LOCUS       NM_032303               3174 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens hydroxysteroid dehydrogenase like 2 (HSDL2),
            transcript variant 1, mRNA.
ACCESSION   NM_032303
VERSION     NM_032303.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3174)
  AUTHORS   Wang,D., Yang,S., Lyu,M., Xu,L., Zhong,S. and Yu,D.
  TITLE     Circular RNA HSDL2 promotes breast cancer progression via miR-7978
            ZNF704 axis and regulating hippo signaling pathway
  JOURNAL   Breast Cancer Res 26 (1), 105 (2024)
   PUBMED   38937788
  REMARK    GeneRIF: Circular RNA HSDL2 promotes breast cancer progression via
            miR-7978 ZNF704 axis and regulating hippo signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3174)
  AUTHORS   Samson,N., Bosoi,C.R., Roy,C., Turcotte,L., Tribouillard,L.,
            Mouchiroud,M., Berthiaume,L., Trottier,J., Silva,H.C.G.,
            Guerbette,T., Plata-Gomez,A.B., Besse-Patin,A., Montoni,A.,
            Ilacqua,N., Lamothe,J., Citron,Y.R., Gelinas,Y., Gobeil,S.,
            Zoncu,R., Caron,A., Morissette,M., Pellegrini,L., Rochette,P.J.,
            Estall,J.L., Efeyan,A., Shum,M., Audet-Walsh,E., Barbier,O.,
            Marette,A. and Laplante,M.
  TITLE     HSDL2 links nutritional cues to bile acid and cholesterol
            homeostasis
  JOURNAL   Sci Adv 10 (22), eadk9681 (2024)
   PUBMED   38820148
  REMARK    GeneRIF: HSDL2 links nutritional cues to bile acid and cholesterol
            homeostasis.
REFERENCE   3  (bases 1 to 3174)
  AUTHORS   Ma,S., Ma,Y., Qi,F., Lei,J., Chen,F., Sun,W., Wang,D., Zhou,S.,
            Liu,Z., Lu,Z. and Zhang,D.
  TITLE     HSDL2 knockdown promotes the progression of cholangiocarcinoma by
            inhibiting ferroptosis through the P53/SLC7A11 axis
  JOURNAL   World J Surg Oncol 21 (1), 293 (2023)
   PUBMED   37718459
  REMARK    GeneRIF: HSDL2 knockdown promotes the progression of
            cholangiocarcinoma by inhibiting ferroptosis through the
            P53/SLC7A11 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3174)
  AUTHORS   Cheng,Y., He,X., Wang,L., Xu,Y., Shen,M., Zhang,W., Xia,Y.,
            Zhang,J., Zhang,M., Wang,Y., Hu,J. and Hu,J.
  TITLE     [HSDL2 overexpression promotes rectal cancer progression by
            regulating cancer cell cycle and promoting cell proliferation]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (4), 544-551 (2023)
   PUBMED   37202189
  REMARK    GeneRIF: [HSDL2 overexpression promotes rectal cancer progression
            by regulating cancer cell cycle and promoting cell proliferation].
REFERENCE   5  (bases 1 to 3174)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 3174)
  AUTHORS   Kowalik,D., Haller,F., Adamski,J. and Moeller,G.
  TITLE     In search for function of two human orphan SDR enzymes:
            hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain
            dehydrogenase/reductase-orphan (SDR-O)
  JOURNAL   J Steroid Biochem Mol Biol 117 (4-5), 117-124 (2009)
   PUBMED   19703561
REFERENCE   7  (bases 1 to 3174)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   8  (bases 1 to 3174)
  AUTHORS   Skogsberg,J., Lundstrom,J., Kovacs,A., Nilsson,R., Noori,P.,
            Maleki,S., Kohler,M., Hamsten,A., Tegner,J. and Bjorkegren,J.
  TITLE     Transcriptional profiling uncovers a network of
            cholesterol-responsive atherosclerosis target genes
  JOURNAL   PLoS Genet 4 (3), e1000036 (2008)
   PUBMED   18369455
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3174)
  AUTHORS   Edqvist,J. and Blomqvist,K.
  TITLE     Fusion and fission, the evolution of sterol carrier protein-2
  JOURNAL   J Mol Evol 62 (3), 292-306 (2006)
   PUBMED   16501878
REFERENCE   10 (bases 1 to 3174)
  AUTHORS   Dai,J., Xie,Y., Wu,Q., Wang,L., Yin,G., Ye,X., Zeng,L., Xu,J.,
            Ji,C., Gu,S., Huang,Q., Zhao,R.C. and Mao,Y.
  TITLE     Molecular cloning and characterization of a novel human
            hydroxysteroid dehydrogenase-like 2 (HSDL2) cDNA from fetal brain
  JOURNAL   Biochem Genet 41 (5-6), 165-174 (2003)
   PUBMED   12834046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098721.1, BC095451.1, AY093428.1 and BC004331.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032303.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.236544.1,
                                           SRR1803613.62003.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398805.8/ ENSP00000381785.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK098721.1         171-194
            25-2882             BC095451.1         1-2858
            2883-3100           AY093428.1         2921-3138
            3101-3174           BC004331.1         2910-2983
FEATURES             Location/Qualifiers
     source          1..3174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..3174
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /note="hydroxysteroid dehydrogenase like 2"
                     /db_xref="GeneID:84263"
                     /db_xref="HGNC:HGNC:18572"
     exon            1..73
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1313
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hydroxysteroid dehydrogenase-like protein 2; short chain
                     dehydrogenase/reductase family 13C member 1"
                     /codon_start=1
                     /product="hydroxysteroid dehydrogenase-like protein 2
                     isoform 1"
                     /protein_id="NP_115679.2"
                     /db_xref="CCDS:CCDS43864.1"
                     /db_xref="GeneID:84263"
                     /db_xref="HGNC:HGNC:18572"
                     /translation="MLPNTGRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTA
                     QPHPKLLGTIYTAAEEIEAVGGKALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNA
                     SAISLTNTLDTPTKRLDLMMNVNTRGTYLASKACIPYLKKSKVAHILNISPPLNLNPV
                     WFKQHCAYTIAKYGMSMYVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQC
                     RKVDIIADAAYSIFQKPKSFTGNFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDE
                     YPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGAVEETFRIVKDSLSDDVVKATQAIYL
                     FELSGEDGGTWFLDLKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKPTMAFMS
                     GKLKIKGNMALAIKLEKLMNQMNARL"
     exon            74..237
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..336
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            337..451
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..555
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..654
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..849
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..921
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1071
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1200
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..3174
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2440..2445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /note="hexamer: AATAAA"
     polyA_site      2466
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /note="major polyA site"
     regulatory      3152..3157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /note="hexamer: AATAAA"
     polyA_site      3174
                     /gene="HSDL2"
                     /gene_synonym="C9orf99; SDR13C1"
                     /note="major polyA site"
ORIGIN      
        1 agctctctgc tcgccgccgc cgctgtcgcc gccacctcct ctgatctacg aaagtcatgt
       61 tacccaacac cgggaggctg gcaggatgta cagtttttat cacaggtgca agccgtggca
      121 ttggcaaagc tattgcattg aaagcagcaa aggatggagc aaatattgtt attgctgcaa
      181 agaccgccca gccacatcca aaacttctag gcacaatcta tactgctgct gaagaaattg
      241 aagcagttgg aggaaaggcc ttgccatgta ttgttgatgt gagagatgaa cagcagatca
      301 gtgctgcagt ggagaaagcc atcaagaaat ttggaggaat tgatattctg gtaaataatg
      361 ccagtgccat tagtttgacc aatacattgg acacacctac caagagattg gatctgatga
      421 tgaacgtgaa caccagaggc acctaccttg catctaaagc atgtattcct tatttgaaaa
      481 agagcaaagt tgctcatatc ctcaatatca gtccaccact gaacctaaat ccagtttggt
      541 tcaaacagca ctgtgcttat accattgcta agtatggtat gtctatgtat gtgcttggaa
      601 tggcagaaga atttaaaggt gaaattgcag tcaatgcatt atggcctaaa acagccatac
      661 acactgctgc tatggatatg ctgggaggac ctggtatcga aagccagtgt agaaaagttg
      721 atatcattgc agatgcagca tattccattt tccaaaagcc aaaaagtttt actggcaact
      781 ttgtcattga tgaaaatatc ttaaaagaag aaggaataga aaattttgac gtttatgcaa
      841 ttaaaccagg tcatcctttg caaccagatt tcttcttaga tgaataccca gaagcagtta
      901 gcaagaaagt ggaatcaact ggtgctgttc cagaattcaa agaagagaaa ctgcagctgc
      961 aaccaaaacc acgttctgga gctgtggaag aaacatttag aattgttaag gactctctca
     1021 gtgatgatgt tgttaaagcc actcaagcaa tctatctgtt tgaactctcc ggtgaagatg
     1081 gtggcacgtg gtttcttgat ctgaaaagca agggtgggaa tgtcggatat ggagagcctt
     1141 ctgatcaggc agatgtggtg atgagtatga ctactgatga ctttgtaaaa atgttttcag
     1201 ggaaactaaa accaacaatg gcattcatgt cagggaaatt gaagattaaa ggtaacatgg
     1261 ccctagcaat caaattggag aagctaatga atcagatgaa tgccagactg tgaaggaaaa
     1321 tataaaaaaa aagtcgactg ctatgctcaa aaagtaaaaa aagctcaaca gttaaaatct
     1381 aatgtttgtt ttctttcctg ttatattata aggatatgca cgtttgttct ggaaaagata
     1441 gaatttgtct ctaaaagact tgaaattgta attaaaatgg caagctaatc aaacataagc
     1501 ttcattaagt gggattctaa gacagtctgt gtttttatat ttcaagggtt taaccctttg
     1561 agccttacat ctcattcact gtctttctcc aagaaaagta ttttgggcgg acagtcagat
     1621 caagcagtaa aattagctct ttcaaatctt cttgtcatgt aaaatgaagc tagtctgttt
     1681 taaaattttt agttttggat tgtatactaa tgaaaatctt aatgatgttt ttgattttta
     1741 tatacttatt ttaaagaaaa tcttatatag tacattttac aaaaattata aaaaatgaat
     1801 tagtactggc gaggactaaa tgaaacaata atttttcatt ttgataacta gctttccagg
     1861 tggacttagc cataggaaaa tattactaat gtaatttaac aaattgctgc atgtattcca
     1921 tttaaaaata tgtttaaatt gtcctaaaac aaaataattt tctccctagg agtatgcatt
     1981 tggctacagt gttttgaaac agaaacctta gaataggtca ttggtatggg ctgaactgtg
     2041 tatcccccaa ttcatttgtt gaggtcctaa ctcccatttc ttttgaatgt gactgttcgg
     2101 agatgaggcc tttaaagagg tgacttaagt tcaaaggagg ctgttagtct aatccaacat
     2161 ggtgtccttt ggacataaga gataccagca atgtgtgcac agaacaaaga ccaggagagg
     2221 acacagtgag aaggcagtta tctgcaagca aagagagagg cttcagaaga aacaaaatca
     2281 ccagcacctt gatctttgac ttctaatctc cagaatagtg agaaataaat ttctgttgtt
     2341 aagccgtcca ctgtgggagg ccgacgcagg aggattgctt gaggccagga gttcaaggcc
     2401 agcctggaca acatagtaag accctatctc taccccccta ataaattaat ttaaaaagcc
     2461 ccccaatctg tggtatttta ttatggcagc cctagcaagc taatacagtg gtttgagagg
     2521 ctgggagggt tgaggggaag ataaactttt aaaaagctct tatctttcat ttcaatcagt
     2581 taaaaatact tgctcagtgt aacaattttg cttctcagct tccactctaa tattgttgtg
     2641 ccattaagca atttagctaa tcctgacatt tcttagattc ataatgttag gagcatttaa
     2701 tctgtatttt acaagttagg aagcagagga tcagagatgg gaaaggacta gcccaaggcc
     2761 aacattaaca agccctctaa caaaaacttt acaatacatt tatgttgaat ggaactccaa
     2821 gatctcacct ctccatccag gaatggagtc catgtaatca aagtgaactt aaaaatagga
     2881 cagtttcaac aagtcaggag attcacagca actgatcaaa gggagtccag tcaacgtgag
     2941 caagcgtgat tatgatgagg aagccccctc tgctttaatc cacacaagga acgtaacctg
     3001 aagtaacctg atgttaacca atctgctgtg tctactatgc tgtttccttg ttcctgctag
     3061 tgctgcttta caaatgcaga ccattctatc atacctggcg gggcttctgt tttattttgt
     3121 aggctggatg ctacccagtt catgaatcgc taataaaagc caattagatc ttta
//
