LOCUS       NM_006040               3267 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens heparan sulfate-glucosamine 3-sulfotransferase 4
            (HS3ST4), mRNA.
ACCESSION   NM_006040 XM_056254
VERSION     NM_006040.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3267)
  AUTHORS   Ohka,S., Yamada,S., Nishizawa,D., Fukui,Y., Arita,H., Hanaoka,K.,
            Iseki,M., Kato,J., Ogawa,S., Hiranuma,A., Kasai,S., Hasegawa,J.,
            Hayashida,M., Fukushi,S., Saijo,M. and Ikeda,A.K.
  TITLE     Heparan sulfate 3-O-sulfotransferase 4 is genetically associated
            with herpes zoster and enhances varicella-zoster virus-mediated
            fusogenic activity
  JOURNAL   Mol Pain 17, 17448069211052171 (2021)
   PUBMED   34904858
  REMARK    GeneRIF: Heparan sulfate 3-O-sulfotransferase 4 is genetically
            associated with herpes zoster and enhances varicella-zoster
            virus-mediated fusogenic activity.
REFERENCE   2  (bases 1 to 3267)
  AUTHORS   Debette,S., Ibrahim Verbaas,C.A., Bressler,J., Schuur,M., Smith,A.,
            Bis,J.C., Davies,G., Wolf,C., Gudnason,V., Chibnik,L.B., Yang,Q.,
            deStefano,A.L., de Quervain,D.J., Srikanth,V., Lahti,J.,
            Grabe,H.J., Smith,J.A., Priebe,L., Yu,L., Karbalai,N., Hayward,C.,
            Wilson,J.F., Campbell,H., Petrovic,K., Fornage,M., Chauhan,G.,
            Yeo,R., Boxall,R., Becker,J., Stegle,O., Mather,K.A., Chouraki,V.,
            Sun,Q., Rose,L.M., Resnick,S., Oldmeadow,C., Kirin,M., Wright,A.F.,
            Jonsdottir,M.K., Au,R., Becker,A., Amin,N., Nalls,M.A.,
            Turner,S.T., Kardia,S.L., Oostra,B., Windham,G., Coker,L.H.,
            Zhao,W., Knopman,D.S., Heiss,G., Griswold,M.E., Gottesman,R.F.,
            Vitart,V., Hastie,N.D., Zgaga,L., Rudan,I., Polasek,O.,
            Holliday,E.G., Schofield,P., Choi,S.H., Tanaka,T., An,Y.,
            Perry,R.T., Kennedy,R.E., Sale,M.M., Wang,J., Wadley,V.G.,
            Liewald,D.C., Ridker,P.M., Gow,A.J., Pattie,A., Starr,J.M.,
            Porteous,D., Liu,X., Thomson,R., Armstrong,N.J., Eiriksdottir,G.,
            Assareh,A.A., Kochan,N.A., Widen,E., Palotie,A., Hsieh,Y.C.,
            Eriksson,J.G., Vogler,C., van Swieten,J.C., Shulman,J.M.,
            Beiser,A., Rotter,J., Schmidt,C.O., Hoffmann,W., Nothen,M.M.,
            Ferrucci,L., Attia,J., Uitterlinden,A.G., Amouyel,P.,
            Dartigues,J.F., Amieva,H., Raikkonen,K., Garcia,M., Wolf,P.A.,
            Hofman,A., Longstreth,W.T. Jr., Psaty,B.M., Boerwinkle,E.,
            DeJager,P.L., Sachdev,P.S., Schmidt,R., Breteler,M.M., Teumer,A.,
            Lopez,O.L., Cichon,S., Chasman,D.I., Grodstein,F.,
            Muller-Myhsok,B., Tzourio,C., Papassotiropoulos,A., Bennett,D.A.,
            Ikram,M.A., Deary,I.J., van Duijn,C.M., Launer,L.,
            Fitzpatrick,A.L., Seshadri,S. and Mosley,T.H. Jr.
  CONSRTM   Cohorts for Heart and Aging Research in Genomic Epidemiology
            Consortium
  TITLE     Genome-wide studies of verbal declarative memory in nondemented
            older people: the Cohorts for Heart and Aging Research in Genomic
            Epidemiology consortium
  JOURNAL   Biol Psychiatry 77 (8), 749-763 (2015)
   PUBMED   25648963
  REMARK    GeneRIF: This study provided that additional genome-wide
            associations, near HS3ST4 were identified and other putative
            modulators of memory performance were revealed by a pathway
            approach and hippocampal gene expression analyses.
REFERENCE   3  (bases 1 to 3267)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3267)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 3267)
  AUTHORS   Mochizuki,H., Yoshida,K., Shibata,Y. and Kimata,K.
  TITLE     Tetrasulfated disaccharide unit in heparan sulfate: enzymatic
            formation and tissue distribution
  JOURNAL   J Biol Chem 283 (45), 31237-31245 (2008)
   PUBMED   18757372
  REMARK    GeneRIF: The 3OST-2 and -4 are specifically expressed in brain.
REFERENCE   6  (bases 1 to 3267)
  AUTHORS   Lawrence,R., Yabe,T., Hajmohammadi,S., Rhodes,J., McNeely,M.,
            Liu,J., Lamperti,E.D., Toselli,P.A., Lech,M., Spear,P.G.,
            Rosenberg,R.D. and Shworak,N.W.
  TITLE     The principal neuronal gD-type 3-O-sulfotransferases and their
            products in central and peripheral nervous system tissues
  JOURNAL   Matrix Biol 26 (6), 442-455 (2007)
   PUBMED   17482450
  REMARK    GeneRIF: 3-OST-2 and 3-OST-4 are the major neural gD-type 3-OSTs,
            and so are prime candidates for participating in HS-dependent
            neurobiologic events.
REFERENCE   7  (bases 1 to 3267)
  AUTHORS   Tiwari,V., O'Donnell,C.D., Oh,M.J., Valyi-Nagy,T. and Shukla,D.
  TITLE     A role for 3-O-sulfotransferase isoform-4 in assisting HSV-1 entry
            and spread
  JOURNAL   Biochem Biophys Res Commun 338 (2), 930-937 (2005)
   PUBMED   16259945
REFERENCE   8  (bases 1 to 3267)
  AUTHORS   Liu,J., Shriver,Z., Pope,R.M., Thorp,S.C., Duncan,M.B.,
            Copeland,R.J., Raska,C.S., Yoshida,K., Eisenberg,R.J., Cohen,G.,
            Linhardt,R.J. and Sasisekharan,R.
  TITLE     Characterization of a heparan sulfate octasaccharide that binds to
            herpes simplex virus type 1 glycoprotein D
  JOURNAL   J Biol Chem 277 (36), 33456-33467 (2002)
   PUBMED   12080045
REFERENCE   9  (bases 1 to 3267)
  AUTHORS   Shworak,N.W., Liu,J., Petros,L.M., Zhang,L., Kobayashi,M.,
            Copeland,N.G., Jenkins,N.A. and Rosenberg,R.D.
  TITLE     Multiple isoforms of heparan sulfate D-glucosaminyl
            3-O-sulfotransferase. Isolation, characterization, and expression
            of human cdnas and identification of distinct genomic loci
  JOURNAL   J Biol Chem 274 (8), 5170-5184 (1999)
   PUBMED   9988767
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092141.4, AF105378.2 and
            AC093511.4.
            
            On Nov 22, 2018 this sequence version replaced NM_006040.2.
            
            Summary: This gene encodes the enzyme heparan sulfate
            D-glucosaminyl 3-O-sulfotransferase 4. This enzyme generates
            3-O-sulfated glucosaminyl residues in heparan sulfate. Cell surface
            heparan sulfate is used as a receptor by herpes simplex virus type
            1 (HSV-1), and expression of this gene is thought to play a role in
            HSV-1 pathogenesis. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834283.1, AF105378.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331351.6/ ENSP00000330606.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC092141.4         38084-38150
            68-187              AF105378.2         1-120
            188-907             AC092141.4         38271-38990
            908-1551            AF105378.2         838-1481
            1552-2390           AC093511.4         113348-114186       c
            2391-3267           AF105378.2         2322-3198
FEATURES             Location/Qualifiers
     source          1..3267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1"
     gene            1..3267
                     /gene="HS3ST4"
                     /gene_synonym="3-OST-4; 30ST4; 3OST4; h3-OST-4"
                     /note="heparan sulfate-glucosamine 3-sulfotransferase 4"
                     /db_xref="GeneID:9951"
                     /db_xref="HGNC:HGNC:5200"
                     /db_xref="MIM:604059"
     exon            1..1193
                     /gene="HS3ST4"
                     /gene_synonym="3-OST-4; 30ST4; 3OST4; h3-OST-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..1830
                     /gene="HS3ST4"
                     /gene_synonym="3-OST-4; 30ST4; 3OST4; h3-OST-4"
                     /EC_number="2.8.2.23"
                     /note="heparan sulfate 3-O-sulfotransferase 4; heparan
                     sulfate D-glucosaminyl 3-O-sulfotransferase 4; heparan
                     sulfate (glucosamine) 3-O-sulfotransferase 4"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     4"
                     /protein_id="NP_006031.2"
                     /db_xref="CCDS:CCDS53995.1"
                     /db_xref="GeneID:9951"
                     /db_xref="HGNC:HGNC:5200"
                     /db_xref="MIM:604059"
                     /translation="MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLS
                     VTYLCYSLLGGSGSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPP
                     LDNASHGEPPEPPEQPAAPGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPERE
                     AQESSTTDEDLAGRRAANGSSERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIR
                     VHPDVRAVGVEPHFFDRNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHS
                     MAKDIKLIVVVRNPVTRAISDYTQTLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIG
                     IYALHLENWLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTK
                     GFPCLKKPEDSSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQWE
                     QEEGDK"
     exon            1194..3267
                     /gene="HS3ST4"
                     /gene_synonym="3-OST-4; 30ST4; 3OST4; h3-OST-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3246..3251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HS3ST4"
                     /gene_synonym="3-OST-4; 30ST4; 3OST4; h3-OST-4"
                     /note="hexamer: TATAAA"
     polyA_site      3267
                     /gene="HS3ST4"
                     /gene_synonym="3-OST-4; 30ST4; 3OST4; h3-OST-4"
                     /note="major polyA site"
ORIGIN      
        1 ctcccctccg cgcctctcct ctctcccggc agaaagttag cagcggggaa ggaactccgg
       61 gctgcaacag cgcgcggcgg cggcggcaga ggctgaagca gaagccgcgg cggagccggg
      121 gaagcggggg cgctgcagac ggagcaggtg ccgccggcgg gtccgcgcgc ccccctcggt
      181 ccccttgcct gaggctgagg ggggggcggt ggtggggggg ccacccggac tcggcgggca
      241 gcgtggggcg gggggccatg cggccgggct cccccctggc gcagcgggac agcggccagg
      301 gccgggggcg cagcggcgtc gcttcatgca gccggggcgg ctgggcagcg gcggcggcgg
      361 cggcggcggc ggcggcggcg ggggcggcgg ctgaaaccat gtccgggcag cgccgggggc
      421 tgccgccgcc gccgccgccg ccgcgagccg ggagccgcga tggcccggtg gcccgcacct
      481 cctccgcctc cgcctccgcc tccacctctg gccgcgccgc cgccgcccgg cgcctctgct
      541 aaggggccgc cggcgcgcaa gctgcttttt atgtgcacct tgtccctgtc tgtcacctac
      601 ctgtgctaca gcctcctggg cggctcgggc tccctgcaat tccctctggc gctgcaggag
      661 tcgccgggcg ccgccgccga gcccccgccg agcccgccgc caccctctct gctgcctacc
      721 cccgtgcgcc tcggcgcccc ctcgcagccg cccgcgccgc cgccgctgga caacgcgagc
      781 cacggggagc cgcccgagcc cccagagcag ccagccgccc ccgggaccga cggctggggg
      841 ctgccgagcg gcggcggagg cgcccaggac gcctggctcc ggaccccgct ggcccccagc
      901 gagatgatca cggctcagag cgcgctgccg gagagggaag cgcaggagtc cagcaccacc
      961 gacgaggatc tcgcaggccg gagagcggcc aacgggagca gcgagagggg cggcgccgtc
     1021 agcacccccg actatgggga gaagaagctg ccacaggcgc tcatcatcgg ggtcaagaaa
     1081 ggagggaccc gcgcgctgct ggaggcgatc cgcgtgcacc cggacgtgcg ggcggtgggc
     1141 gtagagccgc acttcttcga caggaactac gaaaaggggt tggagtggta cagaaatgtg
     1201 atgcccaaga ctttggatgg gcaaataacc atggagaaga ctccaagtta ctttgtgaca
     1261 aatgaggctc ccaagcgcat tcactccatg gccaaggaca tcaaactgat tgtggtggtg
     1321 agaaaccccg tgaccagggc catctctgac tacacgcaga cactgtcaaa gaaacccgag
     1381 atccccacct ttgaggtgct ggccttcaaa aaccggaccc tcgggctgat cgatgcttcc
     1441 tggagtgcca ttcgaatagg gatctatgcg ctgcatctgg aaaactggct ccagtatttc
     1501 cccctctccc agatcctctt tgtcagtggt gagcgactca ttgtggaccc cgccggggaa
     1561 atggccaaag tacaggattt tctaggcctc aaacgtgttg tgactgagaa gcatttctat
     1621 ttcaacaaaa ccaaggggtt cccttgccta aagaagccag aagacagcag tgccccgagg
     1681 tgcttaggca agagcaaagg tcggactcat cctcgcattg acccagatgt catccacaga
     1741 ctgaggaaat tctacaaacc cttcaacttg atgttttacc aaatgactgg tcaagatttt
     1801 cagtgggaac aggaagaggg tgataaatga ggctagagag gcagaggaag gctagtcaat
     1861 aagctaagga ggctccttgc ctgagtcctt gaatacccca gcttctgcag cttcacttgc
     1921 tggagtgcca agtagatctc ctcctccttc atgcagccag gattgcctcc agtgctgtta
     1981 gcttaggcaa acaggtggat cccatggcat ccccatggag gaaccaggcc catctgggca
     2041 gcagcatctg gttgaccaga tggccaccag aacccactgt tcattcttat cttctgctag
     2101 ttaatatagc ctgaagacag aggataaata gttgtcaatg tcagagacag tgctattaat
     2161 gtatatgtga gcgacaaaaa aggtctgctt tataggggtt ctcactctag cttggggagc
     2221 cagggttcta gccctgtatc tgtcatgggc acctgctgtc taaacctctg cttgggcttc
     2281 tccccagaat gcactttgtg gctgagtgct ccaggactcc tagggagcaa ggtcctccct
     2341 ctaaggtgtt tctagtcttc tctttaaagg tctcatccca caacccctga cttcctccct
     2401 ccccacatca tgaaggcaga ggcatgcaca ttcctcactg aaaaagaaaa cacacaccca
     2461 cccacacaca cacacacaga agaaaatgaa agctgacaca cctcgaagcc ttctttccaa
     2521 gagccctcta aatggggttg ggtctcactc ttcatgagta tcctgggttg tgcagaagct
     2581 tagcatatgc ccttgtgttc ggatcaggcc cacagggctg ctcaaagagt agagtaattg
     2641 taaccgaggt cagagctctg gggttggcag agatgagtgg ccatatctgg gggtaaaaga
     2701 agaaatcctg tcctcttggt gggaggttac cttacctgaa gaccatctct cccaagcact
     2761 gtagttctga gcatgttttt ggggtggact ctgtccccta gggtccctag aagggcaaag
     2821 accagagagt tgacaagtct gttattagga ataatcctta gccatgtaat ggagaaagga
     2881 gcagtcagca ttcttccaat ttgccccacc accacctcct cgggcttcat tttctctatt
     2941 tagagatggc agagagtgag gtagtggcga gaaagctgac tccattcatc agatccagtt
     3001 tatgagggtt gggggtgagc aagggctgtc tgcagaaacc cccatcaaga gctgctgaat
     3061 gaagtgtccc ttcccatcag tttgattcaa ttaaaatgca tcatttgaca taaagcactt
     3121 gttcacagat ctccaaaacc aggaattgtt ctagtaaaac tggaaatttg tatgagtggg
     3181 gggagttaaa tctgttcagc tgttattaaa ctgtcatttc tcccgctaaa tgaaaaccgt
     3241 gttgttataa agcttaatgc aacctga
//
