LOCUS       NM_006041               5369 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens heparan sulfate-glucosamine 3-sulfotransferase 3B1
            (HS3ST3B1), transcript variant 1, mRNA.
ACCESSION   NM_006041
VERSION     NM_006041.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5369)
  AUTHORS   Nguyen,N.T., Vives,R.R., Torres,M., Delauzun,V., Saesen,E.,
            Roig-Zamboni,V., Lortat-Jacob,H., Rihet,P. and Bourne,Y.
  TITLE     Genetic and enzymatic characterization of 3-O-sulfotransferase SNPs
            associated with Plasmodium falciparum parasitaemia
  JOURNAL   Glycobiology 28 (7), 534-541 (2018)
   PUBMED   29718295
  REMARK    GeneRIF: The SNP rs28470223 results in decreased promoter activity
            of HS3ST3A1 and slightly higher HS3ST3A1 catalytic activity in
            vitro.
REFERENCE   2  (bases 1 to 5369)
  AUTHORS   Zhang,Z., Jiang,H., Wang,Y. and Shi,M.
  TITLE     Heparan sulfate D-glucosamine 3-O-sulfotransferase 3B1 is a novel
            regulator of transforming growth factor-beta-mediated
            epithelial-to-mesenchymal transition and regulated by miR-218 in
            nonsmall cell lung cancer
  JOURNAL   J Cancer Res Ther 14 (1), 24-29 (2018)
   PUBMED   29516954
  REMARK    GeneRIF: These findings indicate that HS3ST3B1 is a novel regulator
            of TGF-beta-mediated EMT and is regulated by miR-218 in NSCLC.
REFERENCE   3  (bases 1 to 5369)
  AUTHORS   Brusilovsky,M., Cordoba,M., Rosental,B., Hershkovitz,O.,
            Andrake,M.D., Pecherskaya,A., Einarson,M.B., Zhou,Y., Braiman,A.,
            Campbell,K.S. and Porgador,A.
  TITLE     Genome-wide siRNA screen reveals a new cellular partner of NK cell
            receptor KIR2DL4: heparan sulfate directly modulates
            KIR2DL4-mediated responses
  JOURNAL   J Immunol 191 (10), 5256-5267 (2013)
   PUBMED   24127555
  REMARK    GeneRIF: A genome-wide high-throughput siRNA screen revealed that
            KIR2DL4 recognition of cell-surface ligand(s) is directly regulated
            by heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1).
REFERENCE   4  (bases 1 to 5369)
  AUTHORS   Baldwin,J., Shukla,D. and Tiwari,V.
  TITLE     Members of 3-O-Sulfotransferases (3-OST) Family: A Valuable Tool
            from Zebrafish to Humans for Understanding Herpes Simplex Virus
            Entry
  JOURNAL   Open Virol J 7, 5-11 (2013)
   PUBMED   23358893
REFERENCE   5  (bases 1 to 5369)
  AUTHORS   Zhang,Z., Liu,X., Chen,J., Su,H., Luo,Q., Ye,J., Tang,N., Zhang,W.,
            Chen,W., Ko,B.C. and Huang,A.
  TITLE     Heparin sulphate D-glucosaminyl 3-O-sulfotransferase 3B1 plays a
            role in HBV replication
  JOURNAL   Virology 406 (2), 280-285 (2010)
   PUBMED   20705311
  REMARK    GeneRIF: HS3ST3B1 showed potent inhibitory effect on HBV
            replication.
REFERENCE   6  (bases 1 to 5369)
  AUTHORS   Moon,A.F., Edavettal,S.C., Krahn,J.M., Munoz,E.M., Negishi,M.,
            Linhardt,R.J., Liu,J. and Pedersen,L.C.
  TITLE     Structural analysis of the sulfotransferase (3-o-sulfotransferase
            isoform 3) involved in the biosynthesis of an entry receptor for
            herpes simplex virus 1
  JOURNAL   J Biol Chem 279 (43), 45185-45193 (2004)
   PUBMED   15304505
REFERENCE   7  (bases 1 to 5369)
  AUTHORS   Shukla,D., Liu,J., Blaiklock,P., Shworak,N.W., Bai,X., Esko,J.D.,
            Cohen,G.H., Eisenberg,R.J., Rosenberg,R.D. and Spear,P.G.
  TITLE     A novel role for 3-O-sulfated heparan sulfate in herpes simplex
            virus 1 entry
  JOURNAL   Cell 99 (1), 13-22 (1999)
   PUBMED   10520990
REFERENCE   8  (bases 1 to 5369)
  AUTHORS   Liu,J., Shworak,N.W., Sinay,P., Schwartz,J.J., Zhang,L.,
            Fritze,L.M. and Rosenberg,R.D.
  TITLE     Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase
            isoforms reveals novel substrate specificities
  JOURNAL   J Biol Chem 274 (8), 5185-5192 (1999)
   PUBMED   9988768
REFERENCE   9  (bases 1 to 5369)
  AUTHORS   Shworak,N.W., Liu,J., Petros,L.M., Zhang,L., Kobayashi,M.,
            Copeland,N.G., Jenkins,N.A. and Rosenberg,R.D.
  TITLE     Multiple isoforms of heparan sulfate D-glucosaminyl
            3-O-sulfotransferase. Isolation, characterization, and expression
            of human cdnas and identification of distinct genomic loci
  JOURNAL   J Biol Chem 274 (8), 5170-5184 (1999)
   PUBMED   9988767
REFERENCE   10 (bases 1 to 5369)
  AUTHORS   Razi,N. and Lindahl,U.
  TITLE     Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl
            3-O-sulfotransferase reaction: target and inhibitor saccharides
  JOURNAL   J Biol Chem 270 (19), 11267-11275 (1995)
   PUBMED   7744762
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA388077.1, AK023723.1,
            BC063301.1, AC005224.1 and BM968044.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006041.2.
            
            Summary: The protein encoded by this gene is a type II integral
            membrane protein that belongs to the 3-O-sulfotransferases family.
            These proteins catalyze the addition of sulfate groups at the 3-OH
            position of glucosamine in heparan sulfate. The substrate
            specificity of individual members of the family is based on prior
            modification of the heparan sulfate chain, thus allowing different
            members of the family to generate binding sites for different
            proteins on the same heparan sulfate chain. Following treatment
            with a histone deacetylase inhibitor, expression of this gene is
            activated in a pancreatic cell line. The increased expression
            results in promotion of the epithelial-mesenchymal transition. In
            addition, the modification catalyzed by this protein allows herpes
            simplex virus membrane fusion and penetration. A very closely
            related homolog with an almost identical sulfotransferase domain
            maps less than 1 Mb away. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. It encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063301.1, AF105377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360954.3/ ENSP00000354213.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA388077.1         32-33
            3-52                AK023723.1         1-50
            53-2226             BC063301.1         1-2174
            2227-2235           AC005224.1         2066-2074           c
            2236-2547           BC063301.1         2177-2488
            2548-2548           AC005224.1         1753-1753           c
            2549-2800           BC063301.1         2490-2741
            2801-2801           AC005224.1         1500-1500           c
            2802-4120           BC063301.1         2743-4061
            4121-4124           AC005224.1         177-180             c
            4125-5367           BC063301.1         4064-5306
            5368-5369           BM968044.1         17-18               c
FEATURES             Location/Qualifiers
     source          1..5369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..5369
                     /gene="HS3ST3B1"
                     /gene_synonym="3-OST-3B; 3OST3B1; h3-OST-3B"
                     /note="heparan sulfate-glucosamine 3-sulfotransferase 3B1"
                     /db_xref="GeneID:9953"
                     /db_xref="HGNC:HGNC:5198"
                     /db_xref="MIM:604058"
     exon            1..992
                     /gene="HS3ST3B1"
                     /gene_synonym="3-OST-3B; 3OST3B1; h3-OST-3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..1611
                     /gene="HS3ST3B1"
                     /gene_synonym="3-OST-3B; 3OST3B1; h3-OST-3B"
                     /EC_number="2.8.2.30"
                     /note="heparan sulfate 3-O-sulfotransferase 3B1; heparan
                     sulfate D-glucosaminyl 3-O-sulfotransferase 3B1; heparan
                     sulfate (glucosamine) 3-O-sulfotransferase 3B1"
                     /codon_start=1
                     /product="heparan sulfate glucosamine 3-O-sulfotransferase
                     3B1"
                     /protein_id="NP_006032.1"
                     /db_xref="CCDS:CCDS11167.1"
                     /db_xref="GeneID:9953"
                     /db_xref="HGNC:HGNC:5198"
                     /db_xref="MIM:604058"
                     /translation="MGQRLSGGRSCLDVPGRLLPQPPPPPPPVRRKLALLFAMLCVWL
                     YMFLYSCAGSCAAAPGLLLLGSGSRAAHDPPALATAPDGTPPRLPFRAPPATPLASGK
                     EMAEGAASPEEQSPEVPDSPSPISSFFSGSGSKQLPQAIIIGVKKGGTRALLEFLRVH
                     PDVRAVGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMS
                     KDTKLIVVVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIY
                     AKHLEHWLRHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGF
                     PCLKKAEGSSRPHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWD"
     exon            993..5369
                     /gene="HS3ST3B1"
                     /gene_synonym="3-OST-3B; 3OST3B1; h3-OST-3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5350..5355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HS3ST3B1"
                     /gene_synonym="3-OST-3B; 3OST3B1; h3-OST-3B"
                     /note="hexamer: AATAAA"
     polyA_site      5369
                     /gene="HS3ST3B1"
                     /gene_synonym="3-OST-3B; 3OST3B1; h3-OST-3B"
                     /note="major polyA site"
ORIGIN      
        1 gcagttcgcc tctgcagcct ctgcggggaa gtgccggggc tgctcgaggc tcagttctta
       61 ggactgcaag gaggcagccc cggcgtgcgg cggtgcgcac agtctagagt ggccagggcg
      121 cgagagtgca acgtcctcct ggccccgagc gcgtcgtcgc gccccgggag cagaccctcg
      181 cccagcagtt accgccgtcc cgactttccg ttccagttgc agctcctgcc gggcaacatg
      241 tcaagagccg ccgccgctac agctgccgcc gccacctggg gaagagcagc agcagcagcg
      301 gcggccgcgg gcacacgggg gcaataaacc gagccacccg ggcgtccagc gtgccgggga
      361 accctctctg cgctcactgc ccggcgggac ccacgccatg tgctgagcca tgtccctggc
      421 cgcgcccgcg ggcagcgcat ggggcagcgc ctgagtggcg gcagatcttg cctcgatgtc
      481 cccggccggc tcctaccgca gccgccgccg cccccgccgc cggtgaggag gaagctcgcg
      541 ctgctcttcg ccatgctctg cgtctggctc tatatgttcc tgtactcgtg cgccggctcc
      601 tgcgccgccg cgccggggct gctgctcctg ggctctgggt cccgcgccgc acacgacccg
      661 ccagccctgg ccacagctcc ggacgggacg ccccccaggc tgccgttccg ggcgccgcca
      721 gccaccccac tggcttcagg caaggagatg gccgagggcg ctgcgagccc ggaggagcag
      781 agtcccgagg tgccggactc cccaagcccc atctccagct ttttcagtgg gtctgggagc
      841 aagcagctgc cgcaggccat catcatcggc gtgaagaagg gcggcacgcg ggcgctgctg
      901 gagtttctgc gcgtgcaccc cgacgtgcgc gccgtgggcg ccgagcccca tttcttcgat
      961 cgcagctacg acaagggcct cgcttggtac cgggacctga tgcccagaac cctggacggg
     1021 cagatcacca tggagaagac gcccagttac ttcgtcacgc gggaggcccc tgcgcgcatc
     1081 tcggccatgt ccaaggacac caagctcatc gtggtggtgc gggacccggt gaccagggcc
     1141 atctcggact acacgcagac gctgtccaag cggcccgaca tccccacctt cgagagcttg
     1201 acgttcaaaa acaggacagc gggcctcatc gacacgtcgt ggagcgccat ccagatcggc
     1261 atctacgcca agcacctgga gcactggctg cgccacttcc ccatccgcca gatgctcttc
     1321 gtgagcggcg agcggctcat cagcgacccg gccggggagc tgggccgcgt gcaagacttc
     1381 ctgggcctca agaggatcat cacggacaag cacttctact tcaacaagac caagggcttc
     1441 ccctgcctga agaaggcgga gggcagcagc cggccccatt gcctgggcaa gaccaagggc
     1501 aggacccatc ctgagatcga ccgcgaggtg gtgcgcaggc tgcgcgagtt ctaccggcct
     1561 ttcaacctca agttctacca gatgaccggg cacgactttg gctgggattg agcagacccg
     1621 ggctatgtac cttacccacg tggcttatct attgacagag attatatgta tgtaaaatgt
     1681 acagaaatct attttataat aatttatttt taattcataa gcaattaatt cactaagctg
     1741 cctagccaca ctctttagag agttagcttc ataatctgtt aacattccaa agtgtttaac
     1801 tctagtattt cgttctcttc ttcacaattg atggtgcttc tattttttct tctcccctac
     1861 ctgttatatt taaaacaaag aaaagcacaa cttgagattt ttgttgttac gggtattcag
     1921 ccttcagtca ccgtctgagt tctccagttg ctgcctcctt gtcttgtctt gggtctccca
     1981 ttccagcttc cctgtctctt cctgcctgtg tacctcgtag gaacgctgag ctgcctcaac
     2041 agggctgtat tctgaagggc aggcctcatg cagcagcctc cttgcagatg tggtgtcccg
     2101 tccaatgatg tagcctgaaa gccacagccc tagggttctg tccctccctc cattcagcac
     2161 atggggaaat ttctcactcc ctttacaggg acatccacat cctttttttt tctttttttt
     2221 tttttttttt ttttgagatg gagtcttgct cttgttgccc aggctggggc gtaatggtgt
     2281 gatatatgct taccacaacc tctggctccc ggttcaagcg attctcctgt ctcagcctcc
     2341 caagtatctg ggattacagg catgcaccac catgcctggc taattttgta tttttagtag
     2401 agacggggtt tcttcatgtt ggtcaggctg gtatcaaact cccgacctca ggtgatccgc
     2461 ctgccttggc ctccaaagtg ttgggattat aggcgtgagc cactgcgccc gctatccaca
     2521 tccttctaga gtcagaatgg tagggtctgt tgacttcagc ttttgatttt gcaggatggc
     2581 cctgtgtcct cctctgcccc attccctggt tcattaacca gtttgaagtg tatgtagatt
     2641 gttgccccgt ctttcccagg tcacatgtgt gagatgcctg ggtgctgctt cagaaatcaa
     2701 gatgatctcc tttaatttgc atgaaactac accatgctgc gttccccagg cagacagttc
     2761 tgctttgaca caccaaagaa tcccgtaggc tagcagagcc accagcacaa accaagggcg
     2821 ctgggtgtcg agactcagag gggtcagctg tgtccctcgg catcagcgtc taccaaggtg
     2881 ctgctaggta cagagccagc cagtgttggg cagcaggctc acagcctcaa tagggagaaa
     2941 agacaaaggc ctcaaaatga caggcagcct gacagaggaa ggagtctgac acctcagctt
     3001 gatgcgtctt tggaattcct agctcatctc agaattatat cttagagtga taatatgggt
     3061 ggtagccagt ggccaaacag caagaactaa gagtggccct tgcaaaaaaa ggttgggaaa
     3121 gctgggccca tattgcctgt aaacccttga gcctgatgct catacagctg tcccttgttt
     3181 tagccaggtc ttgacagaag ggttaccagc actgtcactg ctctacagaa tgctctcccc
     3241 gtgcctctct gttgatttat aacagttggg taaccagata gcaatatagt ggcaattgag
     3301 tagccatata gtaatacagg ggcagttggt taaacatata gcaatatcac ataatgatat
     3361 gtttaattta acctcagttt tttaaaccag aatgcttcta ccataaaaga attgtgattt
     3421 cagttatact tccatcaagg aatatgtggg aagatataca tattgtcaaa atggttggga
     3481 tgggatagtt acaaaggaca cttttgtatg ttgtatggga tcacttgcct gatagtataa
     3541 ggaacattgt atgaaaagat gaaaagatac ttcattttta gaaactgatc agagatgtca
     3601 ctggtcttta agtgatgtct tgaaaatcca gtatgtattt gcccaaaagt tttagcctac
     3661 atctagctag cttacactta gcagccaaac catcattgtg taggttctgt tttggaggaa
     3721 gctcatgggg gatctgtgta tttcttaggt ttctccctgt tctccaatgt tttatccatt
     3781 tcgtagcttt tttactgtct ccagaaagta gtgtgggacc tgcacttagg ggaataccag
     3841 aatcatagcg tggttctgcc ttcttgatga gtgattgtga aaaacacctg cataagggtg
     3901 ctaattggtt gtgtattttt tcatttattt gaaatcaaac tgagaacacc tcttttcggt
     3961 ttacagcata acatggcttg aagtaaaagg cagtatccaa gtccttcacc tggtcttgcc
     4021 ctgtctactt tctgatcatt ctgatggtct gatgtggctg ttgatgtgga actgcagaag
     4081 agttcagaga agagtatgca acaaagccat aggaaaacac acaggagctt ttccctcccc
     4141 ttcaggtccc cgccctcttt ccaagctgga caatttttta ttaagttgtt tattccctgc
     4201 cttaaaactg aaacaggaaa ttttctggta gaaggagggt catttagtca cgaacactga
     4261 agtgggtcaa aattctattc tgggtcaaat ccttgaattc aaacagatgt ccataatcag
     4321 tactgatgga atagagcaag tttttctatg taagacaaat aaatcaaaca tcatgtgcat
     4381 ctcctcataa gggtctgcaa gggtctgatg gtttaaagtt cctaacagat ctggttgcag
     4441 catctgccgg agcttgcacc ccatcatcgg acggtcatct tcctgctgca gaagttaggt
     4501 aacataagac ttagatttct tcctgttcta gcaatctgca agaccaccag gcttaacttt
     4561 ttagctgcca gaagacaaac ccccttttct gtttcggcaa tttgtcctgg cacgtgtttt
     4621 ggacttcctc cgatttacac gaaaagctct gatattcatt ggagtacttt attttttttc
     4681 ctcagttttg tttcttttct catgtaaaaa caaacaaaaa ggtcaacaaa aaaaaattga
     4741 ggtttttctt gtttctatct agttcatgct ttctttgcgg tgtttgaaca gtagtctgtt
     4801 aacttagtag gtggtacctg gaaaggtatt ttaagtatag tgactgttta ataaatactt
     4861 aattggatga tggaggagga gaaattgttt tcttcccagg attctctttg ggggtcattt
     4921 tgtgtgacag atatatttta gacatttgga gaaacagttt cagatcctgc caggatattt
     4981 ttgtaaaaaa ggaaaatgga agattccaat aaactagaaa cagtacgtat ctaagatgct
     5041 gacacagaag ctaatgtgac ttttcagctt atcaagagga tggccaataa aacttaaagg
     5101 tgtggttaga tgttttctca cttttgtgac attaatttat cactgagtct cattcaacca
     5161 agtaatctaa aatactgtgc aaattctagc agtatgtctt cgataacttg gatgttagga
     5221 tagccaatat gtacaaaaaa ttaaatcaag tattttgtcc tatgtataac acaaattaat
     5281 tttacacaga gaaagatgtt tctaggcaag tgaaattctg gtaattcata ctatttcttt
     5341 gtatgaacaa ataaaatata ttttgccaa
//
