LOCUS       NM_001009606            1236 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens heparan sulfate-glucosamine 3-sulfotransferase 6
            (HS3ST6), mRNA.
ACCESSION   NM_001009606
VERSION     NM_001009606.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1236)
  AUTHORS   Xu,D., Tiwari,V., Xia,G., Clement,C., Shukla,D. and Liu,J.
  TITLE     Characterization of heparan sulphate 3-O-sulphotransferase isoform
            6 and its role in assisting the entry of herpes simplex virus type
            1
  JOURNAL   Biochem J 385 (Pt 2), 451-459 (2005)
   PUBMED   15303968
REFERENCE   2  (bases 1 to 1236)
  AUTHORS   Chen,J., Duncan,M.B., Carrick,K., Pope,R.M. and Liu,J.
  TITLE     Biosynthesis of 3-O-sulfated heparan sulfate: unique substrate
            specificity of heparan sulfate 3-O-sulfotransferase isoform 5
  JOURNAL   Glycobiology 13 (11), 785-794 (2003)
   PUBMED   12907690
REFERENCE   3  (bases 1 to 1236)
  AUTHORS   Mochizuki,H., Yoshida,K., Gotoh,M., Sugioka,S., Kikuchi,N.,
            Kwon,Y.D., Tawada,A., Maeyama,K., Inaba,N., Hiruma,T., Kimata,K.
            and Narimatsu,H.
  TITLE     Characterization of a heparan sulfate 3-O-sulfotransferase-5, an
            enzyme synthesizing a tetrasulfated disaccharide
  JOURNAL   J Biol Chem 278 (29), 26780-26787 (2003)
   PUBMED   12740361
REFERENCE   4  (bases 1 to 1236)
  AUTHORS   Xia,G., Chen,J., Tiwari,V., Ju,W., Li,J.P., Malmstrom,A., Shukla,D.
            and Liu,J.
  TITLE     Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an
            antithrombin-binding site and an entry receptor for herpes simplex
            virus, type 1
  JOURNAL   J Biol Chem 277 (40), 37912-37919 (2002)
   PUBMED   12138164
  REMARK    GeneRIF: generates both an antithrombin-binding site and an entry
            receptor for herpes simplex virus, type 1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031723.56, DY654407.1 and CK300523.1.
            
            On May 23, 2019 this sequence version replaced NM_001009606.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on RNA-seq data and orthologous
            transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279850.3111.1, DY654407.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000454677.3/
                                                ENSP00000416741.3
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               AL031723.56        25493-25818         c
            327-626             DY654407.1         1-300               c
            627-1085            AL031723.56        19029-19487         c
            1086-1236           CK300523.1         26-176              c
FEATURES             Location/Qualifiers
     source          1..1236
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1236
                     /gene="HS3ST6"
                     /gene_synonym="3-OST-6; 3OST6; HAE8; HS3ST5"
                     /note="heparan sulfate-glucosamine 3-sulfotransferase 6"
                     /db_xref="GeneID:64711"
                     /db_xref="HGNC:HGNC:14178"
                     /db_xref="MIM:619210"
     exon            1..505
                     /gene="HS3ST6"
                     /gene_synonym="3-OST-6; 3OST6; HAE8; HS3ST5"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1121
                     /gene="HS3ST6"
                     /gene_synonym="3-OST-6; 3OST6; HAE8; HS3ST5"
                     /EC_number="2.8.2.23"
                     /note="heparan sulfate (glucosamine) 3-O-sulfotransferase
                     5; heparan sulphate D-glucosaminyl 3-O-sulfotransferase-3B
                     like; heparan sulfate D-glucosaminyl 3-O-sulfotransferase
                     6; heparan sulfate (glucosamine) 3-O-sulfotransferase 6"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     6"
                     /protein_id="NP_001009606.3"
                     /db_xref="CCDS:CCDS45381.2"
                     /db_xref="GeneID:64711"
                     /db_xref="HGNC:HGNC:14178"
                     /db_xref="MIM:619210"
                     /translation="MAGSGGLGGGAGGGQGAGAGQGAALRASRAPMLLVALVLGAYCL
                     CALPGRCPPAARAPAPAPAPSEPSSSVHRPGAPGLPLASGPGRRRFPQALIVGVKKGG
                     TRALLEFLRLHPDVRALGSEPHFFDRCYERGLAWYRSLMPRTLDGQITMEKTPSYFVT
                     REAPRRIHAMSPDTKLIVVVRNPVTRAISDYAQTLSKTPGLPSFRALAFRHGLGPVDT
                     AWSAVRIGLYAQHLDHWLRYFPLSHFLFVSGERLVSDPAGEVGRVQDFLGLKRVVTDK
                     HFYFNATKGFPCLKKAQGGSRPRCLGKSKGRPHPRVPQALVRRLQEFYRPFNRRFYQM
                     TGQDFGWG"
     exon            506..1236
                     /gene="HS3ST6"
                     /gene_synonym="3-OST-6; 3OST6; HAE8; HS3ST5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1218..1223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HS3ST6"
                     /gene_synonym="3-OST-6; 3OST6; HAE8; HS3ST5"
                     /note="hexamer: AATAAA"
     polyA_site      1236
                     /gene="HS3ST6"
                     /gene_synonym="3-OST-6; 3OST6; HAE8; HS3ST5"
                     /note="major polyA site"
ORIGIN      
        1 acaagccggg cacccacgga ctgagcggcg cgcgggccga gatgcgcgcc cgcctgctgc
       61 ccccgctccc gggcctggag cggcgcgacc ccatggcagg tagcggcggc ctgggcggcg
      121 gggccggggg cggccagggc gcaggggccg ggcaaggggc cgctctgcgg gcgtcccgcg
      181 cgccgatgct gctcgtggcc ctggtgctcg gcgcctactg cctctgcgcc ctccccggcc
      241 gctgcccgcc ggccgcccgc gcccccgcgc cggcccccgc gccctccgag ccgtccagct
      301 ccgtccaccg cccgggagca cccggcctgc ctttggccag cggtcccggc cgccggcgct
      361 tcccgcaagc gctcatcgtt ggcgtgaaga agggcggcac gcgcgccctg ctggagtttc
      421 tgcggctgca ccccgacgtc cgcgcgctgg gctctgagcc ccacttcttc gacaggtgct
      481 acgagcgcgg cctcgcctgg taccggagtc tgatgccccg aaccctggat gggcagatca
      541 ccatggagaa gacccccagc tacttcgtga cgcgagaggc cccccgccgc atccacgcca
      601 tgtccccgga cacgaagctg atcgtggtgg tgcggaaccc cgtgacccgg gccatctccg
      661 actacgccca gacgctctcc aagaccccgg gcctgcccag cttccgcgcc ctggccttcc
      721 gccacggcct gggccccgtg gacacagcct ggagcgccgt ccgcatcggc ctgtacgccc
      781 agcacctgga ccactggctg cgctacttcc ccctgtccca cttcctgttc gtcagcgggg
      841 agcgtctggt cagcgacccg gccggagagg tcggccgcgt gcaggacttc ctgggcctga
      901 aacgggtcgt cacggacaag cacttctact tcaacgccac caagggcttc ccctgcctca
      961 agaaggccca gggcggcagc cgtccccgct gcctgggcaa gtccaagggc cggccacacc
     1021 cacgcgtgcc ccaggccctg gtccggcgcc tgcaggagtt ctaccggccc ttcaaccgca
     1081 ggttctacca gatgacgggc caggacttcg gctggggctg agcggcaccc tggggatgct
     1141 cagcaccttg attgacaccc gctcgcctgg ccagagcggg ctgcgtgcac atgctgggca
     1201 gagaggaata tttaagaaat aaagcttgga cccaga
//
