LOCUS       NM_198706               1697 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens hydroxysteroid 11-beta dehydrogenase 1 like
            (HSD11B1L), transcript variant b, mRNA.
ACCESSION   NM_198706 XM_351171
VERSION     NM_198706.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1697)
  AUTHORS   Fu,R.H., Hong,S.Y., Tsai,C.W., Liu,S.P., Chiu,S.C., Wu,M.Z.,
            Shyu,W.C. and Lin,S.Z.
  TITLE     Interaction of a Novel Alternatively Spliced Variant of HSD11B1L
            with Parkin Enhances the Carcinogenesis Potential of Glioblastoma:
            Peiminine Interferes with This Interaction
  JOURNAL   Cells 12 (6), 894 (2023)
   PUBMED   36980235
  REMARK    GeneRIF: Interaction of a Novel Alternatively Spliced Variant of
            HSD11B1L with Parkin Enhances the Carcinogenesis Potential of
            Glioblastoma: Peiminine Interferes with This Interaction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1697)
  AUTHORS   Bird,A.D., Greatorex,S., Reser,D., Lavery,G.G. and Cole,T.J.
  TITLE     Hydroxysteroid dehydrogenase HSD1L is localised to the
            pituitary-gonadal axis of primates
  JOURNAL   Endocr Connect 6 (7), 489-499 (2017)
   PUBMED   28871060
REFERENCE   3  (bases 1 to 1697)
  AUTHORS   Baker,M.E.
  TITLE     Evolution of 11beta-hydroxysteroid dehydrogenase-type 1 and
            11beta-hydroxysteroid dehydrogenase-type 3
  JOURNAL   FEBS Lett 584 (11), 2279-2284 (2010)
   PUBMED   20350543
REFERENCE   4  (bases 1 to 1697)
  AUTHORS   Huang,C., Wan,B., Gao,B., Hexige,S. and Yu,L.
  TITLE     Isolation and characterization of novel human short-chain
            dehydrogenase/reductase SCDR10B which is highly expressed in the
            brain and acts as hydroxysteroid dehydrogenase
  JOURNAL   Acta Biochim Pol 56 (2), 279-289 (2009)
   PUBMED   19436836
  REMARK    GeneRIF: cloning, purification, and characterization of SCDR10B;
            highly expressed in brain (especially in hippocampal neurons);
            up-regulated in lung cancer cell lines and lung cancer tissue
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA343367.1 and AY268352.1.
            
            On Jun 2, 2019 this sequence version replaced NM_198706.2.
            
            Summary: This gene is a member of the hydroxysteroid dehydrogenase
            family. The encoded protein is similar to an enzyme that catalyzes
            the interconversion of inactive to active glucocorticoids (e.g.
            cortisone). Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Jun 2012].
            
            Transcript Variant: This variant (b) lacks an exon and a portion of
            the 5' coding region, and initiates translation at a downstream
            in-frame start codon, compared to variant g. The encoded isoform
            (b) is shorter than isoform g.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY268352.1, SRR3476690.1158184.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339423.7/ ENSP00000340436.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                DA343367.1         263-299
            38-1697             AY268352.1         1-1660
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1697
                     /gene="HSD11B1L"
                     /gene_synonym="11-beta-HSD3; 11-DH3; HSD1L; HSD3; SCDR10;
                     SCDR10B; SDR26C2"
                     /note="hydroxysteroid 11-beta dehydrogenase 1 like"
                     /db_xref="GeneID:374875"
                     /db_xref="HGNC:HGNC:30419"
     exon            1..245
                     /gene="HSD11B1L"
                     /gene_synonym="11-beta-HSD3; 11-DH3; HSD1L; HSD3; SCDR10;
                     SCDR10B; SDR26C2"
                     /inference="alignment:Splign:2.1.0"
     exon            246..332
                     /gene="HSD11B1L"
                     /gene_synonym="11-beta-HSD3; 11-DH3; HSD1L; HSD3; SCDR10;
                     SCDR10B; SDR26C2"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1120
                     /gene="HSD11B1L"
                     /gene_synonym="11-beta-HSD3; 11-DH3; HSD1L; HSD3; SCDR10;
                     SCDR10B; SDR26C2"
                     /EC_number="1.1.1.-"
                     /note="isoform b is encoded by transcript variant b; short
                     chain dehydrogenase/reductase family 26C member 2; short
                     chain dehydrogenase/reductase 10; hydroxysteroid
                     11-beta-dehydrogenase 1-like protein;
                     11-beta-hydroxysteroid dehydrogenase type 3"
                     /codon_start=1
                     /product="hydroxysteroid 11-beta-dehydrogenase 1-like
                     protein isoform b"
                     /protein_id="NP_941995.1"
                     /db_xref="CCDS:CCDS12145.1"
                     /db_xref="GeneID:374875"
                     /db_xref="HGNC:HGNC:30419"
                     /translation="MKVLLLTGLGALFFAYYWDDNFDPASLQGARVLLTGANAGVGEE
                     LAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPESVVQFAL
                     DKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSLTDSKGSL
                     VVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRDRASA
                     AEAVRGVTRVKAAPGPKAALAVIRGGATRAAGVFYPWRFRLLCLLRRWLPRPRAWFIR
                     QELNVTAAAA"
     exon            333..463
                     /gene="HSD11B1L"
                     /gene_synonym="11-beta-HSD3; 11-DH3; HSD1L; HSD3; SCDR10;
                     SCDR10B; SDR26C2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..575
                     /gene="HSD11B1L"
                     /gene_synonym="11-beta-HSD3; 11-DH3; HSD1L; HSD3; SCDR10;
                     SCDR10B; SDR26C2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..667
                     /gene="HSD11B1L"
                     /gene_synonym="11-beta-HSD3; 11-DH3; HSD1L; HSD3; SCDR10;
                     SCDR10B; SDR26C2"
                     /inference="alignment:Splign:2.1.0"
     exon            668..761
                     /gene="HSD11B1L"
                     /gene_synonym="11-beta-HSD3; 11-DH3; HSD1L; HSD3; SCDR10;
                     SCDR10B; SDR26C2"
                     /inference="alignment:Splign:2.1.0"
     exon            762..927
                     /gene="HSD11B1L"
                     /gene_synonym="11-beta-HSD3; 11-DH3; HSD1L; HSD3; SCDR10;
                     SCDR10B; SDR26C2"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1697
                     /gene="HSD11B1L"
                     /gene_synonym="11-beta-HSD3; 11-DH3; HSD1L; HSD3; SCDR10;
                     SCDR10B; SDR26C2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1674..1679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HSD11B1L"
                     /gene_synonym="11-beta-HSD3; 11-DH3; HSD1L; HSD3; SCDR10;
                     SCDR10B; SDR26C2"
                     /note="hexamer: AATAAA"
     polyA_site      1697
                     /gene="HSD11B1L"
                     /gene_synonym="11-beta-HSD3; 11-DH3; HSD1L; HSD3; SCDR10;
                     SCDR10B; SDR26C2"
                     /note="major polyA site"
ORIGIN      
        1 gctgggaggc gaagaccagg cgggcactgt tgcccggcga cgctccggcg ctgggtcccc
       61 gaggcccggc ccctccccgg gaggaggtgg gcttcgagtc acgtgacccg tgccctacgg
      121 gagggggtgc ggtcggggac ccggcaggag gcggccgaga agagaggacc gtgggggcgt
      181 tcgcgtggct cccagcccgg gaccccaccc ccgctggaca gtgggggaaa ctgaggcctg
      241 agcgggccca cacaggacca tgaaggtgct tctcctcaca gggctggggg ccctgttctt
      301 cgcctattat tgggatgaca acttcgaccc agccagcctc cagggagcgc gagtgctgct
      361 gacaggggcc aacgctggtg ttggtgagga gctggcctat cactacgcgc gtctgggctc
      421 ccacctggtg ctcactgccc acactgaggc tctcctgcag aaggtggtag ggaactgccg
      481 gaagctgggc gcccccaagg tcttctacat cgcggcggac atggcctccc ctgaggcgcc
      541 cgagagcgtg gtgcagtttg cgctggacaa gctgggcggg ctggactacc tcgtgctgaa
      601 ccacatcggc ggcgccccgg ccggcacgcg agcccgcagc ccccaggcaa ctcgctggct
      661 catgcaggta aactttgtga gctacgtgca actgacgtcg cgggcgctgc ccagcctgac
      721 ggacagcaag ggctccctgg tggtggtgtc ctcgctgctc ggccgcgtgc ccacgtcgtt
      781 ctccactccc tactcggcgg ccaagtttgc gctggacggc ttcttcggct ccctgcggcg
      841 ggagctggac gtgcaggacg tgaacgtggc catcaccatg tgcgtcctgg gcctccgaga
      901 tcgcgcctcc gccgccgagg cagtcagggg agtcacgagg gtcaaggcgg ccccggggcc
      961 caaggcagcc ctggccgtga tccgcggcgg cgccacgcgc gcggccggcg tcttctaccc
     1021 gtggcgtttc cgcctgctgt gcttgctccg gcgctggcta ccgcgcccgc gggcctggtt
     1081 tatccgccag gagctcaacg tcacggccgc ggcagcctga gcaccggggg gtgcccctcc
     1141 agtcccagac ggcaatgttc ctccctccaa ctgtccctgg agccagaaca ctcacagaga
     1201 cacccctgag agggtggcca cagcccaaga tgaagtcatc aagacagaaa agcaaaaccg
     1261 agaaaaacga cgggcacctg gaaccagtca cggcttggga ggtgcaggtg ccccgtgtta
     1321 ggcgcctttg tcggggactt gcaaggcctc acctgtttgg ccatgattga tgacgtgact
     1381 gcttccattt tgcagatgag gaaactaagg ctcagagagg ccacgccacc cttgagccac
     1441 ccatggaccc ctctccatct cctgcctgcg cctttaagtc cctgatttat tctttccatt
     1501 cattccatct gggaggaacc cccccaactc ctgccagctt cccctagctg gggtctctgg
     1561 tactcttcac acctgcaggg gcgtctacac tgttcgtcta cctggtggca gggtctgagc
     1621 gggaggagga gggaaagagt gtgttctgag ctggacccag cctcttgttc gagaataaaa
     1681 actcttcttc tcttgca
//
