LOCUS       NM_014234                977 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens hydroxysteroid 17-beta dehydrogenase 8 (HSD17B8),
            mRNA.
ACCESSION   NM_014234
VERSION     NM_014234.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 977)
  AUTHORS   Nie,Y., Huang,F., Lou,L. and Yan,J.
  TITLE     The Obesity-Related Metabolic Gene HSD17B8 Protects Against Breast
            Cancer: High RNA/Protein Expression Means a Better Prognosis
  JOURNAL   Med Sci Monit 28, e934424 (2022)
   PUBMED   35184130
  REMARK    GeneRIF: The Obesity-Related Metabolic Gene HSD17B8 Protects
            Against Breast Cancer: High RNA/Protein Expression Means a Better
            Prognosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 977)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 977)
  AUTHORS   Venkatesan,R., Sah-Teli,S.K., Awoniyi,L.O., Jiang,G., Prus,P.,
            Kastaniotis,A.J., Hiltunen,J.K., Wierenga,R.K. and Chen,Z.
  TITLE     Insights into mitochondrial fatty acid synthesis from the structure
            of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA
            dehydrogenase
  JOURNAL   Nat Commun 5, 4805 (2014)
   PUBMED   25203508
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 977)
  AUTHORS   Xie,G., Roshandel,D., Sherva,R., Monach,P.A., Lu,E.Y., Kung,T.,
            Carrington,K., Zhang,S.S., Pulit,S.L., Ripke,S., Carette,S.,
            Dellaripa,P.F., Edberg,J.C., Hoffman,G.S., Khalidi,N.,
            Langford,C.A., Mahr,A.D., St Clair,E.W., Seo,P., Specks,U.,
            Spiera,R.F., Stone,J.H., Ytterberg,S.R., Raychaudhuri,S., de
            Bakker,P.I., Farrer,L.A., Amos,C.I., Merkel,P.A. and
            Siminovitch,K.A.
  TITLE     Association of granulomatosis with polyangiitis (Wegener's) with
            HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide
            analysis
  JOURNAL   Arthritis Rheum 65 (9), 2457-2468 (2013)
   PUBMED   23740775
REFERENCE   5  (bases 1 to 977)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 977)
  AUTHORS   Kutsenko,A.S., Gizatullin,R.Z., Al-Amin,A.N., Wang,F., Kvasha,S.M.,
            Podowski,R.M., Matushkin,Y.G., Gyanchandani,A., Muravenko,O.V.,
            Levitsky,V.G., Kolchanov,N.A., Protopopov,A.I., Kashuba,V.I.,
            Kisselev,L.L., Wasserman,W., Wahlestedt,C. and Zabarovsky,E.R.
  TITLE     NotI flanking sequences: a tool for gene discovery and verification
            of the human genome
  JOURNAL   Nucleic Acids Res 30 (14), 3163-3170 (2002)
   PUBMED   12136098
REFERENCE   7  (bases 1 to 977)
  AUTHORS   Aziz,N., Anderson,E., Lee,G.Y. and Woo,D.D.
  TITLE     Arrested testis development in the cpk mouse may be the result of
            abnormal steroid metabolism
  JOURNAL   Mol Cell Endocrinol 171 (1-2), 83-88 (2001)
   PUBMED   11165015
REFERENCE   8  (bases 1 to 977)
  AUTHORS   Fomitcheva,J., Baker,M.E., Anderson,E., Lee,G.Y. and Aziz,N.
  TITLE     Characterization of Ke 6, a new 17beta-hydroxysteroid
            dehydrogenase, and its expression in gonadal tissues
  JOURNAL   J Biol Chem 273 (35), 22664-22671 (1998)
   PUBMED   9712896
REFERENCE   9  (bases 1 to 977)
  AUTHORS   Kikuti,Y.Y., Tamiya,G., Ando,A., Chen,L., Kimura,M., Ferreira,E.,
            Tsuji,K., Trowsdale,J. and Inoko,H.
  TITLE     Physical mapping 220 kb centromeric of the human MHC and DNA
            sequence analysis of the 43-kb segment including the RING1, HKE6,
            and HKE4 genes
  JOURNAL   Genomics 42 (3), 422-435 (1997)
   PUBMED   9205114
REFERENCE   10 (bases 1 to 977)
  AUTHORS   Ando,A., Kikuti,Y.Y., Shigenari,A., Kawata,H., Okamoto,N.,
            Shiina,T., Chen,L., Ikemura,T., Abe,K., Kimura,M. and Inoko,H.
  TITLE     cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes
            at the centromeric end of the human MHC region
  JOURNAL   Genomics 35 (3), 600-602 (1996)
   PUBMED   8812499
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC008185.1 and AW025057.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014234.4.
            
            Summary: In mice, the Ke6 protein is a 17-beta-hydroxysteroid
            dehydrogenase that can regulate the concentration of biologically
            active estrogens and androgens. It is preferentially an oxidative
            enzyme and inactivates estradiol, testosterone, and
            dihydrotestosterone. However, the enzyme has some reductive
            activity and can synthesize estradiol from estrone. The protein
            encoded by this gene is similar to Ke6 and is a member of the
            short-chain dehydrogenase superfamily. An alternatively spliced
            transcript of this gene has been detected, but the full-length
            nature of this variant has not been determined. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.81525.1, BC008185.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374662.4/ ENSP00000363794.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-968               BC008185.1         14-981
            969-977             AW025057.1         8-16                c
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..977
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /note="hydroxysteroid 17-beta dehydrogenase 8"
                     /db_xref="GeneID:7923"
                     /db_xref="HGNC:HGNC:3554"
                     /db_xref="MIM:601417"
     exon            1..66
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..800
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.239"
                     /EC_number="1.1.1.n12"
                     /note="17-beta-hydroxysteroid dehydrogenase 8; 17-beta-HSD
                     8; estrogen 17-oxidoreductase; estradiol
                     17-beta-dehydrogenase 8; short chain
                     dehydrogenase/reductase family 30C member 1; ke-6; protein
                     Ke6; testosterone 17-beta-dehydrogenase 8; really
                     interesting new gene 2 protein;
                     3-oxoacyl-[acyl-carrier-protein] reductase; KAR alpha
                     subunit; 3-ketoacyl-[acyl-carrier-protein] reductase alpha
                     subunit"
                     /codon_start=1
                     /product="(3R)-3-hydroxyacyl-CoA dehydrogenase"
                     /protein_id="NP_055049.1"
                     /db_xref="CCDS:CCDS4769.1"
                     /db_xref="GeneID:7923"
                     /db_xref="HGNC:HGNC:3554"
                     /db_xref="MIM:601417"
                     /translation="MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLD
                     RAAAQETVRLLGGPGSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVS
                     CAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGK
                     VGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKI
                     TEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM"
     exon            67..284
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..401
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..494
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..580
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..665
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..708
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..783
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..977
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      950..955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /note="hexamer: AATAAA"
     polyA_site      977
                     /gene="HSD17B8"
                     /gene_synonym="D6S2245E; dJ1033B10.9; FABG; FABGL; H2-KE6;
                     HKE6; KE6; RING2; SDR30C1"
                     /note="major polyA site"
ORIGIN      
        1 acccacagcc cgccatggcg tctcagctcc agaaccgact ccgctccgca ctggccttgg
       61 tcacaggtgc ggggagcggc atcggccgag cggtcagtgt acgcctggcc ggagaggggg
      121 ccaccgtagc tgcctgcgac ctggaccggg cagcggcaca ggagacggtg cggctgctgg
      181 gcgggccagg gagcaaggag gggccgcccc gagggaacca tgctgccttc caggctgacg
      241 tgtctgaggc cagggccgcc aggtgcctgc tggaacaagt gcaggcctgc ttttctcgcc
      301 caccatctgt cgttgtgtcc tgtgcgggca tcacccagga tgagtttctg ctgcacatgt
      361 ctgaggatga ctgggacaaa gtcatagctg tcaacctcaa gggcaccttc ctagtcactc
      421 aggctgcagc acaagccctg gtgtccaatg gttgtcgtgg ttccatcatc aacatcagta
      481 gcatcgtagg aaaggtgggg aacgtggggc agacaaacta tgcagcatcc aaggctggag
      541 tgattgggct gacccagacc gcagcccggg agcttggacg acatgggatc cgctgtaact
      601 ctgtcctccc agggttcatt gcaacaccca tgacacagaa agtgccacag aaagtggtgg
      661 acaagattac tgaaatgatc ccgatgggac acttggggga ccctgaggat gtggcagatg
      721 tggtcgcatt cttggcatct gaagatagtg gatacatcac agggacctca gtggaagtca
      781 ctggaggtct tttcatgtaa ctgcctcaag gaccctggac tctgctcacc cccccaccac
      841 tctgcctggc ctcctgctga tgaggactct aagttcccag gatacaaaag gggtggcagt
      901 gtatggttca ggaatgctga atatgggaag caggggtgct tgtgacccta ataaattcca
      961 agtcctcttc cctgcca
//
