LOCUS       NM_016371               1528 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens hydroxysteroid 17-beta dehydrogenase 7 (HSD17B7),
            transcript variant 1, mRNA.
ACCESSION   NM_016371
VERSION     NM_016371.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1528)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1528)
  AUTHORS   Xu,X., Tassone,B., Ostano,P., Katarkar,A., Proust,T., Joseph,J.M.,
            Riganti,C., Chiorino,G., Kutalik,Z., Lefort,K. and Dotto,G.P.
  TITLE     HSD17B7 gene in self-renewal and oncogenicity of keratinocytes from
            Black versus White populations
  JOURNAL   EMBO Mol Med 13 (7), e14133 (2021)
   PUBMED   34185380
  REMARK    GeneRIF: HSD17B7 gene in self-renewal and oncogenicity of
            keratinocytes from Black versus White populations.
REFERENCE   3  (bases 1 to 1528)
  AUTHORS   Sang,X., Han,H., Li,T. and Lin,S.X.
  TITLE     Mutual regulations and breast cancer cell control by steroidogenic
            enzymes: Dual sex-hormone receptor modulation upon 17beta-HSD7
            inhibition
  JOURNAL   J Steroid Biochem Mol Biol 193, 105411 (2019)
   PUBMED   31207361
  REMARK    GeneRIF: Inhibition of 17beta-HSD7can provide a new basis for the
            design of combined endocrine therapy for breast cancer by
            controlling E2 and DHT, while up-regulating AR expression and
            stably controlling expression of ERalpha.
REFERENCE   4  (bases 1 to 1528)
  AUTHORS   Theriault,J.F. and Lin,S.X.
  TITLE     The dual sex hormone specificity for human reductive
            17beta-hydroxysteroid dehydrogenase type 7: Synergistic function in
            estrogen and androgen control
  JOURNAL   J Steroid Biochem Mol Biol 186, 61-65 (2019)
   PUBMED   30227243
  REMARK    GeneRIF: Substrate affinity of 17beta-hydroxysteroid dehydrogenase
            type 7 toward estrone and 5alpha-dihydrotestosterone are similar.
REFERENCE   5  (bases 1 to 1528)
  AUTHORS   Wang,X.Q., Aka,J.A., Li,T., Xu,D., Doillon,C.J. and Lin,S.X.
  TITLE     Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates
            breast cancer protein profile and enhances apoptosis by
            down-regulating GRP78
  JOURNAL   J Steroid Biochem Mol Biol 172, 188-197 (2017)
   PUBMED   28645527
  REMARK    GeneRIF: Inhibition of 17beta-HSD 7 modulates breast cancer protein
            profile and enhances apoptosis by down-regulating GRP78.
REFERENCE   6  (bases 1 to 1528)
  AUTHORS   Torn,S., Nokelainen,P., Kurkela,R., Pulkka,A., Menjivar,M.,
            Ghosh,S., Coca-Prados,M., Peltoketo,H., Isomaa,V. and Vihko,P.
  TITLE     Production, purification, and functional analysis of recombinant
            human and mouse 17beta-hydroxysteroid dehydrogenase type 7
  JOURNAL   Biochem Biophys Res Commun 305 (1), 37-45 (2003)
   PUBMED   12732193
REFERENCE   7  (bases 1 to 1528)
  AUTHORS   Gaylor,J.L.
  TITLE     Membrane-bound enzymes of cholesterol synthesis from lanosterol
  JOURNAL   Biochem Biophys Res Commun 292 (5), 1139-1146 (2002)
   PUBMED   11969204
  REMARK    Review article
REFERENCE   8  (bases 1 to 1528)
  AUTHORS   Krazeisen,A., Breitling,R., Imai,K., Fritz,S., Moller,G. and
            Adamski,J.
  TITLE     Determination of cDNA, gene structure and chromosomal localization
            of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1)
  JOURNAL   FEBS Lett 460 (2), 373-379 (1999)
   PUBMED   10544267
REFERENCE   9  (bases 1 to 1528)
  AUTHORS   Peltoketo,H., Nokelainen,P., Piao,Y.S., Vihko,R. and Vihko,P.
  TITLE     Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of estradiol
            biosynthesis: 17HSD type 1 and type 7
  JOURNAL   J Steroid Biochem Mol Biol 69 (1-6), 431-439 (1999)
   PUBMED   10419022
  REMARK    Review article
REFERENCE   10 (bases 1 to 1528)
  AUTHORS   Mendoza-Hernandez,G., Rendon,J.L. and Diaz-Zagoya,J.C.
  TITLE     A single step procedure for purification of estradiol 17
            beta-dehydrogenase from human placenta
  JOURNAL   Biochem Biophys Res Commun 126 (1), 477-481 (1985)
   PUBMED   3855619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL445197.4 and AL392003.11.
            
            On Aug 13, 2020 this sequence version replaced NM_016371.3.
            
            Summary: HSD17B7 encodes an enzyme that functions both as a
            17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the
            biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC
            1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al.,
            2003 [PubMed 12829805]).[supplied by OMIM, May 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290741.1, AJ249179.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254521.8/ ENSP00000254521.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AL445197.4         108366-108499
            135-338             AL445197.4         110323-110526
            339-431             AL445197.4         114249-114341
            432-546             AL445197.4         115466-115580
            547-741             AL392003.11        189314-189508       c
            742-846             AL392003.11        185716-185820       c
            847-903             AL392003.11        184928-184984       c
            904-1002            AL392003.11        183759-183857       c
            1003-1528           AL392003.11        176428-176953       c
FEATURES             Location/Qualifiers
     source          1..1528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..1528
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /note="hydroxysteroid 17-beta dehydrogenase 7"
                     /db_xref="GeneID:51478"
                     /db_xref="HGNC:HGNC:5215"
                     /db_xref="MIM:606756"
     exon            1..134
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1125
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.270"
                     /EC_number="1.1.1.210"
                     /note="isoform 1 is encoded by transcript variant 1; 17
                     beta-hydroxysteroid dehydrogenase type VII; 3-keto-steroid
                     reductase; 17beta hydroxysteroid dehydrogenase;
                     17-beta-HSD 7; estradiol 17-beta-dehydrogenase 7;
                     17-beta-hydroxysteroid dehydrogenase 7;
                     dihydrotestosterone oxidoreductase; short chain
                     dehydrogenase/reductase family 37C member 1;
                     3-keto-steroid reductase/17-beta-hydroxysteroid
                     dehydrogenase 7"
                     /codon_start=1
                     /product="3-keto-steroid reductase/17-beta-hydroxysteroid
                     dehydrogenase 7 isoform 1"
                     /protein_id="NP_057455.1"
                     /db_xref="CCDS:CCDS1242.1"
                     /db_xref="GeneID:51478"
                     /db_xref="HGNC:HGNC:5215"
                     /db_xref="MIM:606756"
                     /translation="MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAV
                     CAALLASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIK
                     ALFFGLFSRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHS
                     DNPSQLIWTSSRSARKSNFSLEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYS
                     NVACPGTALTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKP
                     ESLNPLIKYLSATTGFGRNYIMTQKMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQA
                     RLSGSCL"
     exon            135..338
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /inference="alignment:Splign:2.1.0"
     exon            339..431
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /inference="alignment:Splign:2.1.0"
     exon            432..546
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..741
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..846
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..903
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1002
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1528
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1505..1510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /note="hexamer: AATAAA"
     polyA_site      1528
                     /gene="HSD17B7"
                     /gene_synonym="PRAP; SDR37C1"
                     /note="major polyA site"
ORIGIN      
        1 gtactctgat tggtgacggg tgaggcggcc cgaaatcgta ggacttccga aagcagcggc
       61 ggtgtttgct tcactgcttg gaagtgtgag tgcgcgaaga tgcgaaaggt ggttttgatc
      121 accggggcta gcagtggcat tggcctggcc ctctgcaagc ggctgctggc ggaagatgat
      181 gagcttcatc tgtgtttggc gtgcaggaac atgagcaagg cagaagctgt ctgtgctgct
      241 ctgctggcct ctcaccccac tgctgaggtc accattgtcc aggtggatgt cagcaacctg
      301 cagtcggtct tccgggcctc caaggaactt aagcaaaggt ttcagagatt agactgtata
      361 tatctaaatg ctgggatcat gcctaatcca caactaaata tcaaagcact tttctttggc
      421 ctcttttcaa gaaaagtgat tcatatgttc tccacagctg aaggcctgct gacccagggt
      481 gataagatca ctgctgatgg acttcaggag gtgtttgaga ccaatgtctt tggccatttt
      541 atcctgattc gggaactgga gcctctcctc tgtcacagtg acaatccatc tcagctcatc
      601 tggacatcat ctcgcagtgc aaggaaatct aatttcagcc tcgaggactt ccagcacagc
      661 aaaggcaagg aaccctacag ctcttccaaa tatgccactg accttttgag tgtggctttg
      721 aacaggaact tcaaccagca gggtctctat tccaatgtgg cctgtccagg tacagcattg
      781 accaatttga catatggaat tctgcctccg tttatatgga cgctgttgat gccggcaata
      841 ttgctacttc gcttttttgc aaatgcattc actttgacac catataatgg aacagaagct
      901 ctggtatggc ttttccacca aaagcctgaa tctctcaatc ctctgatcaa atatctgagt
      961 gccaccactg gctttggaag aaattacatt atgacccaga agatggacct agatgaagac
     1021 actgctgaaa aattttatca aaagttactg gaactggaaa agcacattag ggtcactatt
     1081 caaaaaacag ataatcaggc caggctcagt ggctcatgcc tataattcca gcactttggg
     1141 aggccaaggc agaaggatca cttgagacca ggagttcaag accagcctga gaaacatagt
     1201 gagcccttgt ctctacaaaa agaaataaaa ataatagctg ggtgtggtgg catgcgcatg
     1261 tagtcccagc tactcagaag gatgaggtgg gaggatctct tgaggctggg aggcagaggt
     1321 tgcagtgagc tgagattgtg ccactgcact ccagcctggg tgacagcgag accctgtctc
     1381 aaaatatgta tatatttaat atatatataa aaccagagct gacaatgaca ctctggaaca
     1441 ttgcatacct tctgtacatt ctggggtaca tggatttcta ctgagttgga taatatgcat
     1501 ttgtaataaa ctatgaacta tgactgtc
//
