LOCUS       NM_001135564            2643 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens heat shock transcription factor 2 (HSF2), transcript
            variant 2, mRNA.
ACCESSION   NM_001135564
VERSION     NM_001135564.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2643)
  AUTHORS   Joutsen,J., Pessa,J.C., Jokelainen,O., Sironen,R., Hartikainen,J.M.
            and Sistonen,L.
  TITLE     Comprehensive analysis of human tissues reveals unique expression
            and localization patterns of HSF1 and HSF2
  JOURNAL   Cell Stress Chaperones 29 (2), 235-271 (2024)
   PUBMED   38458311
  REMARK    GeneRIF: Comprehensive analysis of human tissues reveals unique
            expression and localization patterns of HSF1 and HSF2.
REFERENCE   2  (bases 1 to 2643)
  AUTHORS   Cao,Z., Ma,L., Cai,W., Niu,X., Yang,N., Ni,J., Wang,X., Wei,M.,
            Chen,S. and Li,Y.
  TITLE     Genome-wide association study reveals HSF2, GJA1 and TRIM36 as
            susceptibility genes for preeclampsia: a community-based population
            study in Tianjin, China
  JOURNAL   Hypertens Pregnancy 42 (1), 2256863 (2023)
   PUBMED   37735976
  REMARK    GeneRIF: Genome-wide association study reveals HSF2, GJA1 and
            TRIM36 as susceptibility genes for preeclampsia: a community-based
            population study in Tianjin, China.
REFERENCE   3  (bases 1 to 2643)
  AUTHORS   de Thonel,A., Ahlskog,J.K., Daupin,K., Dubreuil,V., Berthelet,J.,
            Chaput,C., Pires,G., Leonetti,C., Abane,R., Barris,L.C., Leray,I.,
            Aalto,A.L., Naceri,S., Cordonnier,M., Benasolo,C., Sanial,M.,
            Duchateau,A., Vihervaara,A., Puustinen,M.C., Miozzo,F.,
            Fergelot,P., Lebigot,E., Verloes,A., Gressens,P., Lacombe,D.,
            Gobbo,J., Garrido,C., Westerheide,S.D., David,L., Petitjean,M.,
            Taboureau,O., Rodrigues-Lima,F., Passemard,S., Saberan-Djoneidi,D.,
            Nguyen,L., Lancaster,M., Sistonen,L. and Mezger,V.
  TITLE     CBP-HSF2 structural and functional interplay in Rubinstein-Taybi
            neurodevelopmental disorder
  JOURNAL   Nat Commun 13 (1), 7002 (2022)
   PUBMED   36385105
  REMARK    GeneRIF: CBP-HSF2 structural and functional interplay in
            Rubinstein-Taybi neurodevelopmental disorder.
            Erratum:[Nat Commun. 2023 Sep 28;14(1):6067. doi:
            10.1038/s41467-023-41869-4.. PMID: 37770591]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2643)
  AUTHORS   Tokunaga,Y., Otsuyama,K.I., Kakuta,S. and Hayashida,N.
  TITLE     Heat Shock Transcription Factor 2 Is Significantly Involved in
            Neurodegenerative Diseases, Inflammatory Bowel Disease, Cancer,
            Male Infertility, and Fetal Alcohol Spectrum Disorder: The Novel
            Mechanisms of Several Severe Diseases
  JOURNAL   Int J Mol Sci 23 (22), 13763 (2022)
   PUBMED   36430241
  REMARK    GeneRIF: Heat Shock Transcription Factor 2 Is Significantly
            Involved in Neurodegenerative Diseases, Inflammatory Bowel Disease,
            Cancer, Male Infertility, and Fetal Alcohol Spectrum Disorder: The
            Novel Mechanisms of Several Severe Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2643)
  AUTHORS   Gupta,N., Sarkar,S., Mehta,P., Sankhwar,S.N. and Rajender,S.
  TITLE     Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate
            with sperm motility in idiopathic infertility
  JOURNAL   Andrologia 54 (9), e14517 (2022)
   PUBMED   35768906
  REMARK    GeneRIF: Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes
            correlate with sperm motility in idiopathic infertility.
REFERENCE   6  (bases 1 to 2643)
  AUTHORS   Walsh,D., Li,Z., Wu,Y. and Nagata,K.
  TITLE     Heat shock and the role of the HSPs during neural plate induction
            in early mammalian CNS and brain development
  JOURNAL   Cell Mol Life Sci 53 (2), 198-211 (1997)
   PUBMED   9118008
  REMARK    Review article
REFERENCE   7  (bases 1 to 2643)
  AUTHORS   Nakai,A., Tanabe,M., Kawazoe,Y., Inazawa,J., Morimoto,R.I. and
            Nagata,K.
  TITLE     HSF4, a new member of the human heat shock factor family which
            lacks properties of a transcriptional activator
  JOURNAL   Mol Cell Biol 17 (1), 469-481 (1997)
   PUBMED   8972228
REFERENCE   8  (bases 1 to 2643)
  AUTHORS   Sheldon,L.A. and Kingston,R.E.
  TITLE     Hydrophobic coiled-coil domains regulate the subcellular
            localization of human heat shock factor 2
  JOURNAL   Genes Dev 7 (8), 1549-1558 (1993)
   PUBMED   8339932
  REMARK    Erratum:[Genes Dev 1994 Feb 1;8(3):386]
REFERENCE   9  (bases 1 to 2643)
  AUTHORS   Sarge,K.D., Zimarino,V., Holm,K., Wu,C. and Morimoto,R.I.
  TITLE     Cloning and characterization of two mouse heat shock factors with
            distinct inducible and constitutive DNA-binding ability
  JOURNAL   Genes Dev 5 (10), 1902-1911 (1991)
   PUBMED   1717345
REFERENCE   10 (bases 1 to 2643)
  AUTHORS   Schuetz,T.J., Gallo,G.J., Sheldon,L., Tempst,P. and Kingston,R.E.
  TITLE     Isolation of a cDNA for HSF2: evidence for two heat shock factor
            genes in humans
  JOURNAL   Proc Natl Acad Sci U S A 88 (16), 6911-6915 (1991)
   PUBMED   1871106
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA741774.1, AK225593.1,
            BC121050.1, BC112323.1 and Z99129.1.
            
            Summary: The protein encoded by this gene belongs to the HSF family
            of transcription factors that bind specifically to the heat-shock
            promoter element and activate transcription. Heat shock
            transcription factors activate heat-shock response genes under
            conditions of heat or other stresses. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2011].
            
            Transcript Variant: This variant (2) lacks an in-frame coding exon
            compared to variant 1. This results in a shorter isoform (b)
            missing an internal protein segment compared to isoform a. Updated
            summary and variant texts. [BR].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.197077.1,
                                           SRR1660803.147713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               DA741774.1         1-111
            112-1827            AK225593.1         38-1753
            1828-2383           BC121050.1         1685-2240
            2384-2484           BC112323.1         2341-2441
            2485-2643           Z99129.1           30172-30330
FEATURES             Location/Qualifiers
     source          1..2643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..2643
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /note="heat shock transcription factor 2"
                     /db_xref="GeneID:3298"
                     /db_xref="HGNC:HGNC:5225"
                     /db_xref="MIM:140581"
     exon            1..280
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1744
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /note="isoform b is encoded by transcript variant 2; heat
                     shock factor protein 2"
                     /codon_start=1
                     /product="heat shock factor protein 2 isoform b"
                     /protein_id="NP_001129036.1"
                     /db_xref="CCDS:CCDS47470.1"
                     /db_xref="GeneID:3298"
                     /db_xref="HGNC:HGNC:5225"
                     /db_xref="MIM:140581"
                     /translation="MKQSSNVPAFLSKLWTLVEETHTNEFITWSQNGQSFLVLDEQRF
                     AKEILPKYFKHNNMASFVRQLNMYGFRKVVHIDSGIVKQERDGPVEFQHPYFKQGQDD
                     LLENIKRKVSSSKPEENKIRQEDLTKIISSAQKVQIKQETIESRLSELKSENESLWKE
                     VSELRAKHAQQQQVIRKIVQFIVTLVQNNQLVSLKRKRPLLLNTNGAQKKNLFQHIVK
                     EPTDNHHHKVPHSRTEGLKPRERISDDIIIYDVTDDNADEENIPVIPETNEDVISDPS
                     NCSQYPDIVIVEDDNEDEYAPVIQSGEQNEPARESLSSGSDGSSPLMSSAVQLNGSSS
                     LTSEDPVTMMDSILNDNINLLGKVELLDYLDSIDCSLEDFQAMLSGRQFSIDPDLLVD
                     SENKGLETTKNNVVQPVSEEGRKSKSKPDKQLIQYTAFPLLAFLDGNPASSVEQASTT
                     ASSEVLSSVDKPIEVDELLDSSLDPEPTQSKLVRLEPLTEAEASEATLFYLCELAPAP
                     LDSDMPLLDS"
     exon            281..389
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..517
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            518..642
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..718
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..780
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            781..868
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1017
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1257
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1363
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1448
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..2643
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2461..2466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /note="hexamer: AATAAA"
     polyA_site      2484
                     /gene="HSF2"
                     /gene_synonym="HSF 2; HSTF 2"
                     /note="major polyA site"
ORIGIN      
        1 acttgtccgt cacgtgcggc cgcccggcct ctcggccttg ccgcgcgcct ggcggggttg
       61 ggggggcggg gaccaagatc tgctgcgcct gcgttgtggg cgttctcggg gagctgctgc
      121 cgtagctgcc gccgccgcta ccaccgcgtt cgggtgtaga atttggaatc cctgcgccgc
      181 gttaacaatg aagcagagtt cgaacgtgcc ggctttcctc agcaagctgt ggacgcttgt
      241 ggaggaaacc cacactaacg agttcatcac ctggagccag aatggccaaa gttttctggt
      301 cttggatgag caacgatttg caaaagaaat tcttcccaaa tatttcaagc acaataatat
      361 ggcaagcttt gtgaggcaac tgaatatgta tggtttccgt aaagtagtac atatcgactc
      421 tggaattgta aagcaagaaa gagatggtcc tgtagaattt cagcatcctt acttcaaaca
      481 aggacaggat gacttgttgg agaacattaa aaggaaggtt tcatcttcaa aaccagaaga
      541 aaataaaatt cgtcaggaag atttaacaaa aattataagt agtgctcaga aggttcagat
      601 aaaacaggaa actattgagt ccaggctttc tgaattaaaa agtgagaatg agtccctttg
      661 gaaggaggtg tcagaattac gagcaaagca tgcacaacag caacaagtta ttcgaaagat
      721 tgtccagttt attgttacat tggttcaaaa taaccaactt gtgagtttaa aacgtaaaag
      781 gcctctactt ctaaacacta atggagccca aaagaagaac ctgtttcagc acatagtcaa
      841 agaaccaact gataatcatc atcataaagt tccacacagt aggactgaag gtttaaagcc
      901 aagggagagg atttcagatg acatcattat ttatgatgtt actgatgata atgcagatga
      961 agaaaatatc ccagttattc cagaaactaa tgaggatgtt atatctgatc cctccaactg
     1021 tagccagtac cctgatattg tcatcgttga agatgacaat gaagatgagt atgcacctgt
     1081 cattcagagt ggagagcaga atgaaccagc cagagaatcc ctaagttcag gcagtgatgg
     1141 cagcagccct ctcatgtcta gtgctgtcca gctaaatggc tcatccagtc tgacctcaga
     1201 agatccagtg accatgatgg attccatttt gaatgataac atcaatcttt tgggaaaggt
     1261 tgagctgttg gattatcttg acagtattga ctgcagttta gaggacttcc aggccatgct
     1321 atcaggaaga caatttagca tagacccaga tctcctggtt gattctgaga ataaaggatt
     1381 agaaactacc aagaacaatg tagttcagcc agtttcggaa gagggaagaa aatctaaatc
     1441 caaaccagat aagcagctta tccagtatac cgcctttcca cttcttgcat tcctcgatgg
     1501 gaaccctgct tcttctgttg aacaggcgag tacaacagca tcatcagaag ttttgtcctc
     1561 tgtagataaa cccatagaag ttgatgagct tctggatagc agcctagacc cagaaccaac
     1621 ccaaagtaag cttgttcgcc tggagccatt gactgaagct gaagctagtg aagctacact
     1681 gttttattta tgtgaacttg ctcctgcacc tctggatagt gatatgccac ttttagatag
     1741 ctaaatcccc aggaagtgga ctttacatgt atatattcat caaaatgatg aactatttat
     1801 tttaaagtat catttggtac tttttttgta aattgctttg ttttgtttaa tcagatactg
     1861 tggaataaaa gcaccttttg cttttctcac taaccacaca ctcttgcaga gctttcaggt
     1921 gttactcagc tgcatagtta cgcagatgta atgcacatta ttggcgtatc tttaagttgg
     1981 attcaaatgg ccatttttct ccaattttgg taaattggat atcttttttt tacaaatacg
     2041 accattaacc tcagttaaat ttttgtttgt tttcctgttt gatgctgtct atttgcattg
     2101 agtgtaagtc atttgaacta atggtataac tcctaaagct ttctctgctc cagttatttt
     2161 tattaaatat ttttcacttg gcttattttt aaaactggga acataaagtg cctgtatctt
     2221 gtaaaacttc atttgtttct tttggttcag agaagttcat ttatgttcaa agacgtttat
     2281 tcatgttcaa caggaaagac aaagtgtacg tgaatgctcg ctgtctgata gggttccagc
     2341 tccatatata tagaaagatc gggggtggga tgggatggag tgagccccat ccagttagtt
     2401 ggactagttt taaataaagg ttttccggtt tgtgtttttt tgaaccatac tgtttagtaa
     2461 aataaataca atgaatgttg agtactagtg tctgttatgt gtcttcttta gaggtgacac
     2521 tcacatgaaa caattttttc ttctcatagg aagcagtagc tttaaactgt ctgtggttca
     2581 ttattctcaa tatgaatcat accaagatat ttgtgcctca tctcgaaaat atattgtata
     2641 ttg
//
