LOCUS       NM_002153               1434 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens hydroxysteroid 17-beta dehydrogenase 2 (HSD17B2),
            mRNA.
ACCESSION   NM_002153
VERSION     NM_002153.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Zhang,Y., Fan,A., Li,Y., Liu,Z., Yu,L., Guo,J., Hou,J., Li,X. and
            Chen,W.
  TITLE     Single-cell RNA sequencing reveals that HSD17B2 in
            cancer-associated fibroblasts promotes the development and
            progression of castration-resistant prostate cancer
  JOURNAL   Cancer Lett 566, 216244 (2023)
   PUBMED   37244445
  REMARK    GeneRIF: Single-cell RNA sequencing reveals that HSD17B2 in
            cancer-associated fibroblasts promotes the development and
            progression of castration-resistant prostate cancer.
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   Kanemoto,Y., Nishimura,K., Hayakawa,A., Sawada,T., Amano,R.,
            Mori,J., Kurokawa,T., Murakami,Y. and Kato,S.
  TITLE     A long non-coding RNA as a direct vitamin D target transcribed from
            the antisense strand of the human HSD17B2 locus
  JOURNAL   Biosci Rep 42 (5) (2022)
   PUBMED   35510872
  REMARK    GeneRIF: A long non-coding RNA as a direct vitamin D target
            transcribed from the antisense strand of the human HSD17B2 locus.
REFERENCE   3  (bases 1 to 1434)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1434)
  AUTHORS   Sager,C.P., Weber,S., Negri,M., Banachowicz,P., Moller,G.,
            Adamski,J., Hartmann,R.W. and Marchais-Oberwinkler,S.
  TITLE     Homology modeling meets site-directed mutagenesis: An ideal
            combination to elucidate the topology of 17beta-HSD2
  JOURNAL   J Steroid Biochem Mol Biol 206, 105790 (2021)
   PUBMED   33246154
  REMARK    GeneRIF: Homology modeling meets site-directed mutagenesis: An
            ideal combination to elucidate the topology of 17beta-HSD2.
REFERENCE   5  (bases 1 to 1434)
  AUTHORS   Gao,X., Dai,C., Huang,S., Tang,J., Chen,G., Li,J., Zhu,Z., Zhu,X.,
            Zhou,S., Gao,Y., Hou,Z., Fang,Z., Xu,C., Wang,J., Wu,D., Sharifi,N.
            and Li,Z.
  TITLE     Functional Silencing of HSD17B2 in Prostate Cancer Promotes Disease
            Progression
  JOURNAL   Clin Cancer Res 25 (4), 1291-1301 (2019)
   PUBMED   30228209
  REMARK    GeneRIF: Our findings provide evidence of the clinical relevance,
            significance, and regulation of HSD17B2 in prostate cancer
            progression, which might provide new strategies for clinical
            management by targeting the functional silencing mechanisms of
            HSD17B2.
REFERENCE   6  (bases 1 to 1434)
  AUTHORS   Labrie,Y., Durocher,F., Lachance,Y., Turgeon,C., Simard,J.,
            Labrie,C. and Labrie,F.
  TITLE     The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes
            two alternatively spliced mRNA species
  JOURNAL   DNA Cell Biol 14 (10), 849-861 (1995)
   PUBMED   7546291
REFERENCE   7  (bases 1 to 1434)
  AUTHORS   Andersson,S., Geissler,W.M., Patel,S. and Wu,L.
  TITLE     The molecular biology of androgenic 17 beta-hydroxysteroid
            dehydrogenases
  JOURNAL   J Steroid Biochem Mol Biol 53 (1-6), 37-39 (1995)
   PUBMED   7626483
REFERENCE   8  (bases 1 to 1434)
  AUTHORS   Durocher,F., Morissette,J., Labrie,Y., Labrie,F. and Simard,J.
  TITLE     Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid
            dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2
  JOURNAL   Genomics 25 (3), 724-726 (1995)
   PUBMED   7759109
REFERENCE   9  (bases 1 to 1434)
  AUTHORS   Carsol,J.L., Martin,P.M. and de Launoit,Y.
  TITLE     Characterization of 17 beta-hydroxysteroid dehydrogenase activity
            and mRNA abundance in human meningioma tumors
  JOURNAL   Neuroendocrinology 60 (4), 445-451 (1994)
   PUBMED   7824086
REFERENCE   10 (bases 1 to 1434)
  AUTHORS   Wu,L., Einstein,M., Geissler,W.M., Chan,H.K., Elliston,K.O. and
            Andersson,S.
  TITLE     Expression cloning and characterization of human 17
            beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme
            possessing 20 alpha-hydroxysteroid dehydrogenase activity
  JOURNAL   J Biol Chem 268 (17), 12964-12969 (1993)
   PUBMED   8099587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP270993.1, AU139034.1, BC059170.1 and BM670647.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002153.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.114779.1,
                                           SRR5189664.62898.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000199936.9/ ENSP00000199936.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BP270993.1         22-60
            40-592              AU139034.1         15-567
            593-1430            BC059170.1         506-1343
            1431-1434           BM670647.1         18-21               c
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.3"
     gene            1..1434
                     /gene="HSD17B2"
                     /gene_synonym="EDH17B2; HSD17; SDR9C2"
                     /note="hydroxysteroid 17-beta dehydrogenase 2"
                     /db_xref="GeneID:3294"
                     /db_xref="HGNC:HGNC:5211"
                     /db_xref="MIM:109685"
     exon            1..437
                     /gene="HSD17B2"
                     /gene_synonym="EDH17B2; HSD17; SDR9C2"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1336
                     /gene="HSD17B2"
                     /gene_synonym="EDH17B2; HSD17; SDR9C2"
                     /EC_number="1.1.1.62"
                     /EC_number="1.1.1.239"
                     /note="estradiol 17-beta-dehydrogenase 2; E2DH;
                     20-alpha-HSD; 17-beta-HSD 2; testosterone
                     17-beta-dehydrogenase; 20 alpha-hydroxysteroid
                     dehydrogenase; microsomal 17-beta-hydroxysteroid
                     dehydrogenase; short chain dehydrogenase/reductase family
                     9C member 2"
                     /codon_start=1
                     /product="17-beta-hydroxysteroid dehydrogenase type 2"
                     /protein_id="NP_002144.1"
                     /db_xref="CCDS:CCDS10936.1"
                     /db_xref="GeneID:3294"
                     /db_xref="HGNC:HGNC:5211"
                     /db_xref="MIM:109685"
                     /translation="MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGL
                     CAVCLLILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYL
                     DELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRG
                     LWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVS
                     SMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKW
                     EKLEKDILDHLPAEVQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSP
                     FAYYTPGKGAYLWICLAHYLPIGIYDYFAKRHFGQDKPMPRALRMPNYKKKAT"
     exon            438..650
                     /gene="HSD17B2"
                     /gene_synonym="EDH17B2; HSD17; SDR9C2"
                     /inference="alignment:Splign:2.1.0"
     exon            651..836
                     /gene="HSD17B2"
                     /gene_synonym="EDH17B2; HSD17; SDR9C2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..974
                     /gene="HSD17B2"
                     /gene_synonym="EDH17B2; HSD17; SDR9C2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1434
                     /gene="HSD17B2"
                     /gene_synonym="EDH17B2; HSD17; SDR9C2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1411..1416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSD17B2"
                     /gene_synonym="EDH17B2; HSD17; SDR9C2"
                     /note="hexamer: ATTAAA"
     polyA_site      1434
                     /gene="HSD17B2"
                     /gene_synonym="EDH17B2; HSD17; SDR9C2"
                     /note="major polyA site"
ORIGIN      
        1 acccactggg aatatgatta tgcttaatct atgctcagtt gaaaggggct ggggctgctt
       61 tctcccctcc cttcttgact ctctgttcac agaactcagg ctgcctccag ccagcctttg
      121 cccgctagac tcactggccc tgagcacttg aaggtgcagc aagtcactga gaatgagcac
      181 tttcttctcg gacacagcat ggatctgcct ggctgtcccc acagtactat gtgggacagt
      241 attttgcaaa tacaagaaga gctcagggca gctgtggagc tggatggtct gcctggcagg
      301 cctctgtgca gtctgcctgc tcatcctgtc ccctttttgg ggcttgatcc tcttctcggt
      361 gtcatgcttc ctcatgtata cttacttatc tggccaagaa ttgttacctg tggatcagaa
      421 ggcagtcctg gtgacaggtg gtgattgcgg gcttggccat gctttgtgca agtatctgga
      481 tgagctgggc ttcacggtat ttgccggagt tttgaatgaa aatggcccag gagctgagga
      541 attgcgaaga acctgctctc cgcgcctctc ggtgctccaa atggacatca cgaagccagt
      601 gcagataaaa gatgcttaca gcaaggttgc agcaatgctg caggacagag gactgtgggc
      661 tgtgatcaac aatgctgggg tgcttggctt tccaactgat ggggagcttc ttcttatgac
      721 tgactacaaa caatgcatgg ccgtgaactt ctttggaact gtggaggtca caaagacgtt
      781 tttgcctctt cttagaaaat ccaaagggag gctggtgaat gtcagcagca tgggaggagg
      841 ggccccaatg gaaaggctgg catcttatgg ctcatcaaag gcggctgtga ccatgttctc
      901 atcagttatg agactggagc tttccaagtg gggaattaaa gttgcttcca tccaacctgg
      961 aggcttccta acaaatatcg caggcaccag tgacaagtgg gaaaagctgg agaaggacat
     1021 tctggaccac ctccccgctg aggtacagga agactacggc caggactaca tcttagcaca
     1081 gcggaatttc ctcctattga tcaactcgtt agccagcaag gacttctctc cggtgctgcg
     1141 ggacatccag catgctatct tggcgaagag cccttttgcc tattacacgc cagggaaagg
     1201 cgcttacttg tggatctgcc ttgctcacta tttgcctatt ggcatatatg attactttgc
     1261 taaaagacat tttggccaag acaagcccat gcccagagct ctaagaatgc ctaactacaa
     1321 gaaaaaggcc acctaggcaa tggaagccct caaagaagtc ggaatgtcat agtcttgaaa
     1381 tgaaagggaa actgggaaac tgggtttctc attaaagttg tttcccactc tgta
//
