LOCUS       NM_005526               2134 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens heat shock transcription factor 1 (HSF1), mRNA.
ACCESSION   NM_005526 XM_937718
VERSION     NM_005526.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2134)
  AUTHORS   Ciccarelli,M. and Andreasson,C.
  TITLE     Protein Misfolding Releases Human HSF1 from HSP70 Latency Control
  JOURNAL   J Mol Biol 436 (20), 168740 (2024)
   PUBMED   39122169
  REMARK    GeneRIF: Protein Misfolding Releases Human HSF1 from HSP70 Latency
            Control.
REFERENCE   2  (bases 1 to 2134)
  AUTHORS   Pauciullo,S., Riccio,A., Santopolo,S., Albecka,A., Papa,G.,
            James,L.C., Piacentini,S., Lanzilli,G., Rossi,A. and Santoro,M.G.
  TITLE     Human coronaviruses activate and hijack the host transcription
            factor HSF1 to enhance viral replication
  JOURNAL   Cell Mol Life Sci 81 (1), 386 (2024)
   PUBMED   39243335
  REMARK    GeneRIF: Human coronaviruses activate and hijack the host
            transcription factor HSF1 to enhance viral replication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2134)
  AUTHORS   Kizilboga,T., Ozden,C., Can,N.D., Onay Ucar,E. and Dinler
            Doganay,G.
  TITLE     Bag-1-mediated HSF1 phosphorylation regulates expression of heat
            shock proteins in breast cancer cells
  JOURNAL   FEBS Open Bio 14 (9), 1559-1569 (2024)
   PUBMED   39049197
  REMARK    GeneRIF: Bag-1-mediated HSF1 phosphorylation regulates expression
            of heat shock proteins in breast cancer cells.
REFERENCE   4  (bases 1 to 2134)
  AUTHORS   Selvarajan,I., Kiema,M., Huang,R.T., Li,J., Zhu,J., Polonen,P.,
            Ord,T., Ounap,K., Godiwala,M., Golebiewski,A.K., Ravindran,A.,
            Maklin,K., Toropainen,A., Stolze,L.K., Arce,M., Magnusson,P.U.,
            White,S., Romanoski,C.E., Heinaniemi,M., Laakkonen,J.P., Fang,Y.
            and Kaikkonen,M.U.
  TITLE     Coronary Artery Disease Risk Variant Dampens the Expression of
            CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer
            in Endothelial Cells In Vitro
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (6), 1330-1345 (2024)
   PUBMED   38602103
  REMARK    GeneRIF: Coronary Artery Disease Risk Variant Dampens the
            Expression of CALCRL by Reducing HSF Binding to Shear Stress
            Responsive Enhancer in Endothelial Cells In Vitro.
REFERENCE   5  (bases 1 to 2134)
  AUTHORS   Lee,C.J., Choi,B.H., Kim,S.S., Kim,D.N., Kim,T.H., Choi,J.M.,
            Pak,Y. and Park,J.S.
  TITLE     Intermolecular Interactions between Cysteine and Aromatic Amino
            Acids with a Phenyl Moiety in the DNA-Binding Domain of Heat Shock
            Factor 1 Regulate Thermal Stress-Induced Trimerization
  JOURNAL   Biochemistry 63 (10), 1307-1321 (2024)
   PUBMED   38688031
  REMARK    GeneRIF: Intermolecular Interactions between Cysteine and Aromatic
            Amino Acids with a Phenyl Moiety in the DNA-Binding Domain of Heat
            Shock Factor 1 Regulate Thermal Stress-Induced Trimerization.
REFERENCE   6  (bases 1 to 2134)
  AUTHORS   Nunes,S.L. and Calderwood,S.K.
  TITLE     Heat shock factor-1 and the heat shock cognate 70 protein associate
            in high molecular weight complexes in the cytoplasm of NIH-3T3
            cells
  JOURNAL   Biochem Biophys Res Commun 213 (1), 1-6 (1995)
   PUBMED   7639722
REFERENCE   7  (bases 1 to 2134)
  AUTHORS   Green,M., Schuetz,T.J., Sullivan,E.K. and Kingston,R.E.
  TITLE     A heat shock-responsive domain of human HSF1 that regulates
            transcription activation domain function
  JOURNAL   Mol Cell Biol 15 (6), 3354-3362 (1995)
   PUBMED   7760831
REFERENCE   8  (bases 1 to 2134)
  AUTHORS   Abravaya,K., Myers,M.P., Murphy,S.P. and Morimoto,R.I.
  TITLE     The human heat shock protein hsp70 interacts with HSF, the
            transcription factor that regulates heat shock gene expression
  JOURNAL   Genes Dev 6 (7), 1153-1164 (1992)
   PUBMED   1628823
REFERENCE   9  (bases 1 to 2134)
  AUTHORS   Schuetz,T.J., Gallo,G.J., Sheldon,L., Tempst,P. and Kingston,R.E.
  TITLE     Isolation of a cDNA for HSF2: evidence for two heat shock factor
            genes in humans
  JOURNAL   Proc Natl Acad Sci U S A 88 (16), 6911-6915 (1991)
   PUBMED   1871106
REFERENCE   10 (bases 1 to 2134)
  AUTHORS   Rabindran,S.K., Giorgi,G., Clos,J. and Wu,C.
  TITLE     Molecular cloning and expression of a human heat shock factor, HSF1
  JOURNAL   Proc Natl Acad Sci U S A 88 (16), 6906-6910 (1991)
   PUBMED   1871105
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M64673.1 and BU617486.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005526.3.
            
            Summary: The product of this gene is a transcription factor that is
            rapidly induced after temperature stress and binds heat shock
            promoter elements (HSE). This protein plays a role in the
            regulation of lifespan. Expression of this gene is repressed by
            phosphorylation, which promotes binding by heat shock protein 90.
            [provided by RefSeq, Jul 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222497.1, M64673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000528838.6/ ENSP00000431512.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2131              M64673.1           7-2137
            2132-2134           BU617486.1         25-27               c
FEATURES             Location/Qualifiers
     source          1..2134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2134
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /note="heat shock transcription factor 1"
                     /db_xref="GeneID:3297"
                     /db_xref="HGNC:HGNC:5224"
                     /db_xref="MIM:140580"
     exon            1..271
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1744
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /codon_start=1
                     /product="heat shock factor protein 1"
                     /protein_id="NP_005517.1"
                     /db_xref="CCDS:CCDS6419.1"
                     /db_xref="GeneID:3297"
                     /db_xref="HGNC:HGNC:5224"
                     /db_xref="MIM:140580"
                     /translation="MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSF
                     HVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHP
                     CFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLA
                     MKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGS
                     AHSMPKYSRQFSLEHVHGSGPYSAPSPAYSSSSLYAPDAVASSGPIISDITELAPASP
                     MASPGGSIDERPLSSSPLVRVKEEPPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSI
                     LRESEPAPASVTALTDARGHTDTEGRPPSPPPTSTPEKCLSVACLDKNELSDHLDAMD
                     SNLDNLQTMLSSHGFSVDTSALLDLFSPSVTVPDMSLPDLDSSLASIQELLSPQEPPR
                     PPEAENSSPDSGKQLVHYTAQPLFLLDPGSVDTGSNDLPVLFELGEGSYFSEGDGFAE
                     DPTISLLTGSEPPKAKDPTVS"
     exon            272..380
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..517
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..642
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..718
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..780
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..877
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1014
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1296
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1402
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1468
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1538
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..2134
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2113..2118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /note="hexamer: TATAAA"
     polyA_site      2134
                     /gene="HSF1"
                     /gene_synonym="HSTF1"
                     /note="major polyA site"
ORIGIN      
        1 cgttgcaaga tggcggcggc catgctgggc cccggggctg tgtgtgcgca gcgggcggcg
       61 gcgcggcccg gaaggctggc gcggcgacgg cgttagcccg gccctcggcc cctctttgcg
      121 gccgctccct ccgcctattc cctccttgct cgagatggat ctgcccgtgg gccccggcgc
      181 ggcggggccc agcaacgtcc cggccttcct gaccaagctg tggaccctcg tgagcgaccc
      241 ggacaccgac gcgctcatct gctggagccc gagcgggaac agcttccacg tgttcgacca
      301 gggccagttt gccaaggagg tgctgcccaa gtacttcaag cacaacaaca tggccagctt
      361 cgtgcggcag ctcaacatgt atggcttccg gaaagtggtc cacatcgagc agggcggcct
      421 ggtcaagcca gagagagacg acacggagtt ccagcaccca tgcttcctgc gtggccagga
      481 gcagctcctt gagaacatca agaggaaagt gaccagtgtg tccaccctga agagtgaaga
      541 cataaagatc cgccaggaca gcgtcaccaa gctgctgacg gacgtgcagc tgatgaaggg
      601 gaagcaggag tgcatggact ccaagctcct ggccatgaag catgagaatg aggctctgtg
      661 gcgggaggtg gccagccttc ggcagaagca tgcccagcaa cagaaagtcg tcaacaagct
      721 cattcagttc ctgatctcac tggtgcagtc aaaccggatc ctgggggtga agagaaagat
      781 ccccctgatg ctgaacgaca gtggctcagc acattccatg cccaagtata gccggcagtt
      841 ctccctggag cacgtccacg gctcgggccc ctactcggcc ccctccccag cctacagcag
      901 ctccagcctc tacgcccctg atgctgtggc cagctctgga cccatcatct ccgacatcac
      961 cgagctggct cctgccagcc ccatggcctc ccccggcggg agcatagacg agaggcccct
     1021 atccagcagc cccctggtgc gtgtcaagga ggagcccccc agcccgcctc agagcccccg
     1081 ggtagaggag gcgagtcccg ggcgcccatc ttccgtggac accctcttgt ccccgaccgc
     1141 cctcattgac tccatcctgc gggagagtga acctgccccc gcctccgtca cagccctcac
     1201 ggacgccagg ggccacacgg acaccgaggg ccggcctccc tcccccccgc ccacctccac
     1261 ccctgaaaag tgcctcagcg tagcctgcct ggacaagaat gagctcagtg accacttgga
     1321 tgctatggac tccaacctgg ataacctgca gaccatgctg agcagccacg gcttcagcgt
     1381 ggacaccagt gccctgctgg acctgttcag cccctcggtg accgtgcccg acatgagcct
     1441 gcctgacctt gacagcagcc tggccagtat ccaagagctc ctgtctcccc aggagccccc
     1501 caggcctccc gaggcagaga acagcagccc ggattcaggg aagcagctgg tgcactacac
     1561 agcgcagccg ctgttcctgc tggaccccgg ctccgtggac accgggagca acgacctgcc
     1621 ggtgctgttt gagctgggag agggctccta cttctccgaa ggggacggct tcgccgagga
     1681 ccccaccatc tccctgctga caggctcgga gcctcccaaa gccaaggacc ccactgtctc
     1741 ctagaggccc cggaggagct gggccagccg cccaccccca cccccagtgc agggctggtc
     1801 ttggggaggc agggcagcct cgcggtcttg ggcactggtg ggtcggccgc catagcccca
     1861 gtaggacaaa cgggctcggg tctgggcagc acctctggtc aggagggtca ccctggcctg
     1921 ccagtctgcc ttcccccaac cccgtgtcct gtggtttggt tggggcttca cagccacacc
     1981 tggactgacc ctgcaggttg ttcatagtca gaattgtatt ttggattttt acacaactgt
     2041 cccgttcccc gctccacaga gatacacaga tatatacaca cagtggatgg acggacaaga
     2101 caggcagaga tctataaaca gacaggctct atgc
//
