LOCUS       NM_031463               3648 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens hydroxysteroid dehydrogenase like 1 (HSDL1),
            transcript variant 1, mRNA.
ACCESSION   NM_031463
VERSION     NM_031463.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3648)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3648)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3648)
  AUTHORS   Persson,B., Kallberg,Y., Bray,J.E., Bruford,E., Dellaporta,S.L.,
            Favia,A.D., Duarte,R.G., Jornvall,H., Kavanagh,K.L., Kedishvili,N.,
            Kisiela,M., Maser,E., Mindnich,R., Orchard,S., Penning,T.M.,
            Thornton,J.M., Adamski,J. and Oppermann,U.
  TITLE     The SDR (short-chain dehydrogenase/reductase and related enzymes)
            nomenclature initiative
  JOURNAL   Chem Biol Interact 178 (1-3), 94-98 (2009)
   PUBMED   19027726
REFERENCE   4  (bases 1 to 3648)
  AUTHORS   Meier,M., Tokarz,J., Haller,F., Mindnich,R. and Adamski,J.
  TITLE     Human and zebrafish hydroxysteroid dehydrogenase like 1 (HSDL1)
            proteins are inactive enzymes but conserved among species
  JOURNAL   Chem Biol Interact 178 (1-3), 197-205 (2009)
   PUBMED   19026618
  REMARK    GeneRIF: characterized the subcellular localization as well as the
            tissue distribution and performed a screen for putative substrates
            of HSDL1 enzymes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC306668.1, AK074878.1, BC018084.1, AY028377.1, AK025626.1,
            DB525323.1 and H40440.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031463.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.93034.1,
                                           SRR1660809.193253.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219439.9/ ENSP00000219439.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DC306668.1         19-36
            19-1145             AK074878.1         1-1127
            1146-2217           BC018084.1         1157-2228
            2218-2782           AY028377.1         2100-2664
            2783-2951           AK074878.1         2765-2933
            2952-3508           AK025626.1         2081-2637
            3509-3644           DB525323.1         298-433
            3645-3648           H40440.1           10-13               c
FEATURES             Location/Qualifiers
     source          1..3648
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..3648
                     /gene="HSDL1"
                     /gene_synonym="SDR12C3"
                     /note="hydroxysteroid dehydrogenase like 1"
                     /db_xref="GeneID:83693"
                     /db_xref="HGNC:HGNC:16475"
                     /db_xref="MIM:619067"
     exon            1..98
                     /gene="HSDL1"
                     /gene_synonym="SDR12C3"
                     /inference="alignment:Splign:2.1.0"
     exon            99..160
                     /gene="HSDL1"
                     /gene_synonym="SDR12C3"
                     /inference="alignment:Splign:2.1.0"
     exon            161..386
                     /gene="HSDL1"
                     /gene_synonym="SDR12C3"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1159
                     /gene="HSDL1"
                     /gene_synonym="SDR12C3"
                     /note="isoform a is encoded by transcript variant 1;
                     inactive hydroxysteroid dehydrogenase-like protein 1;
                     steroid dehydrogenase-like protein; short chain
                     dehydrogenase/reductase family 12C member 3"
                     /codon_start=1
                     /product="inactive hydroxysteroid dehydrogenase-like
                     protein 1 isoform a"
                     /protein_id="NP_113651.4"
                     /db_xref="CCDS:CCDS10942.1"
                     /db_xref="GeneID:83693"
                     /db_xref="HGNC:HGNC:16475"
                     /db_xref="MIM:619067"
                     /translation="MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDF
                     YSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEE
                     KLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQ
                     YFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAF
                     SASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYA
                     HHAVSTLGISKRTTGYWSHSIQFLFAQYMPEWLWVWGANILNRSLRKEALSCTA"
     exon            387..832
                     /gene="HSDL1"
                     /gene_synonym="SDR12C3"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1060
                     /gene="HSDL1"
                     /gene_synonym="SDR12C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..3648
                     /gene="HSDL1"
                     /gene_synonym="SDR12C3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3479..3484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSDL1"
                     /gene_synonym="SDR12C3"
                     /note="hexamer: AATAAA"
     polyA_site      3508
                     /gene="HSDL1"
                     /gene_synonym="SDR12C3"
                     /note="major polyA site"
     regulatory      3621..3626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSDL1"
                     /gene_synonym="SDR12C3"
                     /note="hexamer: ATTAAA"
     polyA_site      3648
                     /gene="HSDL1"
                     /gene_synonym="SDR12C3"
ORIGIN      
        1 gtgagggcgc ggcgcggcag cagctccggc ggccgagacg ggggcggcgg ccgcgcgggt
       61 ctggcgggac cggtttggaa gactttgccg gcctgcagat tggccttaag agaaggacgg
      121 agccacatac tgctgacggc ccagaactgg cagagagaag gttgccatgg ctgctgttga
      181 cagtttctac ctcttgtaca gggaaatcgc caggtcttgc aattgctata tggaagctct
      241 agctttggtt ggagcctggt atacggccag aaaaagcatc actgtcatct gtgactttta
      301 cagcctgatc aggctgcatt ttatcccccg cctggggagc agagcagact tgatcaagca
      361 gtatggaaga tgggccgttg tcagcggtgc aacagatggg attggaaaag cctacgctga
      421 agagttagca agccgaggtc tcaatataat cctgattagt cggaacgagg agaagttgca
      481 ggttgttgct aaagacatag ccgacacgta caaagtggaa actgatatta tagttgcgga
      541 cttcagcagc ggtcgtgaga tctaccttcc aattcgagaa gccctgaagg acaaagacgt
      601 tggcatcttg gtaaataacg tgggtgtgtt ttatccctac ccgcagtatt tcactcagct
      661 gtccgaggac aagctctggg acatcataaa tgtgaacatt gccgccgcta gtttgatggt
      721 ccatgttgtg ttaccgggaa tggtggagag aaagaaaggt gccatcgtca cgatctcttc
      781 tggctcctgc tgcaaaccca ctcctcagct ggctgcattt tctgcttcta aggcttattt
      841 agaccacttc agcagagcct tgcaatatga atatgcctct aaaggaatct ttgtacagag
      901 tctaatccct ttctatgtag ccaccagcat gacagcaccc agcaactttc tgcacaggtg
      961 ctcgtggttg gtgccttcgc caaaagtcta tgcacatcat gctgtttcta ctcttgggat
     1021 ttccaaaagg accacaggat attggtccca ttctattcag tttctttttg cacagtatat
     1081 gcctgaatgg ctctgggtgt ggggagcaaa tattctcaac cgttcactac gtaaggaagc
     1141 cttatcctgc acagcctgag tctggatggc cacttgagaa gttttgccaa ctcctgggaa
     1201 cctcgatatt ctgacatttg gaaaaacaca tttaatttat ctcctgtgtt tcattgctga
     1261 ttattcagca tactgttgat tcgtcatttg caaaacacac ataataccgt cagagtgctg
     1321 tgaaaaacct taagggtgtg tggatggcac aggatcaata atgcctgagg ctgattgacg
     1381 acatctacat ttcagtgctt tttccctaag ctgtttgaaa gttacgcttt tctgttgttc
     1441 tagagccaca gcagtctaat attgaaatat aatatgattt gtcaggtctt ataatttcag
     1501 atgttgtttt ttaagggaaa ttgaccattt cactagagga gttgtgctgg tttttaaatg
     1561 tgcatcaaga aagactactg aaaagtatta ttttgtaact aagattgctg gtactattag
     1621 gaaaaatctg tgtgtattgt atagctctag ctgtttgact atctgtaatg aaaatgctgc
     1681 acttcaactg gtatttcatt agagaaccgt gtgtgtgcgt gtgtgtggtg cctttgagca
     1741 actttattta tggttaccat atttttaaaa agattttttg tcagggtgac ttaacatgga
     1801 ctcttatagg gtattaaaac aatctagatt attccttttc atcctaaata agcctaccaa
     1861 atttcatgct gttggtttgc catgaatgat attacttcct acattatatt tgtgtttttt
     1921 caaatctgct atggaatgaa cttattccta gatttggata tgtaagagaa acctgcagtc
     1981 atcttttgat ttataaggca attcttgtgg ataaatagtg atttctcagc ctctgaccca
     2041 ttttataact gaaatttagc cctttagagc ttgttatatc tggttttcct acgtttttct
     2101 atgtaatatt attccattcc agtagcatta ttgatagaaa tagtaagtat ttatggaata
     2161 gtaaaatatg gacaaattac gtgtgtgaca tatctgtcaa tataagttag aagcttattc
     2221 ttggtttgtg taatgaattt atgtattgta gtgaatacct ttactggtgt gaagataatt
     2281 atgcacaaac cctcacaata cgcgttaaca ttgaaacctg tgaaatgtcc ttagtttggg
     2341 tcatataaag ccaaccattt ttgaggacca tgtacctagt gctttgaaaa ctctaagtca
     2401 ctatatgaat atgacaatat gtgcacattt aaaattcaga gctcggcatt gtgatactga
     2461 tgcagaagct agtagattgg ttaaaagtct ggacttctgt ggcatttttt tcgtgacgtg
     2521 ataatctatc ataagcagac ctaagcacag ttttatgaac acaattttgc ccatgacatt
     2581 gcctacagga tttccagatg tgacttgcac tcagaagatc agtggtcaac ttcagaagct
     2641 cttccacgct tagatcatgt cttcagaact tagatgtgaa aatctacaca ctgggagatg
     2701 ctgtgagccc caaggttttg atggagtttg cttggaatcc tcttgacttc atgccacatt
     2761 gacgtgaact ttgatgtata ataagcagca gcaacttcat gtgaaaatat ggtcaggtag
     2821 ttatatgtaa ggttacgtgg tccagtaatg tcttagattg ataaattagg tatggaatcc
     2881 atcagtgtta cgtgatgaga ataggtgaac acaccttgtc agtgatgatg taaacttctc
     2941 tccttggcag gacatgggca aacatgctga ttggtgcaaa tgtggtgccg agctgtccat
     3001 agctgcagtg aaagatgaag agcaagacct tctctaggtt ttctagcttt cattaaatgt
     3061 atttttttcc ccagagctaa tttgaaagtt gattggacca ctgtggatgg ggtgtcatta
     3121 agaatgtggg aaataggggc cgagtgcggt ggctcacacc tgtaatccca gcagtttgga
     3181 aggccagggc aggtggatcg cttgatccca ggaggtcgag accagcctgg ggaacacatc
     3241 ctgtctctac aaaaaataca aaaattagcc aggcagggtg gtgcatgcct gtagtcccag
     3301 ctacttggga ggctgaggca ggagaatttt ttgagcccag gatgcagagg ttgaagtgag
     3361 ccaagatcgt gccactgcac tccagccttg agacagagcg agaccctgtc tcaaaaaaaa
     3421 aaaaagaacg tgggaaatat gaacctttga aagttaatct gtgaattgaa agtttaacaa
     3481 taaaagtagt tgtttgtttc ctttggaaga gttttgttcc agatgtttgt aatttggttg
     3541 tttgtaattt ggaatgagag aatttttttt tcttaggagt gattgcaaga aattaacatg
     3601 aacaacagtg gtcataactg attaaaagct gacacgtcag taacaaaa
//
