctg
     2101 ctccagttat ttttattaaa tatttttcac ttggcttatt tttaaaactg ggaacataaa
     2161 gtgcctgtat cttgtaaaac ttcatttgtt tcttttggtt cagagaagtt catttatgtt
     2221 caaagacgtt tattcatgtt caacaggaaa gacaaagtgt acgtgaatgc tcgctgtctg
     2281 atagggttcc agctccatat atatagaaag atcgggggtg ggatgggatg gagtgagccc
     2341 catccagtta gttggactag ttttaaataa aggttttccg gtttgtgttt ttttgaacca
     2401 tactgtttag taaaataaat acaatgaatg ttgagtacta gtgtctgtta tgtgtcttct
     2461 ttagaggtga cactcacatg aaacaatttt ttcttctcat aggaagcagt agctttaaac
     2521 tgtctgtggt tcattattct caatatgaat cataccaaga tatttgtgcc tcatctcgaa
     2581 aatatattgt atattg
//
