LOCUS       NP_001381002             645 aa            linear   PRI 01-MAY-2025
DEFINITION  heparan-sulfate 6-O-sulfotransferase 2 isoform L [Homo sapiens].
ACCESSION   NP_001381002
VERSION     NP_001381002.1
DBSOURCE    REFSEQ: accession NM_001394073.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 645)
  AUTHORS   Li,S., Shen,H., Wan,Q., Chen,P., Shu,C., Wang,H. and Zhu,W.
  TITLE     Downregulation of HS6ST2 Inhibits Cervical Cancer Cell Migration
            and Invasion in Vivo and in Vitro
  JOURNAL   Discov Med 35 (179), 1147-1159 (2023)
   PUBMED   38058080
  REMARK    GeneRIF: Downregulation of HS6ST2 Inhibits Cervical Cancer Cell
            Migration and Invasion in Vivo and in Vitro.
REFERENCE   2  (residues 1 to 645)
  AUTHORS   Zhang,Y., Yu,Y., Cao,X. and Chen,P.
  TITLE     Role of lncRNA FAM83H antisense RNA1 (FAM83H-AS1) in the
            progression of non-small cell lung cancer by regulating the
            miR-545-3p/heparan sulfate 6-O-sulfotransferase (HS6ST2) axis
  JOURNAL   Bioengineered 13 (3), 6476-6489 (2022)
   PUBMED   35260044
  REMARK    GeneRIF: Role of lncRNA FAM83H antisense RNA1 (FAM83H-AS1) in the
            progression of non-small cell lung cancer by regulating the
            miR-545-3p/heparan sulfate 6-O-sulfotransferase (HS6ST2) axis.
REFERENCE   3  (residues 1 to 645)
  AUTHORS   Paganini,L., Hadi,L.A., Chetta,M., Rovina,D., Fontana,L.,
            Colapietro,P., Bonaparte,E., Pezzani,L., Marchisio,P., Tabano,S.M.,
            Costanza,J., Sirchia,S.M., Riboni,L., Milani,D. and Miozzo,M.
  TITLE     A HS6ST2 gene variant associated with X-linked intellectual
            disability and severe myopia in two male twins
  JOURNAL   Clin Genet 95 (3), 368-374 (2019)
   PUBMED   30471091
  REMARK    GeneRIF: we identified a novel c.916G>C variant in the HS6ST2 gene.
            The mutation caused a significantly reduction in HS6ST2
            6-O-sulfotransferase activity and was associated with a previously
            undescribed form of syndromic XLID with severe congenital myopia
REFERENCE   4  (residues 1 to 645)
  AUTHORS   Guo,Y., Min,Z., Jiang,C., Wang,W., Yan,J., Xu,P., Xu,K., Xu,J.,
            Sun,M., Zhao,Y., Hussain,S., Zhang,R., Wang,Q., Han,Y., Zhang,F.,
            Zhu,W., Li,D., Meng,L., Sun,J. and Lu,S.
  TITLE     Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation
            through p38 MAPK pathway in osteoarthritis
  JOURNAL   Cell Death Dis 9 (6), 699 (2018)
   PUBMED   29899528
  REMARK    GeneRIF: downregulated HS6ST2 targeted by miR-23b-3p promotes
            matrix degradation by activating p38 MAPK in chondrocytes and OA
            cartilage.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 645)
  AUTHORS   Ushakov,V.S., Tsidulko,A.Y., de La Bourdonnaye,G., Kazanskaya,G.M.,
            Volkov,A.M., Kiselev,R.S., Kobozev,V.V., Kostromskaya,D.V.,
            Gaytan,A.S., Krivoshapkin,A.L., Aidagulova,S.V. and Grigorieva,E.V.
  TITLE     Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma
            Due to EXT1/2 and HS6ST1/2 Down-Regulation
  JOURNAL   Int J Mol Sci 18 (11), 2301 (2017)
   PUBMED   29104277
  REMARK    GeneRIF: RT-PCR analysis showed that the overall transcriptional
            activity of the main Heparan Sulfate biosynthesis-involved genes
            (EXT1, EXT2, NDST1, NDST2, GLCE, HS2ST1, HS3ST1, HS3ST2, HS6ST1,
            HS6ST2, SULF1, SULF2, HPSE) was decreased by 1.5-2-fold in Grade
            II-III glioma.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 645)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   7  (residues 1 to 645)
  AUTHORS   Song,K., Li,Q., Peng,Y.B., Li,J., Ding,K., Chen,L.J., Shao,C.H.,
            Zhang,L.J. and Li,P.
  TITLE     Silencing of hHS6ST2 inhibits progression of pancreatic cancer
            through inhibition of Notch signalling
  JOURNAL   Biochem J 436 (2), 271-282 (2011)
   PUBMED   21443520
  REMARK    GeneRIF: HS6ST2 knockdown disrupts epithelial-mesenchymal
            transition and suggesets that HS6ST2 potentiates Notch signaling in
            pancreatic cancer cells.
REFERENCE   8  (residues 1 to 645)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   9  (residues 1 to 645)
  AUTHORS   Habuchi,H., Miyake,G., Nogami,K., Kuroiwa,A., Matsuda,Y.,
            Kusche-Gullberg,M., Habuchi,O., Tanaka,M. and Kimata,K.
  TITLE     Biosynthesis of heparan sulphate with diverse structures and
            functions: two alternatively spliced forms of human heparan
            sulphate 6-O-sulphotransferase-2 having different expression
            patterns and properties
  JOURNAL   Biochem J 371 (Pt 1), 131-142 (2003)
   PUBMED   12492399
  REMARK    GeneRIF: we have characterized HS6ST-2 and HS6ST-1 human isologues,
            including their chromosomal localizations,HS6STs could also
            transfer sulfate to N -sulfoglucosamine residues located at the
            non-reducing terminal of HS with high affinity.
REFERENCE   10 (residues 1 to 645)
  AUTHORS   Habuchi,H., Tanaka,M., Habuchi,O., Yoshida,K., Suzuki,H., Ban,K.
            and Kimata,K.
  TITLE     The occurrence of three isoforms of heparan sulfate
            6-O-sulfotransferase having different specificities for hexuronic
            acid adjacent to the targeted N-sulfoglucosamine
  JOURNAL   J Biol Chem 275 (4), 2859-2868 (2000)
   PUBMED   10644753
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z81365.2 and Z86064.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Heparan sulfate proteoglycans are ubiquitous components of
            the cell surface, extracellular matrix, and basement membranes, and
            interact with various ligands to influence cell growth,
            differentiation, adhesion, and migration. This gene encodes a
            member of the heparan sulfate (HS) sulfotransferase gene family,
            which catalyze the transfer of sulfate to HS. Different family
            members and isoforms are thought to synthesize heparan sulfates
            with tissue-specific structures and functions. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4396219.1,
                                           SRR14038194.1888256.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370833.7/ ENSP00000359870.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     Protein         1..645
                     /product="heparan-sulfate 6-O-sulfotransferase 2 isoform
                     L"
                     /EC_number="2.8.2.-"
                     /note="HS6ST-2"
                     /calculated_mol_wt=73260
     Region          225..531
                     /region_name="Sulfotransfer_2"
                     /note="Sulfotransferase family; pfam03567"
                     /db_xref="CDD:427369"
     CDS             1..645
                     /gene="HS6ST2"
                     /gene_synonym="MRXSPM"
                     /coded_by="NM_001394073.1:28..1965"
                     /note="isoform L is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS48170.1"
                     /db_xref="GeneID:90161"
                     /db_xref="HGNC:HGNC:19133"
                     /db_xref="MIM:300545"
ORIGIN      
        1 malpacavre fepprqperg apvrttcprr hsrveaelaa srpgsvaasv ragpprgvsh
       61 gfhtrplldk prkassslag aacaplfall srgrrrrmhv lrrrwdlgsl cralltrgla
      121 alghslkhvl gaifskifgp masvgnmdek snklllalvm lflfavivlq yvcpgtecql
      181 lrlqafsspv pdpyrsedes sarfvprynf trgdllrkvd fdikgddliv flhiqktggt
      241 tfgrhlvrni qleqpcecrv gqkkctchrp gkretwlfsr fstgwscglh adwteltscv
      301 psvvdgkrda rlrpsrwrif qildaaskdk rgspntnaga nspsstktrn tsksgknfhy
      361 itilrdpvsr ylsewrhvqr gatwkaslhv cdgrpptsee lpscytgddw sgcplkefmd
      421 cpynlannrq vrmlsdltlv gcynlsvmpe kqrnkvlles aksnlkhmaf fgltefqrkt
      481 qylfektfnm nfispftqyn ttrassvein eeiqkriegl nfldmelysy akdlflqryq
      541 fmrqkehqea rrkrqeqrkf lkgrllqthf qsqgqgqsqn pnqnqsqnpn pnanqnltqn
      601 lmqnltqsls qkenrespkq nsgkeqndnt sngtndyigs vekwr
//
