LOCUS       NM_016245               1782 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens hydroxysteroid 17-beta dehydrogenase 11 (HSD17B11),
            mRNA.
ACCESSION   NM_016245 XM_938962
VERSION     NM_016245.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1782)
  AUTHORS   Wei,C., Li,L., Qiao,Y., Chen,Y., Zhang,C., Xie,J., Fang,J.,
            Liang,Z., Huang,D. and Wu,D.
  TITLE     Ferroptosis-related genes DUOX1 and HSD17B11 affect tumor
            microenvironment and predict overall survival of lung
            adenocarcinoma patients
  JOURNAL   Medicine (Baltimore) 103 (22), e38322 (2024)
   PUBMED   39259123
  REMARK    GeneRIF: Ferroptosis-related genes DUOX1 and HSD17B11 affect tumor
            microenvironment and predict overall survival of lung
            adenocarcinoma patients.
REFERENCE   2  (bases 1 to 1782)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1782)
  AUTHORS   Lundova,T., Stambergova,H., Zemanova,L., Svobodova,M.,
            Havrankova,J., Safr,M. and Wsol,V.
  TITLE     Human dehydrogenase/reductase (SDR family) member 8 (DHRS8): a
            description and evaluation of its biochemical properties
  JOURNAL   Mol Cell Biochem 411 (1-2), 35-42 (2016)
   PUBMED   26472732
  REMARK    GeneRIF: knowledge of its in vitro activity together with a newly
            described expression pattern at the protein level in tissues
            involved in steroidogenesis and detoxification could suggest a
            potential role of DHRS8 in vivo
REFERENCE   4  (bases 1 to 1782)
  AUTHORS   Wade,T.D., Gordon,S., Medland,S., Bulik,C.M., Heath,A.C.,
            Montgomery,G.W. and Martin,N.G.
  TITLE     Genetic variants associated with disordered eating
  JOURNAL   Int J Eat Disord 46 (6), 594-608 (2013)
   PUBMED   23568457
REFERENCE   5  (bases 1 to 1782)
  AUTHORS   Rotinen,M., Villar,J., Celay,J., Serrano,I., Notario,V. and
            Encio,I.
  TITLE     Transcriptional regulation of type 11 17beta-hydroxysteroid
            dehydrogenase expression in prostate cancer cells
  JOURNAL   Mol Cell Endocrinol 339 (1-2), 45-53 (2011)
   PUBMED   21549806
  REMARK    GeneRIF: hydroxysteroid (17-beta) dehydrogenase 11 transcription in
            prostate cancer cells is regulated by Sp1 transcription factor and
            C-EBP alpha
REFERENCE   6  (bases 1 to 1782)
  AUTHORS   Fujimoto,Y., Itabe,H., Sakai,J., Makita,M., Noda,J., Mori,M.,
            Higashi,Y., Kojima,S. and Takano,T.
  TITLE     Identification of major proteins in the lipid droplet-enriched
            fraction isolated from the human hepatocyte cell line HuH7
  JOURNAL   Biochim Biophys Acta 1644 (1), 47-59 (2004)
   PUBMED   14741744
REFERENCE   7  (bases 1 to 1782)
  AUTHORS   Chai,Z., Brereton,P., Suzuki,T., Sasano,H., Obeyesekere,V.,
            Escher,G., Saffery,R., Fuller,P., Enriquez,C. and Krozowski,Z.
  TITLE     17 beta-hydroxysteroid dehydrogenase type XI localizes to human
            steroidogenic cells
  JOURNAL   Endocrinology 144 (5), 2084-2091 (2003)
   PUBMED   12697717
  REMARK    GeneRIF: Role for 17-beta-HSDXI in androgen metabolism during
            steroidogenesis.
REFERENCE   8  (bases 1 to 1782)
  AUTHORS   Brereton,P., Suzuki,T., Sasano,H., Li,K., Duarte,C.,
            Obeyesekere,V., Haeseleer,F., Palczewski,K., Smith,I.,
            Komesaroff,P. and Krozowski,Z.
  TITLE     Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung
  JOURNAL   Mol Cell Endocrinol 171 (1-2), 111-117 (2001)
   PUBMED   11165019
REFERENCE   9  (bases 1 to 1782)
  AUTHORS   Haeseleer,F. and Palczewski,K.
  TITLE     Short-chain dehydrogenases/reductases in retina
  JOURNAL   Methods Enzymol 316, 372-383 (2000)
   PUBMED   10800688
REFERENCE   10 (bases 1 to 1782)
  AUTHORS   Li,K.X., Smith,R.E. and Krozowski,Z.S.
  TITLE     Cloning and expression of a novel tissue specific
            17beta-hydroxysteroid dehydrogenase
  JOURNAL   Endocr Res 24 (3-4), 663-667 (1998)
   PUBMED   9888557
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU838518.1, BC014327.1, AF273056.1, BM976691.1 and AC108516.5.
            
            On Nov 22, 2018 this sequence version replaced NM_016245.4.
            
            Summary: Short-chain alcohol dehydrogenases, such as HSD17B11,
            metabolize secondary alcohols and ketones (Brereton et al., 2001
            [PubMed 11165019]).[supplied by OMIM, Jun 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075348.1, SRR1803617.171899.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358290.9/ ENSP00000351035.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BU838518.1         198-220
            24-1453             BC014327.1         5-1434
            1454-1687           AF273056.1         1422-1655
            1688-1775           BM976691.1         14-101              c
            1776-1782           AC108516.5         112525-112531       c
FEATURES             Location/Qualifiers
     source          1..1782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..1782
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /note="hydroxysteroid 17-beta dehydrogenase 11"
                     /db_xref="GeneID:51170"
                     /db_xref="HGNC:HGNC:22960"
                     /db_xref="MIM:612831"
     exon            1..328
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1021
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /EC_number="1.1.1.62"
                     /note="retinal short-chain dehydrogenase/reductase 2;
                     short chain dehydrogenase/reductase family 16C member 2;
                     CTCL tumor antigen HD-CL-03; estradiol
                     17-beta-dehydrogenase 11; 17-beta-hydroxysteroid
                     dehydrogenase type XI; CTCL-associated antigen HD-CL-03;
                     dehydrogenase/reductase SDR family member 8; cutaneous
                     T-cell lymphoma-associated antigen HD-CL-03"
                     /codon_start=1
                     /product="estradiol 17-beta-dehydrogenase 11 precursor"
                     /protein_id="NP_057329.3"
                     /db_xref="CCDS:CCDS3619.1"
                     /db_xref="GeneID:51170"
                     /db_xref="HGNC:HGNC:22960"
                     /db_xref="MIM:612831"
                     /translation="MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGA
                     GHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYS
                     SAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMT
                     KNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCP
                     NFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPER
                     FLAVLKRKISVKFDAVIGYKMKAQ"
     exon            329..436
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /inference="alignment:Splign:2.1.0"
     exon            437..568
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..675
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..813
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..930
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1782
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1667..1672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /note="hexamer: AATAAA"
     polyA_site      1687
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /note="major polyA site"
     regulatory      1738..1743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /note="hexamer: ATTAAA"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
                     /note="hexamer: AATAAA"
     polyA_site      1761
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
     polyA_site      1782
                     /gene="HSD17B11"
                     /gene_synonym="17-BETA-HSD11; 17-BETA-HSDXI; 17BHSD11;
                     DHRS8; PAN1B; RETSDR2; SDR16C2"
ORIGIN      
        1 agttcctcct tgctctcgcc cctactcttt ctggtgttag atcgagctac cctctaaaag
       61 cagtttagag tggtaaaaaa aaaaaaaaac acaccaaacg ctcgcagcca caaaagggat
      121 gaaatttctt ctggacatcc tcctgcttct cccgttactg atcgtctgct ccctagagtc
      181 cttcgtgaag ctttttattc ctaagaggag aaaatcagtc accggcgaaa tcgtgctgat
      241 tacaggagct gggcatggaa ttgggagact gactgcctat gaatttgcta aacttaaaag
      301 caagctggtt ctctgggata taaataagca tggactggag gaaacagctg ccaaatgcaa
      361 gggactgggt gccaaggttc atacctttgt ggtagactgc agcaaccgag aagatattta
      421 cagctctgca aagaaggtga aggcagaaat tggagatgtt agtattttag taaataatgc
      481 tggtgtagtc tatacatcag atttgtttgc tacacaagat cctcagattg aaaagacttt
      541 tgaagttaat gtacttgcac atttctggac tacaaaggca tttcttcctg caatgacgaa
      601 gaataaccat ggccatattg tcactgtggc ttcggcagct ggacatgtct cggtcccctt
      661 cttactggct tactgttcaa gcaagtttgc tgctgttgga tttcataaaa ctttgacaga
      721 tgaactggct gccttacaaa taactggagt caaaacaaca tgtctgtgtc ctaatttcgt
      781 aaacactggc ttcatcaaaa atccaagtac aagtttggga cccactctgg aacctgagga
      841 agtggtaaac aggctgatgc atgggattct gactgagcag aagatgattt ttattccatc
      901 ttctatagct tttttaacaa cattggaaag gatccttcct gagcgtttcc tggcagtttt
      961 aaaacgaaaa atcagtgtta agtttgatgc agttattgga tataaaatga aagcgcaata
     1021 agcacctagt tttctgaaaa ctgatttacc aggtttaggt tgatgtcatc taatagtgcc
     1081 agaattttaa tgtttgaact tctgtttttt ctaattatcc ccatttcttc aatatcattt
     1141 ttgaggcttt ggcagtcttc atttactacc acttgttctt tagccaaaag ctgattacat
     1201 atgatataaa cagagaaata cctttagagg tgactttaag gaaaatgaag aaaaagaacc
     1261 aaaatgactt tattaaaata atttccaaga ttatttgtgg ctcacctgaa ggctttgcaa
     1321 aatttgtacc ataaccgttt atttaacata tatttttatt tttgattgca cttaaatttt
     1381 gtataatttg tgtttctttt tctgttctac ataaaatcag aaacttcaag ctctctaaat
     1441 aaaatgaagg actatatcta gtggtatttc acaatgaata tcatgaactc tcaatgggta
     1501 ggtttcatcc tacccattgc cactctgttt cctgagagat acctcacatt ccaatgccaa
     1561 acatttctgc acagggaagc tagaggtgga tacacgtgtt gcaagtataa aagcatcact
     1621 gggatttaag gagaattgag agaatgtacc cacaaatggc agcaataata aatggatcac
     1681 acttaaactt ttggtgtttc catctttttg tcttaaacag aacatgacaa ccttcaaatt
     1741 aaaggaaaat aaattgtgca atcttttttt aaaaactgga aa
//
